DE3751964D1 - Herstellung und Verwendung von hochmolekularen Polyanhydriden - Google Patents

Herstellung und Verwendung von hochmolekularen Polyanhydriden

Info

Publication number
DE3751964D1
DE3751964D1 DE3751964T DE3751964T DE3751964D1 DE 3751964 D1 DE3751964 D1 DE 3751964D1 DE 3751964 T DE3751964 T DE 3751964T DE 3751964 T DE3751964 T DE 3751964T DE 3751964 D1 DE3751964 D1 DE 3751964D1
Authority
DE
Germany
Prior art keywords
molecular weight
polyanhydrides
high molecular
prepolymers
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3751964T
Other languages
English (en)
Other versions
DE3751964T2 (de
Inventor
Robert S Langer
Abraham J Domb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of DE3751964D1 publication Critical patent/DE3751964D1/de
Application granted granted Critical
Publication of DE3751964T2 publication Critical patent/DE3751964T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G67/00Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
    • C08G67/04Polyanhydrides
DE3751964T 1986-08-01 1987-07-29 Herstellung und Verwendung von hochmolekularen Polyanhydriden Expired - Lifetime DE3751964T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/892,809 US4757128A (en) 1986-08-01 1986-08-01 High molecular weight polyanhydride and preparation thereof

Publications (2)

Publication Number Publication Date
DE3751964D1 true DE3751964D1 (de) 1997-01-09
DE3751964T2 DE3751964T2 (de) 1997-06-05

Family

ID=25400529

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198787110971T Pending DE260415T1 (de) 1986-08-01 1987-07-29 Herstellung und verwendung von hochmolekularen polyanhydriden.
DE3751964T Expired - Lifetime DE3751964T2 (de) 1986-08-01 1987-07-29 Herstellung und Verwendung von hochmolekularen Polyanhydriden

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE198787110971T Pending DE260415T1 (de) 1986-08-01 1987-07-29 Herstellung und verwendung von hochmolekularen polyanhydriden.

Country Status (11)

Country Link
US (1) US4757128A (de)
EP (1) EP0260415B1 (de)
JP (1) JP2700646B2 (de)
KR (1) KR880002904A (de)
AT (1) ATE145657T1 (de)
CA (1) CA1274339A (de)
DE (2) DE260415T1 (de)
ES (1) ES2006417T3 (de)
GR (2) GR880300163T1 (de)
LU (1) LU90462I2 (de)
NL (1) NL990036I2 (de)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512676A (en) 1987-09-03 1996-04-30 The Boeing Company Extended amideimide hub for multidimensional oligomers
US5969079A (en) 1985-09-05 1999-10-19 The Boeing Company Oligomers with multiple chemically functional end caps
US5693741A (en) 1988-03-15 1997-12-02 The Boeing Company Liquid molding compounds
US5210213A (en) 1983-06-17 1993-05-11 The Boeing Company Dimensional, crosslinkable oligomers
US5705598A (en) 1985-04-23 1998-01-06 The Boeing Company Polyester sulfone oligomers and blends
US5516876A (en) 1983-09-27 1996-05-14 The Boeing Company Polyimide oligomers and blends
US5328695A (en) * 1983-03-22 1994-07-12 Massachusetts Institute Of Technology Muscle morphogenic protein and use thereof
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5618907A (en) 1985-04-23 1997-04-08 The Boeing Company Thallium catalyzed multidimensional ester oligomers
US5610317A (en) 1985-09-05 1997-03-11 The Boeing Company Multiple chemically functional end cap monomers
US4789724A (en) * 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US5804178A (en) * 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
US4933431A (en) * 1987-07-31 1990-06-12 Massachusetts Institute Of Technology One step preparation of poly(amide-anhydride)
US4857311A (en) * 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US5817744A (en) 1988-03-14 1998-10-06 The Boeing Company Phenylethynyl capped imides
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US4999417A (en) * 1989-03-30 1991-03-12 Nova Pharmaceutical Corporation Biodegradable polymer compositions
US4997904A (en) * 1989-08-25 1991-03-05 Nova Pharmaceutical Corporation Aromatic polyanhydride compositions
US5001215A (en) * 1989-11-02 1991-03-19 Hoechst Celanese Corp. Aromatic polyester from 1,3-bis(p-carboxyphenoxy)propane
CA2072360A1 (en) * 1989-12-26 1991-06-27 Abraham J. Domb Prodrug anhydride compositions
US5171812A (en) * 1990-01-19 1992-12-15 Nova Pharmaceutical Corporation Polyanhydrides of oligomerized unsaturated aliphatic acids
US5175235A (en) * 1990-06-04 1992-12-29 Nova Pharmaceutical Corporation Branched polyanhydrides
US5179189A (en) * 1990-01-19 1993-01-12 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydrides
US5240963A (en) * 1990-01-19 1993-08-31 Nova Pharmaceutical Corporation Branched polyanhydrides
US5317079A (en) * 1990-01-19 1994-05-31 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydride
US5270419A (en) * 1990-01-19 1993-12-14 Nova Pharmaceutical Corporation Polyanhydrides of oligomerized unsaturated aliphatic acids
US5126147A (en) * 1990-02-08 1992-06-30 Biosearch, Inc. Sustained release dosage form
CA2101742C (en) * 1991-02-01 2005-04-12 Abraham J. Domb Biodegradable polymer blends for drug delivery
US5330768A (en) * 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
ES2038072B1 (es) * 1991-07-12 1994-02-16 Univ Valladolid Procedimiento para la obtencion de polianhidridos a base de acidos dicarboxilicos y anhidrido acetico.
WO1993007913A1 (en) * 1991-10-24 1993-04-29 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
US5418297A (en) * 1991-11-26 1995-05-23 Kansai Paint Company, Limited Crosslinking agent and curable composition
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5264540A (en) * 1992-07-20 1993-11-23 Ethicon, Inc. Aromatic polyanhydrides
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
ATE210969T1 (de) * 1992-09-10 2002-01-15 Childrens Medical Center Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5321113A (en) * 1993-05-14 1994-06-14 Ethicon, Inc. Copolymers of an aromatic anhydride and aliphatic ester
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US5473103A (en) * 1993-12-16 1995-12-05 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Biopolymers derived from hydrolyzable diacid fats
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6123727A (en) * 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
ATE267587T1 (de) 1995-06-09 2004-06-15 Euro Celtique Sa Formulierungen und verfahren für eine verlängerte lokalanästhesie
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
EP0842209B1 (de) 1995-07-28 2006-10-11 Genzyme Corporation Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
US5968543A (en) * 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
US5756652A (en) * 1996-02-29 1998-05-26 Depuy Orthopaedics, Inc. Poly (ester-anhydrides) and intermediates therefor
AU721209B2 (en) * 1996-03-05 2000-06-29 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US5668288A (en) * 1996-04-16 1997-09-16 Depuy Orthopaedics, Inc. Polyester ionomers for implant fabrication
US6299905B1 (en) * 1996-04-16 2001-10-09 Depuy Orthopaedics, Inc. Bioerodable polymeric adhesives for tissue repair
US5905134A (en) * 1996-04-17 1999-05-18 Abbott Laboratories Process for the preparation of polyanhydrides
JPH11511763A (ja) 1996-06-24 1999-10-12 ユーロ―セルティーク,エス.エイ. 安全な局所麻酔の提供方法
US5955096A (en) * 1996-06-25 1999-09-21 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US6046187A (en) * 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
IL132120A0 (en) 1997-04-03 2001-03-19 Guilford Pharm Inc Biodegradable terephthalate polyester-poly (phosphate) polymers compositions articles and methods for making and using the same
EP1009390A4 (de) * 1997-07-02 2004-05-06 Euro Celtique Sa Verlängerte narkose in gelenken und körperzwischenräumen
US6123956A (en) * 1997-07-10 2000-09-26 Keith Baker Methods for universally distributing therapeutic agents to the brain
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6486214B1 (en) 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US7122615B1 (en) 1998-09-10 2006-10-17 Rutgers, The State University Of New Jersey Polyanhydrides with therapeutically useful degradation products
WO1999012990A1 (en) * 1997-09-10 1999-03-18 Rutgers, The State University Polyanhydrides with therapeutically useful degradation products
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6153212A (en) 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6419709B1 (en) 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6350464B1 (en) 1999-01-11 2002-02-26 Guilford Pharmaceuticals, Inc. Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
US6537585B1 (en) 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
US6294643B1 (en) 1999-04-20 2001-09-25 Sumitomo Chemical Co., Ltd. Aromatic polyester and molded article using the same
US6503528B1 (en) 1999-11-19 2003-01-07 Abbott Laboratories Polymeric compositions and a method of making the same
WO2001041753A2 (en) 1999-12-07 2001-06-14 Rutgers, The State University Of New Jersey Therapeutic compositions and methods for treating periodontitis with antiinflamatory compounds
US20040038948A1 (en) 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
US6685928B2 (en) 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
US7029700B2 (en) * 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
US6723733B2 (en) 2000-05-19 2004-04-20 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
US6348475B1 (en) 2000-06-01 2002-02-19 Guilford Pharmaceuticals Inc. Methods, compounds and compositions for treating gout
AU2001279064A1 (en) * 2000-07-27 2002-02-13 Rutgers, The State University Therapeutic azo-compounds for drug delivery
MXPA03000821A (es) * 2000-07-27 2004-03-18 Univ Rutgers Poliesteres y poliamidas terapeuticos.
JP2004521111A (ja) * 2001-01-25 2004-07-15 ユーロ−セルティーク,エス.エイ. 局所麻酔薬および使用法
US20020142304A1 (en) * 2001-03-09 2002-10-03 Anderson Daniel G. Uses and methods of making microarrays of polymeric biomaterials
DE02717541T1 (de) * 2001-05-07 2004-08-26 Cornell Research Foundation, Inc. Biologisch abbaubare copolymere, die an ein segment mit mehreren funktionellen gruppen gebunden sind
EP1406593B1 (de) * 2001-06-22 2010-08-25 Johns Hopkins University School of Medicine Biologisch abbaubare polymerzusammensetzungen, zusammensetzungen und damit in beziehung stehende verwendungen
JP2004537401A (ja) 2001-08-08 2004-12-16 ブラウン ユニバーシティ リサーチ ファウンデーション 疎水性薬物の微粉砕方法
ES2323771T3 (es) 2001-11-23 2009-07-24 Rutgers, The State University Sintesis mejorada de polianhidridos.
US6993846B2 (en) * 2002-05-08 2006-02-07 Eveready Battery Company, Inc. Lubricating strip
WO2004006863A2 (en) * 2002-07-17 2004-01-22 Rutgers, The State University Therapeutic devices for patterned cell growth
CN100366249C (zh) * 2002-09-29 2008-02-06 天津帝士力投资控股集团有限公司 一种替莫唑胺控释给药系统
AU2003304108B2 (en) * 2002-10-30 2007-03-22 Spherics, Inc. Nanoparticulate bioactive agents
US20070218139A1 (en) * 2002-12-20 2007-09-20 Smith Thomas J High Pressure Compaction For Pharmaceutical Formulations
US20040197301A1 (en) * 2003-02-18 2004-10-07 Zhong Zhao Hybrid polymers and methods of making the same
US7662864B2 (en) * 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
CA2549195A1 (en) * 2003-12-09 2005-06-23 Spherics, Inc. Bioadhesive polymers with catechol functionality
WO2005072710A2 (en) * 2004-01-28 2005-08-11 Johns Hopkins University Drugs and gene carrier particles that rapidly move through mucous barriers
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US20070281007A1 (en) * 2004-08-27 2007-12-06 Jacob Jules S Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
BRPI0611452A2 (pt) 2005-05-05 2010-09-08 Antisense Pharma Gmbh dosagem de oligonucleotìdeos
US20090317376A1 (en) 2005-06-06 2009-12-24 Georgetown University Medical School Compositions And Methods For Lipo Modeling
US20070225472A1 (en) * 2006-03-23 2007-09-27 Varshney Sunil K Polyanhydride polymers and their uses in biomedical devices
EP2032614A2 (de) 2006-06-06 2009-03-11 Rutgers, The State University Of New Jersey Jodhaltige polymere
JP2009544406A (ja) * 2006-07-27 2009-12-17 ユニヴァースティ オブ ヴァージニア パテント ファウンデイション 治療又は診断用薬の頭蓋内注入用システム及び方法
WO2008027557A2 (en) * 2006-08-31 2008-03-06 Spherics, Inc. Topiramate compositions and methods of enhancing its bioavailability
ES2360538T3 (es) * 2006-09-08 2011-06-06 Johns Hopkins University Composiciones para aumentar el transporte a través de moco.
WO2008034019A2 (en) 2006-09-13 2008-03-20 Polymerix Corporation Active agents and their oligomers and polymers
US20110223232A1 (en) * 2006-10-23 2011-09-15 Olexander Hnojewyj drug-release composition having a therapeutic carrier
CA2618240C (en) 2006-11-17 2015-01-20 Supernus Pharmaceuticals, Inc. Sustained-release formulations of topiramate
US20120164226A1 (en) 2007-06-11 2012-06-28 Leuthner Brian A Compositions and Methods for Improving Prognosis of a Human with Subarachnoid Hemorrhage
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
US8637593B2 (en) 2008-01-09 2014-01-28 Hitachi Chemical Company, Ltd. Thermosetting resin composition, epoxy resin molding material, and polyvalent carboxylic acid condensate
CN101910239B (zh) 2008-01-09 2013-11-06 日立化成工业株式会社 热固化性树脂组合物、环氧树脂成形材料及多元羧酸缩合体
CN102725401A (zh) 2009-07-10 2012-10-10 哈佛大学校长及研究员协会 作为抗炎药的永久带电荷的钠和钙通道阻断剂
EP2470287A4 (de) 2009-08-28 2015-01-21 Univ Columbia Systeme, verfahren und vorrichtungen zur herstellung gasgefüllter mikroblasen
US10010709B2 (en) 2009-12-16 2018-07-03 The Trustees Of Columbia University In The City Of New York Composition for on-demand ultrasound-triggered drug delivery
CA2790848A1 (en) * 2010-02-22 2011-08-25 Edge Therapeutics Inc. Methods and compositions to treat hemorrhagic conditions of the brain
US8673359B2 (en) 2010-07-08 2014-03-18 Brown University Nanoparticle compositions and methods for improved oral delivery of active agents
US8741317B2 (en) 2010-08-19 2014-06-03 Rutgers, The State University Of New Jersey Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery
CN103517726B (zh) 2011-04-05 2016-08-17 优势医疗 用于改善脑损伤后影响脑血流的结果的脑室内药物递送系统
US10159743B2 (en) 2012-03-16 2018-12-25 The Johns Hopkins University Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
US8962577B2 (en) 2012-03-16 2015-02-24 The Johns Hopkins University Controlled release formulations for the delivery of HIF-1 inhibitors
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
KR102154880B1 (ko) 2012-05-03 2020-09-10 칼라 파마슈티컬스, 인크. 개선된 점막 수송을 나타내는 제약 나노입자
US9056057B2 (en) 2012-05-03 2015-06-16 Kala Pharmaceuticals, Inc. Nanocrystals, compositions, and methods that aid particle transport in mucus
US9399019B2 (en) 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
US9987233B2 (en) 2013-03-21 2018-06-05 Eupraxia Pharmaceuticals USA LLC Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
WO2015058868A1 (en) 2013-10-25 2015-04-30 Pangaea Biotech, S.L. Compositions and methods for the treatment of cancer
US10023521B2 (en) 2014-06-13 2018-07-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
MX2017001863A (es) 2014-08-13 2017-07-17 Univ Johns Hopkins Nanoparticulas cargadas con glucocorticoides para prevencion de rechazo de aloinjerto corneal y neovascularizacion.
CN107206099A (zh) 2015-01-20 2017-09-26 约翰霍普金斯大学 用于持续释放抗青光眼剂以控制眼内压的组合物
US10543162B2 (en) 2015-04-10 2020-01-28 Rutgers, The State University Of New Jersey Kojic acid polymers
AU2016301282B2 (en) 2015-08-03 2022-03-17 Children's Medical Center Corporation Charged ion channel blockers and methods for use
CA2997668C (en) 2015-09-09 2021-06-01 Micell Technologies, Inc. Drug delivery system comprising biodegradable carrier with small particle size and drug in dry powder form
US11351124B2 (en) 2015-10-27 2022-06-07 Eupraxia Pharmaceuticals Inc. Sustained release of formulations of local anesthetics
EP3246050A1 (de) 2016-05-17 2017-11-22 BSN medical GmbH Wund- oder hautauflage
US10449269B2 (en) 2016-08-29 2019-10-22 Yale University Particle conjugated prosthetic patches and methods of making and using thereof
WO2020028907A1 (en) 2018-08-03 2020-02-06 Brown University Compositions and methods for improving the bioavailability of glp1 and analogues thereof
CA3129131A1 (en) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Charged ion channel blockers and methods for use
CA3129089A1 (en) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Ester substituted ion channel blockers and methods for use
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CA3129117A1 (en) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Charged ion channel blockers and methods for use
WO2021091586A1 (en) 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2023500891A (ja) 2019-11-06 2023-01-11 ノシオン セラピューティクス,インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
WO2021183639A1 (en) 2020-03-11 2021-09-16 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2024011218A1 (en) 2022-07-08 2024-01-11 Brown University Polymeric nanoparticles for long acting delivery of a peptide and methods of making and using thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2071250A (en) * 1931-07-03 1937-02-16 Du Pont Linear condensation polymers
US2071251A (en) * 1931-07-03 1937-02-16 Du Pont Fiber and method of producing it
GB968715A (en) * 1961-10-12 1964-09-02 Ici Ltd Polymeric anhydrides
US3526612A (en) * 1969-04-16 1970-09-01 Marathon Oil Co Polyanhydrides,and processes for their production
US3986510A (en) * 1971-09-09 1976-10-19 Alza Corporation Bioerodible ocular device
US3993071A (en) * 1971-09-09 1976-11-23 Alza Corporation Bioerodible ocular device
US3981303A (en) * 1971-09-09 1976-09-21 Alza Corporation Bioerodible ocular device
US3960150A (en) * 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
JPS60141725A (ja) * 1983-12-29 1985-07-26 Okamura Seiyu Kk ポリ酸ポリ無水物粉体
CH671402A5 (de) * 1985-10-02 1989-08-31 Sandoz Ag

Also Published As

Publication number Publication date
DE260415T1 (de) 1989-02-16
JPS63258924A (ja) 1988-10-26
CA1274339A (en) 1990-09-18
JP2700646B2 (ja) 1998-01-21
LU90462I2 (fr) 2000-01-03
ATE145657T1 (de) 1996-12-15
NL990036I2 (nl) 2001-01-02
EP0260415B1 (de) 1996-11-27
GR3022577T3 (en) 1997-05-31
EP0260415A2 (de) 1988-03-23
KR880002904A (ko) 1988-05-12
US4757128A (en) 1988-07-12
GR880300163T1 (en) 1989-01-31
NL990036I1 (nl) 1999-12-01
ES2006417A4 (es) 1989-05-01
ES2006417T3 (es) 1997-07-01
EP0260415A3 (de) 1988-05-18
DE3751964T2 (de) 1997-06-05

Similar Documents

Publication Publication Date Title
DE3751964D1 (de) Herstellung und Verwendung von hochmolekularen Polyanhydriden
FI932442A0 (fi) Kristallina propenpolymerer med foerbaettrad bearbetbarhet i smaelt tillstaond samt foerfarande foer deras framstaellning
DE3675642D1 (de) Einsatz von antistatika zur vermeidung von belagbildung bei der herstellung von ethylenpolymerisaten in gasphasenreakatoren.
DE3751694D1 (de) Metallocen-katalysatorsysteme für die Polymersation von Olefinen, mit einer Silizium-Hydrocarbyl-Brücke.
DE3485955T2 (de) Herstellung von polyarylenetherketonen.
EP0227838A4 (de) Polyäthylenzusammensetzung.
DE3853810D1 (de) Propylenpolymere und Herstellung derselben.
ATE133988T1 (de) Thermoplastische polymere zusammensetzungen, welche modifikatoren der schmelz-rheologie enthalten
BR8800716A (pt) Processo de preparacao de polimeros com grupamentos imidas e polimeros
KR960022679A (ko) 발포된 폴리 (에틸렌 나프탈레이트)의 고체 상태 중합 방법
ES2033425T3 (es) Composicion reticulable de polimeros sililicos.
ATE137778T1 (de) Verfahren zur herstellung von poly(arylensulfid- sulfon)-polymeren
DE3778091D1 (de) Mit harzen verstaerkte emulsionspolymere und verfahren zu deren herstellung.
AU630240B2 (en) Isocyanate-reactive composition
BR8706859A (pt) Processo de preparacao de polimeros com grupamentos imidas e polimeros
DE69004857T2 (de) Stereoreguläre Acrylonitril-Polymere und diese enthaltende Zusammensetzungen.
ATE356135T1 (de) Silikonhaltige polymere
FI874684A (fi) Polymerer innehaollande imidgrupper och deras framstaellningsfoerfaranden.
Smith Jr Process for the Production of Silicon Carbide by the Pyrolysis of a Polycarbosilane Polymer
DE3667064D1 (en) Process for the preparation of nylon 4,6
DE69934021D1 (de) Herstellung von polymeren mit hilfe von sternverknüpfungen
Bhatnagar et al. Phenylacetylene terminated poly (aryl ether) sulfone and poly (aryl ether) ketone oligomers of controlled molecular weights

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: CARMUSTIN 7,7 MG; REGISTRATION NO/DATE: 45692.00.00, 19990803

Spc suppl protection certif: 199 75 057

Filing date: 19990831

V472 Application for supplementary protection certificate rejected

Free format text: PRODUCT NAME: CARMUSTIN 7,7 MG; REGISTRATION NO/DATE: 45692.00.00, 19990803

Spc suppl protection certif: 199 75 057

Filing date: 19990831