DE3066205D1 - Imidazole-5-acetic acid derivatives, their production and use - Google Patents

Imidazole-5-acetic acid derivatives, their production and use

Info

Publication number
DE3066205D1
DE3066205D1 DE8080106915T DE3066205T DE3066205D1 DE 3066205 D1 DE3066205 D1 DE 3066205D1 DE 8080106915 T DE8080106915 T DE 8080106915T DE 3066205 T DE3066205 T DE 3066205T DE 3066205 D1 DE3066205 D1 DE 3066205D1
Authority
DE
Germany
Prior art keywords
imidazole
production
acetic acid
acid derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080106915T
Other languages
English (en)
Inventor
Furukawa Yoshiyasu
Kishimoto Shoji
Nishikawa Kohei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE3066205D1 publication Critical patent/DE3066205D1/de
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68Halogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
DE8080106915T 1979-11-12 1980-11-08 Imidazole-5-acetic acid derivatives, their production and use Expired DE3066205D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14672879A JPS5671074A (en) 1979-11-12 1979-11-12 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative

Publications (1)

Publication Number Publication Date
DE3066205D1 true DE3066205D1 (en) 1984-02-23

Family

ID=15414223

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080106915T Expired DE3066205D1 (en) 1979-11-12 1980-11-08 Imidazole-5-acetic acid derivatives, their production and use

Country Status (19)

Country Link
US (1) US4355040A (de)
EP (1) EP0028834B1 (de)
JP (1) JPS5671074A (de)
AR (1) AR228957A1 (de)
AT (1) ATE5880T1 (de)
AU (1) AU6412280A (de)
CA (1) CA1152516A (de)
DE (1) DE3066205D1 (de)
DK (1) DK478980A (de)
ES (1) ES8204724A1 (de)
FI (1) FI803508L (de)
GR (1) GR72124B (de)
HU (1) HU185389B (de)
IL (1) IL61359A0 (de)
NO (1) NO151966C (de)
NZ (1) NZ195517A (de)
PT (1) PT72049B (de)
SU (1) SU999966A3 (de)
ZA (1) ZA806832B (de)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1181082A (en) * 1981-11-20 1985-01-15 Toni Dockner Substituted benzylimidazolium salts and microbicides containing these compounds
JPS58157768A (ja) * 1982-03-16 1983-09-19 Takeda Chem Ind Ltd 4−クロロ−2−フエニルイミダゾ−ル−5−酢酸誘導体
DE3369845D1 (en) * 1982-12-20 1987-04-02 Merck & Co Inc 5-(amino or substituted amino) imidazoles
US4602093A (en) * 1984-02-08 1986-07-22 Merck & Co., Inc. Novel substituted imidazoles, their preparation and use
US5182264A (en) * 1986-03-07 1993-01-26 Schering Corporation Angiotensin II receptor blockers as antiglaucoma agents
US5036048A (en) * 1986-03-07 1991-07-30 Schering Corporation Angiotensin II receptor blockers as antiglaucoma agents
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
NZ221427A (en) * 1986-08-18 1990-12-21 Smithkline Beckman Corp 2-mercaptoimidazole derivatives and pharmaceutical compositions
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US5315013A (en) * 1988-01-07 1994-05-24 E. I. Du Pont De Nemours And Company Substituted pyrazole angiotensin II antagonists
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
US5081127A (en) * 1988-01-07 1992-01-14 E. I. Du Pont De Nemours And Company Substituted 1,2,3-triazole angiotensin II antagonists
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5189048A (en) * 1988-01-07 1993-02-23 E. I. Du Pont De Nemours And Company Substituted 1,2,3 triazole angiotensin II antagonists
EP0733366B1 (de) * 1988-01-07 1998-04-01 E.I. Du Pont De Nemours And Company Angiotensin II-Rezeptor blockierende Imidazole und Diuretika enthaltende pharmazeutische Zusammensetzungen
JPH029507A (ja) * 1988-06-24 1990-01-12 Teikku Ag 迅速交換形タップホルダ
US5354867A (en) * 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4916129A (en) * 1989-01-19 1990-04-10 E. I. Du Pont De Nemours And Company Combination β-blocking/angiotensin II blocking antihypertensives
CA2016710A1 (en) * 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
US5418250A (en) * 1989-06-14 1995-05-23 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
ATE190051T1 (de) * 1989-06-14 2000-03-15 Smithkline Beecham Corp Imidazoalkensäure
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
US5312828A (en) * 1989-06-14 1994-05-17 Finkelstein Joseph A Substituted imidazoles having angiotensin II receptor blocking activity
CA2018443A1 (en) * 1989-06-14 1990-12-14 Joseph A. Finkelstein Imidazolyl-alkenoic acids
JP2568315B2 (ja) 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
DE69013607T2 (de) * 1989-08-02 1995-03-02 Takeda Chemical Industries Ltd Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung.
US5250554A (en) * 1989-10-24 1993-10-05 Takeda Chemical Industries, Ltd. Benzimidazole derivatives useful as angiotensin II inhibitors
IL95975A (en) * 1989-10-24 1997-06-10 Takeda Chemical Industries Ltd N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
US5177096A (en) * 1989-10-25 1993-01-05 Smithkline Beecham Corporation Substituted 5-((tetrazolyl)alkenyl)imidazoles and pharmaceutical methods of use thereof
US5248689A (en) * 1989-11-06 1993-09-28 Smithkline Beecham Corporation Substituted N-(imidazolyl)alkyl alanine derivatives
CA2028925A1 (en) * 1989-11-06 1991-05-07 Gerald R. Girard Substituted n-(imidazolyl)alkyl alanine derivatives
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
JPH05503691A (ja) * 1989-12-29 1993-06-17 ユニバーシティ・テクノロジーズ・インターナショナル・インコーポレイテッド アゴニストおよびアンタゴニストを含む生物学的に活性なリガンドの3次構造モデルの設計方法およびアンギオテンシンに基づいた新規合成アンタゴニスト
CA2072363A1 (en) * 1989-12-29 1991-06-30 Graham J. Moore Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin
US5234917A (en) * 1989-12-29 1993-08-10 Finkelstein Joseph A Substituted 5-(alkyl)carboxamide imidazoles
JPH0396182U (de) * 1990-01-19 1991-10-01
US5011851A (en) * 1990-02-13 1991-04-30 Bristol-Myers Squibb Co. Imidazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith
CA2036192A1 (en) 1990-02-13 1991-08-14 Nicholas Meanwell Heterocyclic carboxylic acids and esters
US5162326A (en) * 1990-02-15 1992-11-10 Takeda Chemical Industries, Ltd. Pyrimidinedione derivatives, their production and use
ES2084801T3 (es) * 1990-02-19 1996-05-16 Ciba Geigy Ag Acil compuestos.
CA2037630C (en) * 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2665702B1 (fr) * 1990-08-08 1994-02-25 Sanofi Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5703110A (en) * 1990-04-27 1997-12-30 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
ZA912983B (en) 1990-04-27 1992-01-29 Takeda Chemical Industries Ltd Benzimidazole derivatives,their production and use
US6004989A (en) 1990-04-27 1999-12-21 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
KR970005839B1 (ko) 1990-05-11 1997-04-21 화이자 인코포레이티드 상승 치료효과를 얻기 위한 조성물 및 방법
US5821232A (en) * 1990-05-11 1998-10-13 Pfizer Inc. Synergistic therapeutic compositions and methods
NZ238688A (en) * 1990-06-28 1992-05-26 Smithkline Beecham Corp Substituted histidines: pharmaceutical compositions, preparation and uses thereof
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
US5126342A (en) * 1990-10-01 1992-06-30 Merck & Co., Inc. Imidazole angiotensin ii antagonists incorporating acidic functional groups
AU636066B2 (en) * 1990-10-30 1993-04-08 Takeda Chemical Industries Ltd. Thienoimidazole derivatives, their production and use
US5374615A (en) * 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
TW197428B (de) 1991-01-04 1993-01-01 Hoechst Ag
US5153347A (en) * 1991-01-31 1992-10-06 E. R. Squibb & Sons, Inc. Phosphonate, phosphinate derivatives useful as antihypertensive agents
IE920540A1 (en) 1991-02-21 1992-08-26 Sankyo Co 1-biphenylmethylimidazole derivatives, their preparation and¹their therapetuic use
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5104877A (en) * 1991-02-25 1992-04-14 Abbott Laboratories Psoriasis treatment
US5191086A (en) * 1991-03-19 1993-03-02 E.R. Squibb & Sons, Inc. Imidazole and benzimidazole derivatives
US5177074A (en) 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
TW274551B (de) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
US5190942A (en) * 1991-04-22 1993-03-02 E. R. Squibb & Sons, Inc. Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
GB9110635D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
GB9110636D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
US5332820A (en) * 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
US5177097A (en) * 1991-07-24 1993-01-05 E. R. Squibb & Sons, Inc. Acyl amidine and acyl, guanidine substituted biphenyl derivatives
US5322950A (en) * 1991-12-05 1994-06-21 Warner-Lambert Company Imidazole with angiotensin II antagonist properties
US5389661A (en) * 1991-12-05 1995-02-14 Warner-Lambert Company Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties
US5212177A (en) * 1991-12-16 1993-05-18 E. R. Squibb & Sons, Inc. Indole and benzimidazole-substituted dihydropyrimidine derivatives
TW215434B (de) * 1992-03-07 1993-11-01 Hoechst Ag
US5208234A (en) * 1992-03-10 1993-05-04 E. R. Squibb & Sons, Inc. Substituted imidazole phosphonic and phosphinic acid derivatives
DE4208052A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Imidazolyl substituierte phenylessigsaeureamide
DE4208051A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Substituierte phenylessigsaeureamide
US5616591A (en) * 1992-03-27 1997-04-01 E.R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted quinoline derivatives
DE4212796A1 (de) * 1992-04-16 1993-10-21 Bayer Ag Propenoyl-imidazolderivate
US5294722A (en) * 1992-04-16 1994-03-15 E. R. Squibb & Sons, Inc. Process for the preparation of imidazoles useful in angiotensin II antagonism
US5380719A (en) * 1992-04-28 1995-01-10 E. R. Squibb & Sons, Inc. Quinoxaline biphenyl angiotensin II inhibitors
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
DE4220983A1 (de) * 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Phenylpropion- und -zimtsäurederivate
DE4221009A1 (de) * 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Cyclohexanderivate
RU2103262C1 (ru) * 1992-07-16 1998-01-27 Лонца АГ Гампель/Валлис Способ получения 2-замещенных 5-хлоримидазол-4-карбальдегидов
HU219598B (hu) * 1992-12-17 2001-05-28 Sankyo Co. Ltd. Bifenilvegyületek imidazol- és piridinszármazékai, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
US5514811A (en) * 1993-02-15 1996-05-07 Shikoku Chemicals Corporation Process for synthesizing 4-halo-5-(hydroxymethyl) imidazole compounds
US5484939A (en) * 1993-03-12 1996-01-16 Lonza Ltd. 2-substituted 5-chlorimidazoles
EP0614889A1 (de) * 1993-03-12 1994-09-14 Lonza Ag Verfahren zur Herstellung von gegebenenfalls 2-substituierten 5-Chlorimidazol-4-carbaldehyden
DK0614890T3 (da) * 1993-03-12 1997-10-13 Lonza Ag Fremgangsmåde til fremstilling af eventuelt 2-substituerede 5-chlorimidazoler.
US5442075A (en) * 1993-03-12 1995-08-15 Lonza Ltd. Process for the production of 2-substituted 5-chlorimidazole-4-carbaldehydes
EP0693480A4 (de) * 1993-04-07 1996-09-25 Nissan Chemical Ind Ltd Pyrazol-derivate
CA2135541C (en) * 1993-11-15 2006-01-10 Gareth Griffiths Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes
US5395847A (en) * 1993-12-02 1995-03-07 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
HU221905B1 (hu) * 1994-05-20 2003-02-28 Smithkline Beecham Corporation Imidazolszármazék hidrogén-szulfit addíciós vegyülete
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
ES2136782T3 (es) 1994-10-27 1999-12-01 Asahi Glass Co Ltd Procedimiento para producir compuestos de acido quinolin-2-il-benzoico.
CA2175420C (en) * 1995-05-17 2007-04-10 Gareth Griffiths Process for the preparation of optionally 2-substituted 5-chloroimidazole-4-carbaldehydes
JP4103149B2 (ja) 1996-01-05 2008-06-18 ロンザ リミテッド 2−置換5−クロロイミダゾール−4−カルブアルデヒドの製造方法
JPH09202774A (ja) 1996-01-25 1997-08-05 Green Cross Corp:The 2−アリールキノリン類およびその製造方法
JP3890453B2 (ja) 1996-09-18 2007-03-07 リードケミカル株式会社 新規2,4−ジオキソピロリジンおよび2,4−ジオキソテトラヒドロフラン誘導体及び該化合物を有効成分とする医薬
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
HUP0101439A3 (en) 1998-03-04 2002-09-30 Takeda Chemical Industries Ltd Sustained-release preparation for a ii antagonist, production and use thereof
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
EP1444988A4 (de) 2001-11-13 2007-04-25 Takeda Pharmaceutical Krebsmittel
ES2259412T3 (es) * 2002-04-29 2006-10-01 Teva Pharmaceutical Industries Ltd. Procedimientos para la preparacion de losartan y losartan potasico.
DE10335027A1 (de) 2003-07-31 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Angiotensin II Rezeptor Antagonisten
DE10306179A1 (de) * 2003-02-13 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Dipyridamol in Kombination mit Acetylsalicylsäure und einem Angiotensin II-Antagonisten zur Schlaganfall-Prophylaxe
UA90131C2 (en) * 2005-02-03 2010-04-12 Рациофарм Гмбх Method for the production of losartan
DE602006017675D1 (de) * 2005-04-15 2010-12-02 Dishman Pharmaceuticals & Chem Herstellung von 2-substituierten 4-chlor-5-formylimidazolen durch vilsmeier-reaktion des kondensationsprodukts von glycin und einem imidoester mit einem formamid in gegenwart eines triflat- (trifluormethansulfonat-) katalysators
EP1908469A1 (de) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II Rezeptor Antagonisten zur Behandlung von systemischen Krankheiten bei Katzen
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20090299177A1 (en) * 2008-06-03 2009-12-03 Mallinckrodt Inc. Risk Stratification of Patients with Chronic Myocardial Infarction
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN102584628B (zh) * 2011-12-30 2015-04-22 浙江外国语学院 一种n-羧甲基戊脒的合成方法
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (de) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonisten der guanylatcyclase und deren verwendungen
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法
NZ759782A (en) 2017-07-07 2023-06-30 Boehringer Ingelheim Vetmedica Gmbh Angiotensin ii receptor antagonist for the prevention or treatment of systemic diseases in cats

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH510394A (de) * 1969-07-04 1971-07-31 Ciba Geigy Ag Akarizides Mittel
CA1066709A (en) 1975-03-10 1979-11-20 Walter A.M. Helsen Preparation of loweralkyl imidazole carboxylates
JPS54148788A (en) * 1978-05-15 1979-11-21 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation
JPS611022A (ja) * 1985-06-03 1986-01-07 Hitachi Ltd 半導体集積回路装置

Also Published As

Publication number Publication date
ATE5880T1 (de) 1984-02-15
JPS6364428B2 (de) 1988-12-12
ES496709A0 (es) 1982-05-01
NO151966C (no) 1985-07-10
EP0028834B1 (de) 1984-01-18
CA1152516A (en) 1983-08-23
AR228957A1 (es) 1983-05-13
US4355040A (en) 1982-10-19
GR72124B (de) 1983-09-16
PT72049B (pt) 1981-09-24
NO803388L (no) 1981-05-13
ES8204724A1 (es) 1982-05-01
NO151966B (no) 1985-04-01
PT72049A (en) 1980-12-01
NZ195517A (en) 1982-12-07
AU6412280A (en) 1981-05-21
DK478980A (da) 1981-05-13
SU999966A3 (ru) 1983-02-23
EP0028834A1 (de) 1981-05-20
IL61359A0 (en) 1980-12-31
HU185389B (en) 1985-01-28
ZA806832B (en) 1981-10-28
JPS5671074A (en) 1981-06-13
FI803508L (fi) 1981-05-13

Similar Documents

Publication Publication Date Title
DE3066205D1 (en) Imidazole-5-acetic acid derivatives, their production and use
DE3176731D1 (en) 1-sulfo-2-oxoazetidine derivatives, their production and use
DE3061226D1 (en) Quinone derivatives, their production and use
DE3262455D1 (en) Diphenoxypropane derivatives, their production and use
DE3061468D1 (en) 6-deoxyglucosamine-peptide derivatives, their production and use
DE3165091D1 (en) Valienamine derivatives, their production and use
DE2860342D1 (en) Glycylmethyl-phosphinic acid derivatives, their preparation and their use
IL63871A (en) Phenoxyethylcarbamic acid derivatives,their manufacture and their use as pesticides
IL61487A0 (en) Azolyl derivatives,their manufacture and their use as microbicids
ZA802155B (en) Penem-3-carboxylic acid derivatives, their preparation and use
IL56882A0 (en) Acylated1-azolyl-2-hydroxy-butane derivatives,their preparation and their use asfungicides
JPS56161371A (en) Sulfonamide derivative, its manufacture and its use as drug
JPS57131744A (en) Substituted phenoxycinnamic acid derivative, manufacture and use
IL59391A (en) 7-pyrazolyl-oximinoacetylamino-cephalosporanic acid derivatives,their production and chemotherapeutical compositions containing them
PH15473A (en) N-benzylhaloacetamide derivatives,and their production and use
DE3364895D1 (en) Glycerol derivatives, their production and use
DE3162556D1 (en) N-benzylphenylacetamide derivatives, their production and use
IL64318A (en) Pyridyloxy-and quinoxalinyloxy-phenoxypropionic acid derivatives,their manufacture and their use as herbicides
DE2967095D1 (en) Phenyliminomethyl-3-pyridine derivatives, their preparation and use
IL59202A0 (en) Cephalosporin derivatives,their production and their use
IL66472A0 (en) Phenoxyphenylamino acid derivatives,their production and their use as herbicides
ZA811567B (en) 2-penem-3-carboxylic acid derivatives, their preparation and use
DE3062022D1 (en) Dihydronicotinic acid derivatives, their preparation and use
DE3070729D1 (en) Des-a-steroids, their production and some des-a-steroids for use as medicines
ZA818445B (en) 2-oxoazetidine derivatives,their production and use

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee