DE3650055T2 - Fibroblast-wachstumsfaktor. - Google Patents
Fibroblast-wachstumsfaktor.Info
- Publication number
- DE3650055T2 DE3650055T2 DE3650055T DE3650055T DE3650055T2 DE 3650055 T2 DE3650055 T2 DE 3650055T2 DE 3650055 T DE3650055 T DE 3650055T DE 3650055 T DE3650055 T DE 3650055T DE 3650055 T2 DE3650055 T2 DE 3650055T2
- Authority
- DE
- Germany
- Prior art keywords
- bfgf
- growth factor
- fibroblast growth
- amino acid
- acid residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factors [FGF]
- C07K14/503—Fibroblast growth factors [FGF] basic FGF [bFGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/839—Nerves; brain
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/747,154 US4956455A (en) | 1984-03-05 | 1985-06-20 | Bovine fibroblast growth factor |
PCT/US1986/001318 WO1986007595A1 (en) | 1985-06-20 | 1986-06-18 | Fibroblast growth factor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3650055D1 DE3650055D1 (de) | 1994-10-06 |
DE3650055T2 true DE3650055T2 (de) | 1994-12-15 |
Family
ID=25003873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3650055T Expired - Lifetime DE3650055T2 (de) | 1985-06-20 | 1986-06-18 | Fibroblast-wachstumsfaktor. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4956455A (de) |
EP (2) | EP0228449B1 (de) |
JP (1) | JPH0829097B2 (de) |
AT (1) | ATE110744T1 (de) |
CA (1) | CA1341638C (de) |
DE (1) | DE3650055T2 (de) |
WO (1) | WO1986007595A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5235042A (en) * | 1984-02-29 | 1993-08-10 | The Children's Medical Center Corporation | Endothelial cell growth factor |
US5155214A (en) * | 1984-03-05 | 1992-10-13 | The Salk Institute For Biological Studies | Basic fibroblast growth factor |
US5604293A (en) * | 1985-09-12 | 1997-02-18 | Scios Inc. | Recombinant human basic fibroblast growth factor |
US5439818A (en) * | 1985-09-12 | 1995-08-08 | Scios Nova Inc. | DNA encoding human recombinant basic fibroblast growth factor |
DE3689845T3 (de) * | 1985-09-12 | 2001-11-15 | Scios Inc | Rekombinanter fibroblast-wachstumsfaktor. |
US5859208A (en) * | 1988-07-06 | 1999-01-12 | Fiddes; John C. | Human basic fibroblast growth factor analog |
US4994559A (en) * | 1985-12-17 | 1991-02-19 | Synergen, Inc. | Human basic fibroblast growth factor |
US5026839A (en) * | 1985-12-17 | 1991-06-25 | Synergen, Inc | DNA encoding a basic fibroblast growth factor |
US7223842B1 (en) | 1986-08-11 | 2007-05-29 | Massachusetts Eye And Ear Infirmary | Detection of proteins whose absence is associated with a neoplasm |
US7384735B1 (en) | 1986-08-11 | 2008-06-10 | Massachusetts Eye And Ear Infirmary | Retinoblastoma nucleic acids |
US5853988A (en) * | 1986-08-11 | 1998-12-29 | Massachusetts Eye And Ear Infirmary | Diagnosis of retinoblastoma |
JPH01501840A (ja) * | 1987-01-16 | 1989-06-29 | アムジエン・インコーポレーテツド | 繊維芽細胞成長因子の産生 |
US5852177A (en) * | 1987-02-24 | 1998-12-22 | Takeda Chemical Industries, Ltd. | Basic fibroblast growth factor (bFGF) muteins |
JP2526965B2 (ja) * | 1987-02-24 | 1996-08-21 | 武田薬品工業株式会社 | ムテイン,dnaおよびその用途 |
US5459250A (en) | 1987-06-16 | 1995-10-17 | New York University | Truncated mammalian growth factor DNA sequence |
US5750659A (en) * | 1987-06-16 | 1998-05-12 | New York University | Mammalian growth factor |
DE3721081A1 (de) * | 1987-06-26 | 1989-01-19 | Progen Biotechnik Gmbh | Dna-sequenz, die codiert fuer ein zellteilungsfoerderndes polypeptid, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses polypeptids |
AU629176B2 (en) * | 1987-07-07 | 1992-10-01 | Scios Nova Inc. | Recombinant fibroblast growth factors |
KR890701607A (ko) * | 1987-11-24 | 1989-12-21 | 원본미기재 | 섬유아세포 성장 인자의 유사체 |
EP0339905A3 (de) * | 1988-04-25 | 1991-05-08 | Ethicon, Inc. | Wachstumfaktoren und Retinoiden enthaltende Wundheilungzusammensetzungen |
US5126323A (en) * | 1989-11-16 | 1992-06-30 | Genetics Institute, Inc. | Homogeneous purified k-fgf and compositions containing the same |
GB9017008D0 (en) * | 1990-08-02 | 1990-09-19 | Erba Carlo Spa | Process for the enzymatic preparation of basic fibroblast growth factor |
ES2087207T3 (es) * | 1990-11-23 | 1996-07-16 | American Cyanamid Co | Factor del crecimiento de fibroblasto quimerico. |
DE69204990T2 (de) * | 1991-01-03 | 1996-05-15 | Salk Inst For Biological Studi | Mitotoxin zur behandlung von gefässbeschädigung. |
US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
US5492894A (en) * | 1991-03-21 | 1996-02-20 | The Procter & Gamble Company | Compositions for treating wrinkles comprising a peptide |
US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
DE4132005A1 (de) * | 1991-09-26 | 1993-04-01 | Merck Patent Gmbh | Kombination enthaltend wachstumsfaktoren und polyelektrolyte |
EP0580874A4 (en) * | 1992-02-14 | 1997-02-26 | Kaken Pharma Co Ltd | Remedy for airway diseases |
GB9203533D0 (en) * | 1992-02-19 | 1992-04-08 | Erba Carlo Spa | Use of the conjugate between a fibroblast growth factor and a saporin in treating ocular pathologies |
US5348941A (en) * | 1992-04-01 | 1994-09-20 | Merck & Co., Inc. | Stabilizers for fibroblast growth factors |
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
US5795737A (en) * | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
KR100374310B1 (ko) * | 1995-02-14 | 2003-05-22 | 주식회사 엘지생명과학 | 변형된인간염기성섬유아세포성장인자및이의생산방법 |
EP0832216A4 (de) * | 1995-06-05 | 1999-06-16 | Human Genome Sciences Inc | Fibroblaster wachstumsfaktor |
US5773252A (en) | 1995-06-05 | 1998-06-30 | Human Genome Sciences, Inc. | Fibroblast growth factor 15 |
US6274712B1 (en) | 1997-12-23 | 2001-08-14 | 3-Dimensional Pharmaceuticals, Inc. | Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137 |
CA2339330A1 (en) * | 1998-08-13 | 2000-02-24 | University Of Southern California | Methods to increase blood flow to ischemic tissue |
ES2233101T3 (es) | 1998-09-03 | 2005-06-01 | Chiron Corp | Dosis unitaria de fgf-2 angiogenicamente efectiva y su utilizacion. |
US6440934B1 (en) | 1998-10-13 | 2002-08-27 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
US20020072489A1 (en) * | 1998-10-13 | 2002-06-13 | Whitehouse Martha J. | Angiogenically effective unit dose of FGF-2 and method of use |
US8618052B2 (en) | 1998-10-13 | 2013-12-31 | Novartis Vaccines And Diagnostics, Inc. | Method of treating coronary artery disease by administering FGF-5 |
US6451303B1 (en) * | 1998-10-13 | 2002-09-17 | Chiron Corporation | Method of treating coronary artery disease by administering a recombinant FGF |
US20030166550A1 (en) | 1999-08-27 | 2003-09-04 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
WO2001013031A2 (en) * | 1999-08-13 | 2001-02-22 | Chiron Corporation | Dose of an angiogenic factor and method of administering to improve myocardial blood flow |
JP2005503759A (ja) * | 2001-01-24 | 2005-02-10 | アメリカ合衆国 | 幹細胞の膵臓内分泌細胞への分化方法 |
US20030211605A1 (en) * | 2001-05-01 | 2003-11-13 | Lee Sang-Hun | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
DK1541674T3 (da) | 2002-06-18 | 2011-03-14 | Eisai R&D Man Co Ltd | Primære dyrkede adipocyter til genterapi |
JP2007517042A (ja) | 2003-12-30 | 2007-06-28 | デュレクト コーポレーション | 活性物質、好ましくはgnrhの制御放出のための、好ましくはpegおよびplgの混合物を含有するポリマーインプラント |
CA2695321A1 (en) | 2007-08-16 | 2009-02-26 | Andreas Androutsellis-Theotokis | Methods for promoting stem cell proliferation and survival |
US8623820B2 (en) * | 2008-05-02 | 2014-01-07 | University Of Western Ontario | FGF-9 and its use relating to blood vessels |
EP3323884A1 (de) | 2013-02-01 | 2018-05-23 | The United States Of America as Represented by the Secretary, Department of Health an Human Service | Verfahren zur erzeugung von zellen im retinalen pigmentepithel aus induzierten pluripotenten stammzellen |
US11530388B2 (en) | 2017-02-14 | 2022-12-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of engineering human induced pluripotent stem cells to produce liver tissue |
JP2022513073A (ja) | 2018-11-19 | 2022-02-07 | ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 生分解性組織置換インプラントおよびその使用 |
CA3220433A1 (en) | 2021-05-28 | 2022-12-01 | Arvydas Maminishkis | Biodegradable tissue scaffold with secondary matrix to host weakly adherent cells |
EP4347795A1 (de) | 2021-05-28 | 2024-04-10 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Verfahren zur erzeugung von makula-, zentralen und peripheren retinapigmentepithelzellen |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3689845T3 (de) * | 1985-09-12 | 2001-11-15 | Scios Inc | Rekombinanter fibroblast-wachstumsfaktor. |
EP0241830A3 (en) * | 1986-04-08 | 1990-01-10 | The General Hospital Corporation | Hepatoma-derived growth factor |
DE4213967A1 (de) * | 1992-04-29 | 1993-11-04 | Basf Ag | Waessrige polymerisatdispersion |
-
1985
- 1985-06-20 US US06/747,154 patent/US4956455A/en not_active Expired - Lifetime
-
1986
- 1986-06-09 CA CA511143A patent/CA1341638C/en not_active Expired - Fee Related
- 1986-06-18 WO PCT/US1986/001318 patent/WO1986007595A1/en active IP Right Grant
- 1986-06-18 EP EP86904536A patent/EP0228449B1/de not_active Expired - Lifetime
- 1986-06-18 DE DE3650055T patent/DE3650055T2/de not_active Expired - Lifetime
- 1986-06-18 JP JP61503569A patent/JPH0829097B2/ja not_active Expired - Lifetime
- 1986-06-18 EP EP94200028A patent/EP0597827A1/de not_active Withdrawn
- 1986-06-18 AT AT86904536T patent/ATE110744T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0228449B1 (de) | 1994-08-31 |
JPS63500036A (ja) | 1988-01-07 |
US4956455A (en) | 1990-09-11 |
ATE110744T1 (de) | 1994-09-15 |
EP0228449A4 (de) | 1989-04-24 |
DE3650055D1 (de) | 1994-10-06 |
EP0597827A1 (de) | 1994-05-18 |
EP0228449A1 (de) | 1987-07-15 |
JPH0829097B2 (ja) | 1996-03-27 |
CA1341638C (en) | 2014-06-17 |
WO1986007595A1 (en) | 1986-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8365 | Fully valid after opposition proceedings |