DE202010006267U1 - Product with an antimicrobial surface - Google Patents

Abstract

Product with an antimicrobial surface, characterized in that at least the surface of the product consists of a silicone base material and in contact with an aqueous medium has a surface pH of at most 6.5.

Description

The The invention relates to a product having an antimicrobial activity Surface.

microorganisms like bacteria and fungi are omnipresent in our habitat and populate surfaces of various kinds. Many Microorganisms are pathogens and their distribution or Combat plays in health care and hygiene a special role. Get such microorganisms in ours Body, you can be the cause of life-threatening Be infections. The reduction of nosocomial infections is included really important. So it is estimated that at about 0.5% of all hip joints and about 2 to 4% of all Knee joint implants to infections. A high risk of infection especially exists with catheters.

Various Products that are in a temporary or permanent Body contact stand, represent for the person concerned basically a biological "foreign situation", which leads to corresponding foreign body reactions. Therefore, in the contact zone of the product with the hard and soft tissue of a sufferer the unphysiological effects and side effects on its organism as low as possible being held. Conversely, however, it must be ensured that the surface of the product even with longer Staying in or on the person's body as possible germ-free remains. In addition to the defense or the killing of unwanted However, microorganisms also receive preventive measures, d. H. the creation of microorganisms hostile to life Spaces, increasing importance.

From the WO 98/36784 For example, a medical implant for introduction into a vascular system of an animal or a human is known. On the surface of the medical implant, a primer layer of parylene is applied. About this primer layer is a coating of an antimicrobial coating agent. The coating agent is selected depending on the purpose of use of the medical implant and may include, for example, an antibody, heparin, antithrombotic agents or the like as a pharmacologically active component. In order to be able to ensure a controlled release of the pharmacologically active component after the implantation of the medical implant, a porous cover layer of a further polymer is finally provided, which is applied to the pharmacologically active coating. The coating is applied by a chemical vapor deposition method using biocompatible polymers such as polyamides, parylenes or parylene derivatives.

When A disadvantage of this product is the fact that the Production of the multilayer surface very expensive and is expensive. In addition, the used antimicrobial agents to intolerance reactions to lead.

task The present invention is to provide a product with an antimicrobial to provide effective surface, which is cheaper can be produced and increased compatibility has.

These Task becomes with a product with the features of the protection claim 1 solved. Advantageous embodiments of the invention are described in the subclaims.

at a product according to the invention, which is cheaper can be produced and increased compatibility owns, it is provided that at least the surface the product consists of a silicone base material and in contact with an aqueous medium, a surface pH of not more than 6.5. Under a silicone base material is understood in the context of the invention, a material which to at least 50% consists of a silicone. This means, for example, that the surface of the product and / or the entire product to 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95% or 100% a silicone. Of course you can here also corresponding intermediate values such as 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%. Silicones are characterized by elastic behavior, low dependence of their physical properties on the Temperature, good gas permeability, good cold resistance, low surface energy, good film-forming properties, good dielectric properties, water-repellent effect as well due to high heat and aging resistance and behave moreover biologically inert, so that they have a high have biocompatibility and from the body not attacked or dismantled.

To achieve antimicrobial efficacy, the surface of the product will still have a surface pH of at most 6.5 upon contact with an aqueous medium. In the context of the invention, a surface pH is understood to mean the pH which forms on contact of the surface of the product with an aqueous medium in the region of the at least substantially diffusion-controlled boundary layer at the phase boundary between solid surface and liquid, aqueous medium , The measurement of the surface pH can (using commercially available surface pH electrodes z. B. SenTix ^® Sur-Meßkette, WTW Scientific-Technical Workshops GmbH, Weilheim, Germany). By having the silicone base material having a surface pH of at most 6.5, the present invention utilizes the formation of protons and the associated pH lowering against the neutral pH of 7.0 to achieve an antimicrobial effect , Free protons immediately attach to water molecules to form oxonium ions (H ₃ O ⁺ ). If the concentration conditions permit it, links of the oxonium ions with several water molecules occur. Therefore, in addition to H ⁺ , the cations formed by reaction of H ⁺ with water and their hydrates are also obtained. In addition to the oxonium ion (H ₃ O ⁺ ), these are, for example, the so-called Zundelkation (H ₅ O ₂ ⁺ ) and the eigencation (H ₉ O ₄ ⁺ ). It can be provided in the simplest embodiment that the silicone base material has acid end groups, which cause the acidic surface pH in contact with the aqueous medium. It has now been found that with the help of a surface pH of at most 6.5 a reliable antimicrobial efficacy is achieved. In the context of the invention, a surface pH of not more than 6.5 in particular has a surface pH of 6.5, 6.4, 6.3, 6.2, 6.1, 6.0, 5 , 9, 5, 8, 5, 7, 5, 6, 5.5, 5.4, 5.3, 5.2, 5.1, 5.0, 4.9, 4.8, 4.7 , 4,6, 4,5, 4,4, 4,3, 4,2, 4,1, 4,0 or lower. The precise mechanism of antimicrobial efficacy of the lowered surface pH is currently unclear. Without wishing to be bound by this view, the inventor assumes that the so-called zeta potential (ζ), ie the electrokinetic potential in the region of the surface, is increased by the increased proton concentration such that an accumulation of microorganisms on the surface of the product made difficult or impossible. The zeta potential is a measure of the potential of the diffusion-controlled boundary layer and characterizes the repulsive energy between the molecules located there. An increase in the zeta potential causes an increase in the interparticle repulsive forces, in particular, the pH-dependent net charges of proteins (adhesins), which are commonly used by microorganisms for attachment to surfaces, are changed due to the protonation such that an attachment to the silicone Base material of the product is no longer possible. In addition, with the aid of the invention, any incompatibility reactions which frequently occur in the pharmacologically active components used to date, such as antibodies, antibiotics or the like, are ruled out from the outset.

A particularly reliable antimicrobial effectiveness At the same time high compatibility is achieved in an advantageous Embodiment of the invention achieved in that the surface pH in Contact with an aqueous medium between 6.0 and 5.0 is. In other words, it is envisaged that the surface pH 6.0, 5.9, 5.8, 5.7, 5.6, 5.5, 5.4, 5.3, 5.2, 5.1 or 5.0.

By doing the silicone base material can be surface-modified the properties of the product aimed at its later Purpose to be adapted. For example, for a trained as a urine catheter product, for as Food packaging trained product and for one each designed as a table product each different surface modifications be designed to optimally meet the specific product requirements to take into account.

there it has been shown to be advantageous if the silicone base material Silanolate, alkylhydroxide, polyvinylalcohol, polyethyleneoxide, Zinc sulfate, polydimethylsiloxane, polyvinylpyrrolidone, and / or Phosphorylcholine end groups includes. This allows the Surface properties, the surface pH as well as the polarity of the surface of the product be set very precisely and variably.

In a further advantageous embodiment of the invention is provided that the surface at least one physically and / or comprises a compound bound chemically to the silicone base material, in contact with an aqueous medium the formation of Protons causes. With the help of such a compound of the desired surface pH independently from the design of the silicone base material particularly precise and variably generated and adjusted. The firmer the connection it is bound to the silicone base material, the longer their antimicrobial effect can be maintained, as a result prevents washing out, rubbing or the like or at least is slowed down a lot.

In this case, it has proved to be advantageous in a further embodiment if the compound is an essential oil and / or an organic acid and / or an inorganic acid, in particular a metal acid. By using a suitable essential oil, in addition to lowering the surface pH, an additional antimicrobial effectiveness can advantageously be achieved. In addition, essential oils are poorly soluble in water, so that the specific effectiveness is maintained long in moist environments. A non-exhaustive list of plants whose essential oils have been found to be useful in the invention includes, for example, Acanthocardamum, stone bag (Aethionema), Agallis, garlic bush (Alliaria), Alysopsis, Alyssoides, stone herbs (Alyssum), Ammosperma, Anastatica, An chonium, Andrzeiowskia, Anelsonia, Aphragmus, Aplanodes, Arabidella, foam grasses (Arabidopsis), gooseweeds (Arabis), arcyosperma, horseradish (Armoracia), ashersoniodoxa, Asperuginoides, Asta, Atelanthera, Athysanus, blue cuscions (Aubrieta), Aurinia, Ballantinia, barbarian herbs ( Barbarea), gray bark (Berteroa), berteroella, eyeglasses bunnies (Biscutella), bivonaea, blennodia, böcher's rockeries (Boechera), boleum, boreava, bornmuellera, borodinia, botscantzevia, brachycarpaea, cabbage (brassica), braya, brayopsis, brossardia, pinks ( Bunias), Meersenf (Cakile), Wendich (Calepina), Calymmatium, Camelina (Camelina), Camelinopsis, Shepherd's purse (Capsella), Frothy herbs (Cardamine), Cress (Cardaria), Carinavalva, Carrichtera, Catadysia, Catenulina, Caulanthus, Caulostramina, Ceratocnemum , Ceriosperma, Chalcanthus, Chamira, Chartoloma, Cheesemania, Gold lacquer (Cheiranthus), Chlorocrambe, Chorispora, Christolea, Chrysobraya, Chrysochamela, Cithareloma, Clastopus, C lausia, tortillas (Clypeola), weeds (Cochlearia), coelonema, mustardf (Coincya), coluteocarpus, field cabbage (Conringia), cordylocarpus, crowfoot (Coronopus), cabbage (Crambe), Crambella, Cremolobus, Cryptospora, Cuphonotus, Cusickiella, Cycloptychis, Cymatocarpus, Cyphocardamum, Dactylocardamum, Degenia, Delpinophytum, Besenrauke (Descurainia), Diceratella, Dichasianthus, Dictyophragmus, Didesmus, Didymophysa, Dielsiocharis, Dilophia, Dimorphocarpa, Doppelsame (Diplotaxis), Dipoma, Diptychocarpus, Dithyrea, Dolichirhynchus, Dontostemon, Douepea, Felsenblümchen ( Draba), Drabastrum, Drabopsis, Dryopetalon, Eigia, Elburzia, Enarthrocarpus, Englerocharis, Eremobium, Eremoblastus, Eremodraba, Eremophyton, Ermania, Ermaniopsis, Famine-flowers (Erophila), Sen-wineries (Eruca), Erucaria, Dog-hawk (Erucastrum), Schöteriche (Erysimum) , Beaked Eggs (Euclidium), Eudema, Eutrema, Euzomodendron, Farsetia, Fezia, Fibigia, Foleyola, Fortuynia, Galitzkya, Geococcus, Glaribray a, Glastaria, Glaucocarpum, Goldbachia, Gorodkovia, Graellsia, Grammosperma, Guiraoa, Gynophorea, Halimolobos, Harmsiodoxa, Hedinia, Heidia, Heliophila, Hemicrambe, Hemilophia, Night Violet (Hesperis), Heterodraba, Bastard Mustard (Hirschfeldia), Hollermayera, Rock Crag (Hornungia) , Hornwoodia, Hugueninia, Gämskressen (Hutchinsia), Saltwort (Hymenolobus), Issenhus, Idahoa, Iodanthus, Ionopsidium, Irenepharsus, Waid (Isatis), Ischnocarpus, Iskandera, Iti, Ivania, Kugelschötchen (Kernera), Kremeriella, Lachnocapsa, Lachnoloma, Leavenworthia, Kressen (Lepidium), Lepidostemon, Leptaleum, Lesquerella, Lignariella, Lithodraba, Silver Herbs (Lobularia), Lonchophora, Loxostemon, Silver Leaves (Lunaria), Lyocarpus, Lyrocarpa, Macropodium, Malcolmia, Mancoa, Maresia, Mathewsia, Levkojen (Matthiola ), Megacarpaea, Megadenia, Menkea, Menonvillea, Microlepidium, Microsysmbrium, Microstigma, Morettia, Moricandia, Moriera, Morisia, Murbeckiella, Muricaria, Hollow Dotter (Myagru m), Nasturtiopsis, Nasturtium, Neomartinella, Neotchihewewia, Neotorularia, Nerisyrenia, Fescue (Neslia), Neuontobotrys, Notoceras, Notothlaspi, Ochthodium, Octoceras, Onuris, Oreoloma, Oreophyton, Ornithocarpa, Ory chophragmus, Otocarpus, Oudneya, Pachycladon, Pachymitus, Pachyphragma, Pachypterygium, Parlatoria, Parodiodoxa, Parolinia, Parrya, Parryodes, Pegaeophyton, Discus Herbage (Peltaria), Peltariopsis, Pennellia, Petiniotia, Stone Chalice (Petrocallis), Phaeonychium, Phlebolobium, Phlegmatospermum, Phoenicaulis, Physaria, Physocardamum, Physoptychis, Physorrhynchus, Platycraspedum, Polyctenium, Polypsecadium, Pringlea, Prionotrichon, Gemskressen (Pritzelago), Pseuderucaria, Pseudocamelina, Pseudoclausia, Pseudofortuynia, Pseudovesicaria, Psychine, Pterygiosperma, Pterygostemon, Pugionium, Pycnoplinthopsis, Pycnoplinthus, Pyramidium, Quezeliantha, Quidproquo, Raffia, Raphanorhyncha, Hederich (Raphanus ), Rapsdotter (Rapistrum), Reboudia, Redowskia, Rhizobotrya, Ricotia, Robeschia, Rollinsia, Roman Schoolia, Roripella, Marsh Harrier (Rorippa), Rytidocarpus, Sameraria, Sarcodraba, Savignya, Scambopus, Schimpera, Schivereckia, Schizopetalon, Schlechteria, Schoenocrambe, Schouwia, Scoliaxon, Selenia, Sibara, Silicularia, Sinapidendron, Mustard (Sinapis), Sisymbrella, Sisymbriopsis, Rauken (Sisymbrium), Smelowskia, Sobolewslia, Solms-Laubachia, Sophiopsis, Sphaerocardamum, Spirorhynchus, Spryginia, Staintoniella, Stanfordia, Stanleya, Stenopetalum, Sterigmostemum, Stevenia, Straussiella, Streptanthella, Streptanthus, Streptoloma, Stroganowia , Stubebdorffia, Subularia, Succowia, Synstemon, Synthlipsis, Taphrospermum, Tauscheria, Pea Mustard (Teesdalia), Teesdaliopsis, Tetracme, Thelypodiopsis, Thelypodium, Thlaspeocarpa, Hellerweed or Täschelkräuter (Thlaspi), Thysanocarpus, Trachystoma, Trichotolinum, Trochiscus, Tropidocarpum , Turritis, Vella, Warea, Weberbauera, Werdermannia, Winklera, Xerodraba, Vinshania, Zer dana and Zilla. With the help of these essential oils, for example, multidrug-resistant Staphylococcus aureus bacteria, Pseudomonas, Coli bacteria and all common cold and inflammatory agents such as rhinoviruses, coronaviruses or human metapneumo viruses can be killed and inhibited in their regrowth. Essential oils have a high general compatibility due to their biological ingredients. Advantageous plants or plant parts from which the at least one essential oil can be obtained include, for example, angelica root, arnica, basil, mugwort, bergamot, birch, savory, cajeput, citronella, dill, Douglas fir, silver fir, eucalyptus, fennel , Spruce, Geranium, Ginger, St. John's Wort, Camphor, Kanuka, Lavandin, Lavender, Lemongrass, Laurel, Manuka Tea-Tree, Myrrh, Evening primrose, Clove, Neem, Niauli, Rosemary, Sage, pine cones, tea tree oil, turpentine, thuja, thyme, juniper (berries, wood), frankincense, wormwood, cedar, cinnamon, cinnamon and cypress. Alternatively or additionally, organic acids such as citric acid or acetic acid may be attached to and / or covalently bonded to the silicone base material. Alternatively or additionally, it may be provided that an inorganic acid is used as the acidic compound, in particular metal acids such as molybdic acid or tungstic acid or their precursors MoO ₃ and WO ₃ , which form H ₂ MoO ₄ or H ₂ WO ₄ on contact with water , are preferred. In addition, the solubility of molybdenum and tungsten oxide is advantageously less than 0.02 mol / L. Alternatively or additionally, niobium oxide, manganese oxide and / or silicon carbide may also be provided.

By doing the compound has a solubility of at most 0.1 mol / L, in particular of at most 0.02 mol / L, in water owns, their antimicrobial effectiveness can also be extended Moisture contact or under physiological conditions, for example after implantation of a product designed as an implant, especially long to be maintained.

In a further advantageous embodiment of the invention is provided that the product as a medical implant, exoprosthesis, cable, hose, Food packaging, household product, switch, faucet, man-machine interface, housing, Textile or furniture is formed. This can the antimicrobial activity according to the invention Products are realized, in frequent contact with each other stand with living things. It should be emphasized that the product is not is limited to the aforementioned embodiments. The Product can basically be designed as any object in which an antimicrobial surface is beneficial is.

Further Benefits arise when the product is for permanent and / or temporary retention in and / or on a body of a living being, in particular of a mammal. This allows the product designed variable and for various uses in a particularly hygienic demanding technical area are used.

there can be provided in a further embodiment that the product as a stent and / or catheter and / or tube and / or cannula and / or heart valve and / or joint prosthesis and / or pacemaker and / or screw and / or balloon and / or rail is formed. With these for the longer or permanent whereabouts In the body designed implants allows the Invention a particularly significant reduction in the risk of infection for a concerned patient.

In a further advantageous embodiment of the invention is provided that the product consists at least predominantly of the silicone base material. In other words, it is envisaged that 51% to 100% of the product, For example, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95% or 100%, made of the silicone base material.

Further Features of the invention will become apparent from the claims, the embodiments and with reference to the drawings. The features and feature combinations mentioned above in the description and those mentioned below in the embodiments Features and feature combinations are not limited to those specified Combination, but also in other combinations or in isolation usable without departing from the scope of the invention. Showing:

1 a 12-hour series on the antimicrobial efficacy of a first product of the invention against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus;

2 a series of tests for 12 hours on the antimicrobial efficacy of a second product according to the invention against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus;

3 a series of tests for 12 hours on the antimicrobial efficacy of a third product according to the invention against Pseudomonas aeruginosa; Escherichia coli and Staphylococcus aureus;

4 a series of 7 days of antimicrobial activity of the three products according to the invention against Pseudomonas aeroginosa; and

5 a further series of investigations on the antimicrobial effectiveness of the three products according to the invention.

• – Pseudomonas aeruginosa ATCC 10145;
• – E. coli ATCC 27020; und
• – S. aureus: ATCC 25923 (MRSA).

1 shows a series of studies on the antimicrobial efficacy of a first product according to the invention I1 against Pseudomonas aeroginosa (P.a.), Escherichia coli (E. c.) And Staphylococcus aureus (S. a.). The first product I1 was designed as a medical implant (catheter) and consisted entirely of an elastomeric silicone base material which had a surface pH of 6.2 in contact with an aqueous medium. The surface pH was measured using a ProfiLine 3110 pH meter a SenTix ^® Sur surface pH electrode (both: WTW Scientific Technical Workshops GmbH, Weilheim, Germany) determined according to manufacturer specifications. The following reference strains were used for the investigation of the antimicrobial effectiveness:

• Pseudomonas aeruginosa ATCC 10145;
• E. coli ATCC 27020; and
• - S. aureus: ATCC 25923 (MRSA).

The Microorganisms were grown on slant agar at -25 ° C stored and thawed before each examination. The breeding the microorganisms were transferred to sheep blood agar 5% at 37 ° C 24 hours. These media support grampositive growth (MRSA) and gram-negative microorganisms / (E. coli and P. aeruginosa). Single colonies were plated on sheep blood agar 5% and transferred Overnight (12 h) incubated at 37 ° C. Subsequently were the seeds are harvested and resuspended in 1/4 n saline. The germ count is determined according to the McFarland standard and then by means of Photometer (an OD of 0.8 at 475 nm revealed a bacterial count of 1 billion microorganisms per milliliter.) The final documentation done by a serial dilution with a deviation of more than ± 0.2 log to repeat the study led.

Approximately 4 cm long specimens of the implant I1 were in a Germ suspension in 5 ml ¼ n sterile saline in sterile disposable tubes (Sarstedt 60,542,024). The specimen was in this germ suspension for 6 hours incubated. Subsequently, the specimen was removed with sterile forceps and 2 × on an agar plate (OXOID Nutrient Agar with 5% sheep blood). The specimen was then added to 5 ml of sterile 1/4 n saline inserted. The process was at 3 hourly intervals repeated until 12 hours.

The agar plates were incubated at 37 ° C for 24 hours. Subsequently, the germ count determination and the photo documentation took place. 1 shows photographs of the agar plates after 0 h, 3 h, 6 h, 9 h and 12 h. This series of tests was carried out a total of 6 times over 4 weeks after continuous elution in 1/4 n saline.

2 shows an analogous investigation series of a second inventive product I2, which was also designed as a medical implant (catheter). The second medical implant I2 was also made of a silicone base material which, unlike the first implant I1, had a surface pH of 5.7.

3 also shows an analogous investigation series of a third product I3 according to the invention. The third product I3 was likewise designed as a medical implant or as a catheter and, in addition to the silicone base material, additionally comprised 5% by weight of MoO ₃ . The third implant I3, like the second product I2, had a surface pH of 5.7.

4 shows a further series of investigations over 7 days to the antimicrobial efficacy of the three inventive medical implants I1, I2, I3 against Pseudomonas aeroginosa. Here, samples of the three implants I1, I2, I3 were daily loaded for 1 week with 107 CFU / ml of Pseudomonas aeruginosa. Subsequently, the examination was carried out as described above.

5 finally shows a direct comparison of the antimicrobial efficacy of the three inventive medical implants I1, I2 and I3 against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus. For this purpose, samples of the three implants I1, I2, I3 were incubated in the manner described above for 18 h, rinsed for 1 h in 1/4 n saline solution and then rolled out on the culture medium.

Results of the investigation of the three implants I1, I2, I3 with regard to antimicrobial efficacy and biofilm formation:
At the in 5 It was found that the two implants I2, I3 showed a substantially equal antimicrobial efficacy and led to a complete germ elimination within 9 hours. In contrast, the first implant I1 had a comparatively lower antimicrobial efficacy, which correlated with its increased surface pH. After one week of continuous elution in 1/4 n saline, these results were confirmed ( 4 ). Also in 1 to 3 (4 weeks, a total of 6 studies in continuous elution) confirm these results. No deterioration of efficacy could be detected.

at The second research method (biofilm formation) showed that in all samples biofilm formation could be prevented and after 12 hours (I2 and I3) or after 24 hours (I1) no Germ growth showed more.

The implants I2 and I3 according to the invention thus showed a very good activity even with continuous elution in 1/4 n saline. In contrast, the first implant I1 shows a lower effectiveness. However, it must be stressed that a bacterial load of 109 CFU / ml over 6 hours goes far beyond a normal bacterial load. Biofilm formation after continuous germ loading tion was prevented in all samples.

It It should be emphasized that the product according to the invention not just as an implant, but basically as any Article, for example as an exoprosthesis, cable, hose, food packaging, Household Product, Switch, Fitting, Keyboard, Mouse, Joystick, Housing, Textile, clothing or furniture designed can be.

The in the documents specified parameter values for the definition of Process and measurement conditions for characterization of specific characteristics of the subject invention are also in the context of deviations - for example due to Measurement errors, system errors, weight errors, DIN tolerances and the like - as being within the scope of the invention.

QUOTES INCLUDE IN THE DESCRIPTION

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Cited patent literature

• WO 98/36784 [0004]

Claims (11)

Product having an antimicrobial surface, characterized in that at least the surface of the product consists of a silicone base material and in contact with an aqueous medium has a surface pH of at most 6.5. Product according to claim 1, characterized that the surface pH in contact with an aqueous Medium is between 6.0 and 5.0. Product according to claim 1 or 2, characterized that the silicone base material is surface-modified. Product according to claim 3, characterized that the silicone base material silanolate, alkylhydroxide, polyvinylalcohol, Polyethylene oxide, zinc sulfate, polydimethylsiloxane, polyvinylpyrrolidone, and / or phosphorylcholine end groups. Product according to one of claims 1 to 4, characterized in that the surface at least a physically and / or chemically to the silicone base material bonded compound that is in contact with an aqueous Medium causes the formation of protons. Product according to claim 5, characterized that the compound is an essential oil and / or an organic acid and / or an inorganic acid, in particular a metal acid. Product according to claim 5 or 6, characterized that the compound has a solubility of at most 0.1 mol / L, in particular of at most 0.02 mol / L, in water has. Product according to one of claims 1 to 7, characterized in that this as a medical implant, Exoprosthesis, Cable, Hose, Food Packaging, Household Product, Switch, armature, man-machine interface, housing, Textile or furniture is formed. Product according to claim 8, characterized that this for the permanent and / or the temporary Remaining in and / or on a body of a living being, in particular of a mammal. Product according to claim 8 or 9, characterized that this as a stent and / or catheter and / or hose and / or Cannula and / or heart valve and / or joint prosthesis and / or pacemaker and / or screw and / or balloon and / or rail is formed. Product according to one of claims 1 to 10, characterized in that this at least predominantly consists of the silicone base material.