DE3769664D1 - Heterogener spezifischer bindungstest unter verwendung eines anhaeufbaren bindungsreagens. - Google Patents

Heterogener spezifischer bindungstest unter verwendung eines anhaeufbaren bindungsreagens.

Info

Publication number
DE3769664D1
DE3769664D1 DE8787101318T DE3769664T DE3769664D1 DE 3769664 D1 DE3769664 D1 DE 3769664D1 DE 8787101318 T DE8787101318 T DE 8787101318T DE 3769664 T DE3769664 T DE 3769664T DE 3769664 D1 DE3769664 D1 DE 3769664D1
Authority
DE
Germany
Prior art keywords
binding
reagent
labeled reagent
immobilized
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787101318T
Other languages
English (en)
Inventor
Alfred C Greenquist
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of DE3769664D1 publication Critical patent/DE3769664D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G01N33/541—Double or second antibody, i.e. precipitating antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques
DE8787101318T 1986-02-10 1987-01-30 Heterogener spezifischer bindungstest unter verwendung eines anhaeufbaren bindungsreagens. Expired - Fee Related DE3769664D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/827,967 US4772550A (en) 1986-02-10 1986-02-10 Heterogeneous specific binding assay employing an aggregatable binding reagent

Publications (1)

Publication Number Publication Date
DE3769664D1 true DE3769664D1 (de) 1991-06-06

Family

ID=25250597

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787101318T Expired - Fee Related DE3769664D1 (de) 1986-02-10 1987-01-30 Heterogener spezifischer bindungstest unter verwendung eines anhaeufbaren bindungsreagens.

Country Status (9)

Country Link
US (1) US4772550A (de)
EP (1) EP0232816B1 (de)
JP (1) JPH0737987B2 (de)
AT (1) ATE63167T1 (de)
AU (1) AU582293B2 (de)
CA (1) CA1276105C (de)
DE (1) DE3769664D1 (de)
ES (1) ES2022166B3 (de)
IL (1) IL80922A (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK269889A (da) * 1988-06-06 1989-12-07 Photest Diagnostics Inc Heterogen immunoassay
JPH01312463A (ja) * 1988-06-10 1989-12-18 Dai Ichi Pure Chem Co Ltd 免疫学的測定法
AU2684488A (en) 1988-06-27 1990-01-04 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
DE3822750A1 (de) * 1988-07-05 1990-01-11 Boehringer Mannheim Gmbh Verfahren zur bestimmung einer spezifisch bindefaehigen substanz
DE3907651A1 (de) * 1988-07-08 1990-01-11 Boehringer Mannheim Gmbh Verfahren zur bestimmung von antikoerpern
DE3834766A1 (de) * 1988-10-12 1990-04-26 Boehringer Mannheim Gmbh Verfahren zur bestimmung einer spezifisch bindefaehigen substanz
CA2008100A1 (en) * 1989-01-20 1990-07-20 Hubert Bayer Method for the determination of immunologically detectable substance
US5766933A (en) * 1989-04-26 1998-06-16 Diagnostic Products Corporation Method and element for measuring analytes in biological fluids using immobilized binder--analyte labeled complex
US5141850A (en) * 1990-02-07 1992-08-25 Hygeia Sciences, Inc. Porous strip form assay device method
DE4140142A1 (de) * 1991-12-05 1993-06-09 Boehringer Mannheim Gmbh, 6800 Mannheim, De Multivalentes dextranreagenz zum einsatz in praezipitationstests
WO1993017129A1 (en) * 1992-02-28 1993-09-02 Judkins Paul W Method and diagnostic kit for determination of bacteria
DE69331570T2 (de) * 1992-10-21 2002-10-02 Dade Behring Inc Agglutinationstest unter Anwendung eines multivalenten Liganden
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
US6319676B1 (en) 1995-05-02 2001-11-20 Carter Wallace, Inc. Diagnostic detection device and method
US5874216A (en) * 1996-02-23 1999-02-23 Ensys Environmental Products, Inc. Indirect label assay device for detecting small molecules and method of use thereof
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US6103537A (en) * 1997-10-02 2000-08-15 Aclara Biosciences, Inc. Capillary assays involving separation of free and bound species
US6753189B1 (en) * 1998-06-04 2004-06-22 Mizuho Medy Co., Ltd. Detection apparatus and method for the same
EP1211123A1 (de) * 2000-11-27 2002-06-05 Visteon Global Technologies, Inc. Kombination eines Sitzsystems mit einem mehrfach genutzten Sensor
AU2003202026A1 (en) 2002-01-16 2003-09-02 Dynal Biotech Asa Method for isolating nucleic acids and protein from a single sample
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US7402397B2 (en) 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
GB0229287D0 (en) * 2002-12-16 2003-01-22 Dna Res Innovations Ltd Polyfunctional reagents
EP1681983A4 (de) * 2003-10-14 2008-12-10 Monogram Biosciences Inc Rezeptor-tyrosin-kinase-signalpfad-analyse für diagnose und therapie
US20080108147A1 (en) * 2006-11-03 2008-05-08 Tie Wei Reduction of non-specific binding in immunoassays
GB201014805D0 (en) 2010-09-07 2010-10-20 Multi Sense Technologies Ltd Microfluidics based assay device
GB201102037D0 (en) 2011-02-07 2011-03-23 Multi Sense Technologies Ltd Microfluidics based assay device
GB201611442D0 (en) 2016-06-30 2016-08-17 Lumiradx Tech Ltd Fluid control

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033722A (en) * 1975-08-08 1977-07-05 The Salk Institute For Biological Studies Assay for myasthenia gravis
IL51667A (en) * 1977-03-16 1979-10-31 Miles Yeda Ltd Immunoassay for the determination of a hapten
JPS5510590A (en) * 1978-05-04 1980-01-25 Wellcome Found Enzyme immunity quantity analysis
US4228237A (en) * 1978-09-21 1980-10-14 Calbiochem-Behring Corp. Methods for the detection and determination of ligands
US4278653A (en) * 1979-02-01 1981-07-14 New England Nuclear Corporation Methods and kits for double antibody immunoassay providing a colored pellet for easy visualization
US4517288A (en) * 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US4427781A (en) * 1981-03-16 1984-01-24 International Institute Of Cellular And Molecular Pathology Particle agglutination immunoassay with agglutinator for determining haptens; PACIA
DE3211167A1 (de) * 1982-03-26 1983-09-29 Merck Patent Gmbh, 6100 Darmstadt Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten
US4522922A (en) * 1982-04-16 1985-06-11 Jose Carro Soluble assay
US4469787A (en) * 1982-05-14 1984-09-04 Mallinckrodt Inc. Immunoassay involving soluble complex of second antibody and labeled binding protein
EP0101228B1 (de) * 1982-08-06 1986-10-08 International Institute Of Cellular And Molecular Pathology (Icp) Bestimmung von Antigenen durch Teilchenagglutination
US4530900A (en) * 1982-09-13 1985-07-23 Seragen Diagnostics Inc. Soluble insoluble polymers in enzymeimmunoassay
US4687735A (en) * 1983-03-14 1987-08-18 Syntex (U.S.A.) Inc. Enzymatic poly-reactant channeling binding assay
US4547466A (en) * 1983-06-01 1985-10-15 Allied Corporation Detecting rheumatoid factor with synthetic particles having immune complexes thereon
US4551426A (en) * 1983-10-03 1985-11-05 E. I. Du Pont De Nemours And Company Heterogeneous immunoassay for digoxin using ouabain as a separation means

Also Published As

Publication number Publication date
JPS62191765A (ja) 1987-08-22
AU582293B2 (en) 1989-03-16
CA1276105C (en) 1990-11-13
US4772550A (en) 1988-09-20
IL80922A0 (en) 1987-03-31
EP0232816A3 (en) 1988-11-09
ATE63167T1 (de) 1991-05-15
AU6818887A (en) 1987-08-13
ES2022166B3 (es) 1991-12-01
EP0232816A2 (de) 1987-08-19
JPH0737987B2 (ja) 1995-04-26
EP0232816B1 (de) 1991-05-02
IL80922A (en) 1991-03-10

Similar Documents

Publication Publication Date Title
DE3769664D1 (de) Heterogener spezifischer bindungstest unter verwendung eines anhaeufbaren bindungsreagens.
ATE202213T1 (de) Schnellnachweis von analyten mit auf löslichen submikron-teilchen immobilisierten rezeptoren
ATE86670T1 (de) Verwendung von oxidase-enzymsystemen in chemilumineszierenden tests.
DE3485920D1 (de) Kolorimetrisches immunoessay auf fester oberflaeche, sowie dazu zu verwendender teststab und seine herstellung.
ES8703201A1 (es) Un metodo para determinar una secuencia particular de poli- nucleotidos en un medio de ensayo que contiene acidos nu- cleicos monocatenarios
GB2001172A (en) Competitive protein binding assay
ES2053468T3 (es) Procedimiento para la determinacion especifica del contenido de fructosamina del suero, asi como mezcla de reactivos apropiada para ello.
DE68913086D1 (de) Qualitativer Enzymtest zur visuellen Auswertung.
FI875210A (fi) Foerfarande och testanordning foer paovisning av ett aemne i ett prov.
DE69935850D1 (de) Verfahren zur messung der gesamkonzentration eines analytes
KR900014887A (ko) 완전 세포에 적용할 수 있는 효소 분석 키트 및 방법
KR940000870A (ko) β-N- 아세틸글루코사미니다제의 샌드위치 면역 측정법 및 그 측정법에 사용된 모노클론 항체
ES2055031T3 (es) Ensayo de enzima de preincubacion de receptor.
ES8802592A1 (es) Un procedimiento para medir la concentracion de digitoxina
EP0399127A1 (de) Homogene immunochemische Methode zur Bestimmung von Haptenen mittels ionenselektiver Elektroden
Duffy A fully automated method for determining total serum iron and unsaturated ironbinding capacity using a technicon AAII auto analyser system
EP0379347A3 (de) Enzym- markierter Rezeptor-Zusammensetzung,Diagnosesatz und Verwendung in einem Verfahren zum Nachweis
Higgins Ferene S as iron reagent

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee