DE19834812A1 - Use of sterol derivatives, e.g., dihydrocholesterol, to strengthen the barrier function of skin, e.g., to protect against drying of skin and associated skin aging - Google Patents

Abstract

Use of a sterol derivative in cosmetic or dermatological preparations for strengthening the barrier function of skin is new.

Description

The present invention relates to the use of sterol derivatives in cosmetic and dermatological preparations for strengthening the barrier function of the skin.

The skin is the largest organ in humans. Among its many features (for example for heat regulation and sensory organ) is the barrier function, the drying out of the Skin (and ultimately the entire organism) prevents, probably the most important. equal In time, the skin acts as a protective device against the ingress and the absorption of au ßen coming substances. This barrier function is caused by the epidermis, which as outermost layer forms the actual protective cover against the environment. With about one Tenth of the total thickness is at the same time the thinnest layer of the skin.

The epidermis is a stratified tissue in which the outer layer, the horny layer (Stratum corneum), which represents the barrier function important part. She is in the Kon worn out with the environment and is therefore in a constant renewal process, whereby outwardly continuously fine scales are released and from the inside ver horntes cell and lipid material is reproduced.

The skin model of Elias (P.M. Elias, Structure and Funcfion of the Stratum Corneum Permeability Barrier, Drug Dev. Res. 13, 1988, 97-105) describes the horny layer as a two-component system, similar to a brick wall (Bricks and mortar model). In this model, the horny cells (corneocytes) correspond the bricks, the complex composite lipid membrane in the Intercellular spaces correspond to the mortar. This system essentially provides one physical barrier to hydrophilic substances, but can due to its narrow and multi-layered structure equally difficult for lipophilic substances  to be passed. The special structure of the horny layer protects both the skin and On the other hand, it stabilizes its own flexibility by binding a defined one Amount of water.

Also mechanical loads, such as pressure, impact or shear forces, Kings to a surprising degree through the horny layer alone or in combination with the deeper ones Skin layers are intercepted. Greater pressure, turning or shearing forces are transmitted the interlocking of the epidermis with the corium is passed on to deeper skin layers.

The regulation of water and moisture content is one of the most important functions the epidermal lipid membrane. However, not only does it have a barrier against ex ternal chemical and physical influences, but also contributes to the cohesion of Horny layer at.

The lipids of the horny layer consist essentially of ceramides, free fatty acids, Cholesterol and cholesterol sulfate and are distributed over the entire horny layer. The Zu composition of these lipids is responsible for the intact function of the epidermal barrier and thus crucial for the impermeability of the skin.

Already with a cleaning of the skin with the help of a simple water bath - without addition of surfactants - there is initially a swelling of the horny layer of the skin. The degree this swelling depends u. a. from the duration of the bath and its temperature. Gleichzei Tig are water-soluble substances washed off or washed out, such as. B. water-soluble Dirt components, but also the skin's own substances that are responsible for the water binding capacity the horny layer are responsible. By skin's own surface-active substances In addition, skin fats also dissolved and washed out to a certain extent. This conditionally after initial swelling, subsequent dehydration of the skin by washing active additives can be significantly enhanced.

In healthy skin, these processes are generally trivial, since the protective mecha skin disorders such minor disorders of the upper skin layers readily com can pensieren. But even in the case of non-pathological deviations from normal tus, z. B. by environmental wear or irritation, photodamage, Al skin, etc., the protective mechanism on the skin surface is disturbed.  

In old skin, for example, the regenerative renewal slows down, in particular especially the water binding capacity of the horny layer decreases. It becomes inflexible bad, dry and cracked ("physiologically" dry skin). A barrier damage is the result. The skin becomes susceptible to negative environmental influences such as the invasion of microorganisms, Toxins and allergens. As a result, it can even turn into toxic or allergic skin come.

In the case of pathologically dry and sensitive skin, barrier damage is a priori. Epidermal intercellular lipids are apparently incorrect or in insufficient quantity or Composition formed. The consequence is an increased permeability of the horn layer and insufficient protection of the skin from loss of hygroscopic sub punching and water.

The barrier effect of the skin can be determined by determining the transepidermal water ratio (TEWL - transepiderma) water loss). It refers to the evaporation of water from the inside of the body without the involvement of the water loss while sweating. The determination of the TEWL value has proven to be extraordinary is informative and can be used to diagnose cracked or chapped skin, to determine the compatibility of chemically differently structured surfactants and the like be used.

For the beauty and nourishment of the skin is the water content in the uppermost skin layer of utmost importance. You can do it to a limited extent by Einbrin conditions of moisture regulators favorably influence.

Anionic surfactants, which are generally constituents of cleaning preparations can increase the pH in the stratum corneum long-lasting, causing regenerative Processes that serve to restore and renew the barrier function of the skin, severely handicapped. In this case arises in the horny layer between regeneration and the loss of essential substances by regular extraction a new, often very unfavorable state of equilibrium, the external appearance of the skin and the Physiological functioning of the horny layer significantly impaired.

Skincare in the sense of the present invention is to be understood in the first place that the natural function of the skin as a barrier against environmental influences (eg dirt, Chemi  microorganisms) and against the loss of endogenous substances (eg water, Lipids, electrolytes) is strengthened or restored.

Products for the care, treatment and cleaning of dry and stressed skin are on known. However, their contribution to the regeneration of a physiologically intact, hydra tized and smooth horny layer and limited in time.

The effect of ointments and creams on the barrier function and hydration of the horn layer is essentially based on the coverage (occlusion) of the treated skin districts. The ointment or cream is, so to speak, a (second) artificial barrier that to prevent the loss of water of the skin. Accordingly, this physical Barrier - for example, with cleaning agents - are removed again, causing the original, impaired state is achieved again. In addition, the Reduce skin care effect with regular treatment. After discontinuing the Product application quickly returns the skin to the pre-treatment condition start back. For certain products, the condition of the skin deteriorates Circumstances even temporarily. A sustainable product effect is usually so not achieved or only to a limited extent.

The effect of some pharmaceutical preparations on the barrier function of the skin stands even in a selective barrier damage that allows soff active substances in or through the skin into the body. A disturbed appearance of the Skin is partially accepted as a side effect in part.

The effect of nourishing cleansing products is essentially efficiencies Regenerating with sebum lipid-like substances. By the simultaneous reduction tion of the surfactant content of such preparations can be the damage to the horny layer continue to limit the barrier.

However, the prior art lacks preparations which are the barrier function and hydration of the horny layer positively affect and the physical-che mix properties of the horny layer and in particular the intercellular lamellae strengthen or even restore larlipids.  

Object of the present invention was therefore to eliminate the disadvantages of the prior art. In particular, skin care preparations and skin cleansing preparations should be provided which retain or restore the barrier properties of the skin, especially when the natural regeneration of the skin is insufficient. They should also be suitable for the treatment and prophylaxis of secondary damage of skin drying, such as fissures or inflammatory or allergic Pro processes or even eczema. It was also an object of the present invention to provide stable skin-care cosmetic and / or dermatological agents which protect the skin from environmental influences such as sun and wind. In particular, the effect of the preparations should be physiological, fast and sustainable. These objects are achieved surprisingly and unforeseeably for the person skilled in the art
the use of at least one sterol derivative in cosmetic or dermatological preparations to enhance the barrier function of the skin.

Under "barrier strengthening" or "strengthening the barrier function of the skin" is in the sense of in particular the following effect: The invention used agents interact with the lipids of the horny layer in such a way that the An Order of these lipids in the horny layer at the molecular level is improved. this leads to to the fact that the natural function of the skin as a barrier against environmental influences and against the loss of endogenous substances is strengthened or restored.

The preparations according to the invention are extremely satisfactory preparations in every respect. It was not foreseeable for the skilled person that the erfindungsge MAESSEN preparations

• - better maintain or restore the barrier properties of the skin,
• - better counteract skin dehydration,
• - Act better against aging skin and
• - Protect the skin better from environmental influences
  as the preparations of the prior art.

Advantageous in the context of the present invention, for example, derivatives of naturli chen, nature-identical and synthetically accessible sterols used.  

The invention also relates in particular to the use of hydrogenated derivatives said sterols. Advantageously used sterol derivatives can, for. In the 5/6 Position, 7/8 position and / or 8/9 position be hydrogenated. Preference is given to the dihydro derivatives, in particular the 5/6 dihydro derivatives.

Furthermore, the dehydro derivatives of the sterols are also advantageous to use, in especially the 7-dehydroderivatives. Preference is given to dehydrocholesterol, dehydrolano sterol and 7-dehydrocholesterol.

Advantageously to use sterol derivatives, which are also in hydrogenated forms, in particular in Dihydroformen or dehydoform forms are such derivatives by sub Substitution of the 3-hydroxy group of sterols are available.

Preferred derivatives to be used according to the invention are obtainable by reacting the 3-OH groups with inorganic acids or with alcohols, ie esterifying or etherifying them, or else reacting with amines, a substituted one being substituted by the sterol-3-OH group 3-amino group of the sterol skeleton gives:

• - The sterol-3-OH group can, for example, with inorganic acids such as sulfur acid and / or phosphoric acid are esterified. Preferably, the sulfates, esp special z. B. cholesteryl-3-sulfate used.
• - The 3-OH group may also be etherified with alcohols. Preferably z. B. straight-chain and / or branched, saturated and / or mono- to fivefold, preferably example, mono- or diunsaturated monoalcohols having 1 to 40, in particular 1 to 20 carbon atoms used.
• The 3-OH group can also be etherified with polyols. Preferred is its use from straight-chain and / or branched, saturated and / or mono- to fivefold, preferably example, mono- or diunsaturated polyhydroxyalkanols having 2 to 8, preferably 2 to 6, in particular 2 or 3 hydroxy groups. Preference is given to glyceryl lanolate and the sterol ethers obtainable with sorbitol, mannitol or xylitol, in particular those of Used cholesterol.  
• The 3-OH group may also be substituted with cycloalkyl groups, optionally with one or more two or more, hydroxy groups may be substituted, be etherified. The cyclo Alkyl groups may have 4 to 8, in particular 6 carbon atoms and optionally to each the C atom carry a hydroxy group.
• - The 3-OH group can be further substituted with glycosidically bound sugar residues be, for example, mono-, di- or oligosaccharides with preferably 2 or 3 Sugar residues. Suitable saccharides, especially monosaccharides, are trioses, Tetroses, pentoses or hexoses, of which in particular the pentoses and hexoses. Glucose and fructose are particularly preferred. In particular, cholesterol glucoside is preferably used.
• Suitable 3-OH derivatives are furthermore the ethoxylates, eg. As those with ethylene oxide ketone with an E / O number of 1 to 200, in particular 5 to 150 are preferred Choleth-20, Dihydrocholet-30, Laneth-5 to -50, PEG-50-Lanolin to PEG-150-Lanolin, PEG-5 soyasterol to PEG-50 sojasterol, PEG-5 tall oil sterol ether used.
• Suitable 3-OH derivatives are furthermore the propoxylates, eg. For example, those with a P / O number from 1 to 200, in particular from 5 to 30. Preference is given to PPG-5-lanolin wax, PPG-5 Lanonlin alcohol ethers to PPG-30 lanolin alcohol ether.
• Also suitable are the mixed ethoxylate propoxylates of the 3-OH group. Suitable ethoxylate or propoxylate radicals may each have 1 to 100, preferably 10 to 100, of these radicals. Preferred mixed (E / O) _n (P / O) _m chains with the numerical values for n and m given above are PPG-12-PEG-50-lanolin and PPG-40-PEG-60-lanolin oil ,

Particularly preferred for the purposes of the present invention are the above be used derivatives of cholesterol.

It is particularly advantageous for the purposes of the present invention to use the following sterol derivatives:

Very particular preference is given to the use according to the invention of glyceryl lanolate and ethoxylated sterol derivatives.

The cosmetic or dermatological preparations or formu Alloys can be composed as usual and for treatment, care and the cleansing of the skin and / or the hair and as a make-up product in the decorative Cosmetics serve. Accordingly, they can, for example, depending on their structure, verwen be used as skin protection cream, cleansing milk, sunscreen lotion, nutrient cream, Day or night cream, etc. It may be possible and advantageous, the inventive to use appropriate preparations as a basis for pharmaceutical formulations the. The preparations according to the invention contain, for. B. 0.001 to 10 wt .-%, before from 0.01 wt .-% to 1 wt .-%, in particular but 0.1 wt .-% to 0.5 wt .-%, respectively based on the total weight of the preparations of the Wirk according to the invention materials.

Also favorable are those cosmetic and dermatological preparations which are used in the Form of a sunscreen. Preferably, these contain next to one or more active substances according to the invention at least one UV-A filter substance and / or at least one UV-B filter substance and / or at least one inorganic Pigment.

But it is also advantageous for the purposes of the present invention, such cosmetic and dermatological preparations the main purpose of which is not the Protection from sunlight, but still a content of UV-protective substances  contain. So z. B. in day creams usually UV-A or UV-B filter substances incorporated.

The cosmetic and dermatological preparations according to the invention can kos Contain metic excipients, such as those commonly used in such preparations be, for. As preservatives, bactericides, perfumes, substances to prevent the Foaming, dyes, pigments having a coloring effect, thickening agents, surface-active substances, emulsifiers, softening, moistening and / or moisturizing substances, fats, oils, waxes or other common ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, Foam stabilizers, electrolytes, organic solvents or silicone derivatives.

The quantities of cosmetic, dermatological or medical Depending on the nature of each Pro be easily determined by the expert by simple trial and error.

Preparations for the treatment and care of the skin are particularly preferred.

For use, the cosmetic and dermatological according to the invention Preparations in the usual way for cosmetics on the skin and / or hair in out ample amount applied.

Cosmetic and dermatological preparations according to the invention can be used in various ways forms are available. So they can z. B. a solution, an anhydrous preparation, a Water-in-oil (W / O) or oil-in-water emulsion or microemulsion (O / W), a multiple emulsions, for example of the water-in-oil-in-water type (W / O / W), a gel, a solid stick, an ointment or even an aerosol. It is also advantageous to present the active compounds according to the invention in encapsulated form, for. B. in collagen matrices and other common encapsulating materials, e.g. B. as Cellulosever encapsulated in gelatin, wax matrices or liposomally encapsulated.

It is also possible and advantageous for the purposes of the present invention, the erfindungsge Mäß agents in aqueous systems or surfactant preparations for cleaning the skin and to insert the hair.  

In particular, the inventive cosmetic and dermatological Zube preparations also contain antioxidants. According to the invention as a cheap antioxidant All suitable for cosmetic and / or dermatological applications ge common antioxidants are used.

Advantageously, the antioxidants are selected from the group consisting of amino acids (eg, glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg, urocaninic acid) and their derivatives, peptides such as D, L-carnosine, D Carnosine, L-carnosine and their derivatives (eg anserine), carotenoids, carotenes (eg α-carotene, β-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and derivatives thereof ( eg dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (eg thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, Butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and also Sulfoximine compounds (eg, buthionine sulfoximines, homocysteine sulfoximine, buthionine sulfones, penta, hexa, heptathionine sulfoximine) in very low tolerated dosages (e.g. Pmol to μmol / kg), furthermore (metal) chelators (eg α-hydroxyfatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (eg citric acid, lactic acid, malic acid), humic acid, bile acid, Bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg γ-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (eg, ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (eg, vitamin E acetate), vitamin A and derivatives (vitamin A palmitate), as well as coniferyl benzoate of benzoin, rutinic acid, and their derivatives , α-glycosylrutin, ferulic acid, furfurylideneglucitol, carnosine, butylhydroxytoluene, butylhydroxy anisole, nordihydroguaiacetic acid, nordihydroguiaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (eg ZnO, ZnSO ₄ ), selenium and its derivatives (e.g. B. selenium methionine), stilbenes and their derivatives (eg stilbene oxide, trans-stilbene oxide) and the present invention suitable Deriva te (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these genann th drugs.

The amount of the aforementioned antioxidants (one or more compounds) in the inventions The preparations according to the invention are preferably from 0.001 to 30% by weight, especially be preferably 0.05-20% by weight, in particular 1-10% by weight, based on the total weight the preparation.

If vitamin E and / or its derivatives represent the antioxidant (s) is present Partly, their respective concentrations from the range of 0.001-10 wt .-%, based on the total weight of the formulation to choose.

If vitamin A, or vitamin A derivatives, or carotenes or their derivatives, the one or more Antioxidants represent advantageous, their respective concentrations from the field from 0.001-10% by weight, based on the total weight of the formulation.

The following examples are intended to illustrate the present invention, without her zuschränken. The numerical values in the examples are by weight, based on the total weight of the respective preparations.  

example recipes 1. lecithin fluid

Wt .-% lecithin 5.00 Laneth-20 0.50 cetearyl 1.00 glycerin 3.00 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

2. hydrodispersion gel

Wt .-% stearyl 2.00 behenyl 2.00 Ceramide 3 0.20 cholesteryl 0.10 Carbopol 0.30 hydroxyethyl 0.40 glycerin 3.00 panthenol 1.00 Caprylic / Capric triglyceride 3.00 isopropyl palmitate 3.00 Shea butter 2.00 Antioxidants, Preservatives, Neutralizers, Perfume, Dyes q. s. water ad 100

3. Light gel

Wt .-% sucrose stearate 3.00 cetearyl 2.00 PEG-5 soybean oil 2.00 Carbopol 0.50 glycerin 3.00 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

4. O / W cream

Wt .-% sucrose stearate 4.00 sucrose laurate 2.00 Glyceryllanofat 2.00 cetearyl 3.00 glycerin 3.00 Dimethicone 2.00 mineral oil 5.00 isopropyl palmitate 3.00 Sunflower oil 3.00 Hydrogenated coconut fatty acid glycerides 2.50 Licorice root extract 2.00 Carbomer 0.20 45% NaOH 0.10 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

5. O / W lotion

Wt .-% stearic acid 1.50 sorbitan 0.50 PEG-5 soybean oil 2.50 Myristylalkokol 1.00 glycerol 0.50 Paraffin oil, subliquidum 10.00 Dimethicone 1.00 octyldodecanol 2.00 Hydrogenated coconut fatty acid glycerides 0.50 Carbomer 0.10 serine 0.50 glycerin 5.00 tocopherol 0.50 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

6. W / O lotion

Wt .-% PEG-7 hydrogenated castor oil 4.00 Laneth-20 1.50 beeswax 3.00 vaseline 4.00 ozokerite 4.00 Paraffin oil, subliquidum 10.00 glycerin 5.00 Octyl methoxycinnamate 2.50 Methylbenzylidene camphor 2.50 tocopherol 1.00 Magnesium sulfate 7H ₂ O 0.70 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

7. W / O cream

Wt .-% PEG-7 hydrogenated castor oil 4.00 Wool alcohol 1.50 Choleth-24 0.50 vaseline 9.00 ozokerite 4.00 Paraffin oil, subliquidum 10.00 urea 10.00 Magnesium sulfate 7H ₂ O 0.70 lactic acid 0.30 sodium lactate 2.50 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

8. Silicone emulsion

Wt .-% Dimethicone Copolyol 2.00 Cylomethicone 5.00 Dimethicone 3.00 Paraffin oil, subliquidum 8.00 Wheat germ oil 4.00 glyceryl 2.00 glycerin 10.00 sodium chloride 1.00 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

9. ointment

Wt .-% vaseline 36,00 ceresin 10.00 zinc oxide 4.00 Wheat germ oil 20.00 glyceryl 2.00 cholesteryl 0.02 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. paraffin oil ad 100

10. Skin oil

Wt .-% cetyl palmitate 3.00 C _12-15 alkyl benzoate 2.00 polyisobutene 10.00 squalane 2.00 Laneth-40 2.00 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. paraffin oil ad 100

11. bath oil

Wt .-% paraffin oil 20.00 PEG-40 Hydrogenated castor oil 5.00 Choleth-24 0.50 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. soybean oil ad 100

12. Lip balm

Wt .-% Caprylic / Capric triglyceride 25,00 octyldodecanol 25,00 Ceramide 3 0.50 PPG-5 lanolin wax 2.00 beeswax 20.00 cetyl palmitate 8.00 Jojoba oil 5.00 Carnauba wax 4.00 tocopherol 0.75 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. squalane ad 100

13. Emulsion lip balm

Wt .-% Caprylic / Capric Triglycerides 30.00 octyldodecanol 20.00 Polyglyceryl-3 dioleate 3.50 beeswax 10.00 dihydrolanosterol 1.00 C _20-40 alkyl stearate 5.00 Jojoba oil 5.00 Carnauba wax 2.00 tocopherol 0.75 water 5.00 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. squalane ad 100

14. Lipstick

Wt .-% Caprylic / Capric triglyceride 22.00 octyldodecanol 22.00 PEG-5 soyasterol 0.50 Bienenwachshydrolysat 5.00 beeswax 15.00 cetyl palmitate 2.00 Jojoba oil 5.00 Carnauba wax 2.00 tocopherol 0.75 Color pigments, lakes, titanium dioxide q. s. Antioxidants, preservatives, neutralizers, perfume, dyes q. s. squalane ad 100

15. Emulsion Makeup

Wt .-% sorbitan 1.50 sorbitan 1.00 glycerol 1.00 dihydrocholesterol 0.20 glyceryl 1.00 Paraffin oil, subliquidum 7.00 octyldodecanol 7.00 Hydrogenated coconut fatty acid glycerides 4.00 Octyl methoxycinnamate 2.00 butylmethoxydibenzoylmethane 1.00 Carbomer 0.10 glycerin 5.00 1.3 butylene glycol 2.00 tocopherol 1.00 Starch Sodium Octenyl Succinate (Amiogum ™: American Maize Products Company / CERSTAR) 2.50 magnesium silicate 1.00 mica 1.00 iron oxides 1.00 Titanium dioxide 2.50 talc 5.00 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

16. hair care products

Wt .-% TEA - Cocoyl hydrolyzed collagen 30.00 monoethanolamine 25,00 almond oil 2.00 PEG-25 soybean oil 2.00 Sodium chloride 1.00 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

17. Care shampoo

Wt .-% sodium lauryl sulfate 34,00 disodium 6.00 cocoamidopropyl 10.00 Laneth-40 2.00 glycol distearate 5.00 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

18. Pump spray

Wt .-% PEG-40 hydrogenated castor oil 2.00 glycerin 1.00 PEG-25 soybean oil 2.00 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

19. Roll-on emulsion

Wt .-% Tricetearethphosphat 0.30 octyldodecanol 2.00 C _12-15 alkyl benzoate 2.00 C _10-30 alkyl acrylate 0.15 Laneth-20 0.50 Antioxidants, preservatives, neutralizers, perfume, dyes q. s. water ad 100

Claims (4)

1. Use of at least one sterol derivative in cosmetic or dermatologi preparations for strengthening the barrier function of the skin. 2. Use according to claim 1, characterized in that the one or more used Sterol derivatives are sterol esters of inorganic acids. 3. Use according to claim 1, characterized in that the one or more used Sterol derivatives are sterol ethers. 4. Use according to one of the preceding claims, characterized in that the content of one or more sterol derivatives in the cosmetic or dermato logical preparations from the range 0.001 to 10 wt .-%, preferably 0.01 wt .-% to 1 wt .-%, but especially 0.1 wt .-% to 0.5 wt .-%, each based on the Total weight of the preparations is selected.