DE3851225T2 - Blutersatz. - Google Patents

Blutersatz.

Info

Publication number
DE3851225T2
DE3851225T2 DE3851225T DE3851225T DE3851225T2 DE 3851225 T2 DE3851225 T2 DE 3851225T2 DE 3851225 T DE3851225 T DE 3851225T DE 3851225 T DE3851225 T DE 3851225T DE 3851225 T2 DE3851225 T2 DE 3851225T2
Authority
DE
Germany
Prior art keywords
mutant
hemoglobins
solutions
blood substitutes
hemoglobin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE3851225T
Other languages
English (en)
Other versions
DE3851225D1 (de
Inventor
Stephen Hoffman
Kiyoshi Nagai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Biotech Technology SARL
Original Assignee
Medical Research Council
Somatogenetics International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10617467&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3851225(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medical Research Council, Somatogenetics International Inc filed Critical Medical Research Council
Publication of DE3851225D1 publication Critical patent/DE3851225D1/de
Application granted granted Critical
Publication of DE3851225T2 publication Critical patent/DE3851225T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE3851225T 1987-05-16 1988-05-13 Blutersatz. Revoked DE3851225T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878711614A GB8711614D0 (en) 1987-05-16 1987-05-16 Proteins
PCT/US1988/001534 WO1988009179A1 (en) 1987-05-16 1988-05-13 Blood substitutes

Publications (2)

Publication Number Publication Date
DE3851225D1 DE3851225D1 (de) 1994-09-29
DE3851225T2 true DE3851225T2 (de) 1995-04-06

Family

ID=10617467

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3851225T Revoked DE3851225T2 (de) 1987-05-16 1988-05-13 Blutersatz.

Country Status (11)

Country Link
US (1) US5028588A (de)
EP (1) EP0358708B1 (de)
JP (1) JP3034529B2 (de)
AT (1) ATE110276T1 (de)
AU (1) AU614525B2 (de)
CA (1) CA1341286C (de)
DE (1) DE3851225T2 (de)
GB (2) GB8711614D0 (de)
HU (1) HU211989A9 (de)
SG (1) SG26593G (de)
WO (1) WO1988009179A1 (de)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
US6022849A (en) * 1987-05-16 2000-02-08 Baxter Biotech Technology Saarl Mutant recombinant hemoglobins containing heme pocket mutations
US6204009B1 (en) 1988-05-16 2001-03-20 BAXTER BIOTECH TECHNOLOGY SàRL Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
US6150506A (en) * 1989-05-10 2000-11-21 Baxter Biotech Technology Sarl Modified hemoglobin-like compounds and methods of purifying same
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5844090A (en) * 1994-05-09 1998-12-01 Somatogen, Inc. Modified hemoglobin-like compounds
ES2093640T3 (es) 1989-05-10 1997-01-01 Somatogen Inc Produccion de hemoglobina y sus analogos mediante bacterias y levadura.
US6828125B1 (en) * 1989-05-10 2004-12-07 Baxter Biotech Technology, S.A.R.L. DNA encoding fused di-alpha globins and use thereof
US5599907A (en) 1989-05-10 1997-02-04 Somatogen, Inc. Production and use of multimeric hemoglobins
US5173426A (en) * 1989-10-06 1992-12-22 Yale University DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin
CA2025180A1 (en) * 1989-10-12 1991-04-13 William G. Weisburg Nucleic acid probes and methods for detecting pathogenic candida yeasts
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
JPH07504645A (ja) * 1990-04-16 1995-05-25 アペックス　バイオサイエンス　インコーポレーテッド 酵母での組換えヘモグロビンの発現
US5622848A (en) * 1990-05-23 1997-04-22 Medical Discoveries, Inc. Electrically hydrolyzed salines as microbiocides for in vitro treatment of contaminated fluids containing blood
US5334383A (en) * 1990-05-23 1994-08-02 Medical Discoveries, Inc. Electrically hydrolyzed salines as in vivo microbicides for treatment of cardiomyopathy and multiple sclerosis
US5239061A (en) * 1990-06-20 1993-08-24 Research Corporation Technologies, Inc. Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin
US5584804A (en) * 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
DE69132763D1 (de) * 1990-12-20 2001-11-15 Univ Alabama Res Foundation Bi Transgenes, vernetztes hämoglobin
US5610137A (en) * 1990-12-20 1997-03-11 The Uab Research Foundation Transgenic, cross-linked hemoglobin
JPH06508035A (ja) * 1991-06-14 1994-09-14 ディーエヌエックス　コーポレーション トランスジェニックブタにおけるヒトヘモグロビンの生産
US5922854A (en) * 1991-06-14 1999-07-13 Kumar; Ramesh Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids
WO1993008831A1 (en) * 1991-10-30 1993-05-13 Strohtech, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
AU665599B2 (en) * 1991-11-08 1996-01-11 Hemosol Inc. Hemoglobins as drug delivery agents
US5980954A (en) 1992-02-07 1999-11-09 Vasogen Ireland Limited Treatment of autoimmune diseases
US6669965B2 (en) 1992-02-07 2003-12-30 Vasogen Ireland Limited Method of treating atherosclerosis
GB9617611D0 (en) * 1996-08-22 1996-10-02 Vasogen Inc Treatment of autoimmune disease
US5591457A (en) * 1992-02-07 1997-01-07 Vasogen Inc Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human
FR2688784B1 (fr) * 1992-03-18 1995-06-30 Pasteur Merieux Serums Vacc Transporteur d'oxygene.
WO1993025071A1 (en) * 1992-06-12 1993-12-23 Dnx Corporation Production of human hemoglobin in transgenic pigs
US6610654B2 (en) * 1993-03-31 2003-08-26 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
WO1994022915A1 (en) 1993-03-31 1994-10-13 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
US5554638A (en) * 1993-05-24 1996-09-10 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5612310A (en) * 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
IS4198A (is) * 1993-08-13 1995-02-14 Somatogen, Inc Meðferð vegna aukaverkana sem tengjast gjöf á utanfrumublóðrauða
US5665869A (en) * 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US6242417B1 (en) * 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US5507932A (en) * 1994-08-26 1996-04-16 Schlumberger Technology Corporation Apparatus for electrolyzing fluids
US6117285A (en) * 1994-08-26 2000-09-12 Medical Discoveries, Inc. System for carrying out sterilization of equipment
JPH11501829A (ja) * 1995-01-13 1999-02-16 ソマトジェン，インコーポレイテッド 自家血液供与を容易にし、そして酸素負債を処置するための方法
US5962651A (en) * 1995-01-27 1999-10-05 Montefiore Medical Center Modified hemoglobin and its use as a component of an artificial blood substitute
US5843888A (en) * 1995-05-01 1998-12-01 Carnegie Mellon University Low oxygen affinity mutant hemoglobin
US5770404A (en) * 1995-06-14 1998-06-23 Camiener; Gerald W. Preparation of hemoproteins from apoproteins and heme-like porphyrins derived from chlorophyll
US6114505A (en) * 1995-10-23 2000-09-05 William Marsh Rice University Hemoglobin mutants that reduce heme loss
US6812207B1 (en) 1995-10-23 2004-11-02 William Marsh Rice University Hemoglobin mutants that reduce heme loss
JP2000502058A (ja) * 1995-11-30 2000-02-22 ソマトジェン，インコーポレイテッド ヘモグロビン架橋の際の機能性制御のための方法
US6218513B1 (en) 1995-12-22 2001-04-17 Baxter Biotech Technology Sarl Globins containing binding domains
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
AU4652797A (en) 1996-09-27 1998-04-17 Board Of Trustees Of The University Of Illinois, The Oxygen-binding heme proteins incorporating circularly-permuted globins
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6054427A (en) * 1997-02-28 2000-04-25 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
EP1950298A3 (de) 1997-05-02 2008-12-24 Baxter Biotech Technology S.A.R.L. Hämoglobinmutanten mit erhöhtem Löslichkeitswert und/oder reduzierter Stickoxidspülung
JP4512673B2 (ja) * 1997-05-02 2010-07-28 バクスター バイオテク テクノロジー エス． アー． アール． エル． 増大した可溶性発現および／または低下した一酸化窒素の排出を伴うヘモグロビン変異体
US5900402A (en) * 1997-05-29 1999-05-04 Enzon, Inc. Method of reducing side effects associated with administration of oxygen-carrying proteins
US6485450B1 (en) 1998-03-16 2002-11-26 Life Science Holdings, Inc. Brain resuscitation apparatus and method
US6977140B1 (en) 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
US6673594B1 (en) 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US6780892B1 (en) 1998-10-01 2004-08-24 Temple University—Of the Commonwealth System of Higher Education Polymeric hemoglobin mutants
EP1210944A4 (de) * 1999-08-12 2003-01-02 Alexandr Vilenovich Asafov Lösung zur ersetzung des blutplasma
US6894150B1 (en) 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
EP2292657A1 (de) 1999-11-12 2011-03-09 Baxter Biotech Technology S.A.R.L. Hämoglobinzusammensetzungen mit verringerten Nebenwirkungen
US7449544B2 (en) * 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
US6486123B1 (en) 2000-06-21 2002-11-26 Carnegie Mellon University Low oxygen affinity mutant hemoglobins
EP1469811A4 (de) * 2002-01-11 2006-01-04 Sangart Inc Verfahren und zusammensetzungen für den sauerstofftransport mit modifiziertem hämoglobin in plasma
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
EP1894573A3 (de) 2002-01-11 2013-06-12 Sangart, Inc. Verfahren und Zusammensetzungen für den Sauerstofftransport mit hoher Sauerstoffaffinität
US20050119161A1 (en) * 2002-01-11 2005-06-02 Winslow Robert M. Methods and compositions for oxygen transport comprising an oxygen carrier and a crystalloid in hypertonic solution
US20030153491A1 (en) 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050287125A1 (en) * 2002-05-22 2005-12-29 Medtronic, Inc. Cell delivery fluid for prevention of cell settling in delivery system
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
CN100431602C (zh) * 2003-01-29 2008-11-12 北原实验室有限公司 具有低量四聚体的聚合血红蛋白溶液及制备方法
JP2004269386A (ja) * 2003-03-06 2004-09-30 Tokyoto Koreisha Kenkyu Fukushi Shinko Zaidan 組織低酸素状態の改善剤
CA2521427C (en) * 2003-04-04 2012-11-20 Organ Recovery Systems, Inc. Device for separating gas from a liquid path
US7691622B2 (en) * 2003-04-04 2010-04-06 Lifeline Scientific, Inc. Method and apparatus for transferring heat to or from an organ or tissue container
WO2005041898A2 (en) * 2003-10-30 2005-05-12 Temple University Of The Commonwealth System Of Higher Education Blood substitutes
MX2007002187A (es) * 2004-08-31 2007-10-08 Sangart Inc Metodos para mejorar la estabilidad hemodinamica utilizando composiciones que contienen oxigeno.
US7642233B2 (en) * 2004-09-15 2010-01-05 William Marsh Rice University Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein
US20070166792A1 (en) * 2004-09-15 2007-07-19 Olson John S Increasing hemoglobin and other heme protein production in bacteria by co-expression of heme transport genes
WO2006031993A2 (en) * 2004-09-15 2006-03-23 William Marsh Rice University Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
WO2008021577A2 (en) 2006-01-24 2008-02-21 The Board Of Trustees Of The University Of Illinois Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US7759306B2 (en) * 2006-05-16 2010-07-20 Simoni Jan S Methods of treating acute blood loss
US7494974B2 (en) * 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) * 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
GB0712683D0 (en) * 2007-06-29 2007-08-08 Wivenhoe Technology Ltd Improvements relating to oxygen-carrying proteins(1)
GB0712685D0 (en) 2007-06-29 2007-08-08 Wivenhoe Technology Ltd Improvements relating to oxygen-carrying proteins (2)
US9845457B2 (en) * 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
EP2882445B1 (de) 2012-08-13 2019-04-24 Cedars-Sinai Medical Center Exosomen und mikroribonukleinsäuren zur geweberegeneration
ES2699579T3 (es) 2013-05-03 2019-02-11 Univ Washington Composición sustituta de la sangre y procedimiento de uso
EP3200808A4 (de) 2014-10-03 2018-05-16 Cedars-Sinai Medical Center Kardiosphären-zellen und durch diese zellen sekretierte exosomen bei der behandlung von muskeldystrophie
EP3402543B1 (de) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Aus kardiosphäre stammende zellen und durch solche zellen sekretierte exosomen in der behandlung von herzversagen mit konservierter auswurffraktion
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
EP3515459A4 (de) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center Kardiosphärenzellen und deren extrazelluläre vesikel zur verzögerung oder umkehr des alterungsprozesses und altersbedingten erkrankungen
WO2018195210A1 (en) 2017-04-19 2018-10-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
CN109528749B (zh) * 2017-09-22 2023-04-28 上海交通大学医学院附属瑞金医院 长链非编码rna-h19在制备治疗垂体瘤药物中的用途
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
WO2020236952A1 (en) * 2019-05-20 2020-11-26 Ohio State Innovation Foundation Apohemoglobin-haptoglobin complexes and methods of using thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136093A (en) * 1976-04-23 1979-01-23 Biotest-Serum-Institut Gmbh Hemoglobin preparation with increased oxygen release
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
US4826811A (en) * 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
WO1988003408A1 (en) * 1986-11-10 1988-05-19 Biopure Corporation Extra pure semi-synthetic blood substitute

Also Published As

Publication number Publication date
GB2234749A (en) 1991-02-13
AU1796788A (en) 1988-12-21
DE3851225D1 (de) 1994-09-29
HU211989A9 (en) 1996-01-29
GB8711614D0 (en) 1987-06-24
EP0358708A4 (de) 1990-04-10
GB2234749B (en) 1992-01-08
ATE110276T1 (de) 1994-09-15
EP0358708B1 (de) 1994-08-24
US5028588A (en) 1991-07-02
WO1988009179A1 (en) 1988-12-01
SG26593G (en) 1993-05-21
JPH02503509A (ja) 1990-10-25
GB8925769D0 (en) 1990-08-01
JP3034529B2 (ja) 2000-04-17
EP0358708A1 (de) 1990-03-21
AU614525B2 (en) 1991-09-05
CA1341286C (en) 2001-08-28

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: BAXTER BIOTECH TECHNOLOGY S.A.R.L., NEUCHATEL, CH

8328 Change in the person/name/address of the agent

Free format text: MEISSNER, BOLTE & PARTNER, 80538 MUENCHEN

8331 Complete revocation