DE3438284A1 - Nicotine-containing depot plaster - Google Patents

Nicotine-containing depot plaster

Info

Publication number
DE3438284A1
DE3438284A1 DE19843438284 DE3438284A DE3438284A1 DE 3438284 A1 DE3438284 A1 DE 3438284A1 DE 19843438284 DE19843438284 DE 19843438284 DE 3438284 A DE3438284 A DE 3438284A DE 3438284 A1 DE3438284 A1 DE 3438284A1
Authority
DE
Germany
Prior art keywords
nicotine
plaster
depot
containing depot
cigarette
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19843438284
Other languages
German (de)
Inventor
Hans-Harald von 2400 Lübeck Tilly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TILLY HANS HARALD VON
Original Assignee
TILLY HANS HARALD VON
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TILLY HANS HARALD VON filed Critical TILLY HANS HARALD VON
Priority to DE19843438284 priority Critical patent/DE3438284A1/en
Publication of DE3438284A1 publication Critical patent/DE3438284A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof

Abstract

For the extreme reduction of the health-damaging consequences of cigarette smoking, as a cigarette replacement a plaster is prepared which contains a nicotine depot which releases a daily amount of nicotine customary for smokers directly through the epidermis more or less continuously into the human blood stream. Further application possibilities of the nicotine-containing depot plaster consist in use of portions of plaster in stepwise weaning-off, and also as a slimming agent, utilising the appetite-inhibiting side effect of nicotine.

Description

Beschreibungdescription

Titel: Nikotinhaltiges Depotpflaster Die Erfindung betrifft ein Pflaster, welches als Trägersubstanz fungiert und ein Depot von Nikotin enthält, welches etwa dem Tagesbedarf eines gewohnheitsmäßigen, mittelstarken Rauchers ( ca 20 -30 mg/die Nikotin) entspricht.Title: Nicotine-containing depot patch The invention relates to a patch, which acts as a carrier substance and contains a depot of nicotine, which is about the daily requirement of a habitual, medium-heavy smoker (approx. 20-30 mg / die Nicotine).

Aufgabe: Der Erfindung liegt die Aufgabe Eugrunde, besonders dem starken Zigarettenraucher ein Zigarettenersatzmittel in die Hand zu geben, welches es ihm ermöglicht, mit geringem S.ufwand den möglicherweise schweren Gesundheitsschäden wie chronische Bronchitis, Bronchialkarzinam oder auch Herzinfarkt ganz oder teilweise zu entgehen, Lösung: Die gestellte Aufgabe wird dadurch gelöst, daß die chronische Rauchergewohnheit zunächst in einen seelischen Teil ( Ritus, Saugreflex, Beschäftigung etc.) und einen körperlichen Teil getrennt wird, wobei nur das sich wiederholende, suchtähnliche Verlangen nach belebender und aktivierenddr Nikotinzufuhr im Vordergrund steht. Dies wird jetzt dadurch befriedigt, da.S die gewünschte oder gewohnte Nikotintagesmenge durch ein auf die Haut geklebtes Pflaster, welches ein Nikotindepot enthält, mehr octer weniger ontinuierlich über viele Stunden durch die Haut in die Blutbahn abgegeben wird.Task: The invention is based on the task, especially the strong one To give cigarette smokers a cigarette substitute that suits them enables the potentially serious damage to health with little effort such as chronic bronchitis, bronchial carcinoma or heart attack in whole or in part to escape, solution: The problem posed is solved by the chronic Smoking habit is initially divided into an emotional part (rite, sucking reflex, occupation etc.) and a physical part is separated, whereby only the repetitive, addiction-like desires for invigorating and activating nicotine intake in the foreground stands. this is now satisfied by the fact that.S the desired or the usual daily amount of nicotine through a patch stuck to the skin, which is a Nicotine depot contains more octer less oncontinuously over many hours the skin is released into the bloodstream.

UStand der Technik: Nach dem gegenwärtigen Stand der Technik muß gewünschtes Nikotin dem Körper durch wiederholtes Rauchen eingegeben werden, wobei es durch die Schleimhaut der Atemwege resorbiert wird. Dabei werden dem Körper durch den Rauch jedoch auch zwangsläufig andere, z.T. stark gesundheitsgefährdende Stoffe wie Teerkondensate, Kohlenwasserstoffe, Arsen, Kupfer, Kohlenmonoxyd u. Et. eingegeben.State of the art: According to the current state of the art, what is desired Nicotine can be entered into the body through repeated smoking, taking it through the mucous membrane of the respiratory tract is absorbed. In doing so, the body through the However, smoke also inevitably includes other substances, some of which are highly hazardous to health such as tar condensates, hydrocarbons, arsenic, copper, carbon monoxide and the like.

Die anderen denkbaren Wege der Nikotinzufuhr sind langerfristig entweder unpraktikabel ( Spritze und Infusionen ), oder ganz oder häufig unbekömmlich (Tabletten oder Nikotinkaugummi Nicorette y Das Neue der Erfindung besteht nun darin, ein Pflaster mit einem Nikotindenot herzustellen, welches das Nikotin direkt durch die menschliche Außenhaut in die Blutbahn abgibt. Schon bisher werden dem Körper häufig Substanzen durch die Haut zugeführt, z.B. in Badezusätzen oder mit Salben. Neuerdings finden auch Depotpflaster Verwendung als Herzmedikamente wie Deponit Fa.Schwarz Pharma, oder Nitroderm R Fa. Ciba. Das Neue der Erfindung besteht darin, mit dem Nikotinpflaster dem Körper kein Medikament, sondern ein Genussmittel durch die Haut zuzuführen. The other conceivable routes of nicotine intake are either long term impractical (syringe and infusions), or completely or often indigestible (tablets or nicotine chewing gum Nicorette y The novelty of the invention is now a plaster to manufacture with a nicotindenot, which the nicotine directly through the human Releases the outer skin into the bloodstream. Already so far the body Often substances are added through the skin, e.g. in bath additives or with ointments. Lately, depot plasters have also been used as heart medication, such as Deponit Schwarz Pharma or Nitroderm R Ciba. The novelty of the invention is that With the nicotine patch, the body is not given a drug, but a stimulant to supply the skin.

Vorteil: Das Nikotinpflaster kann gewerblich hergestellt und vertrieben werden mit dem Ziel, dem gesundheitsschädlichen Rauchen Konkurenz zu machen durch Zigarettenersatz. Die aktivierende und leicht euphorisierende Substanz Nikotin wird dem Körper weiterhin zugeführt, aber jetzt ohne die anderen Schädlichen Inhaltestoffe des Rauches.Advantage: The nicotine patch can be manufactured and sold commercially with the aim of competing with harmful smoking Cigarette substitute. The activating and slightly euphoric substance is nicotine continued to be supplied to the body, but now without the other harmful ingredients of the smoke.

Der Zigarettenersatz kann Ständig benutzt werden, aber auch nur zeiv eise, z. B. zur tiberbrückung in NiJ aucherumgebung. The cigarette substitute can be used all the time, but also only partially iron, e.g. B. for bridging in NiJ also surroundings.

Das Produkt kann auch pro Tagesdosis billiger sein als Zigaretten, u.a. dadurch, daß es nicht der Tabaksteuer unterliegt. The product can also be cheaper than cigarettes per daily dose, among other things by the fact that it is not subject to tobacco tax.

Weitere Vorteile sind zu erwarten bei der Verwendung als vollständiges Entwöhnun.smittel, wenn es Zurechtgeschnitten oder anders portioniert in immer geringeren Mengen zugeführt wird. Other benefits are to be expected when used as a complete Weaning aid if it is cut to size or differently portioned is supplied in ever smaller quantities.

Ferner ist der Gebrauch als Schlankheitsmittel möglich, da Nikotin eine appetithemmende Wirkung hat,It can also be used as a slimming product because it is nicotine has an appetite suppressant effect,

Claims (1)

Patentanspruch Oberbegriff: Nikotinhaltiges Depotpflaster Kennzeichn. Teil: dadurch gekennzeichnet, daß in ein Pflaster ( ca 10 -20 cm2 ) ein Depot von Nikotin eingebracht wird, welches, auf die menschliche Haut geklebt, an diese und von dieser an die Blutbahn mehr oder weniger kontinuierlich über viele Stunden abgegeben wird.Claim generic term: Nicotine-containing depot plaster marking. Part: characterized in that in a plaster (approx. 10 -20 cm2) a depot of Nicotine is introduced, which, stuck to the human skin, to this and from this released into the bloodstream more or less continuously over many hours will.
DE19843438284 1984-10-16 1984-10-16 Nicotine-containing depot plaster Ceased DE3438284A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19843438284 DE3438284A1 (en) 1984-10-16 1984-10-16 Nicotine-containing depot plaster

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843438284 DE3438284A1 (en) 1984-10-16 1984-10-16 Nicotine-containing depot plaster

Publications (1)

Publication Number Publication Date
DE3438284A1 true DE3438284A1 (en) 1985-03-07

Family

ID=6248255

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843438284 Ceased DE3438284A1 (en) 1984-10-16 1984-10-16 Nicotine-containing depot plaster

Country Status (1)

Country Link
DE (1) DE3438284A1 (en)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61251619A (en) * 1985-04-30 1986-11-08 Nitto Electric Ind Co Ltd Nicotin-containing tape preparation
EP0246385A1 (en) * 1986-05-23 1987-11-25 New Mexico Tech Research Foundation Transcutaneous application of nicotine
DE3639418A1 (en) * 1986-11-18 1988-06-09 Forschungsgesellschaft Rauchen NICOTINE-BASED AGENT
US4781924A (en) * 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
EP0289342A2 (en) * 1987-05-01 1988-11-02 Elan Transdermal Limited Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method
US4837027A (en) * 1987-11-09 1989-06-06 Alza Corporation Transdermal drug delivery device
US4839174A (en) * 1987-10-05 1989-06-13 Pharmetrix Corporation Novel transdermal nicotine patch
US4908213A (en) * 1989-02-21 1990-03-13 Schering Corporation Transdermal delivery of nicotine
EP0366240A1 (en) * 1988-10-28 1990-05-02 Pharmacia AB Prolonged activity nicotine patch
US5077104A (en) * 1989-12-21 1991-12-31 Alza Corporation Nicotine packaging materials
US5342623A (en) * 1986-09-12 1994-08-30 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5411739A (en) * 1987-09-01 1995-05-02 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Apparatus for the controlled delivery of nicotine, process for the production thereof and use thereof
US5462745A (en) * 1986-09-12 1995-10-31 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
LT3670B (en) 1989-11-07 1996-01-25 Anders Dam Stimulating preparation with nicotine
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
US5603947A (en) * 1993-07-09 1997-02-18 Cygnus Terapeutic Systems Method and device for providing nicotine replacement therapy transdermally/transbuccally
US5633008A (en) * 1988-06-14 1997-05-27 Osborne; James L. Method of administering nicotine transdermally
WO1998003175A1 (en) * 1996-07-18 1998-01-29 International Diabetes Institute Treatment of obesity
US6110488A (en) * 1986-08-28 2000-08-29 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US6117448A (en) * 1986-08-28 2000-09-12 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US6224900B1 (en) 1986-08-28 2001-05-01 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Sealing bag for a transdermal therapeutic system
US6264977B1 (en) 1986-08-28 2001-07-24 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61251619A (en) * 1985-04-30 1986-11-08 Nitto Electric Ind Co Ltd Nicotin-containing tape preparation
JPH0583523B2 (en) * 1985-04-30 1993-11-26 Nitto Denko Corp
EP0246385A1 (en) * 1986-05-23 1987-11-25 New Mexico Tech Research Foundation Transcutaneous application of nicotine
EP0498468A1 (en) * 1986-05-23 1992-08-12 New Mexico Tech Research Foundation Device for transcutaneous application of nicotine
US6224900B1 (en) 1986-08-28 2001-05-01 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Sealing bag for a transdermal therapeutic system
US6117448A (en) * 1986-08-28 2000-09-12 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US6110488A (en) * 1986-08-28 2000-08-29 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US6264977B1 (en) 1986-08-28 2001-07-24 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US5462745A (en) * 1986-09-12 1995-10-31 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5342623A (en) * 1986-09-12 1994-08-30 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
DE3645036A1 (en) * 1986-11-18 1989-01-05 Forschungsgesellschaft Rauchen Nicotine-containing composition
DE3639418A1 (en) * 1986-11-18 1988-06-09 Forschungsgesellschaft Rauchen NICOTINE-BASED AGENT
EP0289342A2 (en) * 1987-05-01 1988-11-02 Elan Transdermal Limited Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method
US4946853A (en) * 1987-05-01 1990-08-07 Elan Transdermal Limited Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method
EP0289342A3 (en) * 1987-05-01 1989-01-25 Elan Transdermal Limited Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method
US5298257A (en) * 1987-05-01 1994-03-29 Elan Transdermal Limited Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method
US5411739A (en) * 1987-09-01 1995-05-02 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Apparatus for the controlled delivery of nicotine, process for the production thereof and use thereof
US4943435A (en) * 1987-10-05 1990-07-24 Pharmetrix Corporation Prolonged activity nicotine patch
US4839174A (en) * 1987-10-05 1989-06-13 Pharmetrix Corporation Novel transdermal nicotine patch
USRE39588E1 (en) 1987-11-09 2007-04-24 Alza Corporation Transdermal drug delivery device
US4837027A (en) * 1987-11-09 1989-06-06 Alza Corporation Transdermal drug delivery device
US4781924A (en) * 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US6165497A (en) * 1988-06-14 2000-12-26 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5633008A (en) * 1988-06-14 1997-05-27 Osborne; James L. Method of administering nicotine transdermally
EP0916339A1 (en) * 1988-10-28 1999-05-19 Pharmacia & Upjohn Aktiebolag Prolonged activity nicotine patch
EP0366240A1 (en) * 1988-10-28 1990-05-02 Pharmacia AB Prolonged activity nicotine patch
US4908213A (en) * 1989-02-21 1990-03-13 Schering Corporation Transdermal delivery of nicotine
WO1990009808A1 (en) 1989-02-21 1990-09-07 Schering Corporation Device for the transdermal delivery of nicotine
LT3670B (en) 1989-11-07 1996-01-25 Anders Dam Stimulating preparation with nicotine
US5268209A (en) * 1989-12-21 1993-12-07 Alza Corporation Nicotine packaging materials
US5077104A (en) * 1989-12-21 1991-12-31 Alza Corporation Nicotine packaging materials
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
US5603947A (en) * 1993-07-09 1997-02-18 Cygnus Terapeutic Systems Method and device for providing nicotine replacement therapy transdermally/transbuccally
WO1998003175A1 (en) * 1996-07-18 1998-01-29 International Diabetes Institute Treatment of obesity

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Legal Events

Date Code Title Description
OAV Applicant agreed to the publication of the unexamined application as to paragraph 31 lit. 2 z1
OP8 Request for examination as to paragraph 44 patent law
8131 Rejection