DE3471305D1 - Thiazine and thiazepine containing compounds - Google Patents
Thiazine and thiazepine containing compoundsInfo
- Publication number
- DE3471305D1 DE3471305D1 DE8484400293T DE3471305T DE3471305D1 DE 3471305 D1 DE3471305 D1 DE 3471305D1 DE 8484400293 T DE8484400293 T DE 8484400293T DE 3471305 T DE3471305 T DE 3471305T DE 3471305 D1 DE3471305 D1 DE 3471305D1
- Authority
- DE
- Germany
- Prior art keywords
- thiazepine
- thiazine
- containing compounds
- image
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6544—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/470,882 US4460579A (en) | 1983-02-28 | 1983-02-28 | Thiazine and thiazepine containing compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3471305D1 true DE3471305D1 (en) | 1988-06-23 |
Family
ID=23869447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8484400293T Expired DE3471305D1 (en) | 1983-02-28 | 1984-02-14 | Thiazine and thiazepine containing compounds |
Country Status (6)
Country | Link |
---|---|
US (1) | US4460579A (de) |
EP (1) | EP0120728B1 (de) |
JP (1) | JPS59167577A (de) |
AT (1) | ATE34388T1 (de) |
CA (1) | CA1219862A (de) |
DE (1) | DE3471305D1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985004402A1 (en) * | 1984-03-24 | 1985-10-10 | Takeda Chemical Industries, Ltd. | Fused 7-membered ring compounds and process for their preparation |
WO1984004306A1 (en) * | 1983-04-22 | 1984-11-08 | Takeda Chemical Industries Ltd | Fused 7-membered ring compounds and process for their preparation |
US4564612A (en) * | 1983-04-22 | 1986-01-14 | Takeda Chemical Industries, Ltd. | Condensed, seven-membered ring compounds and their use |
JPS608283A (ja) * | 1983-06-29 | 1985-01-17 | Mitsui Toatsu Chem Inc | ベンゾチアゼピン誘導体およびその製造方法 |
JPS608284A (ja) * | 1983-06-29 | 1985-01-17 | Mitsui Toatsu Chem Inc | ベンゾチアゼピン誘導体およびその製造法 |
US4638000A (en) * | 1983-08-12 | 1987-01-20 | Takeda Chemical Industries, Ltd. | Condensed seven-membered ring compounds, their production and use |
JPS60174775A (ja) * | 1984-02-21 | 1985-09-09 | Mitsui Toatsu Chem Inc | ベンゾチアゼピン誘導体 |
US4512988A (en) * | 1984-03-01 | 1985-04-23 | E. R. Squibb & Sons, Inc. | Acylamino oxo or hydroxy substituted alkylamino thiazines and thiazepines |
US4699905A (en) * | 1984-04-10 | 1987-10-13 | Sankyo Company, Limited | Perhydrothiazepine derivatives, their preparation and their therapeutic use |
JPS6165894A (ja) * | 1984-09-08 | 1986-04-04 | Shionogi & Co Ltd | チアジンホスホン酸誘導体とその製法および殺虫剤 |
JPS61148171A (ja) * | 1984-12-21 | 1986-07-05 | Mitsui Toatsu Chem Inc | ベンゾチアゼピン誘導体 |
JPH07113020B2 (ja) * | 1985-09-12 | 1995-12-06 | 三共株式会社 | ペルヒドロ―1,4―チアゼピン誘導体の製造法 |
CA1336774C (en) * | 1986-04-04 | 1995-08-22 | Hiroaki Yanagisawa | Perhydrothiazepine and perhydroazepine derivatives their preparation and their therapeutic use |
JPH07116224B2 (ja) * | 1987-12-29 | 1995-12-13 | 吉富製薬株式会社 | ベンゾラクタム化合物 |
US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
RU2124503C1 (ru) | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
US5508272A (en) * | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
JP2664865B2 (ja) * | 1994-01-13 | 1997-10-22 | 三共株式会社 | ペルヒドロ−1,4−チアゼピン誘導体の製法 |
US5616775A (en) * | 1994-05-05 | 1997-04-01 | Bristol-Myers Squibb Co. | Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
US5877313A (en) * | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
FR2781483A1 (fr) * | 1998-07-21 | 2000-01-28 | Hoechst Marion Roussel Inc | Derives de thioazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicament et compositions pharmaceutiques les renfermant |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR6915295D0 (pt) * | 1969-01-25 | 1973-04-12 | Tanabe Seiyaku Co | Indicador cronologico de evento em transmissao televisada |
US3691163A (en) * | 1970-08-03 | 1972-09-12 | Exxon Research Engineering Co | Certain phosphorus-containing thiomorpholinones |
PT73522B (en) * | 1980-08-18 | 1983-07-14 | Merck & Co Inc | Process for preparing substituted caprylolactam derivatives as antihypertensives |
GR74635B (de) * | 1980-08-18 | 1984-06-29 | Merck & Co Inc | |
IL63540A0 (en) * | 1980-08-18 | 1981-11-30 | Merck & Co Inc | Substituted enantholactam derivatives as antihypertensives |
US4379146A (en) * | 1981-02-17 | 1983-04-05 | Merck & Co., Inc. | Substituted phosphonamides as antihypertensives |
EP0068173B1 (de) * | 1981-06-05 | 1984-09-26 | Merck & Co. Inc. | Perhydro-1,4-thiazepin-5-one und Perhydro-1,4-thiazocin-5-one, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
JPS58116477A (ja) * | 1981-06-05 | 1983-07-11 | メルク・エンド・カムパニ−・インコ−ポレ−テツド | 抗高血圧剤としてのパ−ヒドロ−1,4−チアゼピン−5−オンおよびパ−ヒドロ−1,4−チアゾシン−5−オン誘導体 |
US4474955A (en) * | 1981-06-17 | 1984-10-02 | Vincenzo Iannella | Process for preparing 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-[N-(2-pyridinyl)carboxamide]-1,1-dioxide, and its phosphoric ester |
-
1983
- 1983-02-28 US US06/470,882 patent/US4460579A/en not_active Expired - Fee Related
-
1984
- 1984-02-10 CA CA000447163A patent/CA1219862A/en not_active Expired
- 1984-02-14 DE DE8484400293T patent/DE3471305D1/de not_active Expired
- 1984-02-14 AT AT84400293T patent/ATE34388T1/de active
- 1984-02-14 EP EP84400293A patent/EP0120728B1/de not_active Expired
- 1984-02-28 JP JP59038452A patent/JPS59167577A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0120728B1 (de) | 1988-05-18 |
EP0120728A1 (de) | 1984-10-03 |
US4460579A (en) | 1984-07-17 |
JPS59167577A (ja) | 1984-09-21 |
CA1219862A (en) | 1987-03-31 |
ATE34388T1 (de) | 1988-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |