DE2347111A1 - Multiple test strip for chemical solution analysis - has several test strip elements which are combined into one multiple test strip - Google Patents

Multiple test strip for chemical solution analysis - has several test strip elements which are combined into one multiple test strip

Info

Publication number
DE2347111A1
DE2347111A1 DE19732347111 DE2347111A DE2347111A1 DE 2347111 A1 DE2347111 A1 DE 2347111A1 DE 19732347111 DE19732347111 DE 19732347111 DE 2347111 A DE2347111 A DE 2347111A DE 2347111 A1 DE2347111 A1 DE 2347111A1
Authority
DE
Germany
Prior art keywords
test strip
multiple test
combined
chemical solution
potassium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19732347111
Other languages
German (de)
Inventor
Wolfgang Dipl P Ludwig-Clarius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LUDWIG CLARIUS WOLFGANG DIPL P
Original Assignee
LUDWIG CLARIUS WOLFGANG DIPL P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE2152099A priority Critical patent/DE2152099C3/en
Application filed by LUDWIG CLARIUS WOLFGANG DIPL P filed Critical LUDWIG CLARIUS WOLFGANG DIPL P
Priority to DE19732347111 priority patent/DE2347111A1/en
Publication of DE2347111A1 publication Critical patent/DE2347111A1/en
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH

Abstract

Multiple test strip comprises separate part strips combined by superimposing them or placing them alongside each other. Each strip contains a different precipitation reagent, thus enabling several constituents of a cpd. to be analysed simultaneously. Uses include determn. of J-Na ratio in urea.

Description

Dr. rer. nat. Wolfgang Ludwig 2ooo Norderstedt 3, Breslauer Str. 29, Postfach 1349Dr. rer. nat. Wolfgang Ludwig 2ooo Norderstedt 3, Breslauer Str. 29, PO Box 1349

Zusatzpatentanmeldung zur Anmeldung P 21 52 099.0Additional patent application for application P 21 52 099.0

Mehrfach-Teststreifen und Verfahren zur Analyse chemischer Lösungen. Multiple test strips and methods for analyzing chemical solutions .

Aus der DT-OS 21 52 099 ist ein Teststreifen und Tesisbreifenverfahren zur Analyse chemischer Lösungen bekannt. Die vorliegende Zusatzanmeldung zu diesem Teststreifen und Teststreifen-Verfahren betrifft einen Mehrfaeh-Teststreifen (1),(2),(3) und seine Anwendung zur gleichzeitigen analytischen Bestimmung mehrerer Substanzen in chemischen Lösungen.From DT-OS 21 52 099 is a test strip and test strip method known for the analysis of chemical solutions. The present additional application for this test strip and test strip method relates to a multiple test strip (1), (2), (3) and its simultaneous use analytical determination of several substances in chemical solutions.

Erfindungsgemäß wird dies erreicht durch Kombination mehrerer Teststreifen-Teile (1),(2); (1),(3) usw. gemäß der DT-OS 21 52 099, die neben- 'oder übereinander angeordnet sind und von denen jeder einzelne Teststreifen-Teil (1),(2); (1),(3) usvr. ein anderes Fällungsreagenz enthält, das mit jeder der zu bestimmenden Substanz je eine schwer- oder unlösliche Verbindung oder Bindung eingeht. According to the invention, this is achieved by combining several test strip parts (1), (2); (1), (3) etc. according to of DT-OS 21 52 099, which are arranged next to or on top of one another and of which each individual test strip part (1), (2); (1), (3) etc. another precipitation reagent contains that enters into a sparingly or insoluble compound or bond with each of the substances to be determined.

Weiterhin betrifft die vorliegende Zusatzanmeldung ein Mehrfach-Teststreifen-Verfahren zur gleichzeitigen Mehrfachanalyse chemischer Lösungen nach dem Fällungsverfahren, bei denKin den Teststreifen-Teilen (1),(2); (1),(3) usw. nach dem Kontakt mit der zu untersuchenden chemischen Lösung erfolgten Trübungen zur Lichtabsorption bzw. zur Lichtstreuung benutzt werden und die LichtSchwächung des durch die Teststreifen-Teile (1),(2); (1),(3) usw. fallenden Lichtes bzw. des von den Teststreifen-Teilen (1),(2); (1)»(3) usw. reflektierten Lichtes als Maß für die zu . bestimmenden Substanzgehalte verwendet wird.Furthermore, the present additional application relates to a multiple test strip method for simultaneous multiple analysis chemical solutions according to the precipitation process, in the case of the test strip parts (1), (2); (1), (3) etc. after contact with the chemical solution to be investigated, cloudiness for light absorption or for Light scattering can be used and the light attenuation of the through the test strip parts (1), (2); (1), (3) etc. light falling or that of the test strip parts (1), (2); (1) »(3) etc. reflected light as a measure of the too. determining substance content is used.

Vorzugsweise wird der Mehrfach-Teststreifen in Form eines Doppel-Teststreifens (1),(2),(3) und seine Anwendung zur Bestimmung des Kalium-Natrium-Quotienten im Harn vorgeschlagen. Eine Bestimmung des Kalium-Natrium-Quotienten The multiple test strip in the form of a double test strip (1), (2), (3) and its use for determining the potassium-sodium quotient in urine is proposed. A determination of the potassium-sodium quotient

509813/0947509813/0947

im Harn ist insbesondere bei Herzpatienten and postopertiv wichtig zur Erkennung eines Hyperaldosteronismus.in the urine is particularly important in cardiac patients and postoperatively for the detection of hyperaldosteronism.

Mithilfe eines Doppel-Teststreifens (1),(2),(3) für Kalium- und Natrium-Analyse kann jeder niedergelassene Arzt oder sogar der Patient selbst eine einfache Schnellbestimmung durchführen. Vorteil der Kombination mehrerer Teststreifen-Teile (1),(2) und (1),(3) usw. ist die Möglichkeit, die verschiedenen Teststreifen-Teile (1),(2) und (1),(3) usw. aus der gleichen Charge herzustellen, sodaß Fehler durch Fremdeinflüsse wie Feuchtigkeit, Alterung usw. auf ein Minimum beschränkt werden. Die Genauigkeit der Analyse, insbesondere bei notwendiger Quotientenbildung, wird also erhöht.Using a double test strip (1), (2), (3) for potassium and sodium analysis can be done by any general practitioner or doctor even the patient himself can carry out a simple quick determination. Advantage of combining several test strip parts (1), (2) and (1), (3) etc. is the possibility to use the different test strip parts (1), (2) and (1), (3) etc. from the same batch, so that errors due to external influences such as moisture, aging, etc. Minimum. The accuracy of the analysis, especially when it is necessary to form a quotient, is thus elevated.

Als Beispiel sei die Bestimmung des Kalium-Natrium-Quotienten im Harn gebracht:The determination of the potassium-sodium quotient in urine is given as an example:

Auf einem substrierten Folienträger (1) von ca. 11 mm Breite und ca. 60 mm Länge werden im Abstand von ca. 1 mm zwei Schichten (2) und (3) von je ca. 5 mm Breite und ca. 40 mm Länge aufgebracht (Figur 1), sodaß eine 11 χ 20 mm große Fläche zum Halten des Folienträgers (1) mit Daumen und Zeigefinger unbeschichtet bleibt. Die Schicht (2) besteht aus Gelatine, die mit Natriumtetraphenylborat und einem Stabilisator gegen Zersetzung durch Bakterien z.B. Natriumsalizylat - versetzt ist. Die Schicht (2) dient dem quantitativen Nachweis von Kaliumionen.On a subbed film carrier (1) approx. 11 mm wide and approx. 60 mm long, approx. 1 mm Two layers (2) and (3) each approx. 5 mm wide and approx. 40 mm long are applied (Figure 1), so that an 11 χ 20 mm large area for holding the film carrier (1) with thumb and forefinger remains uncoated. The layer (2) consists of gelatin treated with sodium tetraphenylborate and a stabilizer against bacterial degradation e.g. Sodium salicylate - is added. The layer (2) is used for the quantitative detection of potassium ions.

Die zweite Schicht (3) besteht aus Gelatine, die mit Kaliumhexahydroxoantimonat und einem Stabilisator versetzt ist. Die Schicht (3) dient dem quantitativen Nachweis von Natriumionen.The second layer (3) consists of gelatin to which potassium hexahydroxoantimonate and a stabilizer are added is. Layer (3) is used for the quantitative detection of sodium ions.

Der Doppel-Teststreifen (1),(2),(3) wird in die zu untersuchende Harnprobe eine bestimmte Zeit lang, z.B. 5 Minuten, eingetaucht, wobei die Schichten (2) und (3) je eine definierte Harnmenge durch Quellen aufnehmen. Die Schicht (2) trübt sich dabei durch ausfallendes Kaliumtetraphenylborat und die Schicht (3) durch ausfallendes Natritrahexahydroxoantimonat. Das Verhältnis der beiden Trübungen ist ein Maß für den Kalium-Natrium-QuotientenThe double test strip (1), (2), (3) is immersed in the urine sample to be examined for a certain time, for example 5 minutes, the layers (2) and (3) each absorbing a defined amount of urine by swelling. Layer (2) is clouded by precipitating potassium tetraphenylborate and layer (3) by precipitating sodium hexahydroxoantimonate. The ratio of the two opacities is a measure of the potassium-sodium quotient

5098 13/09475098 13/0947

Claims (1)

im Harn und kann durch visuellen Vergleich mit einem Trübungskeil bestimmt werden oder durch Eintauehen eines zweiten Doppel-Teststreifens in Standard-Lösungen mit bekanntem Kalium- und Natriumgehalt und Vergleich beider Dopp el-Test streifen.in the urine and can be determined by visual comparison with an opacity wedge or by thawing one second double test strip in standard solutions with known potassium and sodium content and comparison of both Double test strip. Durch das gleichzeitige Erfassen beider Trübungswerte ist besonders deutlich festzustellen, ob der gesuchte Kalium-Natrium-Quotient über oder unter einem bestimmten Wert, z.B. eins, liegt. Durch passende Wahl der Schichtdicken der Schichten (2) und (3) läßt sich erreichen, daß sich bei gesunden Patienten beide Schichten (2) und (3) annähernd gleichstark trüben.The simultaneous recording of both turbidity values makes it particularly easy to determine whether the The potassium-sodium quotient is above or below a certain value, e.g. one. By choosing the right layer thickness of layers (2) and (3) can be achieved that in healthy patients, both layers (2) and (3) opaque approximately equally. 5. und 6. Patentanspruch zur Anmeldung P 21 52 099.05th and 6th patent claim for registration P 21 52 099.0 eststreifen nach Anspruch 1. und 2., dadurch gekenneichnet, daß mehere Teststreifen-Teile (1),(2); (1),(3) usw. zu einem Mehrfach-Teststreifen (1),{2), (3) kombiniert werden, sodaß gleichzeitig metere Bestandteile der zu untersuchenden chemischen Lösung analysiert werden können.test strips according to claim 1 and 2, characterized thereby, that several test strip parts (1), (2); (1), (3) etc. to a multiple test strip (1), {2), (3) are combined, so that at the same time several components of the chemical solution to be examined can be analyzed. Teststreifen-Verfahren nach Anspruch 3.und 4, dadurch gekennzeichnet, daß der in Anspruch 5. genannte kombinierte Teststreifen als Mehrfach-Teststreifen (1),(2),(3) verwendet wird, um meliere Bestandteile der zu untersuchenden chemischen Lösung zu analysieren.Test strip method according to claim 3 and 4, characterized characterized in that the combined test strip mentioned in claim 5 as a multiple test strip (1), (2), (3) is used to analyze mottled components of the chemical solution to be examined. 509813/0947509813/0947 -If--If- Le e rs e i teBlank page
DE19732347111 1971-10-19 1973-09-19 Multiple test strip for chemical solution analysis - has several test strip elements which are combined into one multiple test strip Pending DE2347111A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE2152099A DE2152099C3 (en) 1971-10-19 1971-10-19 Test strips and methods for analyzing chemical solutions
DE19732347111 DE2347111A1 (en) 1971-10-19 1973-09-19 Multiple test strip for chemical solution analysis - has several test strip elements which are combined into one multiple test strip

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2152099A DE2152099C3 (en) 1971-10-19 1971-10-19 Test strips and methods for analyzing chemical solutions
DE19732347111 DE2347111A1 (en) 1971-10-19 1973-09-19 Multiple test strip for chemical solution analysis - has several test strip elements which are combined into one multiple test strip

Publications (1)

Publication Number Publication Date
DE2347111A1 true DE2347111A1 (en) 1975-03-27

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DE2152099A Expired DE2152099C3 (en) 1971-10-19 1971-10-19 Test strips and methods for analyzing chemical solutions
DE19732347111 Pending DE2347111A1 (en) 1971-10-19 1973-09-19 Multiple test strip for chemical solution analysis - has several test strip elements which are combined into one multiple test strip

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Application Number Title Priority Date Filing Date
DE2152099A Expired DE2152099C3 (en) 1971-10-19 1971-10-19 Test strips and methods for analyzing chemical solutions

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4274832A (en) * 1979-02-12 1981-06-23 Eastman Kodak Company Analytical element and method for analysis of multiple analytes
DE4411661A1 (en) * 1994-04-05 1995-10-12 Schoettler Markus Dipl Geol Multi-parameter video technical analysis process for fluid media
DE4444533A1 (en) * 1994-12-14 1996-06-27 Juergen Lehmann Test strips for detecting electrolytes in urine

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260392A (en) * 1978-07-07 1981-04-07 Technicon Instruments Corporation Method and apparatus for obtaining an aliquot of a liquid in a gel medium
US4250257A (en) * 1978-08-24 1981-02-10 Technicon Instruments Corporation Whole blood analyses in porous media
WO1984004165A1 (en) * 1983-04-13 1984-10-25 Little Inc A Film badge for determining carbonyl compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4274832A (en) * 1979-02-12 1981-06-23 Eastman Kodak Company Analytical element and method for analysis of multiple analytes
DE4411661A1 (en) * 1994-04-05 1995-10-12 Schoettler Markus Dipl Geol Multi-parameter video technical analysis process for fluid media
DE4444533A1 (en) * 1994-12-14 1996-06-27 Juergen Lehmann Test strips for detecting electrolytes in urine

Also Published As

Publication number Publication date
DE2152099B2 (en) 1974-05-22
DE2152099C3 (en) 1975-03-13
DE2152099A1 (en) 1973-05-03

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