DE3851856D1 - 1,4-Dihydropyridin-Derivate und diese enthaltende pharmazeutische Zusammensetzungen. - Google Patents

1,4-Dihydropyridin-Derivate und diese enthaltende pharmazeutische Zusammensetzungen.

Info

Publication number
DE3851856D1
DE3851856D1 DE3851856T DE3851856T DE3851856D1 DE 3851856 D1 DE3851856 D1 DE 3851856D1 DE 3851856 T DE3851856 T DE 3851856T DE 3851856 T DE3851856 T DE 3851856T DE 3851856 D1 DE3851856 D1 DE 3851856D1
Authority
DE
Germany
Prior art keywords
vasodilatation
alkyl
pharmaceutical compositions
compositions containing
dihydropyridine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3851856T
Other languages
English (en)
Other versions
DE3851856T2 (de
Inventor
Hiroshi Matsui
Fumio Mutsumi-Ryo Fukata
Takayoshi Mori
Nobuharu Kakeya
Kazuhiko Kitao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Pharmaceutical Industries Ltd
Original Assignee
Kyoto Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharmaceutical Industries Ltd filed Critical Kyoto Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of DE3851856D1 publication Critical patent/DE3851856D1/de
Publication of DE3851856T2 publication Critical patent/DE3851856T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
DE3851856T 1987-03-12 1988-03-10 1,4-Dihydropyridin-Derivate und diese enthaltende pharmazeutische Zusammensetzungen. Expired - Lifetime DE3851856T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62057717A JPH0688973B2 (ja) 1987-03-12 1987-03-12 １，４−ジヒドロピリジン誘導体

Publications (2)

Publication Number Publication Date
DE3851856D1 true DE3851856D1 (de) 1994-11-24
DE3851856T2 DE3851856T2 (de) 1995-03-16

Family

ID=13063696

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3851856T Expired - Lifetime DE3851856T2 (de) 1987-03-12 1988-03-10 1,4-Dihydropyridin-Derivate und diese enthaltende pharmazeutische Zusammensetzungen.

Country Status (10)

Country Link
US (1) US4937242A (de)
EP (1) EP0289746B1 (de)
JP (1) JPH0688973B2 (de)
KR (1) KR960009427B1 (de)
AT (1) ATE113035T1 (de)
AU (1) AU610130B2 (de)
CA (1) CA1337764C (de)
DE (1) DE3851856T2 (de)
DK (1) DK174867B1 (de)
ES (1) ES2061534T3 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137889A (en) * 1983-12-02 1992-08-11 Otsuka Pharmaceutical Co., Ltd. Dihydropyridine derivatives and process for preparing the same
US5166148A (en) * 1990-07-09 1992-11-24 The Du Pont Merck Pharmaceutical Company 2-amino-1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
US5767131A (en) * 1993-04-05 1998-06-16 Synaptic Pharmaceutical Corporation Dihydropyridines and new uses thereof
IL109220A0 (en) * 1993-04-05 1994-07-31 Synaptic Pharma Corp Dihydropyridines and new uses thereof
US6211198B1 (en) 1993-04-05 2001-04-03 Synaptic Pharmaceutical Corporation Dihydropyridines and new uses thereof
AU8142794A (en) * 1993-11-17 1995-06-06 Byk Nederland Bv Use of substituted 1,4-dihydropyridine to reduce intraocular pressure
ES2317650T3 (es) * 1996-10-28 2009-04-16 Senju Pharmaceutical Co., Ltd. Farmacos para mejorar trastornos circulatorios oculares.
ATE290910T1 (de) * 1998-07-16 2005-04-15 Univ Pennsylvania Verwendung von a3-adenosine antagonisten zur herstellung eines arzneimittels zur senkung des augeninnendrucks
CA2360689A1 (en) 1999-01-29 2000-08-03 Senju Pharmaceutical Co., Ltd. Anti-inflammatory agents and inhibitors against increase in ocular tension caused by irradiation with lasers, containing 1,4-dihydropyridine derivatives
DE60014629T2 (de) * 1999-04-14 2006-02-23 Senju Pharmaceutical Co., Ltd. 1,4-dihydropyridinderivate als Inhibitoren einer Sehunterfunktion, hervorgerufen durch eine Sehnervzellenverletzung, die durch andere Faktoren als optischen Durchblutungstörungen induziert wird.
US6566359B1 (en) 2002-05-20 2003-05-20 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College 2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs
KR101419213B1 (ko) * 2013-05-22 2014-07-14 인하대학교 산학협력단 메틸 5-시아노-6-｛[2-(4-메톡시페닐)-2-옥소에틸]술파닐｝-2-메틸-4-(2-티에닐)-1,4-디하이드로-3-피리딘카르복실레이트 화합물을 유효성분으로 함유하는 피부 미백용 조성물 및 이의 용도

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2005116C3 (de) * 1970-02-05 1980-02-14 Bayer Ag, 5090 Leverkusen Symmetrische 1,4-Dihydropyridin-3,5-dicarbonsäureester
US3950336A (en) * 1972-03-06 1976-04-13 Bayer Aktiengesellschaft 2,6-diamino-1,4-dihydropyridine derivatives
US3951993A (en) * 1972-03-06 1976-04-20 Bayer Aktiengesellschaft 2-Amino-4,5-dihydropyridine derivatives and process for their preparation
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
US3959296A (en) * 1972-06-10 1976-05-25 Bayer Aktiengesellschaft 1,4-Dihydropyridines
US3951991A (en) * 1972-08-31 1976-04-20 Bayer Aktiengesellschaft 4-Aryl-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DE3124673A1 (de) * 1981-06-24 1983-01-13 Bayer Ag, 5090 Leverkusen Subsituierte 2-amino-pyridinderivate, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln, sowie deren herstellung
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
HU192166B (en) * 1982-08-06 1987-05-28 Banyu Pharma Co Ltd Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
AU561213B2 (en) * 1983-06-02 1987-04-30 Teijin Limited 1, 4-dihydropyridine derivative
US4603135A (en) * 1983-10-17 1986-07-29 Takeda Chemical Industries, Ltd. Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates
GB8401288D0 (en) * 1984-01-18 1984-02-22 Pfizer Ltd Therapeutic agents
JPS6157556A (ja) * 1984-08-29 1986-03-24 Teijin Ltd １，４−ジヒドロピリジン誘導体その製造法およびそれを有効成分とする薬剤
JPS61137861A (ja) * 1984-10-26 1986-06-25 バイエル・アクチエンゲゼルシヤフト １，４−ジヒドロピリジン−ヒドロキシアミン類
DE3514865A1 (de) * 1985-04-25 1986-11-06 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridin-derivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
EP0289746A3 (en) 1989-09-20
EP0289746A2 (de) 1988-11-09
DK129688A (da) 1988-09-13
KR890002102A (ko) 1989-04-08
DK129688D0 (da) 1988-03-10
EP0289746B1 (de) 1994-10-19
ATE113035T1 (de) 1994-11-15
JPS63225355A (ja) 1988-09-20
US4937242A (en) 1990-06-26
DK174867B1 (da) 2004-01-05
KR960009427B1 (ko) 1996-07-19
AU610130B2 (en) 1991-05-16
CA1337764C (en) 1995-12-19
AU1251988A (en) 1988-09-15
DE3851856T2 (de) 1995-03-16
ES2061534T3 (es) 1994-12-16
JPH0688973B2 (ja) 1994-11-09

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Legal Events

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8364 No opposition during term of opposition