DE3584744D1 - Methoden und vorrichtung zur zellentwicklungsfaehigkeitsanalyse. - Google Patents

Methoden und vorrichtung zur zellentwicklungsfaehigkeitsanalyse.

Info

Publication number
DE3584744D1
DE3584744D1 DE8585304439T DE3584744T DE3584744D1 DE 3584744 D1 DE3584744 D1 DE 3584744D1 DE 8585304439 T DE8585304439 T DE 8585304439T DE 3584744 T DE3584744 T DE 3584744T DE 3584744 D1 DE3584744 D1 DE 3584744D1
Authority
DE
Germany
Prior art keywords
measuring
methods
fluorescence
introducing
cell development
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585304439T
Other languages
English (en)
Inventor
M Boris Rotman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ANALYTICAL BIOSYSTEMS CORP., WARWICK, R.I., US
Original Assignee
Brown University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brown University Research Foundation Inc filed Critical Brown University Research Foundation Inc
Application granted granted Critical
Publication of DE3584744D1 publication Critical patent/DE3584744D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
DE8585304439T 1984-06-21 1985-06-21 Methoden und vorrichtung zur zellentwicklungsfaehigkeitsanalyse. Expired - Fee Related DE3584744D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/623,183 US4734372A (en) 1983-02-04 1984-06-21 Cell culturing methods and apparatus

Publications (1)

Publication Number Publication Date
DE3584744D1 true DE3584744D1 (de) 1992-01-09

Family

ID=24497094

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585304439T Expired - Fee Related DE3584744D1 (de) 1984-06-21 1985-06-21 Methoden und vorrichtung zur zellentwicklungsfaehigkeitsanalyse.

Country Status (5)

Country Link
US (1) US4734372A (de)
EP (1) EP0171896B1 (de)
JP (1) JPS6170972A (de)
AT (1) ATE69837T1 (de)
DE (1) DE3584744D1 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937187A (en) * 1983-02-04 1990-06-26 Brown University Research Foundation Methods for separating malignant cells from clinical specimens
US4816395A (en) * 1985-12-19 1989-03-28 Peralta Cancer Research Institute Method for predicting chemosensitivity of anti-cancer drugs
JPS63158459A (ja) * 1986-09-05 1988-07-01 ライフトレイク 感受性アツセイの精度を調整する方法
AU8123787A (en) * 1986-11-17 1988-05-19 Oncotech Method to monitor and circumvent acquired resistance to chemotherapy in humans
US4835102A (en) * 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
JPH0782009B2 (ja) * 1988-03-24 1995-09-06 工業技術院長 細胞融合方法及び装置
JPH0246298A (ja) * 1988-06-23 1990-02-15 Atomic Energy Canada Ltd 潜在的毒性の試剤に対する有機体の感性の決定法
US5068195A (en) * 1988-11-02 1991-11-26 Du Pont Merck Pharmaceutical Company Dot matrix membrane cell expansion and maintenance vessel
US5139946A (en) * 1988-11-02 1992-08-18 Du Pont Merck Pharmaceutical Company Dot matrix membrane cell expansion
FI83668C (fi) * 1989-09-08 1991-08-12 Johan Eric Walter Ahlqvist Foerfarande och medel foer behandling av cytologiska preparat.
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
SE464763B (sv) * 1989-10-05 1991-06-10 Gunnar Engstroem Metod och anordning foer att studera cellers/cellaggregats reaktionsmoenster vid perfusion med ett testmedium
CA2027694C (en) * 1989-10-20 2002-03-05 Tadashi Matsunaga Process and apparatus for detecting sensitized leukocyte or antigen
US5104804A (en) * 1990-06-04 1992-04-14 Molecular Devices Corporation Cell assay device used in a microphysiometer
US5240856A (en) * 1991-10-23 1993-08-31 Cellpro Incorporated Apparatus for cell separation
US5672481A (en) * 1991-10-23 1997-09-30 Cellpro, Incorporated Apparatus and method for particle separation in a closed field
US5612188A (en) * 1991-11-25 1997-03-18 Cornell Research Foundation, Inc. Automated, multicompartmental cell culture system
IL106662A (en) * 1993-08-11 1996-10-31 Yissum Res Dev Co Install a flow cell to monitor blood or any single cell suspension under flow
US5686301A (en) * 1993-09-02 1997-11-11 Heraeus Instruments Gmbh Culture vessel for cell cultures
US5599688A (en) * 1993-10-18 1997-02-04 Precision Instrument Design Device and method for circulating fluid over a membrane
US6054287A (en) * 1994-05-27 2000-04-25 Methodist Hospital Of Indiana, Inc. Cell-type-specific methods and devices for the low temperature preservation of the cells of an animal species
US5595866A (en) * 1994-05-27 1997-01-21 Methodist Hospital Of Indiana, Inc. Step-wise method to remove cryoprotectant from sperm
US5565353A (en) * 1994-06-22 1996-10-15 Board Of Regents, The University Of Texas System Perfusable culture device
US6916652B2 (en) * 1995-03-28 2005-07-12 Kinetic Biosystems, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation
US6133019A (en) * 1995-03-28 2000-10-17 Kinetic Biosystems, Inc. Centrifugal fermentation process
US5622819A (en) * 1995-03-28 1997-04-22 Kinetic Biosystems, Inc. Centrifugal fermentation process
US6214617B1 (en) 1995-03-28 2001-04-10 Kinetic Biosystems, Inc. Centrifugal fermentation process
US6660509B1 (en) 1995-03-28 2003-12-09 Kinetic Biosystems, Inc. Methods and devices for remediation and fermentation
US20050266548A1 (en) * 1995-03-28 2005-12-01 Kbi Biopharma, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation with improved rotor
US5721135A (en) * 1995-07-06 1998-02-24 Novo Nordisk A/S Apparatus for identifying biologically active substances by their effect on living cells
WO1997017426A1 (en) 1995-11-08 1997-05-15 Trustees Of Boston University Cellular physiology workstations for automated data acquisition and perfusion control
US5641893A (en) * 1996-02-22 1997-06-24 University Of Kentucky Research Foundation Chromatographic separation apparatus
NL1007489C2 (nl) * 1996-11-08 2000-10-24 Konink Grolsch N V Werkwijze en inrichting voor het in een medium aantonen van micro-organismen.
DE19721477A1 (de) * 1997-05-23 1998-11-26 Abb Patent Gmbh Mikrobieller Membranreaktor zur Verwendung in Fließsystemen
DE69903800T2 (de) * 1998-03-18 2003-10-02 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6673008B1 (en) 1998-04-28 2004-01-06 Ronald J. Thompson Fallopian tube and method of in vitro fertilization and embryo development
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6146883A (en) * 1998-09-14 2000-11-14 Navicyte, Inc. Packing device for transporting confluent cell monolayers
DE19932439C2 (de) * 1999-07-12 2002-06-13 Sefar Ag Rueschlikon Bioreaktor
US6642046B1 (en) * 1999-12-09 2003-11-04 Motorola, Inc. Method and apparatus for performing biological reactions on a substrate surface
US6703217B2 (en) 2000-01-31 2004-03-09 Kinetic Biosystems, Inc. Methods and devices for remediation and fermentation
AUPQ653000A0 (en) * 2000-03-28 2000-04-20 Cook Incorporated Perfusion incubator
AU2001249559B2 (en) * 2000-03-28 2004-10-07 Cook Incorporated Perfusion incubator
US6670170B1 (en) 2000-05-15 2003-12-30 The United States Of America As Represented By The Secretary Of The Army Temperature-regulated cell perifusion chamber
CN1484709A (zh) * 2000-09-09 2004-03-24 ŦԼ������ѧ�о������ 分离转移性癌细胞的方法与组合物,及其在检测癌转移性上的应用
US20030036049A1 (en) * 2001-01-03 2003-02-20 Medis El Ltd. Optical method for testing sensitivity of cells
TW581119U (en) * 2001-12-19 2004-03-21 Univ Nat Cheng Kung Petri dish for microscope
EP1502097A2 (de) * 2002-04-26 2005-02-02 Board of Regents, The University of Texas System Verfahren und system zur detektion von kardialen risikofaktoren
AU2003228950A1 (en) * 2002-05-08 2003-11-11 Scion Pharmaceuticals, Inc. Oocyte recording chamber
US6980293B1 (en) * 2002-06-11 2005-12-27 Olympus Optical Co., Ltd. Immersion medium supply apparatus, fluorescence spectrometry inspection apparatus, and culture microscope
CA2494727A1 (en) * 2002-07-24 2004-01-29 Board Of Regents, The University Of Texas System Capture and detection of microbes by membrane methods
GB2433319A (en) * 2002-10-23 2007-06-20 Yissum Res Dev Co In vitro test for studying compound predicting pharmacologic and/or pharmacokinetic and/or pharmacodynamic parameters of a compound
US7245368B2 (en) * 2003-03-31 2007-07-17 C & L Instruments Sample chamber for microscopy
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
WO2004104922A2 (en) 2003-05-16 2004-12-02 Board Of Regents, The University Of Texas System Image and part recognition technology
AU2004300168A1 (en) * 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
US20070037276A1 (en) * 2004-02-23 2007-02-15 Eudes Francois Marie De Crecy Continuous culture apparatus with mobile vessel, allowing selection of fitter cell variants and producing a culture in a continuous manner
US8101431B2 (en) * 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) * 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
KR100850733B1 (ko) * 2004-04-13 2008-08-06 도요 세이칸 가부시키가이샤 이중 배양 용기 및 배양 방법
DK1773978T3 (da) * 2004-05-19 2014-05-26 Univ Pittsburgh Perfunderede, tredimensionelle celle/vævssygdomsmodeller
JP2006025789A (ja) * 2004-06-17 2006-02-02 Olympus Corp 生体試料観察システムおよび生体試料の観察方法
US20060095021A1 (en) * 2004-11-02 2006-05-04 Casas-Bejar Jesus W Introduction of agent with medical device
EP1910824A4 (de) 2005-05-31 2012-11-21 Labnow Inc Verfahren und zusammensetzungen in zusammenhang mit der erstellung und verwendung eines weissen blutbildes
CA2607817C (en) * 2005-06-23 2014-02-25 Gambro Lundia Ab Implantable access device and method for preparing thereof
US20100291588A1 (en) * 2005-06-24 2010-11-18 The Board Of Regents Of The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
WO2007005666A2 (en) * 2005-07-01 2007-01-11 Board Of Regents, The University Of Texas System System and method of analyte detection using differential receptors
DE102005051406A1 (de) * 2005-10-27 2007-05-03 Forschungszentrum Rossendorf E.V. Optisches Koppelelement für eine Durchflusszelle
FR2897783B1 (fr) * 2006-02-24 2008-05-30 Millipore Corp Dispositif pour le controle microbiologique, ensembles de controle et d'incubation le comportant et procede le mettant en oeuvre
FR2901806B1 (fr) * 2006-06-01 2008-08-01 Millipore Corp Dispositif et ensemble de controle microbiologique
US20100151571A1 (en) * 2006-07-07 2010-06-17 Georgia Tech Research Corporation Centimeter-scale, integrated diagnostics incubator for biological culturing
CA2697357A1 (en) * 2007-04-16 2008-10-30 John T. Mcdevitt Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics
EP3778858A1 (de) 2008-07-16 2021-02-17 Children's Medical Center Corporation Vorrichtung mit mikrokanälen sowie verfahren zur verwendung der vorrichtung
EP2158967A1 (de) * 2008-08-26 2010-03-03 F. Hoffmann-La Roche AG Probenträger
US8358411B2 (en) * 2008-12-18 2013-01-22 Biovigilant Systems, Inc. Integrated microbial collector
WO2010127182A1 (en) * 2009-04-29 2010-11-04 Evolugate, Llc Adapting microorganisms for agricultural products
DK2606116T3 (da) * 2010-08-18 2020-08-03 Drugmode Aps Bioreaktorsystem
WO2012079577A1 (en) 2010-12-15 2012-06-21 Drugmode Aps Bioreactor with lid for easy access to incubation cavity
JP6122388B2 (ja) 2011-02-28 2017-04-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞培養システム
WO2013086486A1 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
JP5989483B2 (ja) * 2012-09-24 2016-09-07 テルモ株式会社 膜状組織の保存輸送容器および保存輸送方法
US9855554B2 (en) 2013-07-22 2018-01-02 President And Fellows Of Harvard College Microfluidic cartridge assembly
JP2017504320A (ja) 2013-12-20 2017-02-09 プレジデント アンド フェローズ オブ ハーバード カレッジ 低剪断マイクロ流体デバイスならびにその使用および製造の方法
AU2015289999B2 (en) 2014-07-14 2020-09-10 President And Fellows Of Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
US10202569B2 (en) 2015-07-24 2019-02-12 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
EP3356512B1 (de) 2015-10-02 2021-03-31 Wake Forest University Health Sciences, Inc. Verfahren und vorrichtung zur modellierung von krebsmetastasen in vitro

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2942520A (en) * 1955-12-20 1960-06-28 George G Rose Tissue culture device
US3065148A (en) * 1959-07-14 1962-11-20 Technicon Instr Method and apparatus for use in conducting studies on cells
US3691017A (en) * 1970-05-06 1972-09-12 Worthington Bio Chem Corp Means and method for chemical analysis
US3726597A (en) * 1972-03-09 1973-04-10 Us Health Education & Welfare Controlled environment culture system for light microscopy
US3821087A (en) * 1972-05-18 1974-06-28 Dedrick R Cell culture on semi-permeable tubular membranes
US3883393A (en) * 1972-05-18 1975-05-13 Us Health Education & Welfare Cell culture on semi-permeable tubular membranes
DE2319204B2 (de) * 1973-04-16 1977-04-07 CA. Greiner und Söhne, 7440 Nürtingen Arbeitsgeraet fuer histologische untersuchungen
US3928142A (en) * 1973-07-24 1975-12-23 Dennis B Smith Culture chamber for the study of biological systems and method of fabrication thereof
US4201845A (en) * 1976-04-12 1980-05-06 Monsanto Company Cell culture reactor
US4184922A (en) * 1977-11-11 1980-01-22 The Government Of The United States Dual circuit, woven artificial capillary bundle for cell culture
US4220725A (en) * 1978-04-03 1980-09-02 United States Of America Capillary cell culture device
US4242459A (en) * 1978-11-02 1980-12-30 Chick William L Cell culture device
US4241187A (en) * 1979-03-27 1980-12-23 United States Of America Method and apparatus for cell and tissue culture
JPS5642584A (en) * 1979-09-18 1981-04-20 Asahi Chem Ind Co Ltd Cell cultivation method
SU901266A1 (ru) * 1979-12-20 1982-01-30 Предприятие П/Я А-1631 Камера дл культивировани микроорганизмов
US4308351A (en) * 1980-04-18 1981-12-29 Joseph Leighton System for growing tissue cultures
US4440853A (en) * 1980-08-21 1984-04-03 Board Of Trustees Of The Leland Stanford Junior University Microbiological methods using hollow fiber membrane reactor
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
US4559299A (en) * 1983-02-04 1985-12-17 Brown University Research Foundation Inc. Cytotoxicity assays in cell culturing devices

Also Published As

Publication number Publication date
JPS6170972A (ja) 1986-04-11
ATE69837T1 (de) 1991-12-15
JPH0574358B2 (de) 1993-10-18
EP0171896A1 (de) 1986-02-19
US4734372A (en) 1988-03-29
EP0171896B1 (de) 1991-11-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ANALYTICAL BIOSYSTEMS CORP., WARWICK, R.I., US

8339 Ceased/non-payment of the annual fee