DE3752176D1 - Vernetzte Ester von Hyaluronsäure - Google Patents

Vernetzte Ester von Hyaluronsäure

Info

Publication number
DE3752176D1
DE3752176D1 DE3752176T DE3752176T DE3752176D1 DE 3752176 D1 DE3752176 D1 DE 3752176D1 DE 3752176 T DE3752176 T DE 3752176T DE 3752176 T DE3752176 T DE 3752176T DE 3752176 D1 DE3752176 D1 DE 3752176D1
Authority
DE
Germany
Prior art keywords
cross
hyaluronic acid
linked esters
esters
linked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3752176T
Other languages
English (en)
Other versions
DE3752176T2 (de
Inventor
Valle Francesco Della
Aurelio Romeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia Farmaceutici SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Publication of DE3752176D1 publication Critical patent/DE3752176D1/de
Application granted granted Critical
Publication of DE3752176T2 publication Critical patent/DE3752176T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/00272-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28Polysaccharides or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06At least partially resorbable materials
    • A61L17/10At least partially resorbable materials containing macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
DE3752176T 1986-10-13 1987-10-06 Vernetzte Ester von Hyaluronsäure Expired - Lifetime DE3752176T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48546/86A IT1198449B (it) 1986-10-13 1986-10-13 Esteri di alcoli polivalenti di acido ialuronico

Publications (2)

Publication Number Publication Date
DE3752176D1 true DE3752176D1 (de) 1998-04-16
DE3752176T2 DE3752176T2 (de) 1998-10-29

Family

ID=11267232

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3752176T Expired - Lifetime DE3752176T2 (de) 1986-10-13 1987-10-06 Vernetzte Ester von Hyaluronsäure

Country Status (23)

Country Link
US (1) US4957744A (de)
EP (1) EP0265116B1 (de)
JP (1) JP2648308B2 (de)
KR (1) KR920002702B1 (de)
CN (1) CN1025035C (de)
AR (1) AR247406A1 (de)
AT (1) ATE163942T1 (de)
AU (1) AU610087B2 (de)
CA (1) CA1317287C (de)
DE (1) DE3752176T2 (de)
DK (1) DK536087A (de)
ES (1) ES2115583T3 (de)
FI (1) FI96610C (de)
HU (1) HU204858B (de)
IE (1) IE872618L (de)
IL (1) IL84032A (de)
IN (1) IN170801B (de)
IT (1) IT1198449B (de)
NO (1) NO175374C (de)
NZ (1) NZ221994A (de)
PH (1) PH26025A (de)
PT (1) PT85908B (de)
ZA (1) ZA877559B (de)

Families Citing this family (199)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
US5227157A (en) * 1986-10-14 1993-07-13 Board Of Regents, The University Of Texas System Delivery of therapeutic agents
US5403592A (en) * 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US5470829A (en) * 1988-11-17 1995-11-28 Prisell; Per Pharmaceutical preparation
US5783691A (en) * 1989-02-08 1998-07-21 Biomatrix, Inc. Crosslinked hyaluronate gels, their use and method for producing them
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
US5639738A (en) * 1992-02-20 1997-06-17 Hyal Pharmaceutical Corporation Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
IT1247175B (it) * 1991-04-19 1994-12-12 Fidia Spa Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US5817644A (en) * 1991-07-03 1998-10-06 Hyal Pharmaceutical Corporation Targeting of dosages of medicine and therapeutic agents
US6022866A (en) * 1991-07-03 2000-02-08 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5990095A (en) * 1991-07-03 1999-11-23 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
WO1994007505A1 (en) * 1991-07-03 1994-04-14 Norpharmco Inc. Use of hyaluronic acid and forms to prevent arterial restenosis
EP0610441A4 (de) * 1991-10-29 1996-01-10 Clover Cons Ltd Vernetzbare polysacchariden, polykationen und lipiden verwendbar zum einkapseln und abgabe von arzneimitteln.
US5824335A (en) * 1991-12-18 1998-10-20 Dorigatti; Franco Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives
IT1254170B (it) * 1991-12-18 1995-09-11 Mini Ricerca Scient Tecnolog Membrane composite per la rigenerazione guidata di tessuti
IT1254704B (it) * 1991-12-18 1995-10-09 Mini Ricerca Scient Tecnolog Tessuto non tessuto essenzialmente costituito da derivati dell'acido ialuronico
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US6136793A (en) * 1992-02-20 2000-10-24 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
CA2061567C (en) * 1992-02-20 1998-02-03 Rudolf E. Falk Use of hyaluronic acid to repair ischemia reperfusion damage
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
US6114314A (en) * 1992-02-21 2000-09-05 Hyal Pharmaceutical Corp. Formulations containing hyaluronic acid
DK0627911T3 (da) * 1992-02-28 2000-11-20 Univ Texas Fotopolymeriserbare bionedbrydelige hydrogeler somvævskontaktmaterialer og bærere med reguleret frigivelse
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
IT1259090B (it) 1992-04-17 1996-03-11 Fidia Spa Biomaterialli per protesi d'osso
IT1259100B (it) * 1992-05-20 1996-03-11 Lanfranco Callegaro Uso di idrogeli per il bloccaggio di sistemi protesici
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
US5550112A (en) * 1992-12-30 1996-08-27 Patent Biopharmaceutics, Inc. Hyaluronic acid-urea pharmaceutical compositions and uses
WO1994021299A1 (en) * 1993-03-19 1994-09-29 Medinvent A composition and a method for tissue augmentation
US6005019A (en) * 1993-07-21 1999-12-21 United States Surgical Corporation Plasticizers for fibers used to form surgical devices
CA2127636C (en) * 1993-07-21 2009-10-20 Cheng-Kung Liu Plasticizers for fibers used to form surgical devices
IT1263394B (it) * 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Composizioni farmaceutiche per uso topico a base di acido ialuronico e suoi derivati
US5529987A (en) * 1993-08-04 1996-06-25 Patent Biopharmaceutics, Inc. Hyaluronic acid-urea pharmaceutical compositions and uses
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5399358A (en) * 1993-11-12 1995-03-21 Edward Mendell Co., Inc. Sustained release formulations for 24 hour release of metroprolol
JP3279318B2 (ja) * 1994-04-25 2002-04-30 ペンウェスト ファーマシューティカルズ カンパニー 持続放出性賦形剤
US5399362A (en) * 1994-04-25 1995-03-21 Edward Mendell Co., Inc. Once-a-day metoprolol oral dosage form
US5690961A (en) * 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
CA2212519C (en) * 1995-02-07 2005-08-23 Fidia Advanced Biopolymers, S.R.L. Process for the coating of objects with hyaluronic acid, derivatives thereof, and semisynthetic polymers
DE69635301T2 (de) 1995-03-24 2006-07-20 Genzyme Corp., Cambridge Verminderung von adhäsionen durch gesteuerte verabreichung von aktivsauerstoffinhibitoren
IT1281870B1 (it) * 1995-04-27 1998-03-03 Fidia Advanced Biopolymers Srl Pelle artificiale umana costituita da materiali biocompatibili a base di derivati dell'acido ialuronico
IT1281886B1 (it) * 1995-05-22 1998-03-03 Fidia Advanced Biopolymers Srl Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US5747058A (en) * 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US5968542A (en) * 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US5612321A (en) * 1995-06-22 1997-03-18 Hercules Incorporated Antioxidant grafted polysaccharides
US5827937A (en) * 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
WO1997005185A2 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
IT1282207B1 (it) * 1995-11-20 1998-03-16 Fidia Advanced Biopolymers Srl Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico
AU2068797A (en) * 1996-01-29 1997-08-20 Edward Mendell Co. Inc. Sustained release excipient
US5939047A (en) * 1996-04-16 1999-08-17 Jernberg; Gary R. Local delivery of chemotherapeutic agents for treatment of periodontal disease
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US20050090662A1 (en) * 1997-01-15 2005-04-28 Beavers Ellington M. Method of making free acids from polysaccharide salts
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
DE69809892T2 (de) * 1997-04-04 2003-08-28 Fidia Advanced Biopolymers Srl N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US20060025328A1 (en) * 1997-05-28 2006-02-02 Burns Patrick J Compositions suitable for controlled release of the hormone GnRH and its analogs
IT1294797B1 (it) 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
JP3359909B2 (ja) 1997-08-22 2002-12-24 電気化学工業株式会社 ヒアルロン酸ゲルとその製造方法及びそれを含有する医用材料
CA2308462C (en) 1997-11-17 2009-02-24 Haemacure Corporation Fibrin sealants or adhesives comprising a hyaluronic acid derivative material
ITPD980149A1 (it) 1998-06-17 1999-12-17 Fidia Advanced Biopolymers Srl Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1303735B1 (it) * 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
IT1303738B1 (it) * 1998-11-11 2001-02-23 Aquisitio S P A Processo di reticolazione di polisaccaridi carbossilati.
NZ512676A (en) 1999-01-13 2003-01-31 Meditech Res Ltd A composition and method for the enhancement of the efficacy of drugs
GB9902412D0 (en) * 1999-02-03 1999-03-24 Fermentech Med Ltd Process
IT1306644B1 (it) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.
US6187822B1 (en) * 1999-06-11 2001-02-13 University Of Medicine & Dentistry Of Nj Wound treatment through inhibition of adenosine diphosphate ribosyl transferase
DE60014400T2 (de) 1999-07-28 2005-10-06 United States Surgical Corp., Norwalk Antiadhäsionsschicht aus hyaluronsäure
US7052711B2 (en) * 1999-09-02 2006-05-30 Rice University Nitric oxide-producing hydrogel materials
US7279176B1 (en) 1999-09-02 2007-10-09 Rice University Nitric oxide-producing hydrogel materials
PT1223990E (pt) 1999-10-15 2004-12-31 Fidia Advanced Biopolymers Srl Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
DE60012866T2 (de) * 1999-12-14 2005-09-08 Kibun Food Chemifa Co., Ltd. Propylenglykolhyaluronat und äusserlich anzuwendendes Hautpflegemittel, das dieses enthält
US6710038B1 (en) 1999-12-14 2004-03-23 Kibun Food Chemifa Co., Ltd. Emulsification method using propylene glycol hyaluronate
EP1110971B1 (de) * 1999-12-14 2004-08-11 Kibun Food Chemifa Co., Ltd. Propylenglykolhyaluronat und äusserlich anzuwendendes Hautpflegemittel, dass dieses enthält
DE60120372T2 (de) * 2000-03-24 2007-07-05 Genentech Inc., San Francisco Verwendung von insulin zur behandlung von knorpelkrankheiten
US9066919B2 (en) 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
AU2001270891A1 (en) * 2000-08-17 2002-03-04 Machines Industrielles Etablissements Consumable container
IT1317359B1 (it) * 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
AU2001296770A1 (en) * 2000-10-06 2002-04-15 Durect Corporation Devices and methods for management of inflammation
AU2002239697A1 (en) * 2000-10-24 2002-06-03 Clear Solutions Biotech, Inc. Sodium hyaluronate microspheres
US6576226B1 (en) 2000-11-17 2003-06-10 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6586493B1 (en) 2001-03-07 2003-07-01 Arizona Board Of Regents Arizona State University Polysaccharide-based hydrogels and pre-gel blends for the same
WO2003047462A1 (en) * 2001-03-12 2003-06-12 Clemson University Polysaccharide-based polmerizable hydrogels
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
US20030114061A1 (en) * 2001-12-13 2003-06-19 Kazuhisa Matsuda Adhesion preventive membrane, method of producing a collagen single strand, collagen nonwoven fabric and method and apparatus for producing the same
TW200638946A (en) * 2002-05-17 2006-11-16 Wyeth Corp Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
DE10223310A1 (de) 2002-05-24 2003-12-11 Biotronik Mess & Therapieg Verfahren zum Beschichten von Implantaten mit einer Polysaccharid-Lage
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
KR100507545B1 (ko) * 2002-09-03 2005-08-09 주식회사 엘지생명과학 히알루론산 유도체 및 그의 제조방법
US7407672B2 (en) * 2002-11-04 2008-08-05 National Heart Center Composition derived from biological materials and method of use and preparation
CA2506129C (en) 2002-11-15 2015-02-17 Idenix (Cayman) Limited 2'-branched nucleosides and flaviviridae mutation
JP4636883B2 (ja) * 2002-11-21 2011-02-23 中外製薬株式会社 薬物徐放担体
EP2218448B1 (de) 2002-12-13 2015-09-23 Durect Corporation Orale Darreichungsform mit flüssigen hochviskose Trägersystemen
US20040185022A1 (en) * 2003-02-19 2004-09-23 Steven Rubin Regimen for acne treatment
EP1595892A4 (de) * 2003-02-21 2007-06-20 Terumo Corp Vernetzbares polysaccharidderivat, herstellungsverfahren dafür, vernetzbares polysaccharidderivat enthaltende zusammensetzung und material für die medizinische behandlung
US20040167480A1 (en) * 2003-02-21 2004-08-26 Advanced Medical Optics, Inc. Administration of multiple viscoelastic solutions with a multi-compartment syringe
EP1628529A2 (de) * 2003-05-30 2006-03-01 Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek Träger mit induzierbarer freigabe
DE10328815A1 (de) * 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Beschichtungssystem für Implantate zur Erhöhung der Gewebsverträglichkeit
CA2534033A1 (fr) * 2003-07-30 2005-02-10 Anteis S.A. Matrice complexe a usage biomedical
US20050080313A1 (en) * 2003-10-10 2005-04-14 Stewart Daren L. Applicator for radiation treatment of a cavity
US7783006B2 (en) * 2003-10-10 2010-08-24 Xoft, Inc. Radiation treatment using x-ray source
GB2408741B (en) * 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
US8313765B2 (en) 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
US8124120B2 (en) 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
JP2007517042A (ja) * 2003-12-30 2007-06-28 デュレクト コーポレーション 活性物質、好ましくはgnrhの制御放出のための、好ましくはpegおよびplgの混合物を含有するポリマーインプラント
EP1710257A4 (de) * 2004-01-07 2011-03-23 Seikagaku Kogyo Co Ltd Hyaluronsäurederivat und dieses enthaltendes arzneimittel
US20080241203A1 (en) * 2004-03-31 2008-10-02 Nipro Corporation Antiadhesive Kit, Process for Producing the Same and Method of Adhesion Prevention
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
ES2609105T3 (es) * 2004-05-20 2017-04-18 Mentor Worldwide Llc Método de enlance covalente de ácido hialurónico y quitosano
EP1750769B1 (de) * 2004-05-20 2013-01-23 Mentor Worldwide LLC Verfahren zur herstellung eines injizierbaren polymerhydrogels
US7956180B2 (en) * 2004-05-27 2011-06-07 Novozymes A/S Dried and agglomerated hyaluronic acid product
US20080280973A1 (en) * 2004-06-28 2008-11-13 Wender Paul A Laulimalide Analogues as Therapeutic Agents
CA2592044A1 (en) 2004-07-06 2006-02-09 Zymogenetics, Inc. Pharmaceutical composition comprising fgf18 and il-1 antagonist and method of use
ITMI20041373A1 (it) 2004-07-09 2004-10-09 Lima Lto S P A N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido
US8512730B2 (en) * 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
CA2570521C (en) * 2004-07-12 2013-06-25 Isto Technologies, Inc. Tissue matrix system
US7858107B2 (en) * 2004-09-10 2010-12-28 Medtronic Xomed, Inc. Flexible bioresorbable hemostatic packing and stent having a preselectable in-vivo residence time
ES2496765T3 (es) * 2004-09-17 2014-09-19 Durect Corporation Composición anestésica local prolongada que contiene SAIB
DK1817347T3 (en) 2004-11-24 2017-08-14 Albumedix As Process for Crosslinking Hyaluronic Acid with Divinyl Sulfone
WO2006067608A1 (en) * 2004-12-22 2006-06-29 Laboratoire Medidom S.A. Aqueous formulations based on sodium hyaluronate for parenteral use
JP2008527056A (ja) * 2004-12-30 2008-07-24 ノボザイムス バイオポリマー アクティーゼルスカブ αヒドロキシ酸のポリマーにより結合されたヒアルロン酸
GB0513552D0 (en) 2005-07-01 2005-08-10 Bristol Myers Squibb Co Bandage
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
CN103784960A (zh) 2005-07-27 2014-05-14 阿尔卡米亚肿瘤学股份有限公司 使用乙酰透明质酸的治疗方案
AU2006289651B2 (en) 2005-09-07 2012-07-26 Alchemia Oncology Pty Limited Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
CA2631520A1 (en) * 2005-12-07 2007-06-14 Isto Technologies, Inc. Cartilage repair methods
CN101511170B (zh) * 2005-12-22 2014-03-26 奥克伍德药业有限公司 可升华持续释放传递系统和其制造方法
US20070280986A1 (en) * 2006-06-01 2007-12-06 Carlos Gil Intra-operative coating of implants
EP2037874A1 (de) * 2006-06-28 2009-03-25 Novozymes Biopolymer A/S Zusammensetzungen mit mehreren hyaluronsäure-fraktionen für kosmetische und medizinische zwecke
AU2007295894B2 (en) 2006-09-13 2013-10-17 Enhance Skin Products, Inc. Cosmetic composition for the treatment of skin and methods thereof
ES2388355T3 (es) 2006-11-03 2012-10-11 Durect Corporation Sistemas de suministro transdémico que comprenden bupivacaína
EP1942117A1 (de) * 2006-12-29 2008-07-09 Sigea S.R.L. Derivate aus Carboxypolysacchariden
EP2167039B1 (de) * 2007-05-18 2016-09-28 Durect Corporation Verbesserte depot-formulierungen
WO2008153611A2 (en) 2007-05-25 2008-12-18 Qlt Usa, Inc. Sustained delivery formulations of risperidone compounds
US20100008878A1 (en) * 2007-08-09 2010-01-14 Foodchemifa Co., Ltd Propylene glycol hyaluronate, and skincare preparation for external use comprising same
US8415401B2 (en) 2007-12-06 2013-04-09 Durect Corporation Oral pharmaceutical dosage forms
JP5523338B2 (ja) * 2007-12-19 2014-06-18 エヴォニク ゴールドシュミット ゲーエムベーハー エマルジョン中の架橋ヒアルロン酸
EP3184552B1 (de) 2008-09-02 2020-08-12 Tautona Group LP Stränge aus hyaluronsäure, verfahren zur herstellung davon und verwendungen davon
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
IT1395392B1 (it) 2009-08-27 2012-09-14 Fidia Farmaceutici Geli viscoelastici come nuovi filler
US8273725B2 (en) 2009-09-10 2012-09-25 Genzyme Corporation Stable hyaluronan/steroid formulation
EP2523672B1 (de) 2010-01-15 2016-07-13 Rutgers, the State University of New Jersey Verwendung von vanadiumverbindungen für beschleunigte knochenheilung
IL206739A (en) * 2010-06-30 2016-06-30 David Segal An injectable drug containing silitol as an active substance
TWI561535B (en) 2011-10-06 2016-12-11 Bvw Holding Ag Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption
CN104144714B (zh) * 2011-10-11 2016-10-19 法国阿勒根控股公司 交联透明质酸线及其使用方法
CN104185420B (zh) 2011-11-30 2017-06-09 埃默里大学 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂
FR2983483B1 (fr) 2011-12-02 2014-11-14 Vivacy Lab Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
ITMI20130162A1 (it) * 2013-02-06 2014-08-07 Fidia Farmaceutici Derivati fotoreticolati di acido ialuronico, loro processo di preparazione ed impiego
EA033537B1 (ru) 2013-03-11 2019-10-31 Durect Corp Инъекционная композиция с контролируемым высвобождением, содержащая жидкий носитель с высокой вязкостью
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
WO2014165113A1 (en) * 2013-03-12 2014-10-09 Allergan Holdings France S.A.S. Cross-linked hyaluronic acid threads for treatment of striae
US9572885B2 (en) 2013-03-15 2017-02-21 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
PL3019177T3 (pl) 2013-07-10 2021-04-19 Matrix Biology Institute Kompozycje hialuronianu o dużej sprężystości i ich zastosowania
CN103450368B (zh) * 2013-07-25 2014-05-07 山东福瑞达生物工程有限公司 一种硅烷化玻璃酸酯复合物的制备方法
US10265292B2 (en) * 2013-09-18 2019-04-23 The Werc Shop, LLC Terpene-based compositions, processes methodologies
US9968745B2 (en) 2014-01-27 2018-05-15 Allergan Holdings France S.A.S. Substance delivery device
CA2942078C (en) 2014-03-14 2023-03-14 The University Of North Carolina At Chapel Hill Small molecules for inhibiting male fertility
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
CN107530490B (zh) 2015-03-10 2021-06-25 爱力根销售有限责任公司 多针注射器
RU2582702C1 (ru) * 2015-08-19 2016-04-27 федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "ФНИЦЭМ им. Н.Ф. Гамалеи" Минздрава России) Способ получения композиции на основе модифицированного гиалуроната натрия, композиция на основе модифицированного гиалуроната натрия и ее применение
HUE054874T2 (hu) 2015-09-24 2021-10-28 Matrix Biology Inst Magas elaszticitású hialuronán készítmények és alkalmazási eljárások
CN105418803A (zh) * 2015-12-30 2016-03-23 山东天晟生物科技有限公司 一种透明质酸的酯化方法
KR102288170B1 (ko) 2016-04-08 2021-08-09 알레간 인코포레이티드 흡인 및 주입 디바이스
CN105949478B (zh) * 2016-05-05 2021-10-01 宜昌东阳光生化制药有限公司 除去交联透明质酸中交联剂的方法
US10820900B2 (en) 2017-01-24 2020-11-03 Allergan Industrie Sas Thread insertion devices
US10709444B2 (en) 2017-01-24 2020-07-14 Allergan Industrie Sas Thread insertion devices
US10265151B2 (en) 2017-01-24 2019-04-23 Allergan Industrie Sas Thread insertion devices
US10595977B2 (en) 2017-01-24 2020-03-24 Allergan Industrie, Sas Thread insertion devices
US10258447B2 (en) 2017-01-24 2019-04-16 Allergan Industrie Sas Thread insertion devices
IT201700008651A1 (it) * 2017-01-26 2018-07-26 Beauty System Pharma Ltd Acido ialuronico reticolato con agenti reticolanti di tipo naturale o semisintetico
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
EP3956367A1 (de) * 2019-04-19 2022-02-23 Jointherapeutics S.r.l. Vernetztes polymer aus funktionalisierter hyaluronsäure und dessen verwendung zur behandlung von entzündlichen zuständen
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
IT202100012737A1 (it) 2021-05-18 2022-11-18 Jointherapeutics S R L Miscele di polisaccaridi e poliamminosaccaridi con proprietà reologiche migliorate
IT202100013787A1 (it) 2021-05-27 2022-11-27 Farmigea Spa Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery
CN114085373B (zh) * 2021-12-09 2023-07-14 万华化学集团股份有限公司 一种透明质酸聚醚多元醇及其制备方法和应用
WO2023169949A1 (en) 2022-03-10 2023-09-14 Cmed Aesthetics S.R.L. Process for the preparation of sterile products

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3589364A (en) * 1968-03-14 1971-06-29 Buckeye Cellulose Corp Bibulous cellulosic fibers
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4280954A (en) * 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
DE2833138A1 (de) * 1978-07-28 1980-02-07 Bayer Ag Methylolierte mono- und oligosaccharide
US4303676A (en) * 1980-03-21 1981-12-01 Balazs Endre A Hyaluronate based compositions and cosmetic formulations containing same
FR2482603A1 (fr) * 1980-05-14 1981-11-20 Pharmindustrie Nouveaux esters d'heparine utilisables pour la preparation de medicaments, et procedes pour leur preparation
US4328803B1 (en) * 1980-10-20 1994-01-11 Opthalmic Systems, Inc. Opthalmological procedures
US4487865A (en) * 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
CA1238043A (en) * 1983-12-15 1988-06-14 Endre A. Balazs Water insoluble preparations of hyaluronic acid and processes therefor
US4500676A (en) * 1983-12-15 1985-02-19 Biomatrix, Inc. Hyaluronate modified polymeric articles
JPS60130601A (ja) * 1983-12-15 1985-07-12 バイオマトリツクス,インコ−ポレイテツド ヒアルロン酸水不溶性組成物の製法
CA1295796C (en) * 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
JP2501551B2 (ja) * 1984-05-04 1996-05-29 生化学工業 株式会社 架橋ヒアルロン酸
US4716224A (en) * 1984-05-04 1987-12-29 Seikagaku Kogyo Co. Ltd. Crosslinked hyaluronic acid and its use
SE442820B (sv) * 1984-06-08 1986-02-03 Pharmacia Ab Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut
US4629623A (en) * 1984-06-11 1986-12-16 Biomatrix, Inc. Hyaluronate-poly (ethylene oxide) compositions and cosmetic formulations thereof
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4605691A (en) * 1984-12-06 1986-08-12 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4636524A (en) * 1984-12-06 1987-01-13 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
SE8501022L (sv) * 1985-03-01 1986-09-02 Pharmacia Ab Format alster och forfarande for dess framstellning
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
DE3684887D1 (de) * 1985-11-29 1992-05-21 Biomatrix Inc Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung.
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
SE452469B (sv) * 1986-06-18 1987-11-30 Pharmacia Ab Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma
AU610512B2 (en) * 1986-12-11 1991-05-23 Biomatrix Incorporated Improved hyaluronate-poly (ethylene oxide) mixtures
US4795741A (en) * 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof

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EP0265116B1 (de) 1998-03-11
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IN170801B (de) 1992-05-23
KR920002702B1 (ko) 1992-03-31
DE3752176T2 (de) 1998-10-29
ES2115583T3 (es) 1998-07-01
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NO175374B (no) 1994-06-27
FI874504A (fi) 1988-04-14
IT1198449B (it) 1988-12-21
HU204858B (en) 1992-02-28
PT85908A (en) 1987-11-01
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IE872618L (en) 1988-04-13
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PT85908B (pt) 1990-08-31
PH26025A (en) 1992-01-29
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ATE163942T1 (de) 1998-03-15
JP2648308B2 (ja) 1997-08-27
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IT8648546A0 (it) 1986-10-13
DK536087D0 (da) 1987-10-13
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