DE3582088D1 - Biologisch abbaubare amphiphile copolymere. - Google Patents

Biologisch abbaubare amphiphile copolymere.

Info

Publication number
DE3582088D1
DE3582088D1 DE8585304489T DE3582088T DE3582088D1 DE 3582088 D1 DE3582088 D1 DE 3582088D1 DE 8585304489 T DE8585304489 T DE 8585304489T DE 3582088 T DE3582088 T DE 3582088T DE 3582088 D1 DE3582088 D1 DE 3582088D1
Authority
DE
Germany
Prior art keywords
water
biodegradable
mixtures
copolymers
copolymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585304489T
Other languages
English (en)
Inventor
Jeffrey Richard Churchill
Francis Gowland Hutchinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Application granted granted Critical
Publication of DE3582088D1 publication Critical patent/DE3582088D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/734—Fullerenes, i.e. graphene-based structures, such as nanohorns, nanococoons, nanoscrolls or fullerene-like structures, e.g. WS2 or MoS2 chalcogenide nanotubes, planar C3N4, etc.
    • Y10S977/735—Carbon buckyball
    • Y10S977/737—Carbon buckyball having a modified surface
    • Y10S977/738—Modified with biological, organic, or hydrocarbon material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/795—Composed of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/797—Lipid particle
    • Y10S977/798—Lipid particle having internalized material
    • Y10S977/799—Containing biological material
    • Y10S977/801—Drug
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/849—Manufacture, treatment, or detection of nanostructure with scanning probe
    • Y10S977/86—Scanning probe structure
    • Y10S977/868—Scanning probe structure with optical means
    • Y10S977/869—Optical microscope
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/905—Specially adapted for travel through blood circulatory system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
DE8585304489T 1984-06-26 1985-06-24 Biologisch abbaubare amphiphile copolymere. Expired - Lifetime DE3582088D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848416234A GB8416234D0 (en) 1984-06-26 1984-06-26 Biodegradable amphipathic copolymers

Publications (1)

Publication Number Publication Date
DE3582088D1 true DE3582088D1 (de) 1991-04-18

Family

ID=10562991

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585304489T Expired - Lifetime DE3582088D1 (de) 1984-06-26 1985-06-24 Biologisch abbaubare amphiphile copolymere.

Country Status (19)

Country Link
US (2) US4745160A (de)
EP (1) EP0166596B1 (de)
JP (3) JPH0751517B2 (de)
AT (1) ATE61613T1 (de)
CA (1) CA1247271A (de)
DE (1) DE3582088D1 (de)
DK (1) DK174804B1 (de)
ES (4) ES8609374A1 (de)
FI (1) FI81591C (de)
GB (1) GB8416234D0 (de)
GR (1) GR851474B (de)
HU (2) HU196301B (de)
IE (1) IE58678B1 (de)
IL (1) IL75407A (de)
NO (1) NO167752C (de)
NZ (1) NZ212538A (de)
PT (1) PT80710B (de)
YU (1) YU44510B (de)
ZA (1) ZA854188B (de)

Families Citing this family (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5444113A (en) * 1988-08-08 1995-08-22 Ecopol, Llc End use applications of biodegradable polymers
US5702716A (en) * 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5122367A (en) * 1989-03-31 1992-06-16 Massachusetts Institute Of Technology Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone
CN1040445C (zh) * 1989-06-21 1998-10-28 郭勇 可生物降解高分子薄膜及其制造方法与用途
US5487897A (en) * 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
JPH0662839B2 (ja) * 1989-11-14 1994-08-17 工業技術院長 微生物分解性プラスチック成形物及びその製造方法
KR920002912B1 (ko) * 1990-03-27 1992-04-10 재단법인 한국화학연구소 생분해성 및 고흡수성 수지 조성물의 제조방법
USRE37950E1 (en) 1990-04-24 2002-12-31 Atrix Laboratories Biogradable in-situ forming implants and methods of producing the same
US5360892A (en) * 1990-06-26 1994-11-01 Arch Development Corporation Water and UV degradable lactic acid polymers
US5232984A (en) * 1990-10-15 1993-08-03 The Board Of The Regents The University Of Texas Biocompatible microcapsules
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5486362A (en) * 1991-05-07 1996-01-23 Dynagen, Inc. Controlled, sustained release delivery system for treating drug dependency
US5403595A (en) * 1991-05-07 1995-04-04 Dynagen, Inc. Controlled, sustained release delivery system for smoking cessation
ATE147995T1 (de) * 1991-06-26 1997-02-15 Procter & Gamble Saugfähige einwegartikel mit biodegradierbare schutzfolien
DE69230175T2 (de) * 1991-06-26 2000-04-27 Procter & Gamble Flüssigkeitsundurchlässige, biologisch abbaubare folien
FR2678178A1 (fr) * 1991-06-28 1992-12-31 Rhone Poulenc Rorer Sa Procede de preparation de nanoparticules.
US5766635A (en) * 1991-06-28 1998-06-16 Rhone-Poulenc Rorer S.A. Process for preparing nanoparticles
FR2678168B1 (fr) 1991-06-28 1993-09-03 Rhone Poulenc Rorer Sa Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge.
AU2605592A (en) * 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5346966A (en) * 1991-12-31 1994-09-13 E. I. Du Pont De Nemours And Company L,d-polylactide copolymers with controlled morphology
US5270400A (en) * 1991-12-31 1993-12-14 Maria Spinu L-Dpolylactide copolymers with controlled morphology
US6643527B2 (en) 1992-02-27 2003-11-04 Fujitsu Limited Power switching unit of a portable telephone capable of monitoring and controlling a battery supply voltage thereof
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
DK0627911T3 (da) 1992-02-28 2000-11-20 Univ Texas Fotopolymeriserbare bionedbrydelige hydrogeler somvævskontaktmaterialer og bærere med reguleret frigivelse
US5780051A (en) * 1992-04-02 1998-07-14 Dynagen, Inc. Methods and articles of manufacture for nicotine cessation and monitoring nicotine use
US5219980A (en) * 1992-04-16 1993-06-15 Sri International Polymers biodegradable or bioerodiable into amino acids
AU2234692A (en) * 1992-06-05 1994-01-04 Arch Development Corporation Water and uv degradable lactic acid polymers
US5939467A (en) * 1992-06-26 1999-08-17 The Procter & Gamble Company Biodegradable polymeric compositions and products thereof
BR9306621A (pt) * 1992-06-26 1998-12-08 Procter & Gamble Película de diversas camadas
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5202413A (en) * 1993-02-16 1993-04-13 E. I. Du Pont De Nemours And Company Alternating (ABA)N polylactide block copolymers
US5522841A (en) * 1993-05-27 1996-06-04 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5876438A (en) * 1993-08-02 1999-03-02 Houston Biotechnology Incorporated Polymeric device for the delivery of immunotoxins for the prevention of secondary cataract
US5563238A (en) * 1993-08-05 1996-10-08 Arch Development Corporation Water and UV degradable lactic acid polymers
CN1050619C (zh) * 1993-09-09 2000-03-22 钟纺株式会社 生物分解性聚酯共聚合物、使用它的成形品及该成形品的制法
US5593778A (en) * 1993-09-09 1997-01-14 Kanebo, Ltd. Biodegradable copolyester, molded article produced therefrom and process for producing the molded article
US5681873A (en) * 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
KR0148704B1 (ko) * 1994-01-10 1998-08-17 김상응 생체분해성 약물전달용 고분자
PT754032E (pt) * 1994-04-08 2002-05-31 Atrix Lab Inc Composicoes liquidas para difusao
KR0141431B1 (ko) * 1994-05-17 1998-07-01 김상웅 생분해성 하이드로겔 고분자
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
JPH0827018A (ja) * 1994-07-22 1996-01-30 Sanwa Kagaku Kenkyusho Co Ltd 生理活性ペプチド又は蛋白質を含有する薬剤組成物
US6911216B1 (en) 1994-10-12 2005-06-28 Genzyme Corporation Targeted delivery via biodegradable polymers
US6063116A (en) * 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
US5607686A (en) * 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
EP0717999A1 (de) * 1994-12-19 1996-06-26 The University Of Miami Zusammensetzung zur Arzneistoffabgabe
JPH08268916A (ja) * 1995-03-28 1996-10-15 Dai Ichi Seiyaku Co Ltd 微粒子性運搬体−薬物コンプレックス
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6413539B1 (en) 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US5641502A (en) * 1995-06-07 1997-06-24 United States Surgical Corporation Biodegradable moldable surgical material
KR0180334B1 (ko) * 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5847011A (en) * 1995-12-05 1998-12-08 Mitsui Chemicals, Inc. Degradable copolymer and preparation process thereof
JP3178724B2 (ja) * 1996-03-05 2001-06-25 エイカスフィアー・インコーポレーテッド 画像化剤として使用するためのミクロカプセル化フッ素化ガス
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
DK0914102T3 (da) * 1996-05-24 2006-01-09 Angiotech Pharm Inc Præparater og fremgangsmåder til behandling eller forebyggelse af syddomme i legemskanaler
US5914182A (en) * 1996-06-03 1999-06-22 Gore Hybrid Technologies, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US5874165A (en) * 1996-06-03 1999-02-23 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto polymeric subtrates
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US6191236B1 (en) 1996-10-11 2001-02-20 United States Surgical Corporation Bioabsorbable suture and method of its manufacture
WO1998029506A1 (en) 1996-12-31 1998-07-09 Kimberly-Clark Worldwide, Inc. Water-responsive polymer compositions and method of making the same
US5945480A (en) * 1997-07-31 1999-08-31 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable fibers comprising polylactide modified polylactide and polyvinyl alcohol, and method for making the fibers
US5952433A (en) * 1997-07-31 1999-09-14 Kimberly-Clark Worldwide, Inc. Modified polyactide compositions and a reactive-extrusion process to make the same
US6552162B1 (en) 1997-07-31 2003-04-22 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable compositions and films and articles comprising a blend of polylactide and polyvinyl alcohol and methods for making the same
US6075118A (en) * 1997-07-31 2000-06-13 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable film compositions comprising polylactide and polyvinyl alcohol, and a method for making the films
MXPA02008854A (es) * 1997-07-31 2003-02-10 Kimberly Clark Co Peliculas biodegradables que responden al agua y fibras que comprenden polilactido y poli(alcohol vinilico) y metodos para hacer las mismas.
CA2299393A1 (en) * 1997-08-08 1999-02-18 Sung Wan Kim Injectable biodegradable block copolymer gels for use in drug delivery
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6517869B1 (en) * 1997-12-12 2003-02-11 Expression Genetics, Inc. Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake
US7128927B1 (en) 1998-04-14 2006-10-31 Qlt Usa, Inc. Emulsions for in-situ delivery systems
EP0955331B1 (de) * 1998-04-23 2003-09-10 Dainippon Ink And Chemicals, Inc. In Wasser selbstdispergierbares Teilchen aus bioabbaubarem Polyester und Verfahren zu seiner Herstellung
US6350518B1 (en) 1998-06-01 2002-02-26 Kimberly-Clark Worldwide, Inc. Methods of making blend compositions of an unmodified poly vinyl alcohol and a thermoplastic elastomer
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
DE19851777A1 (de) * 1998-11-10 2000-05-11 Basf Ag Verwendung von Estern oder Amiden hydroxylierter Carbonsäuren als Solubilisatoren
US6217630B1 (en) 1999-05-03 2001-04-17 Cargill, Incorporated Conditioned fertilizer product, method for conditioning fertilizer, and method for using conditioned fertilizer product
US8226598B2 (en) * 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
US7018645B1 (en) * 2000-04-27 2006-03-28 Macromed, Inc. Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
US20050042194A1 (en) * 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US6669959B1 (en) * 2000-07-18 2003-12-30 Aeropharm Technology Incorporated Modulated release particles for lung delivery
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20040092494A9 (en) * 2000-08-30 2004-05-13 Dudley Robert E. Method of increasing testosterone and related steroid concentrations in women
US20040002482A1 (en) * 2000-08-30 2004-01-01 Dudley Robert E. Androgen pharmaceutical composition and method for treating depression
EP1315777B1 (de) * 2000-09-06 2007-10-31 AP Pharma, Inc. Abbaubare polyacetal-polymere
KR100451910B1 (ko) * 2000-10-05 2004-10-08 주식회사 바이오폴리테크 수용성 생체분해성 고분자 겔 및 그의 제조방법
WO2002036073A2 (en) * 2000-11-02 2002-05-10 Smithkline Beecham Corporation Receptor antagonist-lipid conjugates and delivery vehicles containing same
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
EP1418945A2 (de) * 2001-03-13 2004-05-19 Angiotech Pharmaceuticals, Inc. Mizellare arzneimittelabgabe vehikel und ihre anwendungen
EP1392254B1 (de) * 2001-04-20 2007-06-06 The University of British Columbia Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
WO2002092661A1 (en) * 2001-05-11 2002-11-21 Ap Pharma, Inc. Peg-poe, peg-poe-peg, and poe-peg-poe block copolymers
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
CA2451187C (en) * 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
US6592899B2 (en) * 2001-10-03 2003-07-15 Macromed Incorporated PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
US7309498B2 (en) * 2001-10-10 2007-12-18 Belenkaya Bronislava G Biodegradable absorbents and methods of preparation
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
KR100527408B1 (ko) * 2002-01-03 2005-11-09 한국과학기술원 카프로락톤과 락티드의 랜덤공중합체와 폴리에테르를이용한 생분해성 블록공중합체의 제조방법 및 이의 응용
US6780324B2 (en) * 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20030228366A1 (en) * 2002-06-11 2003-12-11 Chung Shih Reconstitutable compositions of biodegradable block copolymers
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
BRPI0314042B8 (pt) 2002-09-06 2021-05-25 Calando Pharmaceuticals Inc polímeros à base de ciclodextrina para o fornecimento de agentes terapêuticos ligados a eles por covalência
EP1555984B1 (de) * 2002-10-21 2008-03-12 L'oreal Verfahren zum auflösen lipophiler verbindungen, und kosmetische zusammensetzung.
WO2004044012A1 (en) * 2002-11-12 2004-05-27 The Polymer Technology Group Incorporated Control of polymer surface molecular architecture via amphipathic endgroups
US7045589B2 (en) * 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
US20060141029A1 (en) * 2003-05-20 2006-06-29 Erimos Pharmaceuticals Llc Methods and compositions for delivery of catecholic butanes for treatment of diseases
JP2006528700A (ja) * 2003-05-20 2006-12-21 エリモス・ファーマスーティカルズ・エルエルシー 肥満の治療のためのカテコールブタンの投与のための方法と組成物
US7728036B2 (en) * 2003-05-20 2010-06-01 Erimos Pharmaceuticals, Llc Methods for delivery of catecholic butanes for treatment of tumors
CA2552241C (en) * 2003-12-30 2013-10-01 Durect Corporation Co-polymeric devices for controlled release of active agents
CN100534527C (zh) * 2003-12-30 2009-09-02 杜雷科特公司 用于控制释放优选为GnRH的活性剂的优选含有PEG和PLG的混合物的聚合植入物
US20070232695A1 (en) * 2004-01-28 2007-10-04 Collegium Pharmaceutical, Inc. Gelled Periodontal Anesthetic Preparation
US7151077B2 (en) * 2004-03-29 2006-12-19 Halliburton Energy Services, Inc. Polymersome compositions and associated methods of use
CN100440843C (zh) * 2004-05-12 2008-12-03 华为技术有限公司 一种环网及其业务实现方法
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
WO2006085987A2 (en) 2004-07-09 2006-08-17 University Of Iowa Research Foundation Rna interference in respiratory epitheial cells
US8440648B2 (en) * 2004-07-20 2013-05-14 Erimos Pharmaceuticals Llc Methods and compositions for treatment of intraepithelial neoplasia
US20060034889A1 (en) 2004-08-16 2006-02-16 Macromed, Inc. Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
WO2006071208A1 (en) * 2004-12-23 2006-07-06 Durect Corporation Polymeric implants, preferably containing a mixture of peg and plg, for controlled release of a gnrh
US8007775B2 (en) 2004-12-30 2011-08-30 Advanced Cardiovascular Systems, Inc. Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same
JP5069131B2 (ja) * 2005-01-27 2012-11-07 エリモス・ファーマスーティカルズ・エルエルシー 動物へのｎｄｇａ化合物を包含するカテコールブタンの注射のための製剤
US20060235084A1 (en) * 2005-03-31 2006-10-19 Jorge Heller PEG-polyacetal diblock and triblock copolymers and pharmaceutical compositions
US20070088012A1 (en) * 2005-04-08 2007-04-19 Woun Seo Method of treating or preventing type-2 diabetes
US7662753B2 (en) * 2005-05-12 2010-02-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7677315B2 (en) 2005-05-12 2010-03-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7608567B2 (en) * 2005-05-12 2009-10-27 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
PT1937276E (pt) 2005-10-12 2013-02-21 Besins Healthcare Luxembourg Gel de testosterona melhorado e método para a sua utilização
US8882747B2 (en) * 2005-11-09 2014-11-11 The Invention Science Fund I, Llc Substance delivery system
CA2629300C (en) 2005-11-17 2014-07-08 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
US20090155349A1 (en) * 2006-02-23 2009-06-18 Jonathan Daniel Heller Methods of treating influenza viral infections
JPWO2007136134A1 (ja) * 2006-05-23 2009-10-01 ナノキャリア株式会社 疎水性薬物内包ポリマーミセルの製造方法
CA2699184A1 (en) * 2006-09-22 2008-03-27 Labopharm Inc. Compositions and methods for ph targeted drug delivery
EP2076252B1 (de) * 2006-10-02 2014-04-02 Erimos Pharmaceuticals LLC Tetra-substituierte ndga-derivate über etherbindungen und carbamat-bindungen und ihre synthese und pharmazeutische verwendung
US9067875B2 (en) 2006-10-02 2015-06-30 Erimos Pharmaceuticals Llc Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use
US20080138397A1 (en) * 2006-10-24 2008-06-12 Aradigm Corporation Processes for taste-masking of inhaled formulations
BRPI0718696A2 (pt) * 2006-11-09 2013-12-31 Alcon Res Ltd Matriz de polímero insolúvel em água para liberação de fármaco.
US20080114076A1 (en) * 2006-11-09 2008-05-15 Alcon Manufacturing Ltd. Punctal plug comprising a water-insoluble polymeric matrix
US20080152724A1 (en) * 2006-12-21 2008-06-26 Mark Hirsh Treatment of periodontitis with an injectable slow release iodine
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
EP2180880A2 (de) * 2007-07-09 2010-05-05 Glen S. Kwon Mizellenverkapselung von therapeutika
AU2009241847B2 (en) * 2008-04-28 2014-07-10 Zogenix, Inc. Novel formulations for treatment of migraine
WO2010068827A1 (en) * 2008-12-11 2010-06-17 A.P. Pharma, Inc. Methods for enhancing stability of polyorthoesters and their formulations
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
KR101721281B1 (ko) 2009-09-25 2017-04-10 위스콘신 얼럼나이 리서어치 화운데이션 치료제의 미셀 캡슐화
CA2775747A1 (en) 2009-10-07 2011-04-14 Sanford Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
US20140200511A1 (en) * 2009-10-30 2014-07-17 Searete Llc Systems, devices, and methods for making or administering frozen particles
CA2781669A1 (en) * 2009-11-23 2011-05-26 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
WO2011119995A2 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Formulations and methods of use
EP2555802A1 (de) 2010-04-08 2013-02-13 Sanford-Burnham Medical Research Institute Verfahren und zusammensetzungen zur optimierten freisetzung von verbindungen
US8727425B1 (en) 2010-05-27 2014-05-20 Strehl, Llc Aerodynamic trucking systems
WO2012118778A1 (en) 2011-02-28 2012-09-07 Sanford-Burnham Medical Research Institute Truncated car peptides and methods and compositions using truncated car peptides
US10179801B2 (en) 2011-08-26 2019-01-15 Sanford-Burnham Medical Research Institute Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
EA031522B1 (ru) * 2012-06-27 2019-01-31 Мединселл Биоразлагаемая композиция для доставки лекарственного средства (варианты) и способ получения биоразлагаемой композиции (варианты)
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
EP3313447A2 (de) 2015-06-25 2018-05-02 Sanford Burnham Prebys Medical Discovery Institute Zusammensetzungen zur abgabe an und behandlung von atherosklerotischen plaques
DK3377041T3 (da) 2015-11-16 2023-12-18 Medincell S A Fremgangsmåde til fragmentering og/eller målretning af farmaceutisk aktive bestanddele til synovialvæv
US10456477B2 (en) 2016-03-14 2019-10-29 Wisconsin Alumni Research Foundation Oligolactic acid conjugates and micelles with enhanced anticancer efficacy
WO2018204392A1 (en) 2017-05-02 2018-11-08 Stanford Burnham Prebys Medical Discovery Institute Tumor associated monocyte/macrophage binding peptide and methods of use thereof
CA3095788A1 (en) 2018-04-02 2019-10-10 Wisconsin Alumni Research Foundation Stereocomplex of oligolactic acid conjugates in micelles for improved physical stability and enhanced antitumor efficacy
AU2020218940A1 (en) 2019-02-04 2021-08-12 University Of Tartu Bi-specific extracellular matrix binding peptides and methods of use thereof
WO2021146215A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3651008A (en) * 1967-12-22 1972-03-21 California Inst Of Techn Polymeric compositions and their method of manufacture
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2460472A1 (de) * 1974-12-20 1976-07-01 Basf Ag Verfahren zur herstellung von polyesterimid-pulvern
JPS5726613A (en) * 1980-07-22 1982-02-12 Fujisawa Pharmaceut Co Ltd Preparation of crystalline freeze-dried pharmaceutical
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
ATE37983T1 (de) * 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
DE3218151A1 (de) * 1982-05-14 1983-11-17 Akzo Gmbh, 5600 Wuppertal Mikroporoese, pulverfoermige polylactide und verfahren zu deren herstellung
CA1196864A (en) * 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions

Also Published As

Publication number Publication date
ES8705222A1 (es) 1987-05-01
JPH07106987B2 (ja) 1995-11-15
JPS6115846A (ja) 1986-01-23
PT80710A (en) 1985-07-01
IE58678B1 (en) 1993-11-03
IL75407A (en) 1988-11-30
YU44510B (en) 1990-08-31
ES8705221A1 (es) 1987-05-01
IE851396L (en) 1985-12-26
HU193994B (en) 1987-12-28
US4877606A (en) 1989-10-31
JPH0751517B2 (ja) 1995-06-05
NO852547L (no) 1985-12-27
NO167752B (no) 1991-08-26
IL75407A0 (en) 1985-10-31
HU196301B (en) 1988-11-28
JPH0769929A (ja) 1995-03-14
DK287885A (da) 1985-12-27
ZA854188B (en) 1986-02-26
DK287885D0 (da) 1985-06-25
DK174804B1 (da) 2003-11-24
AU587977B2 (en) 1989-09-07
GR851474B (de) 1985-11-25
FI81591C (fi) 1990-11-12
FI81591B (fi) 1990-07-31
EP0166596A3 (en) 1987-05-27
HUT38261A (en) 1986-05-28
ES551370A0 (es) 1987-04-16
US4745160A (en) 1988-05-17
ES544580A0 (es) 1986-09-01
GB8416234D0 (en) 1984-08-01
CA1247271A (en) 1988-12-20
ES8704726A1 (es) 1987-04-16
PT80710B (pt) 1987-10-20
EP0166596B1 (de) 1991-03-13
FI852374L (fi) 1985-12-27
NO167752C (no) 1991-12-04
JPH0769930A (ja) 1995-03-14
NZ212538A (en) 1988-02-12
AU4315085A (en) 1986-01-02
FI852374A0 (fi) 1985-06-14
EP0166596A2 (de) 1986-01-02
ES551371A0 (es) 1987-05-01
ES551372A0 (es) 1987-05-01
ES8609374A1 (es) 1986-09-01
ATE61613T1 (de) 1991-03-15
JPH07106988B2 (ja) 1995-11-15
YU106385A (en) 1988-10-31

Similar Documents

Publication Publication Date Title
DE3582088D1 (de) Biologisch abbaubare amphiphile copolymere.
AU566010B2 (en) Continuous release formulations
CA2235401A1 (en) Method for sterilizing medical devices utilizing a room temperature sterilant
IE891744L (en) Controlled Release Dosage Forms Having a Defined Water¹Content
CA2053121A1 (en) Pharmaceutical preparation based on lys-plasminogen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ZENECA LTD., LONDON, GB

8315 Request for restriction filed
8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA UK LTD., LONDON, GB