DE20200220U1 - stent - Google Patents

stent

Info

Publication number
DE20200220U1
DE20200220U1 DE20200220U DE20200220U DE20200220U1 DE 20200220 U1 DE20200220 U1 DE 20200220U1 DE 20200220 U DE20200220 U DE 20200220U DE 20200220 U DE20200220 U DE 20200220U DE 20200220 U1 DE20200220 U1 DE 20200220U1
Authority
DE
Germany
Prior art keywords
polymer
pores
stent according
stent
struts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE20200220U
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Translumina GmbH
Original Assignee
Translumina GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Translumina GmbH filed Critical Translumina GmbH
Priority to DE20200220U priority Critical patent/DE20200220U1/en
Publication of DE20200220U1 publication Critical patent/DE20200220U1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Description

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßtThe description text was not recorded electronically

Claims (19)

1. Stent mit einer Verstrebungen aufweisenden Wandung, wobei in der Wandung und/oder in den Verstrebungen Bereiche zur Aufnahme eines oder mehrerer Medikamente vorgesehen sind, dadurch gekennzeichnet, daß die Bereiche in Form von die Wandung bzw. die Verstrebungen durchdringenden Poren ausgeführt sind.1. Stent with a wall having struts, areas in the wall and / or in the struts for receiving one or more medicaments being provided, characterized in that the areas are designed in the form of pores penetrating the wall or the struts. 2. Stent nach Anspruch 1, dadurch gekennzeichnet, daß der Stent im wesentlichen zylindrisch ausgeführt ist und die Längsachse der Poren gegenüber der Längsachse des Stents vertikal oder schräg verläuft.2. Stent according to claim 1, characterized in that the stent in is essentially cylindrical and the longitudinal axis of the pores runs vertically or obliquely with respect to the longitudinal axis of the stent. 3. Stent nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß die Poren durch Laseranwendung, durch Ätzen, durch Umformverfahren oder durch Abtragsverfahren oder durch Kombinationen dieser Verfahren gefertigt sind. 3. Stent according to claim 1 or 2, characterized in that the pores through Laser application, by etching, by forming processes or by Removal processes or combinations of these processes are made.   4. Stent nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß die Wandungen der Poren im Längsschnitt eine konvexe oder konkave Gestalt annehmen und/oder daß die Poren gerade oder konisch verlaufende Wandungen aufweisen.4. Stent according to one of claims 1 to 3, characterized in that the Walls of the pores in longitudinal section have a convex or concave shape assume and / or that the pores are straight or conical Have walls. 5. Stent nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, daß in den Poren ein oder mehrere Medikamente aufgenommen sind und die Mündungen der Poren mittels eines Polymers verschlossen sind.5. Stent according to one of claims 1 to 4, characterized in that in the Pore one or more drugs are added and the Mouths of the pores are closed by a polymer. 6. Stent nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß in den Poren ein Schichtstruktur vorgesehen ist, deren einzelne Schichten abwechselnd aus einem oder mehren Medikamenten und aus Polymer bestehen.6. Stent according to one of claims 1 to 5, characterized in that in the Pores a layer structure is provided, the individual layers alternating from one or more drugs and polymer consist. 7. Stent nach Anspruch 6, dadurch gekennzeichnet, daß der Porenquerschnitt vollständig durch die Schichtstruktur ausgefüllt ist.7. Stent according to claim 6, characterized in that the pore cross section is completely filled by the layer structure. 8. Stent nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß Kanäle vorgesehen sind, die die Poren miteinander verbinden.8. Stent according to one of claims 1 to 7, characterized in that Channels are provided which connect the pores to one another. 9. Stent nach Anspruch 8, dadurch gekennzeichnet, daß die Kanäle mit einem oder mehreren Medikamenten gefüllt sind und daß die in die Poren mündenden Endbereiche der Kanäle mittels eines Polymers verschlossen sind.9. Stent according to claim 8, characterized in that the channels with a or more drugs are filled and that in the pores opening end regions of the channels closed by a polymer are. 10. Stent nach einem der Ansprüche 5 bis 9, dadurch gekennzeichnet, daß es sich bei den Polymeren um ein biokompatibles, biologisch zersetzbares Polymer, insbesondere um ein Polylactid handelt.10. Stent according to one of claims 5 to 9, characterized in that it the polymers are a biocompatible, biologically decomposable Polymer, in particular a polylactide. 11. Stent nach einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, daß wenigstens einige der Poren in ihrem Längsschnitt eine bauchförmige Gestalt aufweisen, die durch einen Mündungsbereich geringeren Durchmessers und einen ausbauchenden Bereich größeren Durchmessers gekennzeichnet ist.11. Stent according to one of claims 1 to 10, characterized in that at least some of the pores in their longitudinal section have a bulbous shape  have, which through a mouth region of smaller diameter and a bulging area of larger diameter is marked. 12. Stent nach Anspruch 11, dadurch gekennzeichnet, daß in den Poren Polymer und Medikament enthaltende Teilchen aufgenommen sind, deren äußere Schicht aus einem Polymer, vorzugsweise aus einem Polymer nach Anspruch 10, besteht und in deren Inneren ein oder mehrere Medikamente aufgenommen sind, wobei der kleinste Durchmesser der Teilchen über dem Durchmesser des Mündungsbereichs liegt.12. Stent according to claim 11, characterized in that polymer in the pores and drug-containing particles are included, the outer Layer of a polymer, preferably of a polymer according to claim 10, and there are one or more drugs inside are recorded, the smallest diameter of the particles above that Diameter of the mouth area is. 13. Stent nach Anspruch 12, dadurch gekennzeichnet, daß im Inneren der Teilchen mehrere aufeinanderfolgende Schichten aus Polymer und Medikament angeordnet sind.13. Stent according to claim 12, characterized in that inside the Particles of several successive layers of polymer and Drug are arranged. 14. Stent nach einem der Ansprüche 1 bis 13, dadurch gekennzeichnet, daß die Poren in den Bereichen der Verstrebungen aufgenommen sind, die sich in Längsrichtung des Stents erstrecken.14. Stent according to one of claims 1 to 13, characterized in that the Pores are included in the areas of the struts that are in Extend the longitudinal direction of the stent. 15. Stent nach einem der Ansprüche 1 bis 14, dadurch gekennzeichnet, daß die Poren in den Bereichen der Verstrebungen aufgenommen sind, die sich in Umfangsrichtung des Stents erstrecken.15. Stent according to one of claims 1 to 14, characterized in that the Pores are included in the areas of the struts that are in Extend circumferential direction of the stent. 16. Stent mit einer Verstrebungen aufweisenden Wandung, wobei in der Wandung und/oder in den Verstrebungen Bereiche zur Aufnahme von Medikamenten vorgesehen sind, dadurch gekennzeichnet, daß die Bereiche als Ausnehmungen ausgebildet sind, die einen Mündungsbereich geringeren Durchmessers und einen ausbauchenden Bereich größeren Durchmessers aufweisen. 16. Stent with a wall having struts, wherein in the Wall and / or areas in the struts for receiving Medication are provided characterized, that the areas are formed as recesses that one Mouth area of smaller diameter and a bulging Have area of larger diameter.   17. Stent nach Anspruch 16, dadurch gekennzeichnet, daß die Ausnehmungen durch eine Kombination aus Laseranwendung und Ätzen hergestellt sind und der Mündungsbereich abgerundete Kanten aufweist.17. Stent according to claim 16, characterized in that the recesses are produced by a combination of laser application and etching and the mouth region has rounded edges. 18. Stent nach Anspruch 16 oder 17, dadurch gekennzeichnet, daß in den Ausnehmungen Polymer und Medikament aufweisende Teilchen aufgenommen sind, deren äußere Schicht aus einem Polymer, vorzugsweise aus einem Polymer nach Anspruch 10 besteht und in deren Inneren ein oder mehrere Medikamente aufgenommen sind, wobei der kleinste Durchmesser der Teilchen über dem größten Durchmesser der Mündungen der Ausnehmungen liegt.18. Stent according to claim 16 or 17, characterized in that in the Particles containing polymer and drug are included, the outer layer of a polymer, preferably consists of a polymer according to claim 10 and inside or a several drugs are included, the smallest diameter of the particles over the largest diameter of the mouths of the Recesses. 19. Stent nach Anspruch 16 oder 17, dadurch gekennzeichnet, daß in den Ausnehmungen Polymer und Medikament aufweisende Teilchen aufgenommen sind, wobei das Polymer vorzugsweise aus einem Polymer nach Anspruch 10 besteht, wobei das Medikament in einer Polymermatrix verteilt ist und wobei der kleinste Durchmesser der Teilchen über dem größten Durchmesser des Mündungsbereichs der Ausnehmungen liegt.19. Stent according to claim 16 or 17, characterized in that in the Particles containing polymer and drug are included, the polymer preferably being a polymer of claim 10, wherein the medicament is in a polymer matrix is distributed and the smallest diameter of the particles over the largest Diameter of the mouth area of the recesses.
DE20200220U 2002-01-08 2002-01-08 stent Expired - Lifetime DE20200220U1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE20200220U DE20200220U1 (en) 2002-01-08 2002-01-08 stent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE20200220U DE20200220U1 (en) 2002-01-08 2002-01-08 stent

Publications (1)

Publication Number Publication Date
DE20200220U1 true DE20200220U1 (en) 2002-03-21

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE20200220U Expired - Lifetime DE20200220U1 (en) 2002-01-08 2002-01-08 stent

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003015664A1 (en) * 2001-08-20 2003-02-27 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
WO2004043510A1 (en) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
WO2004087011A2 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
DE10320262A1 (en) * 2003-05-07 2004-12-02 Meko Laserstrahl-Materialbearbeitungen E.K. Process for producing a medical implant and an implant produced in this way
EP1604697A1 (en) * 2004-06-09 2005-12-14 J.A.C.C. GmbH Implantable device
EP1635893A2 (en) * 2003-06-05 2006-03-22 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
DE102007060497A1 (en) 2007-12-06 2009-06-10 Joline Gmbh & Co. Kg Implantable vascular support
US7658758B2 (en) 2001-09-07 2010-02-09 Innovational Holdings, Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US7758636B2 (en) 2002-09-20 2010-07-20 Innovational Holdings Llc Expandable medical device with openings for delivery of multiple beneficial agents
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US7850728B2 (en) 2000-10-16 2010-12-14 Innovational Holdings Llc Expandable medical device for delivery of beneficial agent
US7896912B2 (en) 1998-03-30 2011-03-01 Innovational Holdings, Llc Expandable medical device with S-shaped bridging elements
EP2289571A1 (en) * 2003-03-28 2011-03-02 Conor Medsystems, Inc. Implantable medical device with beneficial agent concentration gradient
EP1402849B2 (en) † 2002-09-20 2011-03-16 Abbott Laboratories Vascular Enterprises Limited Stent with rough surface and its manufacturing method
US8197881B2 (en) 2003-09-22 2012-06-12 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US8291854B2 (en) 2003-04-17 2012-10-23 Translumina Gmbh Device for applying active substances to surfaces of medical implants, in particular stents

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7896912B2 (en) 1998-03-30 2011-03-01 Innovational Holdings, Llc Expandable medical device with S-shaped bridging elements
US8206435B2 (en) 1998-03-30 2012-06-26 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US8052735B2 (en) 1998-03-30 2011-11-08 Innovational Holdings, Llc Expandable medical device with ductile hinges
US7850728B2 (en) 2000-10-16 2010-12-14 Innovational Holdings Llc Expandable medical device for delivery of beneficial agent
US8187321B2 (en) 2000-10-16 2012-05-29 Innovational Holdings, Llc Expandable medical device for delivery of beneficial agent
US7850727B2 (en) 2001-08-20 2010-12-14 Innovational Holdings, Llc Expandable medical device for delivery of beneficial agent
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
WO2003015664A1 (en) * 2001-08-20 2003-02-27 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US7658758B2 (en) 2001-09-07 2010-02-09 Innovational Holdings, Llc Method and apparatus for loading a beneficial agent into an expandable medical device
EP1402849B2 (en) † 2002-09-20 2011-03-16 Abbott Laboratories Vascular Enterprises Limited Stent with rough surface and its manufacturing method
US7758636B2 (en) 2002-09-20 2010-07-20 Innovational Holdings Llc Expandable medical device with openings for delivery of multiple beneficial agents
US8349390B2 (en) 2002-09-20 2013-01-08 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US9254202B2 (en) 2002-09-20 2016-02-09 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
EP2338538A1 (en) * 2002-11-08 2011-06-29 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
WO2004043510A1 (en) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
EP2289572A3 (en) * 2003-03-28 2012-04-04 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
WO2004087011A2 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US8449901B2 (en) 2003-03-28 2013-05-28 Innovational Holdings, Llc Implantable medical device with beneficial agent concentration gradient
EP2289571A1 (en) * 2003-03-28 2011-03-02 Conor Medsystems, Inc. Implantable medical device with beneficial agent concentration gradient
WO2004087011A3 (en) * 2003-03-28 2004-12-16 Conor Medsystems Inc Therapeutic agent delivery device with controlled therapeutic agent release rates
US8291854B2 (en) 2003-04-17 2012-10-23 Translumina Gmbh Device for applying active substances to surfaces of medical implants, in particular stents
DE10320262A1 (en) * 2003-05-07 2004-12-02 Meko Laserstrahl-Materialbearbeitungen E.K. Process for producing a medical implant and an implant produced in this way
EP1635893A4 (en) * 2003-06-05 2010-07-07 Conor Medsystems Inc Drug delivery device and method for bi-directional drug delivery
EP1635893A2 (en) * 2003-06-05 2006-03-22 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
US8197881B2 (en) 2003-09-22 2012-06-12 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
EP1604697A1 (en) * 2004-06-09 2005-12-14 J.A.C.C. GmbH Implantable device
WO2005120393A3 (en) * 2004-06-09 2006-06-08 J A C C Gmbh Implantable device for drug delivery and improved visibility
EP2364677A1 (en) 2007-12-06 2011-09-14 Translumina GmbH Implantable vessel support
DE102007060497A1 (en) 2007-12-06 2009-06-10 Joline Gmbh & Co. Kg Implantable vascular support

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