DE3675421D1 - Lypoxygenasehemmende verbindungen. - Google Patents

Lypoxygenasehemmende verbindungen.

Info

Publication number
DE3675421D1
DE3675421D1 DE8686104470T DE3675421T DE3675421D1 DE 3675421 D1 DE3675421 D1 DE 3675421D1 DE 8686104470 T DE8686104470 T DE 8686104470T DE 3675421 T DE3675421 T DE 3675421T DE 3675421 D1 DE3675421 D1 DE 3675421D1
Authority
DE
Germany
Prior art keywords
lypoxygenase
inhibiting compounds
inhibiting
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686104470T
Other languages
English (en)
Inventor
Summers, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE3675421D1 publication Critical patent/DE3675421D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24Anthracenes; Hydrogenated anthracenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26Phenanthrenes; Hydrogenated phenanthrenes
DE8686104470T 1985-04-26 1986-04-02 Lypoxygenasehemmende verbindungen. Expired - Fee Related DE3675421D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/727,934 US4623661A (en) 1985-04-26 1985-04-26 Lipoxygenase inhibiting compounds

Publications (1)

Publication Number Publication Date
DE3675421D1 true DE3675421D1 (de) 1990-12-13

Family

ID=24924704

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686104470T Expired - Fee Related DE3675421D1 (de) 1985-04-26 1986-04-02 Lypoxygenasehemmende verbindungen.

Country Status (4)

Country Link
US (1) US4623661A (de)
EP (1) EP0199151B1 (de)
JP (1) JPS61251642A (de)
DE (1) DE3675421D1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59397B1 (en) * 1985-03-16 1994-02-23 Wellcome Found New aryl derivatives
DE3604050A1 (de) * 1986-02-08 1987-08-13 Boehringer Mannheim Gmbh Thioether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4906667A (en) * 1986-07-30 1990-03-06 E. R. Squibb & Sons, Inc. Phenyl hydroxamic acids including a hetero-containing substituent
US4681894A (en) * 1986-09-26 1987-07-21 Ortho Pharmaceutical Corporation Hydroxamic acids and esters
US4731382A (en) * 1986-12-29 1988-03-15 Bristol-Myers Company Lipoxygenase inhibitory phenylalkanohydroxamic acids
US4820828A (en) * 1987-03-04 1989-04-11 Ortho Pharmaceutical Corporation Cinnamohydroxamic acids
JPH02196767A (ja) * 1988-10-11 1990-08-03 Kyowa Hakko Kogyo Co Ltd ヒドロキサム酸誘導体
US5068251A (en) * 1988-12-16 1991-11-26 Abbott Laboratories Lipoxygenase inhibiting compounds
US5096919A (en) * 1989-01-05 1992-03-17 Ciba-Geigy Corporation Pyrrolylphenyl-substituted hydroxamic acid derivatives
US5175183A (en) * 1989-02-01 1992-12-29 Abbott Laboratories Lipoxygenase inhibiting compounds
US4960787A (en) * 1989-02-06 1990-10-02 Ciba-Geigy Corporation Certain pyrrolyl-substituted hydroxamic acid derivatives
JP3065636B2 (ja) * 1989-06-29 2000-07-17 塩野義製薬株式会社 [ジ―tert―ブチル(ヒドロキシ)フェニルチオ]置換ヒドロキサム酸誘導体
US5032588A (en) * 1989-12-08 1991-07-16 Abbott Laboratories Thiazole lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
US5028629A (en) * 1990-03-28 1991-07-02 Eli Lilly And Company 5-Lipoxygenase inhibitors
US5476873A (en) * 1990-07-25 1995-12-19 Abbott Laboratories Acetylene derivatives having lipoxygenase inhibitory activity
US5804601A (en) * 1995-04-10 1998-09-08 Takeda Chemical Industries, Ltd. Aromatic hydroxamic acid compounds, their production and use
US5972980A (en) * 1995-10-05 1999-10-26 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
US6001866A (en) * 1995-10-05 1999-12-14 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7842727B2 (en) 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
WO2003057184A2 (en) * 2001-12-28 2003-07-17 Integriderm, Inc. Hydroxamic acid and its derivatives as inhibitors of melanocyte tyrosinase for topical skin lighteners
RU2319483C2 (ru) * 2002-02-08 2008-03-20 Ф.Хоффманн-Ля Рош Аг Способ лечения и предупреждения потери костной ткани
WO2003099272A1 (en) 2002-05-22 2003-12-04 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
JP2006508986A (ja) 2002-11-20 2006-03-16 エルラント ゲネ セラペウチクス エルエルシー ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法
JP6463366B2 (ja) 2013-10-10 2019-01-30 イースタン バージニア メディカル スクール 12−リポキシゲナーゼ阻害物質としての4−((2−ヒドロキシ−3−メトキシベンジル)アミノ)ベンゼンスルホンアミド誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3268542A (en) 1965-07-13 1966-08-23 Sinclair Research Inc Certain arylenepoly-1, 3, 2, 4-dioxathiazole oxide compounds
NL6615003A (de) 1965-10-22 1967-04-24
US3681445A (en) 1968-01-19 1972-08-01 Merck & Co Inc Substituted phenyl benzoic acid compounds
US3565944A (en) 1968-03-04 1971-02-23 Du Pont Pharmaceutically active derivatives of ethanooctahydrophenanthrene
US3560518A (en) 1968-03-18 1971-02-02 Sinclair Research Inc Aromatic-poly(nitrile carbonates)
BE791826A (fr) 1971-11-26 1973-05-23 Bayer Ag Nouveaux isocyanates et leur preparation
US4109013A (en) 1974-12-20 1978-08-22 Klinge Pharma Gmbh & Co. Substituted propanol-(2) derivatives of hydroxamic acids and the use thereof as hypolipemic drugs

Also Published As

Publication number Publication date
US4623661A (en) 1986-11-18
JPS61251642A (ja) 1986-11-08
EP0199151B1 (de) 1990-11-07
EP0199151A2 (de) 1986-10-29
EP0199151A3 (en) 1987-10-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee