DE2230565A1 - SAMPLE PLATES - Google Patents

Description

Jjie Jrvinduiif: relates to a sample tray for holding a Much?,; i.lil of sample containers for liquid samples for analysis, especially for chemical, biochemical or seio-hamato - Lofian analysis, in an automatic analysis machine.

In the automatic analysis devices and apparatus for organic liquids, such as blood, a support for a plurality yon vessels must CBX ^v Verfüfcunf-; stand, in which oxiiiar don tflüasigicGitö samples to be analyzed also the fiGKiiiu'.oton iioaktiorismittel v / ground to a variety of voj. Samples at the same time; one or more to one .U-UXy ¹ J (J ^ iUiJr ¹ ; fiehüioiide Arbeitsgänf <e, v / ie eg moving, uau Zc-Jibriiurieron et al.

ijii. ·. ii. ';i'a2'ti- ^r ' or 'l.'räf; he or sample plate must during a /.i:u:.lvi;o;v;.iü''üi3 of the "üoihe after vevschiedanon workstations

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des AppEirates, in which, for example, the i'ro'bon is filled into the sample and the _: e.: "J: tior.snii"!: tel trains j'uhi't v / erden, a photonietrischo detachment, "e.rxfollows, etc., iiiiü in strict dependence on the work ::: y] -: lus des ... nnaratea, so that an absolutely z'-veijf eis free assignment of the analysis results to; each of the χει same analyüo-: ^ri : an ^p 'treated variety of Pioben is possible.

The;.! Ridr.dung is based on the task of creating a sample bag with simple idtels, which is economical, using conventional ^ 'orraveri'eihreii, incbesondei-e from Kunatstorf-I ^{: 1} ormverf ;. Its sample vessels, which are to be used both for the sample divider itself and for the r.iit aioscra, can be divided up and for use in an automatic analysis apparatus _; y, _eei: ^r giet, that is placed on the sample tray such i-'orderunfxn both in terms eggs identification of one or a plurality of the same analysis sample containing samples; .cflißen and in terms of x'orrabeständigiceit, the ^\: / iderstandsi 'ü.higlceit against the v / honoring a / m £ ily3e, ^c : an *: it fulfills mechanical stresses, etc.

Furthermore, such a sample plate should be the photometric Reading the analysis results from a large number of spatial do not allow excessively large samples and moreover on the one hand insensitive to go ^ en chemical or biochemical Medium and, on the other hand, at temperatures such as those required for sterilizing the piobon refinement, tempei'a, temperature-resistant be.

3in the sample plate of the irt mentioned at the beginning stands out according to the invention in that to guide the sample plate running at right angles in at least one another Positioning devices are provided which i: dt Subdividing the apparatus in which the sample plate is used, cooperate.

209882/1061 bad original

In one embodiment of the sample divider according to the invention, in which the same sample is accommodated in a large number of sample vessels for the simultaneous performance of a large number of chemical, bio-chemical or sero-hematological reactions, the sample vessels belonging to the same large number are combined in groups along circle involute lines between the inner vt-.C \ the outer edge of the sample dividerD ■ χι v;: c arranges.

This arrangement makes it possible to use a sample divider small dimensions a relatively large number of To accommodate sample vessels.

The ^ rfindim ·· :; will be explained in the following on the basis of visual drawings eii'jes .usfülirunf's example with further details is explained. ID of the character is ^ t:

■ 'ig. 1 is a view from below of a sample plate,

j ^ i, ". 2 a section along the line 2-2 in Fig. 1,

a 2-wire section corresponding to line 3-3 in ffiff. 1,

-. ^: 'i ·· ". 4 a side view of the rope looking in the direction corresponding to arrow 1? in? ig. 1,

S'xg. 5 is a plan view of a part of the sample plate and FIG

. ^x ± r- :. 6 shows a section on an enlarged scale through a sample vessel of the sample plate.

In accordance with the invention, the sample plate 10 would be designed to receive it of samples: A ring disk 11 has an annular disk 11 for liquid samples

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on, which is advantageously made of plastic, for example from a Acrylonitrile-butadiene-styrene polymer, is produced. At The washer 11 has a ring 30 on its inner circumference its outer circumference a-Hing 12, which is formed by a standing perpendicular on an axis 23 of the washer 11 Planar surface 13 »which is connected via its cylindrical surface 14 to a conical surface 15 which is divided into a conical surface 13 parallel annular plane surface 16 merges.

The Hing 12 has in one section a thickening or bulge 20 in which a V-shaped Hadial notch 21 is formed, the plane surfaces 22 and 22 ^f converge in the direction of the axis 2 ^ of the Hiiigscheibe. In order to guide the sample plate in the vertical direction of movement, this hadial notch interacts with a member of the apparatus equipped with the sample plate according to the invention, which member is designed with a corresponding counter-shape.

On the underside of the boy 12 and at an angular distance of about 13! 5 ° from the bulge 20 are two bulges 25, 26 provided, in the blind holes 27 and 28 are drilled. In these Sacldöehern are available on the automatic analysis apparatus Warts or pegs or similar can be picked up, which serve to keep the washer 11 moving parallel to its plane lead when coming from a workstation of the apparatus another, for example for centrifugation or for shaking, is proceeded.

The inner ring 30 is limited by a cylindrical surface 31, the one with two conical surfaces 32,33 in upper and lower ring-shaped Planar surfaces 34 and 35 transitions. On the inner ring 30 are according to the invention furthermore devices for positioning the trial component 10 relative to the drive elements of the automatic analysis apparatus, such as a centrifuge shaft and / or advantageously longitudinally a circular path movable drive shaft of a shaking device, intended.

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liei of the form of training described and illustrated the cxi inner ring 30 devices for positioning dec l'robenteller 10 an in cross-section essentially liL.l ": Jkroisi-shaped, extending over the entire height of the inner ring 30 extending recess? 6 and a U-shaped cross-section having recess 37, which of substantially radially directed surfaces 3Ö »39 and a rear wall or a Korbaugrund 40 is limited. In the upper and lower areas the recess or Eerbe 37 are with inclined surfaces 41 »42 ,. 43 and 44 formed expansions provided (Fig. 4).

Circular holes 50 are drilled into the washer. 11 Represented training form a total of 144 pieces, which are summarized in twelve groups of twelve holes and for Serve uptake of a sample vessel, which is a partial amount the liquid sample to be analyzed and, if applicable, contains a suitable reagent.

According to the invention, each group of twelve holes consists of two subgroups, each with six holes 51-t c and 52., r , where

I .. «O ι« · «O

so the six holes 51 as well as the six holes 52 respectively are arranged along an iCreisevolventenlinie, which by one formed on the top of the annular disc with a low height Rib .53 is formed, which is interrupted near the holes and emerges from the area of the inner umlarifvoo up to the area of the outer circumference of the washer 11 extends. Each of the ribs 53 associated with the holes 51 is associated with one of the holes 52 ″ at its end points Similar rib 54 via circular arc-shaped, also formed with a low height on the upper side 59 of the annular disk 11 Ribs 55,56 connected. In this way, between the ribs 53, 54, 55 and 56 is in each case a group of twelve holes Included portion of the annular disc 11 belonging to the one, preferably cast in die'Ringscheibe 11 or oingeformton code number 57 can be designated.

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Each of the holes 50 is suitable for receiving a sample vessel 70, which, according to FIG. 6, is composed of a transparent, concave base 60, which is given the properties of an optical cut by appropriate treatment and which seals with the upper part of its outer wall is welded to an attachment piece 62 with opaque side walls. The attachment piece 62 has a recess 6? in its upper region. Enclosing its upper recess 63 there is a conical section 66, which continues in the direction of the shell 60 in a cylindrical side wall 67 which is elevated with a shoulder or shoulder 68 into a lower cylindrical section 69. The outer diameter of the side wall 67 corresponds to that of the holes ¹ JO, so that the sample vessels 70 in the annular T carriers or can be pressed into the "washer 11".

With a modified form of training everyone can. Sample vessels one and the same sample divider ?, interconnected so that they can be applied as a whole to the actual sample plate and / wtF can be removed from it.

sample plates formed according to the invention meet the various conditions related by its use are provided with an automatic analyzer. In particular, its outer diameter can be due to the Keep the arrangement of the same sample assigned sample vessel groups along circular involute lines small, so that on the No great mechanical forces act on the sample plate. As a result, forces are excluded, especially during centrifugation, the geometry of the disc, i.e. the sample plate, for example could change r so by twisting that by a resulting relative change in the arrangement

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"or position of the sample vessel shells in relation to a photometric Measuring device automatic measurements impossible would be made.

209882 / 1QS1

Claims (7)

Sample divider for holding a large number of sample vessels for liquid samples for analysis, especially for chemical, biochemical or sero-haematological analysis in an automatic analysis device, thereby marked e t that for guiding the sample plate (10) in at least two mutually perpendicular directions Positioning devices (36,37; 21,25,26) are provided which, with members of the apparatus in which the sample plate (10) is used to work together. 2. Sample plate according to claim 1, characterized in that the positioning devices (36,37; 21, 25, 26) are formed on the inner circumference (30) and on the outer circumference (12) of an actual support ring (11). 3. Sample plate according to claim 2, characterized in that the positioning devices (36,37; 21,25,26) notches (21; 36,37) belong in rings (30, 12) on the inner and outer circumference of the actual, as a flat Ring disk · formed carrier (11) are provided. 209882/1051 «40 - 9 - 41 337 4. Sample divider according to one of claims 1 to 3> thereby g e k e η η ζ e i c h η e t that, in addition, on the outer circumferential ring (12) bulges (25,26) are formed into which holes (27,28) are drilled, and dstß with these for the process the disk (11) between successive work stations Warts or Ζει / pfen o.ä, a Pühruiigsorgans of the apparatus work together. 5. sample divider according to claim 1, characterized in that g e k e η η, that the actual carrier (11) is designed as a flat annular disk, and that in these holes (50) are drilled, which serve to receive the sample vessels (70) and are arranged along a plurality of lines, which Circular involute lines match and move out of the area dec inner circumference (30) up to the area of the outer circumference (12) the disc (11) extend. C. Sample divider according to claim 5, characterized in that the involute circular lines along which the holes (50) of the carrier disk (11) are arranged are adhered to by ribs (5?, 54) formed on the upper side (59) of the carrier (11) are. 7. Sample divider according to claim 6, characterized in that adjacent ribs (53,54) on their inner circumference (30) and the outer circumference (12) opposite ο η end points by Icreisbogenförmigo ribs (55,56) are connected to one another that these together with the ribs (53, 54) in the form of Croisovolventenlinien on the upper side (59) of the disc (11) sections with a number of sample vessels (70) each limit that each of these sections of a sample to be analyzed is assigned and has a code ( ^[ >'() . 209882/1051 - 10 - 41? 37 ό. Sample divider according to claim 1, characterized in that the actual sample vessels (70), which can be taken out in the actual carrier (11), are interconnected in their entirety and can be attached as a whole to the carrier (11) can be taken from this. OFiIGfNAl. 209882/1051 Blank page