DE3588243T2 - Nachweisverfahren durch Induktion von Elektrochemilumineszenz - Google Patents

Nachweisverfahren durch Induktion von Elektrochemilumineszenz

Info

Publication number
DE3588243T2
DE3588243T2 DE3588243T DE3588243T DE3588243T2 DE 3588243 T2 DE3588243 T2 DE 3588243T2 DE 3588243 T DE3588243 T DE 3588243T DE 3588243 T DE3588243 T DE 3588243T DE 3588243 T2 DE3588243 T2 DE 3588243T2
Authority
DE
Germany
Prior art keywords
substance
compound
ligands
formula
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3588243T
Other languages
English (en)
Other versions
DE3588243D1 (de
Inventor
Allen J Bard
George M Whitesides
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioveris Corp
Original Assignee
IGEN International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IGEN International Inc filed Critical IGEN International Inc
Publication of DE3588243D1 publication Critical patent/DE3588243D1/de
Application granted granted Critical
Publication of DE3588243T2 publication Critical patent/DE3588243T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0046Ruthenium compounds
    • C07F15/0053Ruthenium compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/002Osmium compounds
    • C07F15/0026Osmium compounds without a metal-carbon linkage
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/806Electrical property or magnetic property
DE3588243T 1984-10-31 1985-10-30 Nachweisverfahren durch Induktion von Elektrochemilumineszenz Expired - Lifetime DE3588243T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66698784A 1984-10-31 1984-10-31
US06/789,113 US5238808A (en) 1984-10-31 1985-10-24 Luminescent metal chelate labels and means for detection

Publications (2)

Publication Number Publication Date
DE3588243D1 DE3588243D1 (de) 2003-01-30
DE3588243T2 true DE3588243T2 (de) 2003-10-30

Family

ID=27099589

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3588243T Expired - Lifetime DE3588243T2 (de) 1984-10-31 1985-10-30 Nachweisverfahren durch Induktion von Elektrochemilumineszenz
DE3587793T Expired - Lifetime DE3587793T2 (de) 1984-10-31 1985-10-30 Lumineszierende metallchelatmarker und mittel zu deren nachweis.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3587793T Expired - Lifetime DE3587793T2 (de) 1984-10-31 1985-10-30 Lumineszierende metallchelatmarker und mittel zu deren nachweis.

Country Status (10)

Country Link
US (1) US5238808A (de)
EP (2) EP0199804B1 (de)
JP (4) JPH0826054B2 (de)
AT (2) ATE230114T1 (de)
AU (1) AU5020085A (de)
CA (1) CA1339835C (de)
DE (2) DE3588243T2 (de)
HK (2) HK1007349A1 (de)
IL (1) IL76872A (de)
WO (1) WO1986002734A1 (de)

Families Citing this family (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK365785A (da) * 1984-09-17 1986-03-18 Hoffmann La Roche Metalcomplexer
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5585279A (en) * 1986-01-23 1996-12-17 Davidson; Robert S. Time-resolved luminescence binding assays using a fluorescent transition metal label other than ruthenium
GB8601646D0 (en) * 1986-01-23 1986-02-26 Davidson R S Binding assay & reagent
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
CA1339465C (en) * 1986-04-30 1997-09-16 Richard J. Massey Electrochemiluminescent assays
US6165729A (en) * 1986-04-30 2000-12-26 Hyperion Catalysis International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US6271041B1 (en) * 1986-04-30 2001-08-07 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US5591581A (en) * 1986-04-30 1997-01-07 Igen, Inc. Electrochemiluminescent rhenium moieties and methods for their use
US6316607B1 (en) 1986-04-30 2001-11-13 Igen International, Inc. Electrochemiluminescent assays
US6451225B1 (en) * 1986-04-30 2002-09-17 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US5770459A (en) * 1986-04-30 1998-06-23 Igen International, Inc. Methods and apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence detection
US6881536B1 (en) * 1986-04-30 2005-04-19 Bioveris Corporation Particle based electrochemiluminescent assays
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
WO1988007670A2 (en) * 1987-03-27 1988-10-06 Chimerix Corporation Time-resolved fluorescence apparatus and immunoassay
US4855930A (en) * 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
US6881589B1 (en) * 1987-04-30 2005-04-19 Bioveris Corporation Electrochemiluminescent localizable complexes for assay compositions
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
HU204856B (en) * 1987-08-12 1992-02-28 Orszagos Mueszaki Fejlesztesi Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates
ATE259064T1 (de) * 1987-11-04 2004-02-15 Igen Int Inc Lumineszente rhenium-komplexe und verfahren zur herstellung
SE8800613D0 (sv) * 1988-02-23 1988-02-23 Wallac Oy A novel spectrofluorometric method and compounds that are of value for the method
US5308754A (en) * 1988-03-21 1994-05-03 Kankare Jouko J Electrogenerated luminescence in solution
SE461117B (sv) * 1988-03-21 1990-01-08 Jouko J Kankare Foerfarande foer bestaemning av koncentrationen av en luminiscerande lantanid foerening
US5093268A (en) * 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
CA1325527C (en) * 1988-04-28 1993-12-28 Nicholas Leventis Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US6702986B1 (en) 1988-04-29 2004-03-09 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
EP0441894B1 (de) * 1988-11-03 1997-12-10 Igen, Inc. Elektrochemilumineszente reaktion unter verwendung eines von einem amin abgeleiteten reduktionsmittels
US5068088A (en) * 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5247243A (en) * 1988-11-03 1993-09-21 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5061445A (en) * 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
CA2002083C (en) * 1988-11-03 2001-01-09 Haresh P. Shah Enhanced electrochemiluminescence
US5298427A (en) * 1990-04-24 1994-03-29 The Board Of Trustees Of The University Of Arkansas Chemiluminescent detection of amino acids
ZA92804B (en) 1991-02-06 1992-12-30 Igen Inc Methods and apparatus for improved luminescence assays
IL100866A (en) * 1991-02-06 1995-10-31 Igen Inc Luminescence test method and device based on magnetic tiny particles, containing many magnets
FR2673183B1 (fr) * 1991-02-21 1996-09-27 Asulab Sa Complexes mono, bis ou tris (2,2'-bipyridine substituee) d'un metal choisi parmi le fer, le ruthenium, l'osmium ou le vanadium et leurs procedes de preparation .
WO1993001308A1 (en) * 1991-07-10 1993-01-21 Igen, Inc. Methods and apparatus for improved luminescence assays using particle concentration and chemiluminescence detection
ZA929351B (en) * 1991-12-11 1993-06-04 Igen Inc Electrochemiluminescent label for DNA assays.
US5541113A (en) * 1993-09-22 1996-07-30 Beckman Instruments, Inc. Method for detecting an analyte using an electrochemical luminescent transition metal label
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
AU689626B2 (en) 1994-07-25 1998-04-02 Boehringer Mannheim Gmbh Peptides marked with metal chelates
CN1075817C (zh) * 1994-07-25 2001-12-05 罗切诊断学有限公司 亲水的金属络合物
WO1996003409A1 (de) * 1994-07-25 1996-02-08 Boehringer Mannheim Gmbh Metallkomplexe mit geladenem linker
US5786141A (en) * 1994-08-26 1998-07-28 Bard; Allen J. Electrogenerated chemiluminescence labels for analysis and/or referencing
JPH10509025A (ja) * 1994-08-26 1998-09-08 アイジェン, インコーポレイテッド 固体表面に吸着された核酸の電気的に発生した化学ルミネッセンス性検出のためのバイオセンサーおよび方法
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6472148B1 (en) 1994-09-26 2002-10-29 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5744367A (en) * 1994-11-10 1998-04-28 Igen International, Inc. Magnetic particle based electrochemiluminescent detection apparatus and method
FR2727415A1 (fr) * 1994-11-30 1996-05-31 Commissariat Energie Atomique Complexes du ruthenium utilisables en particulier pour determiner la topologie des proteines, et leur procede de preparation
US20010003647A1 (en) * 1995-06-07 2001-06-14 Ji Sun Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same
US5610075A (en) * 1995-01-17 1997-03-11 Stahl-Rees; Marianne Competitive electrochemiluminescence assays for endotoxins using a ruthenium label
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
AU720625B2 (en) * 1995-03-10 2000-06-08 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
AU5665196A (en) * 1995-04-18 1996-11-07 Igen, Inc. Electrochemiluminescence of rare earth metal chelates
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
WO1996036870A1 (en) * 1995-05-18 1996-11-21 Igen, Inc. Method for derivitizing electrodes and assay methods using such derivitized electrodes
CA2223027A1 (en) 1995-06-07 1996-12-19 Igen, Inc. Electrochemiluminescent enzyme immunoassay
US5807978A (en) * 1995-06-07 1998-09-15 Kokolus; William J. Immunogenic peptides of prostate specific antigen
US6099760A (en) * 1995-06-07 2000-08-08 Igen, Inc. Hydrogen peroxide based ECL
CA2205050A1 (en) * 1995-09-12 1997-03-20 Yuzaburo Namba Method and apparatus for measuring electrochemiluminescent emission
FR2747694B1 (fr) * 1996-04-18 1998-06-05 France Etat Cathode pour la reduction de dioxyde de carbone et procede de fabrication d'une telle cathode
US20030078416A1 (en) * 1996-04-30 2003-04-24 Yitzhak Tor Substituted phenanthrolines
AU739391B2 (en) * 1996-07-03 2001-10-11 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7045285B1 (en) * 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US5958573A (en) * 1997-02-10 1999-09-28 Quantum Energy Technologies Electroluminescent device having a structured particle electron conductor
US5976887A (en) * 1997-06-02 1999-11-02 Applied Research Associates, Inc. Electrochemiluminescence assays based on interactions with soluble metal ions and diaminoaromatic ligands
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6613583B1 (en) 1997-06-27 2003-09-02 Igen International, Inc. Electrochemiluminescent label based on multimetallic assemblies
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
DE19811582A1 (de) * 1998-03-17 1999-09-23 Roche Diagnostics Gmbh Stabilisierung und Verstärkung von Elektrochemilumineszenz-Signalen
EP0957360B1 (de) 1998-05-06 2002-07-31 Roche Diagnostics GmbH Entstörung durch Rheumafaktoren
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
WO1999059578A1 (en) 1998-05-19 1999-11-25 Research Development Foundation Triterpene compositions and methods for use thereof
WO1999063346A1 (en) 1998-06-01 1999-12-09 Roche Diagnostics Corporation Method and device for electrochemical immunoassay of multiple analytes
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
DE19828441A1 (de) 1998-06-25 1999-12-30 Roche Diagnostics Gmbh Verwendung derivatisierter Reagenzien in Chemilumineszenz- und Elektrochemilumineszenz-Nachweisverfahren
WO2000001848A1 (fr) * 1998-07-01 2000-01-13 Hitachi, Ltd. Appareil et methode de criblage de polynucleotide
US6656471B1 (en) 1998-11-17 2003-12-02 Board Of Regents, The University Of Texas System HIV-specific T-cell induction
US6833267B1 (en) * 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US20030068635A1 (en) * 1999-02-16 2003-04-10 Boehringer Mannheim Gmbh Determination of an analyte using two labels
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
DE19933104A1 (de) * 1999-07-15 2001-01-18 Ingo Klimant Phosphoreszierende Mikro- und Nanopartikel als Referenzstandard und Phosphoreszenzmarker
CA2380258C (en) 1999-07-26 2008-07-15 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
US6136268A (en) * 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
US7141436B2 (en) * 1999-11-03 2006-11-28 Science And Technology Corp. Immunoassay and reagents and kits for performing the same
KR100937470B1 (ko) * 1999-12-01 2010-01-19 더 트러스티즈 오브 프린스턴 유니버시티 유기 led용 인광성 도펀트로서 l2mx 형태의 화합물
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
WO2001094951A2 (en) * 2000-06-08 2001-12-13 Board Of Regents, The University Of Texas System Inhibitors of c-reactive protein induced inflammation
WO2002007779A1 (en) * 2000-07-21 2002-01-31 University Of Maryland, Baltimore Long wavelength long lifetime luminophores
US20060148732A1 (en) * 2000-11-17 2006-07-06 Gutterman Jordan U Inhibition of NF-kappaB by triterpene compositions
GB0103765D0 (en) * 2001-02-15 2001-04-04 Affitech As Assay
US20020173042A1 (en) * 2001-03-16 2002-11-21 Timothy Oolman Method of tagging agricultural products
US7695919B2 (en) * 2001-05-10 2010-04-13 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US6989276B2 (en) 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
USRE46351E1 (en) 2001-05-10 2017-03-28 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
USRE44031E1 (en) 2001-05-10 2013-02-26 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
SE0102327D0 (sv) 2001-06-28 2001-06-28 Active Biotech Ab A novel engineered superantigen for human therapy
EP2423673B8 (de) 2001-06-29 2020-10-28 Meso Scale Technologies, LLC. Vorrichtung zum Messen der Lumineszenz aus einer Multi-Well-Testplatte mit mehreren Wells, Verfahren zum Messen der Lumineszenz unter Verwendung der Vorrichtung und System welches die Vorrichtung umfasst
DE60236732D1 (de) 2001-07-30 2010-07-29 Meso Scale Technologies Llc Assay-elektroden mit schichten aus immobilisiertem lipid/protein sowie verfahren zu deren herstellung und verwendung
KR100454868B1 (ko) * 2001-08-01 2004-11-05 주식회사 아이센스 신규의 전기화학발광 면역분석 표지물질인 루테늄착화합물 및 그의 제조방법
CA2459893C (en) * 2001-09-10 2014-01-21 Meso Scale Technologies, Llc Methods and apparatus for conducting multiple measurements on a sample
US7553448B2 (en) 2002-06-20 2009-06-30 Bioveris Corporation Electrochemiluminescence flow cell and flow cell components
EP1546359A4 (de) * 2002-09-12 2007-05-09 Molecular Probes Inc Stellenspezifische markierung von affinitätstags in fusionsproteinen
US7000870B2 (en) * 2002-11-07 2006-02-21 Aerion Corporation Laminar flow wing for transonic cruise
US20050003422A1 (en) 2003-07-01 2005-01-06 Mitch Reponi Methods for assessing and treating cancer
US7238536B1 (en) 2004-03-22 2007-07-03 Florida State University Research Foundation, Inc. Controlled transport through multiple reversible interaction point membranes
EP1769243A2 (de) * 2004-05-15 2007-04-04 Genentech, Inc. Kreuzscreening-system und verfahren für den nachweis eines moleküls mit bindungsaffinität für ein zielmolekül
EP1836495A2 (de) * 2004-11-17 2007-09-26 BioVeris Corporation Elektrochemilumineszente untersuchung
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
JP5205062B2 (ja) * 2005-02-10 2013-06-05 イエダ リサーチ アンド デベロップメント カンパニー リミテッド 酸化還元活性構造体およびそれを利用するデバイス
KR101311815B1 (ko) 2005-06-03 2013-10-22 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 단일 패러데이 전극에서의 전기발생 화학발광 및 전기화학
WO2007002580A2 (en) * 2005-06-23 2007-01-04 Bioveris Corporation Diagnostic as say system with multi -well reagent container
US20070026012A1 (en) 2005-08-01 2007-02-01 Cornell Research Foundation, Inc. Compositions and methods for monitoring and altering protein folding and solubility
WO2008019162A2 (en) 2006-01-18 2008-02-14 University Of Chicago Compositions and methods related to staphylococcal bacterium proteins
EP1996943B1 (de) 2006-03-09 2014-06-25 F.Hoffmann-La Roche Ag Assay für antikörper gegen arzneistoff
US20080108513A1 (en) * 2006-06-01 2008-05-08 Northwestern University Cellular Arrays
US7749772B1 (en) 2006-06-29 2010-07-06 Varian, Inc. Antibody and immunoassays for determining the presence of Δ9-Tetrahydrocannabinol
WO2008031532A1 (en) 2006-09-12 2008-03-20 F. Hoffmann-La Roche Ag Anti-drug antibody assay
CA2666968A1 (en) 2006-10-20 2008-10-30 Arizona Board Of Regents For And On Behalf Of Arizona State University Modified cyanobacteria
KR100869589B1 (ko) 2006-12-19 2008-11-21 단국대학교 산학협력단 바이오센서를 이용한 생체 물질의 정량적 측정 방법
US8951632B2 (en) 2007-01-03 2015-02-10 Applied Nanostructured Solutions, Llc CNT-infused carbon fiber materials and process therefor
US9005755B2 (en) 2007-01-03 2015-04-14 Applied Nanostructured Solutions, Llc CNS-infused carbon nanomaterials and process therefor
US8158217B2 (en) 2007-01-03 2012-04-17 Applied Nanostructured Solutions, Llc CNT-infused fiber and method therefor
US8951631B2 (en) 2007-01-03 2015-02-10 Applied Nanostructured Solutions, Llc CNT-infused metal fiber materials and process therefor
US20100323373A1 (en) 2007-02-27 2010-12-23 Stefan Evers Method for the assessment of the inhibitory activity of antibodies against insulin-like growth factor i receptor
US8351674B2 (en) 2007-05-31 2013-01-08 Battelle Energy Alliance, Llc Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture
GB0711849D0 (en) 2007-06-19 2007-07-25 Oxford Biosensors Ltd Redox Mediators
EP2223118B1 (de) 2007-12-15 2013-02-27 F. Hoffmann-La Roche AG Unterscheidungsprobe
US9383369B2 (en) 2008-03-31 2016-07-05 Barb Ariel Cohen Methods for improving fertility and selectivity for desired offspring sex in artificial insemination
WO2009146043A1 (en) * 2008-03-31 2009-12-03 Cohen B Arial Assay for semen optimization
SI2271938T1 (sl) 2008-04-11 2014-07-31 Board Of Regents Of The University Of Texas System Postopek in naprava za ojačenje električno generirane kemiluminiscence nanodelcev
EP2626692A3 (de) 2008-05-08 2014-10-01 Board of Regents of the University of Texas System Nanostrukturierte lumineszente Materialien zur Verwendung in elektrogenerierter Chemolumineszenz
US8264347B2 (en) 2008-06-24 2012-09-11 Trelleborg Sealing Solutions Us, Inc. Seal system in situ lifetime measurement
US20110262477A1 (en) 2008-10-06 2011-10-27 University Of Chicago Compositions and Methods Related to Bacterial EAP, EMP, and/or ADSA Proteins
US8614297B2 (en) 2008-12-22 2013-12-24 Hoffmann-La Roche Inc. Anti-idiotype antibody against an antibody against the amyloid β peptide
WO2010144161A2 (en) 2009-02-17 2010-12-16 Lockheed Martin Corporation Composites comprising carbon nanotubes on fiber
BRPI1008131A2 (pt) 2009-02-27 2016-03-08 Applied Nanostructured Sols "crescimento de nanotubo de carbono de baixa temperatura usando método de preaquecimento de gás".
US20100224129A1 (en) 2009-03-03 2010-09-09 Lockheed Martin Corporation System and method for surface treatment and barrier coating of fibers for in situ cnt growth
WO2011127032A1 (en) 2010-04-05 2011-10-13 University Of Chicago Compositions and methods related to protein a (spa) antibodies as an enhancer of immune response
CN102612523B (zh) 2009-04-03 2016-01-20 芝加哥大学 与蛋白a(spa)变体相关的组合物和方法
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
US8325079B2 (en) 2009-04-24 2012-12-04 Applied Nanostructured Solutions, Llc CNT-based signature control material
US9111658B2 (en) 2009-04-24 2015-08-18 Applied Nanostructured Solutions, Llc CNS-shielded wires
JP5744008B2 (ja) 2009-04-27 2015-07-01 アプライド ナノストラクチャード ソリューションズ リミテッド ライアビリティー カンパニーApplied Nanostructuredsolutions, Llc 複合材料構造体を除氷するためのcntベース抵抗加熱
EP2470914B1 (de) 2009-07-27 2020-05-13 Meso Scale Technologies, LLC Assay-vorrichtungen und -verfahren
EP2461953A4 (de) 2009-08-03 2014-05-07 Applied Nanostructured Sols Einsatz von nanopartikeln in verbundfasern
US9410965B2 (en) 2009-09-17 2016-08-09 Battelle Energy Alliance, Llc Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US8969009B2 (en) 2009-09-17 2015-03-03 Vicki S. Thompson Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
KR20120120172A (ko) 2009-11-23 2012-11-01 어플라이드 나노스트럭처드 솔루션스, 엘엘씨. Cnt 맞춤형 복합재 해상 기반의 구조체
CA2775619A1 (en) 2009-11-23 2011-05-26 Applied Nanostructured Solutions, Llc Ceramic composite materials containing carbon nanotube-infused fiber materials and methods for production thereof
JP2013520328A (ja) 2009-12-14 2013-06-06 アプライド ナノストラクチャード ソリューションズ リミテッド ライアビリティー カンパニー カーボン・ナノチューブ浸出繊維材料を含んだ難燃性複合材料及び製品
US9167736B2 (en) 2010-01-15 2015-10-20 Applied Nanostructured Solutions, Llc CNT-infused fiber as a self shielding wire for enhanced power transmission line
KR101906262B1 (ko) 2010-02-02 2018-10-10 어플라이드 나노스트럭처드 솔루션스, 엘엘씨. 평행하게-정렬된 카본 나노튜브를 포함하는 섬유
JP2013521656A (ja) 2010-03-02 2013-06-10 アプライド ナノストラクチャード ソリューションズ リミテッド ライアビリティー カンパニー カーボン・ナノチューブ浸出電極材料を含む螺旋に巻き付けられた電気機器及びその生産方法並びに生産装置
AU2011223743A1 (en) 2010-03-02 2012-08-30 Applied Nanostructured Solutions,Llc Electrical devices containing carbon nanotube-infused fibers and methods for production thereof
US8780526B2 (en) 2010-06-15 2014-07-15 Applied Nanostructured Solutions, Llc Electrical devices containing carbon nanotube-infused fibers and methods for production thereof
CA2803298C (en) 2010-07-02 2020-07-14 The University Of Chicago Compositions and methods related to protein a (spa) variants
WO2012022774A1 (en) 2010-08-19 2012-02-23 Roche Diagnostics Gmbh An assay for measurement of antibodies binding to a therapeutic monoclonal antibody
US9017854B2 (en) 2010-08-30 2015-04-28 Applied Nanostructured Solutions, Llc Structural energy storage assemblies and methods for production thereof
US9095540B2 (en) 2010-09-09 2015-08-04 The University Of Chicago Methods and compositions involving protective staphylococcal antigens
JP2013540683A (ja) 2010-09-14 2013-11-07 アプライド ナノストラクチャード ソリューションズ リミテッド ライアビリティー カンパニー 成長したカーボン・ナノチューブを有するガラス基材及びその製造方法
AU2011305809A1 (en) 2010-09-22 2013-02-28 Applied Nanostructured Solutions, Llc Carbon fiber substrates having carbon nanotubes grown thereon and processes for production thereof
AU2011305751A1 (en) 2010-09-23 2012-06-21 Applied Nanostructured Solutions, Llc CNT-infused fiber as a self shielding wire for enhanced power transmission line
JP5943927B2 (ja) 2010-10-14 2016-07-05 メソ スケール テクノロジーズ エルエルシー アッセイデバイスにおける試薬貯蔵
US9244073B2 (en) 2011-02-25 2016-01-26 Wellstat Diagnostics, Llc Assays for detecting enzymatic activity
WO2012143380A1 (en) 2011-04-20 2012-10-26 F. Hoffmann-La Roche Ag Microwaves for immunohistochemical analysis
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
JP6246711B2 (ja) 2011-06-22 2017-12-13 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 複合体を含むmhcクラスiを用いてウイルス特異的細胞傷害性t細胞を循環させることによる標的細胞の除去
EP2776833B1 (de) 2011-11-11 2018-09-05 Eli N. Glezer Cobinder-unterstützte testverfahren
BR112014011535A2 (pt) 2011-12-19 2017-05-09 Hoffmann La Roche método para a determinação in vitro e imunológica de presença da presença e/ou da quantidade de um parceiro de ligação, método in vitro e utilização de um anticorpo
ES2555867T3 (es) 2012-01-25 2016-01-11 F. Hoffmann-La Roche Ag Un método de luminiscencia para detectar un analito en una muestra líquida y sistema de análisis
MX349661B (es) 2012-02-01 2017-08-08 Hoffmann La Roche Metodo para la deteccion de una molecula de union de un enlazador multiespecifico.
US9085464B2 (en) 2012-03-07 2015-07-21 Applied Nanostructured Solutions, Llc Resistance measurement system and method of using the same
CN104136923B (zh) 2012-03-08 2016-08-24 霍夫曼-拉罗奇有限公司 用于表征循环免疫复合物的多重层析-免疫测定方法
CA2910319C (en) 2012-04-26 2022-06-14 University Of Chicago Staphylococcal coagulase antigens and methods of their use
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
BR112015000665A2 (pt) 2012-07-13 2017-06-27 Hoffmann La Roche método para a determinação da quantidade de um anticorpo
SG11201504414UA (en) 2012-12-21 2015-07-30 Hoffmann La Roche Disulfide-linked multivalent mhc class i comprising multi-function proteins
JP6416785B2 (ja) 2013-01-04 2018-10-31 メソ スケール テクノロジーズ エルエルシー マルチウェルプレートおよびコンタクトプラットフォームを利用した電気化学発光分析用計器
DK2972353T3 (da) 2013-03-11 2023-03-27 Meso Scale Technologies Llc Forbedrede fremgangsmåder til udførelse af multipleksanalyser
AU2014248759B2 (en) 2013-03-13 2020-02-27 Meso Scale Technologies, Llc. Improved assay methods
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
EP3404116B1 (de) 2013-03-15 2022-10-19 The University of Chicago Verfahren und zusammensetzungen in zusammenhang mit t-zell aktivität
EP2970631B1 (de) 2013-03-15 2017-05-03 Lubrizol Advanced Materials, Inc. Schwermetallfreie, chlorierte pvc zusammensetzungen
EP2816345A1 (de) 2013-06-19 2014-12-24 Roche Diagniostics GmbH Elektrolumineszenzverfahren zur Erkennung eines Analyts in einer Flüssigkeitsprobe und Analysesystem
CN105378480B (zh) 2013-07-04 2018-06-12 豪夫迈·罗氏有限公司 检测血清样品中抗药物抗体的干扰抑制性免疫测定
IL229525A0 (en) 2013-11-20 2014-01-30 Yeda Res & Dev Metal complexes of tris-bipyridyl and their uses in electrochromic applications
CA3229509A1 (en) 2014-05-09 2015-11-12 Meso Scale Technologies, Llc. Graphene-modified electrodes
CN106796218B (zh) 2014-05-15 2020-10-13 中尺度技术有限责任公司 改进的测定方法
JP6949016B2 (ja) 2015-10-29 2021-10-13 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 抗バリアントFc領域抗体および使用法
EP3384293B1 (de) 2015-11-30 2020-07-08 H. Hoffnabb-La Roche Ag Immunoassay zur bestimmung von fc-region-modifizierten antikörpern
WO2017129803A1 (en) 2016-01-29 2017-08-03 Roche Diagnostics Gmbh Electrochemiluminescence method and apparatus for detecting an analyte in a liquid sample
EP3662268B1 (de) 2017-08-01 2021-03-24 Roche Diagnostics GmbH Verfahren zur überwachung des nachweisvorgangs eines analyten in einer flüssigen probe
JP7161534B2 (ja) 2017-11-29 2022-10-26 エフ.ホフマン-ラ ロシュ アーゲー 標的による干渉が抑制された抗薬物抗体アッセイ
US11686013B2 (en) 2018-02-23 2023-06-27 Meso Scale Technologies, Llc. Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule
WO2019222708A2 (en) 2018-05-17 2019-11-21 Meso Scale Technologies, Llc. Methods for isolating surface marker displaying agents
EP3870348A1 (de) 2018-10-23 2021-09-01 Meso Scale Technologies, LLC Verfahren zur isolierung von oberflächenmarkerindikatoren
EP3902830A1 (de) 2018-12-30 2021-11-03 F. Hoffmann-La Roche AG Antikörper gegen karnickel-cd19 und verfahren zur verwendung
US20220018846A1 (en) 2019-01-03 2022-01-20 Meso Scale Technologies, Llc. Compositions and methods for carrying out assay measurements
WO2020180645A1 (en) 2019-03-01 2020-09-10 Meso Scale Technologies, Llc. Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same
EP3969907A1 (de) 2019-05-13 2022-03-23 F. Hoffmann-La Roche AG Interferenzunterdrücktes pharmakokinetisches immunoassay
JP2022535580A (ja) 2019-06-07 2022-08-09 エフ.ホフマン-ラ ロシュ アーゲー 全lnaオリゴヌクレオチドのハイブリダイズ
US11913945B2 (en) 2020-01-02 2024-02-27 Hoffmann-La Roche Inc. Method for determining the amount of a therapeutic antibody in the brain
MX2022015899A (es) 2020-06-16 2023-01-24 Hoffmann La Roche Metodo para determinar antigeno libre de un anticuerpo en una muestra.
WO2022006236A1 (en) 2020-07-01 2022-01-06 Meso Scale Technologies, Llc. Compositions and methods for assay measurements
WO2022051481A2 (en) 2020-09-04 2022-03-10 Meso Scale Technologies, Llc. Methods for isolating central nervous system surface marker displaying agents
EP4267961A1 (de) 2020-12-22 2023-11-01 F. Hoffmann-La Roche AG Verfahren zum nachweis eines analyten von interesse in einer probe
EP4320444A1 (de) 2021-04-09 2024-02-14 F. Hoffmann-La Roche AG Verfahren zur selektion von zellklonen, die ein heterologes polypeptid exprimieren
WO2022231900A1 (en) 2021-04-26 2022-11-03 Meso Scale Technologies, Llc. Methods for isolating and analyzing a target analyte encapsulated by a surface marker displaying agent
CN117858905A (zh) 2021-08-19 2024-04-09 豪夫迈·罗氏有限公司 多价抗变体fc区抗体及使用方法
WO2023117325A1 (en) 2021-12-21 2023-06-29 F. Hoffmann-La Roche Ag Method for the determination of hydrolytic activity
WO2023129884A1 (en) 2021-12-30 2023-07-06 Meso Scale Technologies, Llc. Methods for electrochemiluminescence detection
WO2023156510A1 (en) 2022-02-18 2023-08-24 F. Hoffmann-La Roche Ag Method for detecting an analyte of interest in a sample
WO2023212315A2 (en) 2022-04-29 2023-11-02 Meso Scale Technologies, Llc. Methods for detecting and isolating extracellular vesicles
WO2024044622A1 (en) 2022-08-24 2024-02-29 Amgen Inc. Anti-drug antibody assays

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3504052A (en) * 1964-10-06 1970-03-31 Mc Donnell Douglas Corp Organometallic polymers
US3804869A (en) * 1967-12-11 1974-04-16 Rhone Poulenc Sa Ruthenium complexes and processes for their preparation
US3530049A (en) * 1968-10-02 1970-09-22 Technic Gold and ruthenium plating baths
GB1405592A (en) * 1971-08-11 1975-09-10 Johnson Matthey Co Ltd Compounds of ruthenium
US3966556A (en) * 1972-11-06 1976-06-29 Syva Company Compounds for enzyme amplification assay methadone analogs
DE2345412C2 (de) * 1973-09-08 1983-11-03 Bomag-Menck GmbH, 5407 Boppard Zweiachsige Straßenwalze
US4199559A (en) * 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4058732A (en) * 1975-06-30 1977-11-15 Analytical Radiation Corporation Method and apparatus for improved analytical fluorescent spectroscopy
IL49685A (en) * 1976-05-31 1978-10-31 Technion Res & Dev Foundation Specific binding assay method for determining the concentration of materials and reagent means therefor
JPS6015957B2 (ja) * 1976-09-08 1985-04-23 株式会社日立製作所 液晶マトリクス表示装置の駆動方法
US4220722A (en) * 1978-02-10 1980-09-02 Syva Company Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4363759A (en) * 1978-04-10 1982-12-14 Miles Laboratories, Inc. Chemiluminescent-labeled haptens and antigens
US4238395A (en) * 1978-07-24 1980-12-09 Miles Laboratories, Inc. Dimethyl 7-[ω-N-(phthalimido)alkyl]aminonaphthalene-1,2-dicarboxylates
US4238195A (en) * 1979-01-18 1980-12-09 Miles Laboratories, Inc. Fluorescer-labeled specific binding assays
SE428332B (sv) * 1979-03-08 1983-06-20 Wallac Oy Forfarande for fluorescensspektroskopisk bestemning av biologiskt aktivt emne, sasom hapten, antikropp eller antigen
US4432907A (en) * 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
WO1981001883A1 (en) * 1979-12-19 1981-07-09 Electro Nucleonics Chemical luminescence amplification substrate system for immunochemistry
US4293310A (en) * 1980-03-14 1981-10-06 University Of Pittsburgh Photoelectrochemical immunoassay
US4637988A (en) * 1981-07-01 1987-01-20 Eastman Kodak Company Fluorescent labels for immunoassay
CA1205028A (en) * 1981-07-01 1986-05-27 Jerald C. Hinshaw Fluorescent chelates and labeled specific binding reagents prepared therefrom
US4707454A (en) * 1981-08-10 1987-11-17 Bio-Diagnostics, Inc. Fluorescent chlorophyll labeled assay reagents
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4943523A (en) * 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4687747A (en) * 1984-07-02 1987-08-18 Mallinckrodt, Inc. Phenanthridinium ester as a labelling compound in luminometric immunoassay
DK365785A (da) * 1984-09-17 1986-03-18 Hoffmann La Roche Metalcomplexer
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US4699978A (en) * 1985-01-18 1987-10-13 The Trustees Of Columbia University In The City Of New York Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
US4721669A (en) * 1985-01-18 1988-01-26 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents

Also Published As

Publication number Publication date
EP0199804B1 (de) 1994-04-06
JPH0665271A (ja) 1994-03-08
JPH0826054B2 (ja) 1996-03-13
ATE104057T1 (de) 1994-04-15
JPH09110890A (ja) 1997-04-28
US5238808A (en) 1993-08-24
IL76872A0 (en) 1986-02-28
EP0580979A2 (de) 1994-02-02
JPH07173185A (ja) 1995-07-11
CA1339835C (en) 1998-04-21
EP0199804A4 (de) 1988-02-16
IL76872A (en) 2000-12-06
DE3587793T2 (de) 1994-08-18
AU5020085A (en) 1986-05-15
EP0580979B1 (de) 2002-12-18
WO1986002734A1 (en) 1986-05-09
DE3588243D1 (de) 2003-01-30
JP2702075B2 (ja) 1998-01-21
JP2710534B2 (ja) 1998-02-10
HK1007349A1 (en) 1999-04-09
JPS62500663A (ja) 1987-03-19
HK1013861A1 (en) 1999-09-10
JP2706650B2 (ja) 1998-01-28
EP0199804A1 (de) 1986-11-05
EP0580979A3 (de) 1994-02-16
ATE230114T1 (de) 2003-01-15
DE3587793D1 (de) 1994-05-11

Similar Documents

Publication Publication Date Title
ATE230114T1 (de) Nachweisverfahren durch induktion von elektrochemilumineszenz
DK0629617T3 (da) Heteroatombærende ligander og metalkomplekser deraf
PT99556A (pt) Processo para a preparacao de novos compostos poliazamacrociclicos para a complexacao de metais
ES2060002T3 (es) Compuestos formadores de quelatos para la complejacion de isotopos radiactivos, sus complejos con metales, asi como su utilizacion en diagnostico y terapia.
ATE137805T1 (de) Verfahren zur erhöhung von chemilumineszenz
ATE169827T1 (de) Tetraazamakrocyclische metallkomplexe
ES2053517T3 (es) Compuesto de elevado peso molecular que comprende una unidad de un compuesto dirigido hacia el aceotir asialoglicoproteinico y una unidad de un compuesto que forma un quelato ligado quimicamente a este y su utilizacion.
ATE259064T1 (de) Lumineszente rhenium-komplexe und verfahren zur herstellung
DE3177284T2 (de) Organische phosphinsaeureverbindungen.
ATE227137T1 (de) Liganden zur verbesserung der metallchelatbildungskinetik
DE3889772D1 (de) Verfahren zur Herstellung von 3,3-Diarylacrylsäureamiden.
DE69001603D1 (de) Verfahren zum herstellen von perfluoroalkylbromiden.
DK120087D0 (da) 2,3-naphthalendicarboxaldehyder til analysebrug
ES2064052T3 (es) Un compuesto de yodo radiactivo para marcar un anticuerpo.
KR910000733A (ko) 피롤리진 유도체 제조방법
Barrett Metals, Electronics Industries Urge Boosted Immigration
EA199800688A1 (ru) Усовершенствованные бета-дикетоны для экстракции меди из водных аммиачных растворов
TH3052A (th) ออกซิเรนที่ถูกแทนที่
KR890009823A (ko) 2-(4-브로모페닐)-2-메틸 프로필 클로라이드의 제조방법
BR8706887A (pt) Processo para a preparacao de compostos

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIOVERIS CORP.(N.D.GES.D.STAATES DELAWARE), GAITHE