DE3267039D1 - Stable s-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle - Google Patents

Stable s-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle

Info

Publication number
DE3267039D1
DE3267039D1 DE8282107334T DE3267039T DE3267039D1 DE 3267039 D1 DE3267039 D1 DE 3267039D1 DE 8282107334 T DE8282107334 T DE 8282107334T DE 3267039 T DE3267039 T DE 3267039T DE 3267039 D1 DE3267039 D1 DE 3267039D1
Authority
DE
Germany
Prior art keywords
stable
contain
preparation
active principle
therapeutic compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282107334T
Other languages
English (en)
Inventor
Federico Gennari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioresearch SRL
Original Assignee
Bioresearch SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch SRL filed Critical Bioresearch SRL
Application granted granted Critical
Publication of DE3267039D1 publication Critical patent/DE3267039D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
DE8282107334T 1981-08-24 1982-08-12 Stable s-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle Expired DE3267039D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23602/81A IT1137640B (it) 1981-08-24 1981-08-24 Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo

Publications (1)

Publication Number Publication Date
DE3267039D1 true DE3267039D1 (en) 1985-11-28

Family

ID=11208476

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282107334T Expired DE3267039D1 (en) 1981-08-24 1982-08-12 Stable s-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle

Country Status (6)

Country Link
US (1) US4465672A (de)
EP (1) EP0072980B1 (de)
JP (1) JPS5843996A (de)
AT (1) ATE16191T1 (de)
DE (1) DE3267039D1 (de)
IT (1) IT1137640B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1169773B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1177373B (it) * 1984-12-06 1987-08-26 Bioresearch Spa Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica
EP0260429A3 (de) * 1986-08-07 1991-04-17 MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG N-alkylierte quartäre stickstoffhaltige Heterozyklen, Verfahren zu deren Herstellung und deren Verwendung in Arzneimitteln
DE3874352T2 (de) * 1987-10-09 1992-12-17 Vincenzo Zappia Lipophile salze von s-adenosyl-l-methionin (sam) mit acyltaurinderivaten.
FR2623396B1 (fr) * 1987-11-25 1990-03-30 Sanofi Sa Utilisation de l'ademetionine contre le vieillissement de la peau
IT1229477B (it) * 1989-03-13 1991-09-03 Bioresearch Spa Impiego di 5' deossi - 5' metiltioadenosina, s adenosilmetionina e dei loro sali per la preparazione di composizioni farmaceutiche atte a ridurre la seborrea e composizioni farmaceutiche relative
JPH02290896A (ja) * 1989-04-28 1990-11-30 Fuji Kagaku Kogyo Kk 新規なｓ―アデノシルメチオニン誘導体
US6492349B1 (en) * 1993-03-31 2002-12-10 Nutramax Laboratories, Inc. Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue
AU721067B2 (en) 1995-04-25 2000-06-22 Oridigm Corporation S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
US6020139A (en) * 1995-04-25 2000-02-01 Oridigm Corporation S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
DE69935140T2 (de) * 1998-06-05 2007-05-31 Nutramax Laboratories, Inc. Verwendung von anabolika, anti-katabolischen mitteln, antioxidanzien und analgetika zum schutz, zur behandlung und reparation von bindegeweben in menschen und tieren
IT1317920B1 (it) * 2000-10-20 2003-07-15 Univ Roma S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer.
US6649753B2 (en) 2001-06-07 2003-11-18 Orchid Chemicals & Pharmaceuticals Ltd. Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
KR101330352B1 (ko) 2006-01-17 2013-11-15 미츠비시 가스 가가쿠 가부시키가이샤 Ｓ-아데노실-ｌ-메티오닌의 안정화법 및 안정화된 조성물
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
JP5136409B2 (ja) 2006-05-16 2013-02-06 三菱瓦斯化学株式会社 保存安定性に優れたｓ−アデノシル−ｌ−メチオニン含有乾燥酵母の製造方法、その製造物及び経口摂取用組成物
KR101525263B1 (ko) 2007-01-25 2015-06-10 미츠비시 가스 가가쿠 가부시키가이샤 보존 안정성이 뛰어난 ｓ-아데노실-ｌ-메티오닌 함유 건조 효모의 제조 방법, 그 제조물 및 그 성형된 조성물
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
EP2189154A1 (de) 2008-11-25 2010-05-26 Gnosis S.p.A. Efferveszenztabletten und im Mund lösliche Granulate aus S-Adenosy-Methionin und Herstellungsverfahren dafür
IT1393331B1 (it) 2009-02-09 2012-04-20 Graal S R L Composizioni orosolubili e/o effervescenti contenenti almeno un sale di s-adenosilmetionina (same)
KR102186066B1 (ko) 2013-01-16 2020-12-04 허버트 샘-이 엘엘씨 S-아데노실-l-메티오닌의 안정한 인돌-3-프로피오네이트염
ITMI20130426A1 (it) * 2013-03-20 2014-09-21 Gnosis Spa S-adenosilmetionina sterile ad alto contenuto di isomero attivo per soluzioni iniettabili e procedimento per ottenerla
FR3059327B1 (fr) * 2016-11-25 2021-10-15 Arkema France Composition acide pour le traitement d'acides gras

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2969353A (en) 1957-02-06 1961-01-24 Merck & Co Inc Process for the preparation of "active methionine" and products obtained thereby
DE1803978C2 (de) 1968-10-18 1985-05-02 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Gewinnung von S-Adenosyl-l-methionin und S-Adenosyl-l-ethionin
IE37913B1 (en) * 1972-08-02 1977-11-09 Bioresearch Sas Salt of s-adenosyl-l-methionine
IE39517B1 (en) 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
AR221676A1 (es) * 1974-07-12 1981-03-13 Bioresearch Sas Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
JPS53107485A (en) * 1977-02-28 1978-09-19 Yamasa Shoyu Co Ltd Preparation of s-adenosyl-l-methionine salt
GB2064523B (en) 1979-12-04 1983-06-29 Kanegafuchi Chemical Ind Stable composition of s-adenosyl-l-methionine
JPS57192399A (en) * 1981-05-18 1982-11-26 Kanegafuchi Chem Ind Co Ltd Composition containing s-adenosyl-l-methionine and its preparation

Also Published As

Publication number Publication date
ATE16191T1 (de) 1985-11-15
EP0072980A1 (de) 1983-03-02
JPS5843996A (ja) 1983-03-14
US4465672A (en) 1984-08-14
IT8123602A0 (it) 1981-08-24
JPH0149275B2 (de) 1989-10-24
IT1137640B (it) 1986-09-10
EP0072980B1 (de) 1985-10-23

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8327 Change in the person/name/address of the patent owner

Owner name: BIORESEARCH S.P.A., LISCATE, MAILAND/MILANO, IT

8328 Change in the person/name/address of the agent

Free format text: HOFFMANN, EITLE & PARTNER PATENT- UND RECHTSANWAELTE, 81925 MUENCHEN

8339 Ceased/non-payment of the annual fee