DE3650706D1 - Substituierte Dicarboxypyridin-Verbindungen - Google Patents

Substituierte Dicarboxypyridin-Verbindungen

Info

Publication number
DE3650706D1
DE3650706D1 DE3650706T DE3650706T DE3650706D1 DE 3650706 D1 DE3650706 D1 DE 3650706D1 DE 3650706 T DE3650706 T DE 3650706T DE 3650706 T DE3650706 T DE 3650706T DE 3650706 D1 DE3650706 D1 DE 3650706D1
Authority
DE
Germany
Prior art keywords
dicarboxypyridine
substituted
compounds
substituted dicarboxypyridine
dicarboxypyridine compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3650706T
Other languages
English (en)
Other versions
DE3650706T2 (de
Inventor
Ron L Hale
Dennis W Solas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wallac Oy
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Publication of DE3650706D1 publication Critical patent/DE3650706D1/de
Application granted granted Critical
Publication of DE3650706T2 publication Critical patent/DE3650706T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
DE3650706T 1985-03-18 1986-03-18 Substituierte Dicarboxypyridin-Verbindungen Expired - Lifetime DE3650706T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/712,774 US4761481A (en) 1985-03-18 1985-03-18 Substituted pyridine derivatives

Publications (2)

Publication Number Publication Date
DE3650706D1 true DE3650706D1 (de) 1999-01-21
DE3650706T2 DE3650706T2 (de) 1999-08-19

Family

ID=24863508

Family Applications (2)

Application Number Title Priority Date Filing Date
DE86103662T Expired - Lifetime DE3689288T2 (de) 1985-03-18 1986-03-18 Substituierte Pyridinderivate.
DE3650706T Expired - Lifetime DE3650706T2 (de) 1985-03-18 1986-03-18 Substituierte Dicarboxypyridin-Verbindungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE86103662T Expired - Lifetime DE3689288T2 (de) 1985-03-18 1986-03-18 Substituierte Pyridinderivate.

Country Status (5)

Country Link
US (1) US4761481A (de)
EP (2) EP0525825B1 (de)
JP (2) JPH07116148B2 (de)
CA (1) CA1276028C (de)
DE (2) DE3689288T2 (de)

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SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
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EP0272320B1 (de) 1986-06-17 1994-03-23 Baxter Diagnostics Inc. Homogenes fluortestverfahren mit abstoss des fluorzenten hintergrundes.
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US5106957A (en) * 1987-11-06 1992-04-21 Baxter Diagnostics Inc. Fluorescent poly(arylpyridine) rare earth chelates
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US5162508A (en) * 1987-12-18 1992-11-10 Compagnie Oris Industrie Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
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US4940796A (en) * 1989-03-17 1990-07-10 The University Of Southern Mississippi 2,6-substituted-4-aminopyridines and their corresponding intermediates
US5026802A (en) * 1989-03-17 1991-06-25 The University Of Southern Mississippi Polymers derived from 2,6-substituted-4-amino-pyridines
US5094759A (en) * 1989-03-17 1992-03-10 The University Of Southern Mississippi Method of water treatment using 2,6-substituted aminopyridines and polymer derived therefrom
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US5367080A (en) * 1990-11-08 1994-11-22 Sterling Winthrop Inc. Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods
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US5158703A (en) * 1991-04-03 1992-10-27 Mitsui Toatsu Chemicals Inc. Resin composition for ultraviolet luminescent screen
FR2680787B1 (fr) * 1991-08-30 1994-11-04 Cis Bio Int Complexes macrocycliques de terres rares et leur utilisation pour reduire les interferences dans un dosage par fluorescence.
EP0626068B1 (de) * 1991-12-05 1999-05-06 Wallac Oy Lumineszierende lanthanidenchelate
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US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
CA2488819A1 (en) * 2002-03-28 2003-11-06 Rutgers, The State University Of New Jersey Bis-transition-metal-chelate-probes
US7018851B2 (en) * 2003-02-13 2006-03-28 Innotrac Diagnostics Oy Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
US8071626B2 (en) * 2003-12-18 2011-12-06 Wallac Oy Chelating agents and highly luminescent and stable chelates and their use
WO2005058877A1 (en) * 2003-12-18 2005-06-30 Wallac Oy Novel chelating agents and highly luminescent and stable chelates and their use
CA2573869A1 (en) * 2004-07-23 2006-02-09 Amgen Inc. Generic probes for the detection of phosphorylated sequences
WO2006039505A2 (en) * 2004-09-30 2006-04-13 Molecular Devices Corporation Luminescent lanthanide complexes
FR2890174B1 (fr) * 2005-08-30 2009-04-24 Cis Bio Internat Sa Procede pour la mise en evidence d'un processus biologique par mesure d'un fret
FR2890446B1 (fr) * 2005-09-05 2008-04-18 Cis Bio Internat Sa Methode de detection d'interaction intracellulaire entre bio-molecules
US7482444B2 (en) * 2006-03-13 2009-01-27 Wallac Oy Terminating substrates for DNA polymerases
EP2052252B1 (de) * 2006-08-18 2010-11-10 Abacus Diagnostica OY Lumineszierende lanthanid-markierungsreagentien und deren verwendung
FI7931U1 (fi) 2007-12-17 2008-07-01 Wallac Oy Kelaatteja
FI7930U1 (fi) 2007-12-17 2008-07-01 Wallac Oy Kelaatteja
FI7928U1 (fi) 2007-12-17 2008-07-01 Wallac Oy Kelaatit ja leimausreagenssit
FI7929U1 (fi) 2007-12-17 2008-07-01 Wallac Oy Kelaatit ja leimausreagenssit
JP5606435B2 (ja) * 2008-07-16 2014-10-15 ラジオメーター・メディカル・アー・ペー・エス トロンビン基質およびサンプル中の生体活性トロンビンのレベルを測定するためのアッセイ
FR2934684B1 (fr) 2008-07-31 2012-11-16 Cis Bio Int Methode de detection de l'internalisation de proteines membranaires.
FR2936245B1 (fr) 2008-09-23 2012-07-06 Cis Bio Int Nouveaux substrats d'o6-alkylguanine-adn alkyltransferase et ses mutants.
NZ592831A (en) * 2008-12-15 2013-06-28 Taigen Biotechnology Co Ltd Stereoselective synthesis of piperidine derivatives
FI20090100A0 (fi) 2009-03-16 2009-03-16 Wallac Oy Biotinidaasimääritys
WO2010125314A1 (fr) 2009-04-30 2010-11-04 Cis-Bio International Procede de detection de composes modulateurs de dimeres de proteines membranaires a domaine vft
WO2010142004A2 (en) 2009-06-10 2010-12-16 Katholieke Universifeit Leuven Controlled biosecure aquatic farming system in a confined environment
FR2949156B1 (fr) 2009-08-13 2016-04-15 Cis-Bio Int Methode de determination de la liaison d'un compose donne a un recepteur membranaire
CN102146284B (zh) * 2010-02-10 2014-01-01 中国科学院大连化学物理研究所 一种比率型荧光探针及其应用
CN103687864A (zh) * 2011-06-17 2014-03-26 国家科研中心 双官能膦酸酯螯合剂
FR2977674B1 (fr) 2011-07-06 2015-08-14 Cisbio Bioassays Methode amelioree de detection et/ou de quantification d'un analyte present a la surface d'une cellule
FR2978149B1 (fr) 2011-07-18 2014-01-10 Cisbio Bioassays Nouveaux agents complexants et complexes de lanthanide correspondant, et leur utilisation comme marqueurs luminescents
FR2980271B1 (fr) 2011-09-16 2013-10-11 Cisbio Bioassays Procede de determination de la glycosylation d'un anticorps
EP2817614A1 (de) 2012-02-22 2014-12-31 Cisbio Bioassays Verfahren zur normalisierung der von einem messmedium emittierten lumineszenz
FR2988174B1 (fr) 2012-03-19 2014-04-25 Cisbio Bioassays Procede de determination de la capacite d'un anticorps a maintenir des cellules a proximite l'une de l'autre
EP2897967B1 (de) 2012-09-24 2017-06-21 Qi Wang Chelate, chelatbildner, davon abgeleitete konjugate und deren verwendung
FR3000960B1 (fr) 2013-01-16 2015-03-06 Cisbio Bioassays Nouveaux agents complexants hydrosolubles et complexes de lanthanide correspondants
FR3004189B1 (fr) 2013-04-04 2015-09-04 Ecole Norm Superieure Lyon Complexes de lanthanide comprenant au moins deux groupes betaines, utiles comme marqueurs luminescents
EP3137573B1 (de) 2014-05-02 2018-08-01 Radiometer Turku Oy Neue chromophore strukturen für lanthanid-chelate
FR3032797B1 (fr) 2015-02-13 2017-03-03 Cisbio Bioassays Procede de quantification d'une proteine d'interet presente dans un echantillon biologique
FR3045053B1 (fr) 2015-12-09 2018-01-05 Cisbio Bioassays Agents complexants hydrosolubles a base de triazapyridinophane et complexes de lanthanide fluorescents correspondants
CN105823777B (zh) * 2016-05-12 2018-03-23 江西理工大学 一种用于快速测定离子吸附型稀土含量的检测装置
JP7215999B2 (ja) 2016-12-21 2023-01-31 エフ．ホフマン－ラ ロシュ アーゲー 抗体またはリガンドの結合および機能を決定するためのアッセイ法
FR3067349B1 (fr) 2017-06-12 2020-12-04 Cisbio Bioassays Nouveaux agents mono et di-antennes complexants hydrosolubles et complexes de lanthanide correspondants
FR3067712B1 (fr) 2017-06-14 2019-08-02 Cisbio Bioassays Nouveaux agents complexants de type trimethoxyphenyl pyridine hydrosolubles et complexes de lanthanide correspondants
FR3069644A1 (fr) 2017-07-28 2019-02-01 Cisbio Bioassays Methode pour mesurer la modulation de l'activation d'un recepteur couple a une proteine g
FR3084365B1 (fr) 2018-07-27 2020-10-23 Cisbio Bioassays Anticorps a domaine unique qui se lient a la proteine g alpha
FR3092172B1 (fr) 2019-01-30 2021-02-12 Cisbio Bioassays Méthode pour mesurer la modulation de l’activation d’un récepteur couplé à une protéine G avec des analogues du GTP

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Also Published As

Publication number Publication date
EP0525825B1 (de) 1998-12-09
DE3689288T2 (de) 1994-03-03
JPH07267927A (ja) 1995-10-17
US4761481A (en) 1988-08-02
EP0525825A3 (en) 1993-04-07
EP0195413A2 (de) 1986-09-24
DE3650706T2 (de) 1999-08-19
EP0525825A2 (de) 1993-02-03
DE3689288D1 (de) 1993-12-23
JPS62187454A (ja) 1987-08-15
EP0195413B1 (de) 1993-11-18
CA1276028C (en) 1990-11-06
JPH07116148B2 (ja) 1995-12-13
EP0195413A3 (en) 1990-04-25
JP2623452B2 (ja) 1997-06-25

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