DE3677364D1 - Markierte makromolekuele; verfahren zu ihrer herstellung und ihre verwendung in immunologischen oder immunocytochemischen testen. - Google Patents

Markierte makromolekuele; verfahren zu ihrer herstellung und ihre verwendung in immunologischen oder immunocytochemischen testen.

Info

Publication number
DE3677364D1
DE3677364D1 DE8686904953T DE3677364T DE3677364D1 DE 3677364 D1 DE3677364 D1 DE 3677364D1 DE 8686904953 T DE8686904953 T DE 8686904953T DE 3677364 T DE3677364 T DE 3677364T DE 3677364 D1 DE3677364 D1 DE 3677364D1
Authority
DE
Germany
Prior art keywords
macromolecules
immunological
marked
production
immunocytochemical tests
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686904953T
Other languages
English (en)
Inventor
Johannes Tanke
Cornelis Slats
Sebastian Ploem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiteit Leiden
Original Assignee
Universiteit Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Leiden filed Critical Universiteit Leiden
Application granted granted Critical
Publication of DE3677364D1 publication Critical patent/DE3677364D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
DE8686904953T 1985-08-05 1986-08-04 Markierte makromolekuele; verfahren zu ihrer herstellung und ihre verwendung in immunologischen oder immunocytochemischen testen. Expired - Lifetime DE3677364D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8502187 1985-08-05
PCT/NL1986/000022 WO1987000926A1 (en) 1985-08-05 1986-08-04 Labelled macromolecules; a process for their preparation and their use for immunological or immunocytochemical assays

Publications (1)

Publication Number Publication Date
DE3677364D1 true DE3677364D1 (de) 1991-03-07

Family

ID=19846391

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686904953T Expired - Lifetime DE3677364D1 (de) 1985-08-05 1986-08-04 Markierte makromolekuele; verfahren zu ihrer herstellung und ihre verwendung in immunologischen oder immunocytochemischen testen.

Country Status (5)

Country Link
US (1) US5043265A (de)
EP (1) EP0232357B1 (de)
JP (1) JPS63500400A (de)
DE (1) DE3677364D1 (de)
WO (1) WO1987000926A1 (de)

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US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
EP0834576B1 (de) 1990-12-06 2002-01-16 Affymetrix, Inc. (a Delaware Corporation) Detektion von Nukleinsäuresequenzen
CA2069464A1 (en) * 1991-05-28 1992-11-29 Daniel K. Kohn Phosphorescent identification device
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US6864101B1 (en) 1991-11-22 2005-03-08 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
WO1993009668A1 (en) * 1991-11-22 1993-05-27 Affymax Technology N.V. Combinatorial strategies for polymer synthesis
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
DE4210970C2 (de) * 1992-04-02 1996-10-17 Markus Dipl Chem Sauer Verfahren zur simultanen optischen qualitativen und quantitativen Erfassung von verschiedenen mit Fluorochromen oder Fluorogenen markierten Molekülen eines Gemisches mittels Laserspektroskopie
JP3311752B2 (ja) * 1992-07-02 2002-08-05 ソイニ，エルッキ 生体特異的多変数検定法
FR2693740B1 (fr) * 1992-07-17 1994-10-14 Univ Joseph Fourier Procédé de détection tissulaire ou cellulaire mettant en Óoeuvre des réactifs chimiluminescents.
US5736410A (en) * 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
ATE463744T1 (de) * 1992-09-14 2010-04-15 Stanford Res Inst Int Hochkonvertierende reportermoleküle für biologische und andere testverfahren unter verwendung von laseranregungstechniken
US5674698A (en) * 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5698397A (en) * 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US6159686A (en) * 1992-09-14 2000-12-12 Sri International Up-converting reporters for biological and other assays
US6399397B1 (en) * 1992-09-14 2002-06-04 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
JP3410777B2 (ja) * 1993-09-13 2003-05-26 株式会社東芝 超微粒子無機蛍光体標識特異的結合物質およびこれを用いた検出方法
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US6132642A (en) * 1994-07-01 2000-10-17 Sarnoff Corporation Method of preparing small particle size phosphors
US8236493B2 (en) 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
KR970051664A (ko) * 1995-12-29 1997-07-29 윤종용 칼라 음극선관용 형광체 및 그 제조방법
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
GB9811480D0 (en) * 1998-05-29 1998-07-29 Photonic Research Systems Limi Evanescent-wave excitation of upconverting labels
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US6376149B2 (en) * 1999-05-26 2002-04-23 Yale University Methods and compositions for imaging acids in chemically amplified photoresists using pH-dependent fluorophores
CA2406307A1 (en) 2000-04-17 2001-10-25 Yale University Method for measuring diffusion of photogenerated catalyst in chemically amplified resists
AU2001276867A1 (en) * 2000-07-11 2002-01-21 Sri International Encoding methods using up-converting phosphors for high-throughput screening of catalysts
DE10153829A1 (de) 2001-11-05 2003-05-28 Bayer Ag Assay basierend auf dotierten Nanoteilchen
CA2472690A1 (en) * 2002-01-07 2003-07-17 Abbott Gmbh & Co. Kg Crystallization of amino acids using ultrasonic agitation
DE10214019A1 (de) * 2002-03-30 2003-10-16 Detlef Mueller-Schulte Lumineszierende, sphärische, nicht autofluoreszierende Silicagel-Partikel mit veränderbaren Emissionsintensitäten und -frequenzen
US8796030B2 (en) 2003-07-12 2014-08-05 Parallel Synthesis Technologies, Inc. Methods for optically encoding an object with upconverting materials and compositions used therein
US7056473B2 (en) * 2004-04-29 2006-06-06 Response Biomedical Corp. Method and apparatus of quantitative assays
US7919325B2 (en) * 2004-05-24 2011-04-05 Authentix, Inc. Method and apparatus for monitoring liquid for the presence of an additive
US8927892B2 (en) * 2004-10-22 2015-01-06 Parallel Synthesis Technologies Rare earth downconverting phosphor compositions for optically encoding objects and methods and apparatus relating to same
WO2006093966A2 (en) * 2005-02-28 2006-09-08 The Trustees Of Princeton University Sem cathodoluminescent imaging using up-converting nanophosphors
US8673107B2 (en) * 2005-10-28 2014-03-18 Parallel Synthesis Technologies Methods for fabricating optically encoded particles and methods for optically encoding objects with such particles
US7858396B2 (en) * 2005-10-31 2010-12-28 Orasure Technologies, Inc. Lateral flow assay device with multiple equidistant capture zones
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
US10054593B2 (en) 2015-06-05 2018-08-21 Intelleigent Material Solutions, Inc. Multiplexed spectral lifetime detection of phosphors
JP2014531031A (ja) 2011-10-21 2014-11-20 デシマドックス， エルエルシー 小分析物の定量的検出のためのポイントオブケア免疫アッセイ
CN102866252B (zh) * 2012-08-09 2015-01-21 河南省农业科学院 磷光二氧化硅纳米颗粒标记的定量检测西马特罗的免疫层析试纸条及制备方法
US10241045B2 (en) 2012-08-23 2019-03-26 The Regents Of The University Of California Spectrally encoded microbeads and methods and devices for making and using same
US10533996B2 (en) 2013-08-19 2020-01-14 University Of Houston Phosphorescent reporters

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US3886394A (en) * 1973-09-04 1975-05-27 Rca Corp Image display employing filter coated phosphor particles
US4000252A (en) * 1974-01-04 1976-12-28 Kenneth Kosak Immunoscintillation cell
CA1111762A (en) * 1977-12-28 1981-11-03 David S. Frank Fluorescent rare earth chelate in polymeric latex particles
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US4452861A (en) * 1982-05-20 1984-06-05 Rca Corporation Solid particles encapsulated with cyanoacrylate polymer

Also Published As

Publication number Publication date
EP0232357A1 (de) 1987-08-19
US5043265A (en) 1991-08-27
WO1987000926A1 (en) 1987-02-12
JPS63500400A (ja) 1988-02-12
EP0232357B1 (de) 1991-01-30

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Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN