DE3688075T2 - Transdermales verabreichungssystem. - Google Patents

Transdermales verabreichungssystem.

Info

Publication number
DE3688075T2
DE3688075T2 DE8787900446T DE3688075T DE3688075T2 DE 3688075 T2 DE3688075 T2 DE 3688075T2 DE 8787900446 T DE8787900446 T DE 8787900446T DE 3688075 T DE3688075 T DE 3688075T DE 3688075 T2 DE3688075 T2 DE 3688075T2
Authority
DE
Germany
Prior art keywords
transdermal administration
administration system
weight
carrier
oleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787900446T
Other languages
English (en)
Other versions
DE3688075D1 (de
Inventor
Nicholas Bodor
Thorsteinn Loftsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Key Pharmaceuticals Inc
Original Assignee
Key Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Key Pharmaceuticals Inc filed Critical Key Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3688075D1 publication Critical patent/DE3688075D1/de
Publication of DE3688075T2 publication Critical patent/DE3688075T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
DE8787900446T 1985-12-06 1986-12-05 Transdermales verabreichungssystem. Expired - Fee Related DE3688075T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/806,257 US4764381A (en) 1985-12-06 1985-12-06 Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
PCT/US1986/002584 WO1987003490A2 (en) 1985-12-06 1986-12-05 Transdermal delivery system

Publications (2)

Publication Number Publication Date
DE3688075D1 DE3688075D1 (de) 1993-04-22
DE3688075T2 true DE3688075T2 (de) 1993-06-24

Family

ID=25193671

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787900446T Expired - Fee Related DE3688075T2 (de) 1985-12-06 1986-12-05 Transdermales verabreichungssystem.

Country Status (11)

Country Link
US (2) US4764381A (de)
EP (2) EP0250542B1 (de)
JP (1) JPS63502108A (de)
KR (1) KR900002653B1 (de)
AT (1) ATE86870T1 (de)
AU (2) AU602324B2 (de)
CA (1) CA1280974C (de)
DE (1) DE3688075T2 (de)
DK (1) DK407587D0 (de)
MY (1) MY102378A (de)
WO (1) WO1987003490A2 (de)

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US4933184A (en) * 1983-12-22 1990-06-12 American Home Products Corp. (Del) Menthol enhancement of transdermal drug delivery
US4983396A (en) * 1985-12-06 1991-01-08 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol
US5051260A (en) * 1987-07-16 1991-09-24 The Regents Of The University Of California Method and composition for enhancing the cutaneous penetration of pharmacologically active agents
US4971800A (en) * 1988-07-08 1990-11-20 The Regents Of The University Of California Method and compositions for enhancing the cutaneous penetration of pharmacologically active agents
US5045317A (en) * 1987-07-16 1991-09-03 The Regents Of The University Of California Enhancing the cutaneous penetration of pharmacologically active agents
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
US5059603A (en) * 1989-06-12 1991-10-22 Centuries Laboratories, Inc. Method and composition for treating impotence
US5262165A (en) * 1992-02-04 1993-11-16 Schering Corporation Transdermal nitroglycerin patch with penetration enhancers
CA2064845A1 (en) * 1989-08-17 1991-02-18 Sharad K. Govil Transdermal nitroglycerin patch with penetration enhancers
AR246186A1 (es) * 1989-11-17 1994-07-29 Beta Pharm Co Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica.
JP2849950B2 (ja) * 1990-11-30 1999-01-27 日東電工株式会社 経皮吸収製剤
US5202125A (en) * 1990-12-10 1993-04-13 Theratech, Inc. Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
US5518734A (en) * 1991-09-25 1996-05-21 Beta Pharmaceuticals Co. Transdermal delivery system for estradiol and process for manufacturing said device
US5705185A (en) * 1991-09-25 1998-01-06 Beta Pharmaceuticals Co. Transdermal delivery of estradiol and process for manufacturing said device
JP2960832B2 (ja) * 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト エストラジオールの投与システム
US5613958A (en) * 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
WO1995006466A1 (en) * 1993-09-01 1995-03-09 Koren Laboratories Pty. Limited Treatment of anorectal disorders
US5552153A (en) * 1994-04-28 1996-09-03 Hoffman-La Roche Inc. Pharmaceutical composition for transdermal delivery
US5580574A (en) * 1994-04-28 1996-12-03 Hoffmann-La Roche Inc. Pharmaceutical composition for transdermal delivery
DE69518729T2 (de) 1994-05-27 2001-05-31 Cellegy Pharma Inc Stickstoffoxyd abgebendes präparat zur behandlung von analen erkrankungen
FR2732223B1 (fr) * 1995-03-30 1997-06-13 Sanofi Sa Composition pharmaceutique pour administration transdermique
US5707612A (en) * 1996-04-08 1998-01-13 Alzo, Inc. Use urethane polymers of castor oil skin and personal care product compositiions
SK284332B6 (sk) * 1996-10-14 2005-01-03 Kowa Company, Ltd. Lokálne anestetikum na vonkajšie použitie
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
IT1294748B1 (it) 1997-09-17 1999-04-12 Permatec Tech Ag Formulazione per un dispositivo transdermico
US7198801B2 (en) * 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
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US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
ATE356636T1 (de) * 2000-08-03 2007-04-15 Antares Pharma Ipl Ag Zusammensetzung zur transdermalen und/oder transmukosalen verabreichung von wirkstoffen, die ausreichende therapeutische spiegel garantiert
DE60227157D1 (de) 2001-02-13 2008-07-31 Us Gov Sec Army Impstoffe zur transkutanen immunisierung gegen reisediarrhö
US6727287B2 (en) 2001-04-16 2004-04-27 Pts International, Inc. Toluene sulfonamide-containing anti-tumor composition and method of use thereof
DE20107040U1 (de) * 2001-04-24 2002-10-02 Novartis Ag Dosierlanze
AT411327B (de) * 2001-08-23 2003-12-29 Heil Bettina Hormonpräparat mit ungesättigten fettsäuren
US20070269379A1 (en) * 2003-07-23 2007-11-22 Samir Mitragotri Penetration Enhancer Combinations for Transdermal Delivery
PT1670433E (pt) * 2003-10-10 2012-02-08 Ferring Bv Fórmula farmacológica transdérmica para a minimização de resíduos na pele
EP1747033A1 (de) 2004-04-30 2007-01-31 Burrell E. Clawson Gerät und verfahren zur isolierung von bereichen eines menschlichen körpers für lokalisierte kühlung
US7425340B2 (en) * 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
US20060078580A1 (en) 2004-10-08 2006-04-13 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US7740875B2 (en) * 2004-10-08 2010-06-22 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
WO2007124250A2 (en) 2006-04-21 2007-11-01 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
WO2007102241A1 (ja) * 2006-03-08 2007-09-13 Nihon Nohyaku Co., Ltd. 外用の医薬組成物
JP5160409B2 (ja) * 2006-03-08 2013-03-13 日本農薬株式会社 外用の医薬組成物
EP2005959B1 (de) * 2006-03-08 2015-01-21 Nihon Nohyaku Co., Ltd. Pharmazeutische zusammensetzung zur ausserlichen verwendung
WO2008067991A2 (en) * 2006-12-08 2008-06-12 Antares Pharma Ipl Ag Skin-friendly drug complexes for transdermal administration
US9283177B2 (en) * 2007-01-16 2016-03-15 Juventio, Llc Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic
CA2675797A1 (en) * 2007-01-16 2008-07-24 Dermworx, Incorporated Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic
CN101808638B (zh) * 2007-09-05 2012-07-25 宝丽制药股份有限公司 抗真菌组合物
HUE030028T2 (en) * 2007-09-05 2017-04-28 Pola Pharma Inc Antifungal drug
JP5529539B2 (ja) 2007-09-05 2014-06-25 株式会社ポーラファルマ 医薬組成物
CA2730787A1 (en) * 2008-07-16 2010-01-21 David M. Cohen Topical drug delivery system
DE102009013469B4 (de) 2009-03-19 2014-04-17 Bubbles And Beyond Gmbh Zubereitung zur äußerlichen Anwendung
JP5688405B2 (ja) 2009-04-09 2015-03-25 株式会社ポーラファルマ 抗真菌医薬組成物
KR101409792B1 (ko) 2009-04-09 2014-06-19 니혼노야쿠가부시키가이샤 항진균성 약제학적 조성물
WO2011024620A1 (en) 2009-08-25 2011-03-03 Pola Pharma Inc. Antimycotic pharmaceutical composition
ITMI20111284A1 (it) 2011-07-11 2013-01-12 Giovanni Nusca Composizione farmaceutica.
KR101839864B1 (ko) 2012-09-21 2018-03-20 인텐시티 쎄라퓨틱스, 인코포레이티드 암을 치료하는 방법
CN111620830A (zh) 2014-03-14 2020-09-04 北卡罗来纳大学教堂山分校 用于抑制雄性生育力的小分子
EP4054549A4 (de) 2019-11-06 2023-12-06 Smartech Topical, Inc. Topische formulierungen von cyclooxygenase-inhibitoren und deren verwendung

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DE2707878C2 (de) * 1977-02-24 1986-01-30 Kali-Chemie Pharma Gmbh, 3000 Hannover Verwendung von Mono- und/oder Diglyceriden mittelkettiger Fettsäuren
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FR2435950A1 (fr) * 1978-06-05 1980-04-11 Riker Laboratories Inc Pansement medical comprenant une composition a base de nitroglycerine, sa fabrication et son application
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CA1163561A (en) * 1979-11-06 1984-03-13 Cyril Boroda Preparation containing nitroglycerine and optionally other medicaments and preparation thereof
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US4305936A (en) * 1980-10-09 1981-12-15 Dermik Laboratories Topical corticosteroid formulations
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Also Published As

Publication number Publication date
KR900002653B1 (ko) 1990-04-21
MY102378A (en) 1992-06-17
JPS63502108A (ja) 1988-08-18
AU625830B2 (en) 1992-07-16
DK407587A (da) 1987-08-05
US4885174A (en) 1989-12-05
EP0250542A1 (de) 1988-01-07
KR880700675A (ko) 1988-04-11
EP0393727A3 (de) 1990-11-22
AU602324B2 (en) 1990-10-11
AU6115890A (en) 1991-02-07
EP0250542B1 (de) 1993-03-17
CA1280974C (en) 1991-03-05
EP0393727A2 (de) 1990-10-24
DK407587D0 (da) 1987-08-05
US4764381A (en) 1988-08-16
DE3688075D1 (de) 1993-04-22
WO1987003490A2 (en) 1987-06-18
AU6733687A (en) 1987-06-30
ATE86870T1 (de) 1993-04-15
WO1987003490A3 (en) 1987-07-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee