DE3366920D1 - Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them - Google Patents

Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them

Info

Publication number: DE3366920D1
Authority: DE; Germany
Prior art keywords: processes; production; pharmaceutical compositions; compositions containing; ischaemic
Prior art date: 1982-03-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

DE8383301227T

Other languages

English (en)

Inventor

Simon Fraser Campbell

Peter Edward Cross

John Kendrick Stubbs

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Ltd

Pfizer Corp

Original Assignee

Pfizer Ltd

Pfizer Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-03-11

Filing date

1983-03-08

Publication date

1986-11-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10528947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3366920(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1983-03-08 Application filed by Pfizer Ltd, Pfizer Corp filed Critical Pfizer Ltd

1986-11-20 Application granted granted Critical

1986-11-20 Publication of DE3366920D1 publication Critical patent/DE3366920D1/de

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
230000002253 anti-ischaemic effect Effects 0.000 title 1
229940030600 antihypertensive agent Drugs 0.000 title 1
239000002220 antihypertensive agent Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 abstract 1
206010002383 Angina Pectoris Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

DE8383301227T 1982-03-11 1983-03-08 Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them Expired DE3366920D1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8207180		1982-03-11

Publications (1)

Publication Number	Publication Date
DE3366920D1 true DE3366920D1 (en)	1986-11-20

Family

ID=10528947

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE8383301227T Expired DE3366920D1 (en)	1982-03-11	1983-03-08	Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
DE1993175111 Active DE19375111I2 (de)	1982-03-11	1983-03-08	Dihydropyridine als antiischaemische und antihypertonische Mittel Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE1993175111 Active DE19375111I2 (de)	1982-03-11	1983-03-08	Dihydropyridine als antiischaemische und antihypertonische Mittel Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Country Status (37)

Country	Link
US (1)	US4572909A (de)
EP (1)	EP0089167B1 (de)
JP (1)	JPS58167569A (de)
KR (1)	KR870000809B1 (de)
AT (1)	ATE22884T1 (de)
AU (1)	AU540769B2 (de)
BA (2)	BA97147B1 (de)
BG (1)	BG60658B2 (de)
CA (1)	CA1253865A (de)
CS (3)	CS240954B2 (de)
DD (2)	DD218887A5 (de)
DE (2)	DE3366920D1 (de)
DK (1)	DK161312C (de)
EG (1)	EG16987A (de)
ES (2)	ES8503654A1 (de)
FI (1)	FI81090C (de)
GR (1)	GR77429B (de)
HK (1)	HK16288A (de)
HR (2)	HRP930369B1 (de)
HU (1)	HU187868B (de)
IE (2)	IE54667B1 (de)
IL (1)	IL68091A (de)
KE (1)	KE3778A (de)
LU (1)	LU88332I2 (de)
LV (2)	LV5235A3 (de)
MY (1)	MY101985A (de)
NL (1)	NL930063I2 (de)
NO (3)	NO162818C (de)
NZ (1)	NZ203521A (de)
PL (3)	PL140278B1 (de)
PT (1)	PT76370B (de)
SG (1)	SG98687G (de)
SI (2)	SI8310586A8 (de)
SU (2)	SU1238730A3 (de)
UA (2)	UA7083A1 (de)
YU (2)	YU43541B (de)
ZA (1)	ZA831651B (de)

Families Citing this family (183)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL140069B1 (en) *	1982-12-21	1987-03-31	Pfizer	Method of obtaining new derivatives of dihydropiridine
GB8306666D0 (en) *	1983-03-10	1983-04-13	Pfizer Ltd	Therapeutic agents
EP0125803A3 (de) *	1983-04-27	1987-01-21	FISONS plc	Pharmazeutisch aktive Dihydropyridine
EP0168841B1 (de) *	1983-12-19	1988-09-28	Pfizer Limited	Dihydropyridin-Zwischenprodukt
JPS60156671A (ja) *	1984-01-25	1985-08-16	Yamanouchi Pharmaceut Co Ltd	ジヒドロピリジン誘導体およびその製造法
GB8414518D0 (en) *	1984-06-07	1984-07-11	Pfizer Ltd	Therapeutic agents
GR851819B (de) *	1984-08-17	1985-11-26	Wyeth John & Brother Ltd
GB8421039D0 (en) *	1984-08-17	1984-09-19	Wyeth John & Brother Ltd	Heterocyclic compounds
IL77843A (en) *	1985-02-11	1989-07-31	Syntex Inc	Dihydropyridine derivatives,process and novel intermediates for their preparation and pharmaceutical compositions containing them
EP0200524A3 (de) *	1985-05-03	1987-06-16	Pfizer Limited	Dihydropyridin-Calcium-Antagonisten
DE3531498A1 (de) *	1985-09-04	1987-03-05	Bayer Ag	Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln
EP0225175A3 (de) *	1985-11-28	1988-12-28	FISONS plc	Dihydropyridin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE3544211A1 (de) *	1985-12-13	1987-06-19	Bayer Ag	Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IT1204460B (it) *	1986-02-20	1989-03-01	Glaxo Spa	Derivati eterociclici
GB8608335D0 (en) *	1986-04-04	1986-05-08	Pfizer Ltd	Pharmaceutically acceptable salts
FR2602231B1 (fr) *	1986-08-04	1988-10-28	Adir	Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4983740A (en) *	1986-08-04	1991-01-08	Adir Et Compagnie	Process for 1,4-dihydropyridine compounds
FR2649395B1 (fr) *	1989-07-04	1992-11-06	Adir	Nouveau derive de la dihydro-1,4 pyridine denomme (-) i1(((amino-2 ethoxy)-2 ethoxy) methyli1) -2 (dichloro-2,3 phenyl)-4 ethoxycarbonyl-3 methoxycarbonyl-5 methyl-6 dihydro-1,4 pyridine, son procede de preparation et les compositions qui le contiennent
US5196410A (en) *	1986-10-31	1993-03-23	Pfizer Inc.	Transdermal flux enhancing compositions
IT1213555B (it) *	1986-12-11	1989-12-20	Boehringer Biochemia Srl	2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono.
JPS63196564A (ja) *	1987-02-10	1988-08-15	Agency Of Ind Science & Technol	イミドオリゴマ−の製造方法
IT1215381B (it) *	1987-03-12	1990-02-08	Boehringer Biochemia Srl	Farmaceutiche che le contengono. carbonil- e solfonil- derivati di 2-(aminoalchiltio)metil-1,4-diidropiridine, un metodo per la loro preparazione e composizioni
GB8709447D0 (en) *	1987-04-21	1987-05-28	Pfizer Ltd	Dihydropyridines
GB8710493D0 (en) *	1987-05-02	1987-06-03	Pfizer Ltd	Dihydropyridines
DE3906406C1 (de) *	1989-03-01	1990-10-25	Goedecke Ag, 1000 Berlin, De
DE4128132A1 (de) *	1991-08-24	1993-02-25	Bayer Ag	3-(2-chlor-3-trifluormethylphenyl)-4-cyanopyrrol, dessen herstellung und verwendung und neue zwischenprodukte
US5234943A (en) *	1989-04-13	1993-08-10	Bayer Aktiengesellschaft	Fungicidal 3-(2-chloro-3-trifluoromethylphenyl)-4-cyanopyrrole
FR2652083B1 (fr) *	1989-09-20	1992-01-24	Ador Cie	Nouveau procede de separation d'isomeres optiques des derives de la dihydro-1,4 pyridine.
US5270323A (en) *	1990-05-31	1993-12-14	Pfizer Inc.	Method of treating impotence
US6057344A (en)	1991-11-26	2000-05-02	Sepracor, Inc.	Methods for treating hypertension, and angina using optically pure (-) amlodipine
JPH07501547A (ja) *	1991-11-26	1995-02-16	セプラコア，インコーポレーテッド	光学的に純粋な（−）アムロジピンを用いる，高血圧，狭心症および他の疾患を治療するための方法および組成物
US6162802A (en) *	1992-03-10	2000-12-19	Papa; Joseph	Synergistic combination therapy using benazepril and amlodipine for the treatment of cardiovascular disorders and compositions therefor
EP1614420A3 (de) *	1992-11-25	2006-04-19	Sepracor Inc.	Behandlung von Bluthochdruck, Angina und anderen Erkrankungen mit (-)Amlodipin
US5389654A (en) *	1992-11-26	1995-02-14	Lek, Tovarna, Farmacevtskih In Kemicnih . . .	3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
SI9200344B (sl) *	1992-11-26	1998-06-30	Lek,	Postopek za pripravo amlodipin benzensulfonata
US6221335B1 (en) *	1994-03-25	2001-04-24	Isotechnika, Inc.	Method of using deuterated calcium channel blockers
CA2215234C (en)	1995-03-16	2001-12-11	Pfizer Inc.	Composition containing amlodipine, or its salt and an ace inhibitor
NZ280378A (en) *	1995-11-01	1998-04-27	Apotex Inc	4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid compounds, preparation, intermediate compounds
HU221810B1 (hu) *	1997-08-12	2003-01-28	EGIS Gyógyszergyár Rt.	Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
GT199800127A (es)	1997-08-29	2000-02-01		Combinaciones terapeuticas.
ZA9810320B (en) *	1997-11-14	2000-05-11	Gea Farmaceutisk Fabrik As	Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose.
ZA9810319B (en) *	1997-11-14	2000-05-11	Gea Farmaceutisk Fabrik As	Process for the preparation of acetal derivatives of 1,4-dihydropyridines, novel acetal derivatives and the use of the acetal derivatives for the preparation of other 1,4-dihydropyridines.
ES2151850B1 (es) *	1998-10-26	2001-08-16	Esteve Quimica Sa	Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
HN2000000050A (es)	1999-05-27	2001-02-02	Pfizer Prod Inc	Sal mutua de amlodipino y atorvastatina
EP1180102B9 (de)	1999-05-27	2005-03-02	Pfizer Products Inc.	Gegenseitige prodrugs von amlopidin und atorvastatin
UA72768C2 (en)	1999-07-05	2005-04-15	Richter Gedeon Vegyeszet	A method for obtaining amilodipine benzenesulphonate
CN1091441C (zh) *	1999-12-04	2002-09-25	昆明赛诺制药有限公司	甲磺酸氨氯地平及其制法和应用
US6521647B2 (en)	2000-04-04	2003-02-18	Pfizer Inc.	Treatment of renal disorders
DE60128683T2 (de) *	2000-04-11	2008-01-24	Sankyo Co., Ltd.	Stabilisierte pharmazeutische zusammenstellungen die den calziumkanalblocker azelnidipine enthalten
EP1314425A4 (de) *	2000-08-30	2004-06-02	Sankyo Co	Medizinische zusammenstellung zur prophylaxe und behandlung von herzversagen
US6737430B2 (en)	2000-11-09	2004-05-18	Pfizer, Inc.	Mutual prodrug of amlodipine and atorvastatin
GB0027410D0 (en) *	2000-11-09	2000-12-27	Pfizer Ltd	Mutual prodrug of amlodipine and atorvastatin
DE60116514T2 (de)	2000-12-29	2006-08-17	Pfizer Ltd., Sandwich	Amlodipinhemimaleat
CA2433193C (en)	2000-12-29	2006-01-31	Pfizer Limited	Amide derivative of amlodipine
AT5874U1 (de)	2000-12-29	2003-01-27	Bioorg Bv	Pharmazeutische zubereitungen enthaltend amlodipinmaleat
WO2002053540A1 (en)	2000-12-29	2002-07-11	Pfizer Limited	Aspartate derivative of amlodipine as calcium channel antagonist
AP2003002820A0 (en) *	2000-12-29	2003-06-30	Pfizer Ltd	"Process for making amlodipine maleate"
US7335380B2 (en)	2000-12-29	2008-02-26	Synthon Ip Inc.	Amlodipine free base
OA13133A (en) *	2000-12-29	2006-12-13	Pfizer Ltd	Process for making amlodipine maleate.
EP1309556B1 (de)	2000-12-29	2004-11-24	Pfizer Limited	Amlodipinfumarat
CZ20031779A3 (cs) *	2000-12-29	2004-10-13	Bioorganicsáb@V	Způsob přípravy amlodipinuŹ jeho derivátů a jejich prekurzorů
CA2433284A1 (en) *	2000-12-29	2002-07-11	Pfizer Limited	Reference standards and processes for determining the purity or stability of amlodipine maleate
MXPA03005882A (es)	2000-12-29	2005-04-19	Pfizer Ltd	Derivado amida de amlodipina.
US6653481B2 (en)	2000-12-29	2003-11-25	Synthon Bv	Process for making amlodipine
KR100374767B1 (ko) *	2001-03-13	2003-03-03	한미약품공업 주식회사	개선된 암로디핀의 제조 방법
KR100452491B1 (ko) *	2001-03-29	2004-10-12	한미약품 주식회사	신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법
WO2003004025A1 (en) *	2001-07-06	2003-01-16	Lek Pharmaceutical And Chemical Company D.D.	High purity amlodipine benzenesulfonate and a process for its preparation
US6680334B2 (en)	2001-08-28	2004-01-20	Pfizer Inc	Crystalline material
GB0120808D0 (en) *	2001-08-28	2001-10-17	Pfizer Ltd	Crystalline material
US20040001886A1 (en) *	2001-10-17	2004-01-01	Dr. Reddy's Laboratories Limited	Stabilized pharmaceutical formulations containing amlodipine maleate
US20030180354A1 (en) *	2001-10-17	2003-09-25	Dr. Reddy's Laboratories Limited	Amlodipine maleate formulations
IL163666A0 (en)	2002-02-22	2005-12-18	New River Pharmaceuticals Inc	Active agent delivery systems and methods for protecting and administering active agents
US6562983B1 (en) *	2002-03-18	2003-05-13	Council Of Scientific And Industrial Research	Process for the preparation of alkyl 4[2-(phthalimido)ethoxy]-acetoacetate
WO2003089414A1 (en) *	2002-04-13	2003-10-30	Hanlim Pharmaceutical Co., Ltd.	Amlodipine nicotinate and process for the preparation thereof
US6699892B2 (en)	2002-06-04	2004-03-02	Yung Shin Pharmaceutical Industrial Co., Ltd.	Pharmaceutically acceptable salt of amlodipine and method of preparing the same
KR20040011751A (ko) *	2002-07-30	2004-02-11	씨제이 주식회사	암로디핀의 유기산염
KR100538641B1 (ko)	2002-07-30	2005-12-22	씨제이 주식회사	암로디핀의 유기산염
KR100496436B1 (ko)	2002-07-30	2005-06-20	씨제이 주식회사	암로디핀의 유기산염
KR100462304B1 (ko)	2002-07-30	2004-12-17	씨제이 주식회사	암로디핀의 유기산염
CN1681495B (zh)	2002-08-19	2010-05-12	辉瑞产品公司	用于治疗过度增生性疾病的组合物
KR100467669B1 (ko) *	2002-08-21	2005-01-24	씨제이 주식회사	암로디핀의 유기산염
US6784297B2 (en) *	2002-09-04	2004-08-31	Kopran Limited	Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
AU2003260984A1 (en)	2002-09-11	2004-04-30	Hanlim Pharmaceutical Co., Ltd.	S-(-)-amlodipine nicotinate and process for the preparation thereof
WO2004026834A1 (en) *	2002-09-19	2004-04-01	Cj Corporation	Crystalline organic acid salt of amlodipine
KR100596369B1 (ko)	2002-09-19	2006-07-03	씨제이 주식회사	결정형의 암로디핀 유기산염
US20040072879A1 (en) *	2002-10-10	2004-04-15	Dr. Reddy's Laboratories Limited	Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
AU2002368531A1 (en) *	2002-12-30	2004-07-22	Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S.	Isolation of dihydropyridine derivative and preparation salts thereof
DE10335027A1 (de) *	2003-07-31	2005-02-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von Angiotensin II Rezeptor Antagonisten
EA009983B1 (ru) *	2003-01-31	2008-04-28	Дайити Санкио Компани, Лимитед	Лекарственное средство для профилактики и лечения артериосклероза и гипертензии
WO2004091614A2 (en) *	2003-04-14	2004-10-28	Teva Pharmaceutical Industries Ltd.	Stabilized amlodipine maleate formations
US20060135506A1 (en) *	2003-04-22	2006-06-22	Pharmacia Corporation	Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
WO2004093816A2 (en) *	2003-04-22	2004-11-04	Pharmacia Corporation	Compositions comprising a selective cox-2 inhibitor and a calcium modulating agent
DE112004000712T5 (de) *	2003-04-25	2006-10-19	Cipla Ltd.	Verfahren zur Herstellung von Amlodipinmesilat-Monohydrat
US20050182125A1 (en) *	2003-05-16	2005-08-18	Ambit Biosciences Corporation	Pyrrole compounds and uses thereof
WO2004103959A2 (en) *	2003-05-16	2004-12-02	Ambit Biosciences Corporation	Heterocyclic compounds and uses thereof
EP1658283A2 (de) *	2003-05-30	2006-05-24	Ranbaxy Laboratories, Ltd.	Substituierte pyrrolderivate und deren verwendung als hmg-co-inhibitoren
CA2532807A1 (en) *	2003-07-17	2005-02-03	Cotherix, Inc.	Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
CH697952B1 (de) *	2003-07-25	2009-03-31	Siegfried Generics Int Ag	Verfahren zur Reinigung der freien Amlodipinbase.
WO2005023769A1 (en) *	2003-09-04	2005-03-17	Cipla Limited	Process for the preparation of amlodipine salts
US20050203119A1 (en) *	2003-09-10	2005-09-15	Mitsunori Ono	Dihydropyridine compounds for treating or preventing metabolic disorders
KR100841409B1 (ko)	2003-12-16	2008-06-25	에스케이케미칼주식회사	암로디핀 겐티세이트 염과 이의 제조방법
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
US20060035940A1 (en) *	2004-03-16	2006-02-16	Sepracor Inc.	(S)-Amlodipine malate
US7244765B2 (en) *	2004-06-25	2007-07-17	Cytokine Pharmasciences, Inc	Guanylhydrazone salts, compositions, processes of making and methods of using
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
WO2006003672A1 (en) *	2004-07-02	2006-01-12	Matrix Laboratories Ltd	Process for the preparation of pure amlodipine
JP2008507585A (ja) *	2004-07-26	2008-03-13	コセリックスインク	微粒子製剤を用いて吸入したイロプロストによる肺高血圧症の治療
DK1814527T4 (da) *	2004-11-05	2020-12-07	Boehringer Ingelheim Int	Dobbeltlagstablet omfattende telmisartan og amlodipin
ES2328384T3 (es) *	2004-11-23	2009-11-12	Warner-Lambert Company Llc	Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia.
WO2006070248A1 (en) *	2004-12-28	2006-07-06	Ranbaxy Laboratories Limited	Methods for the preparation of stable pharmaceutical solid dosage forms of atorvastatin and amlodipine
US20080268049A1 (en) *	2005-02-11	2008-10-30	Dhaliwal Mona	Stable Solid Dosage Forms of Amlodipine and Benazepril
WO2007001066A1 (en) *	2005-06-27	2007-01-04	Daiichi Sankyo Company, Limited	Pharmaceutical preparation containing an angiotensin ii receptor antagonist and a calcium channel blocker
US20080200533A1 (en) *	2005-07-04	2008-08-21	Ramu Krishnan	Drug or Pharmaceutical Compounds and a Preparation Thereof
ES2265781B1 (es) *	2005-08-04	2007-12-01	Ercros Industrial, S.A.	Procedimiento para la obtencion de besilato de amlodipina.
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7893050B2 (en) *	2005-10-26	2011-02-22	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (de)	2005-10-26	2012-08-22	Asahi Kasei Pharma Corporation	Kombinationstherapie mit Fasudil zur Behandlung von pulmonaler Hypertonie
BRPI0618379A2 (pt) *	2005-11-08	2011-08-30	Ranbaxy Lab Ltd	processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
TW200806648A (en) *	2005-11-29	2008-02-01	Sankyo Co	Acid addition salts of dihydropyridine derivatives
TW200736245A (en) *	2005-11-29	2007-10-01	Sankyo Co	Acid addition salts of optically active dihydropyridine derivatives
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
TW200744583A (en) *	2006-03-14	2007-12-16	Ranbaxy Lab Ltd	Statin stabilizing dosage formulations
US20070260065A1 (en) *	2006-05-03	2007-11-08	Vijayabhaskar Bolugoddu	Process for preparing amlodipine
BRPI0714361A2 (pt) *	2006-07-14	2013-03-26	Ranbaxy Lab Ltd	polimorfo cristalino, composiÇço farmacÊutica contendo o mesmo, mÉtodo para sua preparaÇço e mÉtodo de tratamento
WO2008023869A1 (en) *	2006-08-24	2008-02-28	Hanall Pharmaceutical Co., Ltd.	Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
TWI399223B (zh)	2006-09-15	2013-06-21	Daiichi Sankyo Co Ltd	奧美沙坦酯及氨氯地平之固體劑型
US20080096863A1 (en) *	2006-10-19	2008-04-24	Torrent Pharmaceuticals Limited	Stable pharmaceutical compositions of calcium channel blocker and an ACE inhibitor
CN101167724B (zh) *	2006-10-25	2012-08-22	北京华安佛医药研究中心有限公司	含有氨氯地平的药物组合物在制备治疗下尿路疾病药物中的用途
KR100830003B1 (ko)	2006-10-31	2008-05-15	씨제이제일제당 (주)	결정성 ｓ-(-)-암로디핀 아디핀산 염 무수물 및 이의 제조방법
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
GB0624087D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril combination salt
GB0624084D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril amino acid salts
GB0624090D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril amine salts
CL2008000070A1 (es) *	2007-01-17	2008-07-25	Lg Life Sciences Ltd	Monosal del acido maleico (3-[({1-[(2-amino-9h-purin-9-il)metil]ciclopropil}oxi)metil]-8,8-dimetil-3,7-dioxo-2,4,6-trioxa-3 lambda 5-fosfanon-1-il-pivalato; composicion farmaceutica que comprende a dicha monosal; y uso para el tratamiento del virus h
CN101230035B (zh) *	2007-03-23	2010-11-03	浙江尖峰药业有限公司	门冬氨酸氨氯地平系列盐及其制备方法和其组合物、制剂以及片剂
EP1975167A1 (de) *	2007-03-30	2008-10-01	Esteve Quimica, S.A.	Acetonsolvat von Phthaloylamlodipin
WO2008124121A1 (en) *	2007-04-06	2008-10-16	Scidose, Llc	Co-therapy with and combinations of statins and 1,4-dihydropyridine-3,5-dicarboxydiesters
US20090062352A1 (en) *	2007-08-29	2009-03-05	Protia, Llc	Deuterium-enriched amlodipine
US8748648B2 (en)	2007-09-06	2014-06-10	Nektar Therapeutics	Oligomer-calcium channel blocker conjugates
UY31531A1 (es) *	2007-12-17	2009-08-03		Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
AU2008344891A1 (en) *	2007-12-31	2009-07-09	Lupin Limited	Pharmaceutical compositions of amlodipine and valsartan
WO2009113420A1 (ja)	2008-03-13	2009-09-17	第一三共株式会社	オルメサルタンメドキソミルを含む製剤の溶出性の改善
CN101560181B (zh) *	2008-04-16	2013-02-27	北京万全阳光医学技术有限公司	一种氨氯地平游离碱的制备方法
CN101367759B (zh) *	2008-10-06	2011-03-16	北京赛科药业有限责任公司	一种高纯度苯磺酸氨氯地平的合成方法
JP2010100562A (ja) *	2008-10-23	2010-05-06	Daito Kk	アムロジピン製造中間体の精製方法
EP2437733A4 (de)	2009-06-02	2014-01-08	Dow Global Technologies Llc	Retard-darreichungsform
ES2758554T3 (es)	2009-12-08	2020-05-05	Univ Case Western Reserve	Aminoácidos gama para tratamiento de trastornos oculares
WO2011117876A1 (en)	2010-03-26	2011-09-29	Fdc Limited	An improved process for the preparation of amlodipine free base and acid addition salts thereof
IT1400309B1 (it) *	2010-05-10	2013-05-24	Menarini Int Operations Lu Sa	Associazione di inibitori della xantina ossidasi e calcio antagonisti e loro uso.
WO2011149438A1 (en)	2010-05-28	2011-12-01	Mahmut Bilgic	Combination of antihypertensive agents
EP2575757A1 (de)	2010-06-03	2013-04-10	Mahmut Bilgic	Wasserlösliche formulierung mit einer kombination aus amlodipin und einem statin
US8883844B2 (en)	2010-09-24	2014-11-11	Nitrogenix Inc.	Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
EP2632438A1 (de)	2010-10-27	2013-09-04	KRKA, tovarna zdravil, d.d., Novo mesto	Mehrschichtige pharmazeutische zusammensetzung mit telmisartan und amlodipin
TR201100152A2 (tr)	2011-01-06	2012-07-23	Bi̇lgi̇ç Mahmut	Amlodipin içeren efervesan bileşimler.
CN102070516A (zh) *	2011-02-22	2011-05-25	广东东阳光药业有限公司	一种制备氨氯地平的方法
WO2012123966A1 (en)	2011-03-04	2012-09-20	Arch Pharmalabs Limited	Process for the preparation of 4 -substituted -1, 4-dihydropyridines
SG194162A1 (en)	2011-04-12	2013-11-29	Boryung Pharm	Antihypertensive pharmaceutical composition
BR112014004370A2 (pt)	2011-08-26	2017-03-21	Wockhardt Ltd	métodos para tratar distúrbios cardiovasculares
CN102382041B (zh) *	2011-12-02	2016-01-20	东北制药集团股份有限公司	一种马来酸氨氯地平的制备方法
PL236001B1 (pl)	2012-12-21	2020-11-30	Adamed Spolka Z Ograniczona Odpowiedzialnoscia	Złożona kompozycja farmaceutyczna zawierająca kandesartan cyleksetylu oraz amlodypinę, sposób jej wytwarzania oraz jednostkowa postać dawkowania zawierająca tę kompozycję
CN103044314A (zh) *	2013-01-06	2013-04-17	先声药业有限公司	马来酸氨氯地平的制备方法
JP5952748B2 (ja) *	2013-01-25	2016-07-13	東和薬品株式会社	フタロイルアムロジピンの新規結晶形態およびそれを用いる高純度なアムロジピンベシル酸塩の製造方法
US20150374713A1 (en)	2013-02-08	2015-12-31	Wockhardt Limited	Stable pharmeceutical composition of amlodipine and benazepril or salts thereof
SG11201507496UA (en)	2013-04-17	2015-11-27	Pfizer	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
JP6422868B2 (ja)	2013-07-23	2018-11-14	第一三共株式会社	高血圧症の予防又は治療のための医薬
CN104262237A (zh) *	2014-09-28	2015-01-07	常州瑞明药业有限公司	氨氯地平自由碱的合成方法
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
CN104529877A (zh) *	2015-01-22	2015-04-22	华东理工常熟研究院有限公司	氨氯地平-癸酸离子液体及其制备方法和用途
CZ2015687A3 (cs)	2015-10-02	2017-04-12	Zentiva, K.S.	Farmaceutická kompozice obsahující kombinaci kandesartanu, amlodipinu a hydrochlorthiazidu
US20180303811A1 (en)	2015-10-23	2018-10-25	Ftf Pharma Private Limited	Oral solution of dihydropyridine derivatives
CA3015964C (en)	2016-03-24	2021-08-03	Daiichi Sankyo Company, Limited	Medicine for treating renal disease
US20200316029A1 (en)	2016-05-30	2020-10-08	Boehringer Ingelheim International Gmbh	Fixed dose combination of telmisartan, hydrochlorothiazide and amlodipine
WO2018067959A1 (en)	2016-10-07	2018-04-12	Silvergate Pharmaceuticals, Inc.	Amlodipine formulations
US10350171B2 (en)	2017-07-06	2019-07-16	Dexcel Ltd.	Celecoxib and amlodipine formulation and method of making the same
WO2019200143A1 (en)	2018-04-11	2019-10-17	Silvergate Pharmaceuticals, Inc.	Amlodipine formulations
AU2019287541A1 (en)	2018-06-14	2021-01-21	Astrazeneca Uk Limited	Methods for treating and preventing symptoms of asthma with a corticosteroid pharmaceutical composition
CN112955965B (zh)	2018-06-14	2024-04-09	阿斯利康(英国)有限公司	使用二氢吡啶类钙通道阻断剂医药组合物降低血压的方法
AU2020209215B2 (en)	2019-01-18	2023-02-02	Astrazeneca Ab	PCSK9 inhibitors and methods of use thereof
WO2020234348A1 (en)	2019-05-21	2020-11-26	Société des Produits Nestlé S.A.	Dietary butyrate
GB2595203A (en)	2020-03-03	2021-11-24	Alkaloid Ad Skopje	Formulation
GB202102575D0 (en)	2021-02-23	2021-04-07	Teva Pharmaceutical Industries Ltd	Fixed-dose pharmaceutical compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1552911A (en) *	1975-07-02	1979-09-19	Fujisawa Pharmaceutical Co	1,4 dihydropyridine derivatives and the preparation thereof
JPS5547656A (en) *	1978-09-29	1980-04-04	Dainippon Pharmaceut Co Ltd	2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative
SE7910521L (sv) *	1979-12-20	1981-06-21	Haessle Ab	Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
CS228917B2 (en) *	1981-03-14	1984-05-14	Pfizer	Method of preparing substituted derivatives of 1,4-dihydropyridine
DE3739854A1 (de) *	1987-11-25	1989-06-08	Philips Patentverwaltung	Verfahren zur herstellung von titandioxid-pulver

1983
- 1983-02-23 DK DK081383A patent/DK161312C/da not_active IP Right Cessation
- 1983-03-03 PL PL1983240854A patent/PL140278B1/pl unknown
- 1983-03-03 PL PL1983250767A patent/PL140575B1/pl unknown
- 1983-03-03 PL PL1983255811A patent/PL141830B1/pl unknown
- 1983-03-03 CS CS831499A patent/CS240954B2/cs unknown
- 1983-03-04 UA UA3571949A patent/UA7083A1/uk unknown
- 1983-03-04 SU SU833571949A patent/SU1238730A3/ru active
- 1983-03-04 HU HU83759A patent/HU187868B/hu unknown
- 1983-03-04 UA UA3675004A patent/UA7082A1/uk unknown
- 1983-03-08 ES ES520389A patent/ES8503654A1/es not_active Expired
- 1983-03-08 DE DE8383301227T patent/DE3366920D1/de not_active Expired
- 1983-03-08 AT AT83301227T patent/ATE22884T1/de active
- 1983-03-08 GR GR70728A patent/GR77429B/el unknown
- 1983-03-08 EP EP83301227A patent/EP0089167B1/de not_active Expired
- 1983-03-08 KR KR1019830000935A patent/KR870000809B1/ko not_active IP Right Cessation
- 1983-03-08 DE DE1993175111 patent/DE19375111I2/de active Active
- 1983-03-09 CA CA000423148A patent/CA1253865A/en not_active Expired
- 1983-03-09 NZ NZ203521A patent/NZ203521A/en unknown
- 1983-03-09 EG EG163/83A patent/EG16987A/xx active
- 1983-03-09 IL IL68091A patent/IL68091A/xx not_active IP Right Cessation
- 1983-03-09 FI FI830789A patent/FI81090C/fi not_active IP Right Cessation
- 1983-03-10 AU AU12351/83A patent/AU540769B2/en not_active Expired
- 1983-03-10 YU YU586/83A patent/YU43541B/xx unknown
- 1983-03-10 ZA ZA831651A patent/ZA831651B/xx unknown
- 1983-03-10 DD DD83264890A patent/DD218887A5/de unknown
- 1983-03-10 PT PT76370A patent/PT76370B/pt unknown
- 1983-03-10 IE IE520/83A patent/IE54667B1/en not_active IP Right Cessation
- 1983-03-10 IE IE3092/86A patent/IE54765B1/en not_active IP Right Cessation
- 1983-03-10 DD DD83248690A patent/DD209622A5/de unknown
- 1983-03-10 SI SI8310586A patent/SI8310586A8/sl unknown
- 1983-03-10 NO NO830847A patent/NO162818C/no not_active IP Right Cessation
- 1983-03-11 JP JP58040534A patent/JPS58167569A/ja active Granted
- 1983-10-14 ES ES526459A patent/ES526459A0/es active Granted
- 1983-12-14 SU SU833675004A patent/SU1227110A3/ru active
1984
- 1984-02-03 US US06/576,982 patent/US4572909A/en not_active Expired - Lifetime
- 1984-04-06 CS CS841592A patent/CS240998B2/cs unknown
1985
- 1985-09-10 SI SI8511419A patent/SI8511419A8/sl unknown
- 1985-09-10 YU YU1419/85A patent/YU43417B/xx unknown
1986
- 1986-11-06 NO NO864435A patent/NO170275C/no not_active IP Right Cessation
1987
- 1987-08-14 MY MYPI87001340A patent/MY101985A/en unknown
- 1987-10-08 KE KE3778A patent/KE3778A/xx unknown
- 1987-11-05 SG SG986/87A patent/SG98687G/en unknown
1988
- 1988-03-03 HK HK162/88A patent/HK16288A/xx not_active IP Right Cessation
1991
- 1991-12-31 CS CS914188A patent/CS418891A3/cs unknown
1992
- 1992-03-17 BG BG96079A patent/BG60658B2/xx unknown
1993
- 1993-03-16 HR HR930369A patent/HRP930369B1/xx not_active IP Right Cessation
- 1993-03-16 HR HR930370A patent/HRP930370B1/xx not_active IP Right Cessation
- 1993-06-11 NL NL930063C patent/NL930063I2/nl unknown
- 1993-06-24 LU LU88332C patent/LU88332I2/fr unknown
- 1993-06-28 LV LV930667A patent/LV5235A3/xx unknown
- 1993-06-28 LV LV930666A patent/LV5236A3/xx unknown
1994
- 1994-11-02 NO NO1994020C patent/NO1994020I1/no unknown
1997
- 1997-03-28 BA BA970147A patent/BA97147B1/bs active Active
1998
- 1998-03-04 BA BA980207A patent/BA98207B1/bs active

Also Published As

Publication number	Publication date
CS240954B2 (en)	1986-03-13
HK16288A (en)	1988-03-11
KR870000809B1 (ko)	1987-04-20
BG60658B2 (en)	1995-11-30
LV5235A3 (lv)	1993-10-10
IL68091A (en)	1986-11-30
NO162818B (no)	1989-11-13
SU1227110A3 (ru)	1986-04-23
NO162818C (no)	1990-02-21
PL140278B1 (en)	1987-04-30
YU58683A (en)	1986-06-30
FI830789A0 (fi)	1983-03-09
PL141830B1 (en)	1987-08-31
NO1994020I1 (no)	1994-11-02
PL250767A1 (en)	1985-12-17
EP0089167A2 (de)	1983-09-21
FI81090C (fi)	1990-09-10
PT76370A (en)	1983-04-01
IE863092L (en)	1983-09-11
IE830520L (en)	1983-09-11
SI8310586A8 (sl)	1996-02-29
CS149983A2 (en)	1985-06-13
JPS58167569A (ja)	1983-10-03
NO170275B (no)	1992-06-22
NO864435D0 (no)	1986-11-06
NO830847L (no)	1983-09-12
YU141985A (en)	1986-06-30
AU1235183A (en)	1983-09-22
MY101985A (en)	1992-02-29
UA7083A1 (uk)	1995-06-30
LV5236A3 (lv)	1993-10-10
DD218887A5 (de)	1985-02-20
GR77429B (de)	1984-09-14
NZ203521A (en)	1985-09-13
SG98687G (en)	1988-09-23
FI830789L (fi)	1983-09-12
IE54667B1 (en)	1990-01-03
NO170275C (no)	1992-09-30
ES8505201A1 (es)	1985-05-16
ATE22884T1 (de)	1986-11-15
HRP930369B1 (en)	1996-02-29
KR840004073A (ko)	1984-10-06
DK161312B (da)	1991-06-24
AU540769B2 (en)	1984-12-06
JPS626703B2 (de)	1987-02-13
US4572909A (en)	1986-02-25
ES520389A0 (es)	1985-03-16
EG16987A (en)	1991-03-30
ES8503654A1 (es)	1985-03-16
YU43541B (en)	1989-08-31
CA1253865A (en)	1989-05-09
CS159284A2 (en)	1985-06-13
PL140575B1 (en)	1987-05-30
IL68091A0 (en)	1983-06-15
HU187868B (en)	1986-02-28
DK81383A (da)	1983-09-12
BA97147B1 (bs)	1998-12-28
IE54765B1 (en)	1990-01-31
NO864435L (no)	1983-09-12
DK81383D0 (da)	1983-02-23
PT76370B (en)	1986-03-27
SI8511419A8 (sl)	1996-10-31
DK161312C (da)	1991-12-09
ZA831651B (en)	1983-12-28
SU1238730A3 (ru)	1986-06-15
LU88332I2 (fr)	1994-05-04
CS418891A3 (en)	1992-09-16
HRP930370B1 (en)	1996-02-29
NL930063I1 (nl)	1993-09-01
UA7082A1 (uk)	1995-06-30
DD209622A5 (de)	1984-05-16
CS240998B2 (en)	1986-03-13
FI81090B (fi)	1990-05-31
YU43417B (en)	1989-06-30
BA98207B1 (bs)	1999-08-02
KE3778A (en)	1987-11-27
EP0089167A3 (en)	1984-07-11
DE19375111I2 (de)	2001-06-13
EP0089167B1 (de)	1986-10-15
ES526459A0 (es)	1985-05-16
NL930063I2 (nl)	1993-10-01
PL240854A1 (en)	1985-04-09

Legal Events

Date	Code	Title	Description
1987-11-05	8364	No opposition during term of opposition
1993-09-14	V448	Application of spc	Free format text: PRODUCT NAME: AMLODIPINBESILAT; REGISTRATION NO/DATE: 16909.00.00, 19930511 Spc suppl protection certif: 193 75 111 Filing date: 19930914
2000-11-27	V457	Spc granted	Free format text: PRODUCT NAME: AMLODIPINBESILAT; REGISTRATION NO/DATE: 16909.00.00, 19930511 Spc suppl protection certif: 193 75 111 Filing date: 19930914
2004-03-09	V464	Spc expired	Free format text: PRODUCT NAME: AMLODIPINBESILAT; REGISTRATION NO/DATE: 16909.00.00, 19930511 Spc suppl protection certif: 193 75 111 Filing date: 19930914