DE3486262T3 - Verfahren zur Herstellung eines monoklonalen Antikörpers mit Spezifizität für vernetzte Fibrinderivate und ein Testverfahren mittels dieses Antikörpers. - Google Patents

Verfahren zur Herstellung eines monoklonalen Antikörpers mit Spezifizität für vernetzte Fibrinderivate und ein Testverfahren mittels dieses Antikörpers.

Info

Publication number
DE3486262T3
DE3486262T3 DE3486262T DE3486262T DE3486262T3 DE 3486262 T3 DE3486262 T3 DE 3486262T3 DE 3486262 T DE3486262 T DE 3486262T DE 3486262 T DE3486262 T DE 3486262T DE 3486262 T3 DE3486262 T3 DE 3486262T3
Authority
DE
Germany
Prior art keywords
derivative
crosslinked fibrin
monoclonal antibody
antibody
fibrin derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3486262T
Other languages
English (en)
Other versions
DE3486262T2 (de
DE3486262D1 (de
Inventor
Peter Gregory Bundesen
Dennis Brian Rylatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agen Biomedical Ltd
Original Assignee
Agen Biomedical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3770042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3486262(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Agen Biomedical Ltd filed Critical Agen Biomedical Ltd
Application granted granted Critical
Publication of DE3486262D1 publication Critical patent/DE3486262D1/de
Publication of DE3486262T2 publication Critical patent/DE3486262T2/de
Publication of DE3486262T3 publication Critical patent/DE3486262T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
DE3486262T 1983-03-17 1984-03-16 Verfahren zur Herstellung eines monoklonalen Antikörpers mit Spezifizität für vernetzte Fibrinderivate und ein Testverfahren mittels dieses Antikörpers. Expired - Lifetime DE3486262T3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPF849483 1983-03-17

Publications (3)

Publication Number Publication Date
DE3486262D1 DE3486262D1 (de) 1994-02-17
DE3486262T2 DE3486262T2 (de) 1994-06-16
DE3486262T3 true DE3486262T3 (de) 2000-10-26

Family

ID=3770042

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3486262T Expired - Lifetime DE3486262T3 (de) 1983-03-17 1984-03-16 Verfahren zur Herstellung eines monoklonalen Antikörpers mit Spezifizität für vernetzte Fibrinderivate und ein Testverfahren mittels dieses Antikörpers.

Country Status (18)

Country Link
US (1) US4758524A (de)
EP (1) EP0122478B2 (de)
JP (1) JPS59183696A (de)
KR (1) KR840008288A (de)
AT (1) ATE99738T1 (de)
AU (1) AU572125B2 (de)
CA (1) CA1247022A (de)
DE (1) DE3486262T3 (de)
DK (1) DK158284A (de)
ES (1) ES8507694A1 (de)
GR (1) GR81951B (de)
IL (1) IL71264A (de)
IN (1) IN158324B (de)
NO (1) NO167338C (de)
NZ (1) NZ207459A (de)
PH (1) PH22957A (de)
PT (1) PT78267B (de)
ZA (1) ZA841878B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4722903A (en) * 1983-11-14 1988-02-02 New York Blood Center, Inc. Monoclonal antibodies specific to in vivo fragments derived from human fibrinogen, human fiberin I or human fibrin II
DE3400434A1 (de) * 1984-01-09 1985-09-26 Behringwerke Ag, 3550 Marburg Bestimmung von fibrin mit fibrin-spezifischen antikoerpern
JPS60166698A (ja) * 1984-02-09 1985-08-29 Dai Ichi Pure Chem Co Ltd モノクロ−ナル抗体
US5357042A (en) * 1984-04-23 1994-10-18 The General Hospital Corporation Synthetic peptides capable of eliciting fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity
US4927916A (en) * 1984-04-23 1990-05-22 The General Hospital Corporation Method of producing fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity using fibrin-specific peptides
FR2569276B1 (fr) * 1984-08-14 1988-02-05 Stago Diagnostica Procede de dosage de produits de degradation du fibrinogene
US5116613A (en) * 1985-01-08 1992-05-26 The General Hospital Corporation Antibody-thrombolytic agent product and method of use
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
FR2593518B1 (fr) * 1985-05-02 1989-09-08 Transgene Sa Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
US4916070A (en) * 1986-04-14 1990-04-10 The General Hospital Corporation Fibrin-specific antibodies and method of screening for the antibodies
JPH0746104B2 (ja) * 1986-09-22 1995-05-17 株式会社ヤトロン Ｆｄｐの測定法
FI89634C (fi) * 1987-07-10 1993-10-25 Yamanouchi Pharma Co Ltd Foerfarande, anordning och kitt foer maetning av vaevnadsplasminogenaktivator-aktivitet
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US5453359A (en) * 1988-06-13 1995-09-26 American Biogenetic Sciences, Inc. Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers
US5120834A (en) * 1988-06-13 1992-06-09 American Biogenetic Sciences, Inc. Fibrin-specific monoclonal antibody
US5206140A (en) * 1988-06-24 1993-04-27 Research Corporation Technologies, Inc. Assay for soluble crosslinked fibrin polymers
IE67430B1 (en) * 1988-06-24 1996-04-03 Res Corp Technologies Inc Assay for soluble crosslinked fibrin polymers
US5609869A (en) * 1988-08-19 1997-03-11 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
US5811265A (en) * 1988-08-19 1998-09-22 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
CA2023354C (en) * 1989-08-17 2002-08-13 Karen Ann Thomas Method for direct chemical binding of d-dimer from a biological sample for diagnosing and monitoring thrombolytic and hypercoagulable states
EP0489061A4 (en) * 1989-08-24 1992-10-14 Australian Nuclear Science And Technology Organisation Radio-labelled antibodies for imaging
FR2663748B1 (fr) * 1990-06-22 1992-10-09 Oris Ind Cie Anticorps specifiques de la liaison isopeptidique induite par les transglutaminases, antigenes constitues par des isopeptides glu-lys reconnus par lesdits anticorps, agents de diagnostic et compositions therapeutiques les contenant.
US5807535A (en) * 1992-07-31 1998-09-15 Australian Nuclear Science & Technology Organisation Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
DE69327760T2 (de) * 1992-07-31 2000-09-07 Australian Nuclear Science Tec Hydroxyaryl enthaltenden aminocarboxylsäure-chelatbildnern
US5487892A (en) * 1994-02-24 1996-01-30 American Biogenetic Sciences, Inc. Method for treating thrombotic disease using a fibrin specific monoclonal antibody
WO1998012329A2 (en) * 1996-09-20 1998-03-26 The General Hospital Corporation Composition and method for enhancing fibrinolysis using antibodies to alpha-2-antiplasmin
WO2002039114A2 (en) * 2000-11-13 2002-05-16 Sigma-Aldrich Co. Improved assay and reagents or immunological determination of analyte concentration
AU2002220255A1 (en) * 2000-12-05 2002-06-18 The Penn State Research Foundation A monoclonal antibody-based diagnostic assay for gamma fibrinogen
DE60239467D1 (de) * 2001-06-26 2011-04-28 Agen Biomedical Ltd Von dd 3b6/22 abgeleitete humanisierte antikörper mit spezifität für das d-dimer fragment von fibrin
US20030219853A1 (en) * 2002-03-01 2003-11-27 Szu-Yi Chou Method of cross-linking a compound
US20040001848A1 (en) * 2002-03-01 2004-01-01 Szu-Yi Chou Method of producing disease-specific antigens
US20030224476A1 (en) * 2002-03-01 2003-12-04 Szu-Yi Chou Method of producing transglutaminase reactive compound
US7485438B2 (en) * 2002-03-01 2009-02-03 Szu-Yi Chou Method of producing polyvalent antigens
DE102004052082A1 (de) 2004-10-26 2006-04-27 Dade Behring Marburg Gmbh Durchstoßbare, flexible Vorrichtung zur Abdeckung von Flüssigkeitsbehältnissen
US11506674B2 (en) 2005-07-29 2022-11-22 Princeton Biomeditech Corporation Monoclonal antibody against D-dimer and diagnosis agent for detecting D-dimer, crosslinked fibrin and its derivatives containing D-dimer by using the antibody
US8940489B2 (en) 2005-07-29 2015-01-27 Hyun-Ju Doh Monoclonal antibody against D-dimer and diagnosis agent for detecting D-dimer, crosslinked fibrin and its derivatives containing D-dimer by using the antibody
ES2655099T3 (es) 2010-04-01 2018-02-16 Lsi Medience Corporation Nuevos anticuerpos monoclonales y procedimiento de análisis inmunológico del dímero D
CN103026231B (zh) 2010-07-30 2015-06-24 希森美康株式会社 Fdp测定用试剂及试剂盒、以及测定方法
TWI658268B (zh) * 2017-11-29 2019-05-01 國立清華大學 血液檢測方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) * 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
AU2373384A (en) * 1982-12-06 1984-06-14 Fielder Gillespie Davis Ltd. Field immunoassay reaction system
EP0113075A3 (de) * 1982-12-06 1985-05-02 Fielder Gillespie Davis Limited Tragbares Immunoassay-Reaktionssystem, Verfahren zur Diagnose durch eine Immunbestimmung und Sonde oder Träger zur Durchführung des Verfahrens
US4722903A (en) * 1983-11-14 1988-02-02 New York Blood Center, Inc. Monoclonal antibodies specific to in vivo fragments derived from human fibrinogen, human fiberin I or human fibrin II

Also Published As

Publication number Publication date
EP0122478B1 (de) 1994-01-05
KR840008288A (ko) 1984-12-14
PT78267B (en) 1986-04-21
DE3486262T2 (de) 1994-06-16
DK158284A (da) 1984-09-18
AU572125B2 (en) 1988-05-05
NZ207459A (en) 1987-11-27
AU2538784A (en) 1984-09-20
EP0122478A2 (de) 1984-10-24
ES530691A0 (es) 1985-09-01
GR81951B (de) 1984-12-12
IN158324B (de) 1986-10-18
ES8507694A1 (es) 1985-09-01
IL71264A (en) 1987-10-20
JPH0583240B2 (de) 1993-11-25
NO167338C (no) 1993-12-15
EP0122478B2 (de) 2000-04-12
NO167338B (no) 1991-07-15
CA1247022A (en) 1988-12-20
DE3486262D1 (de) 1994-02-17
IL71264A0 (en) 1984-06-29
ZA841878B (en) 1984-10-31
ATE99738T1 (de) 1994-01-15
NO841023L (no) 1984-09-18
DK158284D0 (da) 1984-03-16
EP0122478A3 (en) 1987-04-01
US4758524A (en) 1988-07-19
PT78267A (en) 1984-04-01
PH22957A (en) 1989-02-03
JPS59183696A (ja) 1984-10-18

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Legal Events

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8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings