DE3567470D1 - Copolymer and method for producing the same - Google Patents

Copolymer and method for producing the same

Info

Publication number
DE3567470D1
DE3567470D1 DE8585304733T DE3567470T DE3567470D1 DE 3567470 D1 DE3567470 D1 DE 3567470D1 DE 8585304733 T DE8585304733 T DE 8585304733T DE 3567470 T DE3567470 T DE 3567470T DE 3567470 D1 DE3567470 D1 DE 3567470D1
Authority
DE
Germany
Prior art keywords
copolymer
producing
same
weight
dispersity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585304733T
Other languages
English (en)
Inventor
Motoaki Tanaka
Yasuaki Ogawa
Tsutomu Miyagawa
Toshio Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Fujifilm Wako Pure Chemical Corp
Original Assignee
Wako Pure Chemical Industries Ltd
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15266918&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3567470(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP59140356A external-priority patent/JPH0678425B2/ja
Application filed by Wako Pure Chemical Industries Ltd, Takeda Chemical Industries Ltd filed Critical Wako Pure Chemical Industries Ltd
Application granted granted Critical
Publication of DE3567470D1 publication Critical patent/DE3567470D1/de
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
DE8585304733T 1984-07-06 1985-07-03 Copolymer and method for producing the same Expired DE3567470D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59140356A JPH0678425B2 (ja) 1984-07-06 1984-07-06 重合体の新規製造法

Publications (1)

Publication Number Publication Date
DE3567470D1 true DE3567470D1 (en) 1989-02-16

Family

ID=15266918

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8585304733T Expired DE3567470D1 (en) 1984-07-06 1985-07-03 Copolymer and method for producing the same
DE8585304734T Expired DE3567471D1 (en) 1984-07-06 1985-07-03 Method for producing a polymer or copolymer of lactic acid and/or glycolic acid

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8585304734T Expired DE3567471D1 (en) 1984-07-06 1985-07-03 Method for producing a polymer or copolymer of lactic acid and/or glycolic acid

Country Status (8)

Country Link
US (2) US4677191A (de)
EP (2) EP0172636B2 (de)
AT (2) ATE39936T1 (de)
BG (1) BG61520B2 (de)
CA (2) CA1256638A (de)
DE (2) DE3567470D1 (de)
HK (1) HK19592A (de)
SG (1) SG108191G (de)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
GB8609537D0 (en) * 1986-04-18 1986-05-21 Ici Plc Polyesters
DE3720806C2 (de) * 1986-07-03 1997-08-21 Clariant Finance Bvi Ltd Verwendung eines Stabilisators in Peroxydbleichverfahren
US4758435A (en) * 1986-08-11 1988-07-19 American Cyanamid Company Estradiol implant composition and method for preparation
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
DE3710175A1 (de) * 1987-02-12 1988-08-25 Hoechst Ag Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung
AU634723B2 (en) * 1988-08-08 1993-03-04 Biopak Technology, Ltd. Degradable thermoplastic from lactides
US5424346A (en) * 1988-08-08 1995-06-13 Ecopol, Llc Biodegradable replacement of crystal polystyrene
US5180765A (en) * 1988-08-08 1993-01-19 Biopak Technology, Ltd. Biodegradable packaging thermoplastics from lactides
WO1990001521A1 (en) * 1988-08-08 1990-02-22 Battelle Memorial Institute Degradable thermoplastic from lactides
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US5250584A (en) * 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
US5126147A (en) * 1990-02-08 1992-06-30 Biosearch, Inc. Sustained release dosage form
DE4005415C2 (de) * 1990-02-21 1996-04-11 Boehringer Ingelheim Kg Verfahren zum Herstellen von Polyestern auf der Basis von Hydroxycarbonsäuren
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5288496A (en) * 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
US6353030B1 (en) * 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
NZ240214A (en) 1990-10-16 1993-02-25 Takeda Chemical Industries Ltd Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs
IT1249045B (it) * 1991-02-21 1995-02-11 Himont Inc Processo per la sintesi allo stato solido di polimeri dell'acido lattico e prodotti cosi ottenuti
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
US6005067A (en) * 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5294469A (en) * 1992-06-17 1994-03-15 Mitsui Toatsu Chemicals, Incorporated Industrial woven fabric and composite sheet comprising same
US5758053A (en) * 1992-07-22 1998-05-26 Hitachi, Ltd. Fault handling and recovery for system having plural processors
US6005068A (en) * 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
WO1994008078A1 (en) * 1992-10-02 1994-04-14 Cargill, Incorporated A melt-stable lactide polymer fabric and process for manufacture thereof
ATE173520T1 (de) * 1992-10-02 1998-12-15 Cargill Inc Papier mit einer beschichtung aus schmelzstabilem polymer und dessen verfahren zur herstellung
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
US5643595A (en) * 1992-11-24 1997-07-01 Alkermes Controlled Therapeutics Inc. Ii Growth promoters for animals
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
JP3645906B2 (ja) 1993-11-19 2005-05-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ マイクロカプセル封入された3−ピペリジニル−置換1,2−ベンズイソオキサゾール類及び1,2−ベンズイソチアゾール類
EP0789045B1 (de) * 1995-08-29 2001-01-10 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur herstellung von polyhydroxycarbonsäure
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
WO1997031049A1 (fr) * 1996-02-23 1997-08-28 Kyowa Hakko Kogyo Co., Ltd. Procede d'elaboration d'acide polyhydroxycarboxylique
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20070185032A1 (en) * 1996-12-11 2007-08-09 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US6113947A (en) * 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6663899B2 (en) 1997-06-13 2003-12-16 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6733767B2 (en) 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
US6217844B1 (en) 1998-04-27 2001-04-17 Praecis Pharmaceuticals, Inc. Methods for detecting lesions in dense breast tissue using LHRH antagonists
DE60019638T2 (de) * 1999-12-10 2005-09-22 Equipolymers Gmbh Katalysatorsysteme für polykondensationsreaktionen
US6960626B2 (en) * 2000-01-21 2005-11-01 Cyclics Corporation Intimate physical mixtures containing macrocyclic polyester oligomer and filler
DK1310517T4 (da) * 2000-08-07 2011-01-17 Wako Pure Chem Ind Ltd Mælkesyrepolymer og fremgangsmåde til fremstilling af denne
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
AU9051501A (en) * 2000-08-16 2002-02-25 Tyco Healthcare High consistency absorbable polymeric resin
US7750109B2 (en) 2000-09-01 2010-07-06 Cyclics Corporation Use of a residual oligomer recyclate in the production of macrocyclic polyester oligomer
US7767781B2 (en) 2000-09-01 2010-08-03 Cyclics Corporation Preparation of low-acid polyalkylene terephthalate and preparation of macrocyclic polyester oligomer therefrom
CA2451187C (en) * 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
CA2451767A1 (en) 2001-06-27 2003-01-09 Cyclics Corporation Isolation, formulation, and shaping of macrocyclic oligoesters
TWI332407B (en) * 2001-06-29 2010-11-01 Takeda Chemical Industries Ltd Controlled release composition and method of producting the same
TWI225416B (en) 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
US6849600B2 (en) * 2002-03-25 2005-02-01 The Regents Of The University Of California, Berkeley Corticotropin-releasing hormone analogs
WO2004029129A1 (ja) * 2002-09-24 2004-04-08 Asahi Kasei Chemicals Corporation グリコール酸共重合体及びその製造方法
EP1440992A1 (de) * 2003-01-21 2004-07-28 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Katalysatorzusammensetzung für die (Co)polymerisation von Lactid und Glycolid
US20060193825A1 (en) * 2003-04-29 2006-08-31 Praecis Phamaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20050112087A1 (en) * 2003-04-29 2005-05-26 Musso Gary F. Pharmaceutical formulations for sustained drug delivery
CA2533314C (en) 2003-07-18 2013-07-09 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
US20060210614A1 (en) * 2003-12-26 2006-09-21 Nastech Pharmaceutical Company Inc. Method of treatment of a metabolic disease using intranasal administration of exendin peptide
US20060074025A1 (en) * 2003-12-26 2006-04-06 Nastech Pharmaceutical Company Inc. Therapeutic formulations for transmucosal administration that increase glucagon-like peptide-1 bioavailability
US20080318837A1 (en) * 2003-12-26 2008-12-25 Nastech Pharmaceutical Company Inc. Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide
US20050143303A1 (en) * 2003-12-26 2005-06-30 Nastech Pharmaceutical Company Inc. Intranasal administration of glucose-regulating peptides
WO2005105908A1 (ja) * 2004-04-28 2005-11-10 Keio University 主鎖にエステル結合を有するポリマーの解重合方法及び解重合生成物から主鎖にエステル結合を有するポリマーを製造する方法
CA2567331C (en) * 2004-05-21 2012-08-14 Microtherapeutics, Inc. Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity
US20070254314A1 (en) * 2004-09-16 2007-11-01 Geier Mark R Methods of treating autism and autism spectrum disorders
ATE448737T1 (de) 2004-09-22 2009-12-15 Dendron Gmbh Vorrichtung zur implantation von mikrowendeln
DE102005019782A1 (de) * 2005-04-28 2006-11-09 Dendron Gmbh Vorrichtung zur Implantation von Okklusionswendeln mit innenliegendem Sicherungsmittel
US7342048B2 (en) * 2005-04-28 2008-03-11 Nipro Corporation Bioabsorbable pharmaceutical formulation
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US8882747B2 (en) * 2005-11-09 2014-11-11 The Invention Science Fund I, Llc Substance delivery system
RU2008124109A (ru) * 2005-12-08 2010-01-20 МДРНА, Инк. (US) Чресслизистая доставка стабилизированных композиций эксендина
DK2444807T3 (da) 2006-11-01 2014-08-11 Ventana Med Syst Inc Mono- og dinitropyrazolhaptenkonjugater
EA016176B1 (ru) 2006-12-18 2012-02-28 Такеда Фармасьютикал Компани Лимитед Композиция с замедленным высвобождением и способ её получения
ES2437619T3 (es) 2007-03-13 2014-01-13 Covidien Lp Un implante que incluye un arrollamiento helicoidal y un elemento resistente al estiramiento
US20100120811A1 (en) 2008-07-17 2010-05-13 Peter Hanson Long-acting injectable analgesic formulations for animals
AU2008363295B2 (en) 2008-10-20 2015-05-07 Forschungsverbund Berlin E.V. Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists
US8653086B2 (en) 2008-10-21 2014-02-18 Oregon Health & Science University Naphthamides as anticancer agents
CN101445595B (zh) * 2008-12-26 2011-01-19 上海新上化高分子材料有限公司 聚乙丙交酯及其制备方法和应用
US9365612B2 (en) 2010-01-29 2016-06-14 United States Of America As Represented By The Secretary, Department Of Health And Human Services Caspase inhibitors
EP2563777A4 (de) 2010-04-08 2013-09-04 Us Health Inverse agonisten und neutrale agonisten für den tsh-rezeptor
WO2012125486A1 (en) 2011-03-11 2012-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination chemotherapy for treating cancer
WO2012125787A1 (en) 2011-03-17 2012-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic METHODS FOR TREATING LEUKEMIA AND DISORDERS MEDIATED BY CBFβ AND RUNX1 PROTEINS
CN102295765B (zh) * 2011-06-30 2012-11-28 南京大学 生物质肌酐催化共缩聚法合成聚乳酸-乙醇酸
CN102329269B (zh) * 2011-06-30 2013-07-17 南京大学 仿生氯化肌酐胍催化缩聚法合成高分子量聚乳酸
WO2013039792A1 (en) 2011-09-12 2013-03-21 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Immunogens based on an hiv-1 gp120 v1v2 epitope
US20140234360A1 (en) 2011-09-30 2014-08-21 The United States of America, as represented by the Secretary, Dept.of Health and Human Services Influenza vaccine
EP2802565A4 (de) 2012-01-13 2015-07-08 Univ Oregon Health & Science Verbindungen, zusammensetzungen und zugehörige verfahren mit 3-aryl-chinolinen
CN104684895B (zh) 2012-06-08 2017-09-15 高等教育联邦系统-匹兹堡大学 Fbxo3抑制剂
JP6272626B2 (ja) 2012-11-13 2018-01-31 ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ カンナビノイド受容体媒介性化合物
US9775895B2 (en) 2012-12-12 2017-10-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HIV therapeutics and methods of making and using same
WO2014186398A1 (en) 2013-05-16 2014-11-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds for inhibiting drug-resistant strains of hiv-1 integrase
CA2924527C (en) 2013-09-20 2022-07-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compounds for treating prostate cancer
WO2015106003A1 (en) 2014-01-08 2015-07-16 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Ras pathways as markers of protection against hiv and methods to improve vaccine efficacy
CN106660968B (zh) 2014-05-09 2020-02-07 美国政府(由卫生和人类服务部的部长所代表) 吡唑衍生物及其作为大麻素受体介体的用途
EP3185868B1 (de) 2014-08-25 2022-04-06 Salk Institute for Biological Studies Neuartige ulk1-inhibitoren und verfahren zur verwendung davon
EP3189067B1 (de) 2014-09-04 2021-05-19 The United States of America, as represented by The Secretary, Department of Health and Human Services Rekombinante hiv-1 hüllproteine und deren verwendung
WO2016064716A1 (en) 2014-10-20 2016-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination therapy of tshr antagonist and igfr inhibitor
WO2016103238A1 (en) 2014-12-24 2016-06-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Recombinant metapneumovirus f proteins and their use
WO2016112036A1 (en) 2015-01-05 2016-07-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Myc g-quadruplex stabilizing small molecules and their use
PE20180021A1 (es) 2015-02-20 2018-01-09 Univ Oregon Health & Science Derivados de sobetiroma
EP3303325A1 (de) 2015-06-04 2018-04-11 The U.S.A. as represented by the Secretary, Department of Health and Human Services Cannabinoid-rezeptorvermittelnde verbindungen
EP3347047A1 (de) 2015-09-09 2018-07-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Expressionsvektor-abgabesystem und dessen verwendung zur induzierung einer immunantwort
EP3423448A1 (de) 2016-03-04 2019-01-09 The U.S.A. as represented by the Secretary, Department of Health and Human Services Cannabinoid-rezeptorvermittelnde verbindungen
EP3936497A1 (de) 2016-05-18 2022-01-12 Oregon Health & Science University Verfahren zur herstellung von derivate von sobetirom
WO2017218963A1 (en) 2016-06-16 2017-12-21 Acies Bio D.O.O. Compositions and methods useful for treating diseases characterized by insufficient pantothenate kinase activity
EP3554538A2 (de) 2016-12-16 2019-10-23 Institute for Research in Biomedicine Neuartige rekombinante rsv-f-präfusionsproteine und verwendungen davon
EP3675921A1 (de) 2017-08-31 2020-07-08 Evonik Corporation Verbessertes reinigungsverfahren für resorbierbare polymere
WO2019118803A1 (en) 2017-12-14 2019-06-20 The United States Of America, As Represented By The Secretary,Department Of Health And Human Services Chemical entities for lytic activation of kshv and therapeutic targeting of viral enzymes/proteins
BR112020018832A2 (pt) 2018-03-29 2021-02-09 Elex Biotech, Inc. compostos para o tratamento de arritimias cardíacas e insuficiência cardíaca
CA3110224A1 (en) 2018-09-25 2020-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
AU2019397067A1 (en) 2018-12-12 2021-07-22 Autobahn Therapeutics, Inc. Novel thyromimetics
EP3931180A1 (de) 2019-03-01 2022-01-05 Autobahn Therapeutics, Inc. Neuartige thyromimetika
EP3937917B1 (de) 2019-03-11 2023-11-15 Oregon State University Analoga und derivate von cephalotaxin und verfahren zur herstellung und verwendung der verbindungen
AU2022288631A1 (en) 2021-06-09 2024-01-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds that bind non-canonical g-quadruplex structures and methods of making and using the same
WO2023059867A1 (en) 2021-10-08 2023-04-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds for treating or preventing alzheimer's disease
WO2023146771A1 (en) 2022-01-25 2023-08-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gingerenone a prodrugs as senotherapeutics and methods of use
WO2023177568A1 (en) 2022-03-14 2023-09-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cannabinoid receptor modulating compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1995970A (en) * 1931-04-04 1935-03-26 Du Pont Polymeric lactide resin
US2362511A (en) * 1939-11-21 1944-11-14 Du Pont Modified glycolide resins
US2438208A (en) * 1943-07-10 1948-03-23 Us Agriculture Continuous process of converting lactic acid to polylactic acid
US2683136A (en) * 1950-10-25 1954-07-06 Du Pont Copolymers of hydroxyacetic acid with other alcohol acids
US2703316A (en) * 1951-06-05 1955-03-01 Du Pont Polymers of high melting lactide
US2758987A (en) * 1952-06-05 1956-08-14 Du Pont Optically active homopolymers containing but one antipodal species of an alpha-monohydroxy monocarboxylic acid
US3531561A (en) * 1965-04-20 1970-09-29 Ethicon Inc Suture preparation
US3498957A (en) * 1965-09-14 1970-03-03 Ethicon Inc Polymerization of cyclic carboxylic esters in the presense of a nonpolymerizable ester plasticizer
US3468853A (en) * 1966-06-15 1969-09-23 American Cyanamid Co Process of polymerizing a glycolide
BE758156R (fr) * 1970-05-13 1971-04-28 Ethicon Inc Element de suture absorbable et sa
US3839297A (en) * 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
US4137921A (en) * 1977-06-24 1979-02-06 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions

Also Published As

Publication number Publication date
HK19592A (en) 1992-03-20
EP0172636A1 (de) 1986-02-26
EP0171907A1 (de) 1986-02-19
EP0172636B1 (de) 1989-01-11
ATE39936T1 (de) 1989-01-15
EP0171907B1 (de) 1989-01-11
EP0171907B2 (de) 1994-08-10
CA1256638A (en) 1989-06-27
ATE39935T1 (de) 1989-01-15
US4683288A (en) 1987-07-28
CA1236641A (en) 1988-05-10
US4677191A (en) 1987-06-30
EP0172636B2 (de) 1992-11-11
DE3567471D1 (en) 1989-02-16
SG108191G (en) 1992-06-12
BG61520B2 (bg) 1997-10-31

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