DE3680989D1 - Verfahren zur herstellung von festen nifedipinzusammensetzungen mit verzoegerter abgabe und so erhaltene zusammensetzungen. - Google Patents

Verfahren zur herstellung von festen nifedipinzusammensetzungen mit verzoegerter abgabe und so erhaltene zusammensetzungen.

Info

Publication number
DE3680989D1
DE3680989D1 DE8686201704T DE3680989T DE3680989D1 DE 3680989 D1 DE3680989 D1 DE 3680989D1 DE 8686201704 T DE8686201704 T DE 8686201704T DE 3680989 T DE3680989 T DE 3680989T DE 3680989 D1 DE3680989 D1 DE 3680989D1
Authority
DE
Germany
Prior art keywords
polyethylene glycol
active substance
solution
micronized
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686201704T
Other languages
English (en)
Inventor
Massimo Calanchi
Piergiorgio Rossi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adare Pharmaceuticals SRL
Original Assignee
Eurand International SpA
Eurand Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand International SpA, Eurand Italia SpA filed Critical Eurand International SpA
Application granted granted Critical
Publication of DE3680989D1 publication Critical patent/DE3680989D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
DE8686201704T 1985-10-15 1986-10-02 Verfahren zur herstellung von festen nifedipinzusammensetzungen mit verzoegerter abgabe und so erhaltene zusammensetzungen. Expired - Lifetime DE3680989D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22494/85A IT1187751B (it) 1985-10-15 1985-10-15 Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute

Publications (1)

Publication Number Publication Date
DE3680989D1 true DE3680989D1 (de) 1991-09-26

Family

ID=11197023

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686201704T Expired - Lifetime DE3680989D1 (de) 1985-10-15 1986-10-02 Verfahren zur herstellung von festen nifedipinzusammensetzungen mit verzoegerter abgabe und so erhaltene zusammensetzungen.

Country Status (18)

Country Link
US (1) US4880623A (de)
EP (1) EP0220760B1 (de)
JP (1) JPH0811731B2 (de)
KR (1) KR940006320B1 (de)
AT (1) ATE66367T1 (de)
AU (1) AU590622B2 (de)
CA (1) CA1280976C (de)
DE (1) DE3680989D1 (de)
DK (1) DK168691B1 (de)
ES (1) ES2040209T3 (de)
FI (1) FI87424C (de)
GR (1) GR3003150T3 (de)
HK (1) HK12595A (de)
IT (1) IT1187751B (de)
NO (1) NO172168C (de)
NZ (1) NZ217841A (de)
PT (1) PT83522B (de)
ZA (1) ZA867767B (de)

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US5145859A (en) * 1991-03-20 1992-09-08 Case Western Reserve University Methods of treating interstitial cystitis and urethral syndrome
US5271944A (en) * 1991-04-05 1993-12-21 Biofor, Ltd. Pharmacologically enhanced formulations
US5302397A (en) * 1991-11-19 1994-04-12 Amsden Brian G Polymer-based drug delivery system
EP0557244B1 (de) * 1992-02-17 1996-03-13 Siegfried Pharma AG Darreichungsformen mit verlaengerter Wirkstoffreigabe
IL104192A (en) * 1992-02-17 1998-01-04 Siegfried Ag Pharma Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient
WO1994005262A1 (en) * 1992-09-10 1994-03-17 F.H. Faulding & Co. Limited Sustained release matrix composition
US6726930B1 (en) * 1993-09-09 2004-04-27 Penwest Pharmaceuticals Co. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5773025A (en) * 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5543099A (en) * 1994-09-29 1996-08-06 Hallmark Pharmaceutical, Inc. Process to manufacture micronized nifedipine granules for sustained release medicaments
US5618845A (en) * 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
JP3148256B2 (ja) 1996-07-08 2001-03-19 エドワード メンデル カンパニー．，インコーポレーテッド 高用量難溶性薬物用持続放出マトリックス
IT1284604B1 (it) * 1996-09-27 1998-05-21 Roberto Valducci Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva
US5837379A (en) * 1997-01-31 1998-11-17 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
US5922352A (en) * 1997-01-31 1999-07-13 Andrx Pharmaceuticals, Inc. Once daily calcium channel blocker tablet having a delayed release core
US6056977A (en) 1997-10-15 2000-05-02 Edward Mendell Co., Inc. Once-a-day controlled release sulfonylurea formulation
US6485748B1 (en) 1997-12-12 2002-11-26 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US8293277B2 (en) 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
DE60038536T2 (de) * 1999-09-30 2009-06-10 Penwest Pharmaceuticals Co. Matrixsystem mit verzögerter freisetzung für hochlösliche wirkstoffe
JP2003518485A (ja) * 1999-12-23 2003-06-10 ファイザー・プロダクツ・インク 向上された薬物濃度を与える医薬組成物
IL134701A0 (en) 2000-02-23 2001-04-30 J P M E D Ltd Homogeneous solid matrix containing vegetable proteins
US7198795B2 (en) 2000-09-21 2007-04-03 Elan Pharma International Ltd. In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
EP1401399A2 (de) * 2001-06-22 2004-03-31 Pfizer Products Inc. Pharmzeutische zubereitungen enthaltend anlagerungsprodukte aus polymer und wirkstoff
EP1269994A3 (de) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmazeutische Zusammensetzungen die ein Arzneimittel und die Konzentration verbesserende Polymere enthalten
DE10142417A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Arzneimittel
DE10142416A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Verfahren zur Herstellung von Lösungen
US7429238B2 (en) * 2001-10-15 2008-09-30 The Regents Of The University Of Michigan Systems and methods for the generation of crystalline polymorphs
GB0205253D0 (en) * 2002-03-06 2002-04-17 Univ Gent Immediate release pharmaceutical granule compositions and a continuous process for making them
US20040048931A1 (en) * 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
CN1753867A (zh) * 2003-02-24 2006-03-29 马林克罗特公司 制备二苯甲基硫代乙酰胺的方法
CA2519779A1 (en) * 2003-03-26 2004-10-14 Teva Pharmaceutical Industries Ltd. A process for preparing a pharmaceutical active ingredient with high specific surface area
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
CN101490017B (zh) * 2006-02-28 2013-01-23 海利空医疗公司 作为pde4抑制剂的用于治疗的哌嗪类
US20080181966A1 (en) * 2006-10-18 2008-07-31 Cephalon, Inc. Modafinil pharmaceutical compositions
JP2010524919A (ja) * 2007-04-23 2010-07-22 サン、ファーマスーティカル、インダストリーズ、リミテッド 医薬組成物
RU2629843C1 (ru) * 2016-05-24 2017-09-04 федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) Способ получения мази нифедипина (варианты)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO98434A (de) * 1959-04-30
US3988439A (en) * 1973-11-05 1976-10-26 Eli Lilly And Company Dibenzo[b,d]pyranone dispersions
US3920809A (en) * 1973-11-05 1975-11-18 Lilly Co Eli Dibenzo(b,d)pyranone dispersions
DE2400819C2 (de) * 1974-01-09 1982-04-22 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung
US4151273A (en) * 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
EP0001247A1 (de) * 1977-09-14 1979-04-04 Kanebo, Ltd. Nifedipine enthaltendes Arzneipräparat und Verfahren zu seiner Herstellung.
JPS55129221A (en) * 1979-03-29 1980-10-06 Kaken Pharmaceut Co Ltd Preparation of oral preparation containing hardly soluble medicine
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4311694A (en) * 1979-12-31 1982-01-19 American Cyanamid Company Amorphous coprecipitates of 4-(monoalkylamino) benzoic acid and derivatives and certain water-soluble materials
DE3033919A1 (de) * 1980-09-09 1982-04-22 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung
JPS58116414A (ja) * 1981-12-23 1983-07-11 Yamanouchi Pharmaceut Co Ltd ニカルジピン持続性製剤用球形顆粒およびその製造法
DE3318649A1 (de) * 1983-05-21 1984-11-22 Bayer Ag, 5090 Leverkusen Zweiphasenformulierung
HU198844B (en) * 1984-06-14 1989-12-28 Sandoz Ag Process for producing new galenic pharmaceutical composition ensuring retarded release of active ingredient
IT1178511B (it) * 1984-09-14 1987-09-09 Pharmatec Spa Procedimento per la preparazione di una forma solida per uso orale a base di nifedipina con rilascio
DE3438830A1 (de) * 1984-10-23 1986-04-30 Rentschler Arzneimittel Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0220760B1 (de) 1991-08-21
EP0220760A3 (en) 1987-09-23
ATE66367T1 (de) 1991-09-15
HK12595A (en) 1995-02-03
IT1187751B (it) 1987-12-23
PT83522B (pt) 1988-11-30
NO864060L (no) 1987-04-21
AU6383286A (en) 1987-04-16
ES2040209T3 (es) 1993-10-16
KR870003779A (ko) 1987-05-04
ZA867767B (en) 1987-06-24
CA1280976C (en) 1991-03-05
FI87424C (fi) 1993-01-11
NZ217841A (en) 1990-01-29
EP0220760A2 (de) 1987-05-06
US4880623A (en) 1989-11-14
FI87424B (fi) 1992-09-30
FI864151A0 (fi) 1986-10-14
JPS62167727A (ja) 1987-07-24
GR3003150T3 (en) 1993-02-17
NO864060D0 (no) 1986-10-13
FI864151A (fi) 1987-04-16
JPH0811731B2 (ja) 1996-02-07
DK481186D0 (da) 1986-10-08
KR940006320B1 (ko) 1994-07-16
DK481186A (da) 1987-04-16
NO172168B (no) 1993-03-08
AU590622B2 (en) 1989-11-09
DK168691B1 (da) 1994-05-24
PT83522A (en) 1986-11-01
NO172168C (no) 1993-06-16
IT8522494A0 (it) 1985-10-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EURAND INTERNATIONAL S.P.A., MAILAND/MILANO, IT

8328 Change in the person/name/address of the agent

Free format text: TERGAU, E., DIPL.-ING., PAT.-ANW., 90482 NUERNBERG

8339 Ceased/non-payment of the annual fee