DE3567278D1 - Metachromatic dye sorption means for differential determination of sub-populations of lymphocytes - Google Patents
Metachromatic dye sorption means for differential determination of sub-populations of lymphocytesInfo
- Publication number
- DE3567278D1 DE3567278D1 DE8585902017T DE3567278T DE3567278D1 DE 3567278 D1 DE3567278 D1 DE 3567278D1 DE 8585902017 T DE8585902017 T DE 8585902017T DE 3567278 T DE3567278 T DE 3567278T DE 3567278 D1 DE3567278 D1 DE 3567278D1
- Authority
- DE
- Germany
- Prior art keywords
- lymphocytes
- populations
- sub
- differential determination
- metachromatic dye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 230000003458 metachromatic effect Effects 0.000 title 1
- 238000001179 sorption measurement Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N2001/305—Fixative compositions
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/604,869 US4615878A (en) | 1980-03-12 | 1984-04-27 | Metachromatic dye sorption means for differential determination of sub-populations of lymphocytes |
PCT/EP1985/000161 WO1985005179A1 (en) | 1984-04-27 | 1985-04-12 | Metachromatic dye sorption means for differential determination of sub-populations of lymphocytes |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3567278D1 true DE3567278D1 (en) | 1989-02-09 |
Family
ID=24421387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585902017T Expired DE3567278D1 (en) | 1984-04-27 | 1985-04-12 | Metachromatic dye sorption means for differential determination of sub-populations of lymphocytes |
Country Status (4)
Country | Link |
---|---|
US (1) | US4615878A (de) |
EP (1) | EP0179107B1 (de) |
DE (1) | DE3567278D1 (de) |
WO (1) | WO1985005179A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4840784A (en) * | 1982-12-22 | 1989-06-20 | Eastman Kodak Company | Use of pyrylium and thiapyrylium compounds as biological stains |
US4810487A (en) * | 1986-01-02 | 1989-03-07 | Cytocolor, Inc. | Method of identifying polymethine stained lymphocyte subpopulations and compositions thereof |
JPH0668491B2 (ja) * | 1986-06-30 | 1994-08-31 | 株式会社日立製作所 | 細胞自動分類装置 |
US5089384A (en) * | 1988-11-04 | 1992-02-18 | Amoco Corporation | Method and apparatus for selective cell destruction using amplified immunofluorescence |
US5340719A (en) * | 1990-11-23 | 1994-08-23 | Corporation Coulter | Method and apparatus for optically screening microscopic cells |
EP0558639A1 (de) * | 1990-11-23 | 1993-09-08 | Coulter Corporation | Methode und vorrichtung zum optischen sortieren mikrokopischer zellen |
US5348859A (en) * | 1990-11-23 | 1994-09-20 | Coulter Corporation | Method and apparatus for obtaining an absolute white blood cell subset count and white blood cell multipart differential |
US5352613A (en) * | 1993-10-07 | 1994-10-04 | Tafas Triantafillos P | Cytological screening method |
US6136540A (en) | 1994-10-03 | 2000-10-24 | Ikonisys Inc. | Automated fluorescence in situ hybridization detection of genetic abnormalities |
JP3929491B2 (ja) * | 1995-04-04 | 2007-06-13 | ウーンド・ヒーリング・オブ・オクラホマ・インコーポレーテッド | イムノアジュバントを併用する光力学療法による癌治療 |
US6316007B1 (en) * | 1995-04-04 | 2001-11-13 | Wound Healing Of Oklahoma | Combined physical and immunotherapy for cancer |
EP1405058A4 (de) * | 2001-03-19 | 2007-07-04 | Ikonisys Inc | System und verfahren zur erhöhung des kontrasts eines durch ein epifluoreszenzmikroskop erzeugten bildes |
US9023641B2 (en) * | 2004-05-13 | 2015-05-05 | Advanced Animal Diagnostics | Microfluidic device and leucocyte antigen mediated microfluidic assay |
JP2010500573A (ja) * | 2006-08-04 | 2010-01-07 | イコニシス インコーポレーテッド | 顕微鏡システムのための画像処理方法 |
CN102084241B (zh) * | 2008-03-21 | 2015-02-18 | 艾博特健康公司 | 使用荧光淬灭和/或漂白分析个体细胞或微粒的方法及设备 |
WO2009117678A1 (en) | 2008-03-21 | 2009-09-24 | Abbott Point Of Care, Inc. | Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample |
US7903241B2 (en) | 2008-03-21 | 2011-03-08 | Abbott Point Of Care, Inc. | Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
WO2009117682A1 (en) | 2008-03-21 | 2009-09-24 | Abbott Point Of Care, Inc. | Method and apparatus for detecting and counting platelets individually and in aggregate clumps |
EP2265946B1 (de) | 2008-03-21 | 2012-08-01 | Abbott Point Of Care, Inc. | Verfahren und vorrichtung zur bestimmung des hämatokrit einer blutprobe unter nutzung der intrinsischen pigmentierung von in den roten blutzellen enthaltenem hämoglobin |
JP5189201B2 (ja) | 2008-04-02 | 2013-04-24 | アボット ポイント オブ ケア インコーポレイテッド | 全血を含む生体体液のイムノアッセイを実施するためのリガンドアッセイにおける結合標識と遊離標識との仮想分離 |
ES2597927T3 (es) * | 2008-04-09 | 2017-01-24 | Abbott Point Of Care, Inc. | Procedimiento para medir el área de una muestra dispuesta dentro de una cámara de análisis |
US20090258371A1 (en) * | 2008-04-09 | 2009-10-15 | Abbott Point Of Care, Inc. | Method of detecting very low levels of analyte within a thin film fluid sample contained in a thin thickness chamber |
US20100255605A1 (en) * | 2009-04-02 | 2010-10-07 | Abbott Point Of Care, Inc. | Method and device for transferring biologic fluid samples |
ES2438841T3 (es) * | 2009-12-31 | 2014-01-20 | Abbott Point Of Care, Inc. | Método y aparato para determinar el volumen celular medio de los glóbulos rojos en la sangre |
WO2011116305A1 (en) | 2010-03-18 | 2011-09-22 | Abbott Point Of Care, Inc. | Method and apparatus for optically determining at least one hemoglobin related parameter of a whole blood sample |
US10041937B2 (en) | 2013-05-30 | 2018-08-07 | Canon Kabushiki Kaisha | Macrophage identification agent, and identification method, sorting method, evaluation method, screening method and kit using the macrophage identifier agent |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE403179A (de) * | 1933-05-16 | |||
US3617185A (en) * | 1968-08-19 | 1971-11-02 | Gaf Corp | Stable highly concentrated solutions of basic dyes |
US4146604A (en) * | 1973-05-31 | 1979-03-27 | Block Engineering, Inc. | Differential counting of leukocytes and other cells |
US4581223A (en) * | 1980-03-12 | 1986-04-08 | Lawrence Kass | Individual leukocyte determination by means of differential metachromatic dye sorption |
US4400370A (en) * | 1980-03-12 | 1983-08-23 | Lawrence Kass | Metachromatic dye sorption means for differential determination of leukocytes |
DE3014563A1 (de) * | 1980-04-16 | 1981-10-29 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur bestimmung leukaemischer zellen |
US4500509A (en) * | 1981-03-11 | 1985-02-19 | Lawrence Kass | Metachromatic dye sorption and fluorescent light emmisive means for differential determination of developmental stages of neutrophilic granulocytic cells and other leukocytes |
US4492752A (en) * | 1982-09-03 | 1985-01-08 | Ortho Diagnostics Systems Inc. | Method for discriminating between unstained and absorbing dye stained cells |
-
1984
- 1984-04-27 US US06/604,869 patent/US4615878A/en not_active Expired - Lifetime
-
1985
- 1985-04-12 EP EP85902017A patent/EP0179107B1/de not_active Expired
- 1985-04-12 DE DE8585902017T patent/DE3567278D1/de not_active Expired
- 1985-04-12 WO PCT/EP1985/000161 patent/WO1985005179A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
US4615878A (en) | 1986-10-07 |
EP0179107A1 (de) | 1986-04-30 |
EP0179107B1 (de) | 1989-01-04 |
WO1985005179A1 (en) | 1985-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: CYTOCOLOR INC., HINCKLEY, OHIO, US |
|
8381 | Inventor (new situation) |
Free format text: KASS, LAWRENCE, HINCKLEY, OHIO, US |
|
8364 | No opposition during term of opposition |