DE19782095T1 - DNA-Diagnose auf der Basis von Massenspektrometrie - Google Patents

DNA-Diagnose auf der Basis von Massenspektrometrie

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Publication number
DE19782095T1
DE19782095T1 DE19782095T DE19782095T DE19782095T1 DE 19782095 T1 DE19782095 T1 DE 19782095T1 DE 19782095 T DE19782095 T DE 19782095T DE 19782095 T DE19782095 T DE 19782095T DE 19782095 T1 DE19782095 T1 DE 19782095T1
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Germany
Prior art keywords
branching
well
sub
outlet
branch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19782095T
Other languages
English (en)
Inventor
Hubert Koester
Daniel P Little
Andreas Braun
David M Lough
Goubing Xiang
Den Boom Dirk Van
Christian Jurinke
Andreas Ruppert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sequenom Inc
Original Assignee
Sequenom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/744,590 external-priority patent/US6074823A/en
Priority claimed from US08/744,481 external-priority patent/US6428955B1/en
Priority claimed from US08/746,036 external-priority patent/US5900481A/en
Priority claimed from US08/786,988 external-priority patent/US7285422B1/en
Priority claimed from US08/787,639 external-priority patent/US6024925A/en
Priority claimed from US08/933,792 external-priority patent/US6133436A/en
Application filed by Sequenom Inc filed Critical Sequenom Inc
Publication of DE19782095T1 publication Critical patent/DE19782095T1/de
Ceased legal-status Critical Current

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    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00725Peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178Special arrangements of analysers
    • G01N2035/00237Handling microquantities of analyte, e.g. microvalves, capillary networks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1034Transferring microquantities of liquid
    • G01N2035/1037Using surface tension, e.g. pins or wires
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065Multiple transfer devices
    • G01N35/1067Multiple transfer devices for transfer to or from containers having different spacing
    • G01N2035/1069Multiple transfer devices for transfer to or from containers having different spacing by adjusting the spacing between multiple probes of a single transferring head
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065Multiple transfer devices
    • G01N35/1074Multiple transfer devices arranged in a two-dimensional array
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
DE19782095T 1996-11-06 1997-11-06 DNA-Diagnose auf der Basis von Massenspektrometrie Ceased DE19782095T1 (de)

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US74605596A 1996-11-06 1996-11-06
US08/744,590 US6074823A (en) 1993-03-19 1996-11-06 DNA sequencing by mass spectrometry via exonuclease degradation
US08/744,481 US6428955B1 (en) 1995-03-17 1996-11-06 DNA diagnostics based on mass spectrometry
US08/746,036 US5900481A (en) 1996-11-06 1996-11-06 Bead linkers for immobilizing nucleic acids to solid supports
US08/786,988 US7285422B1 (en) 1997-01-23 1997-01-23 Systems and methods for preparing and analyzing low volume analyte array elements
US08/787,639 US6024925A (en) 1997-01-23 1997-01-23 Systems and methods for preparing low volume analyte array elements
US08/933,792 US6133436A (en) 1996-11-06 1997-09-19 Beads bound to a solid support and to nucleic acids
US94780197A 1997-10-08 1997-10-08
PCT/US1997/020444 WO1998020166A2 (en) 1996-11-06 1997-11-06 Dna diagnostics based on mass spectrometry

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US7198893B1 (en) 2007-04-03
DE69738206D1 (de) 2007-11-22
US7501251B2 (en) 2009-03-10
EP1164203B1 (de) 2007-10-10
EP1164203A2 (de) 2001-12-19
WO1998020166A2 (en) 1998-05-14
US20090023150A1 (en) 2009-01-22
WO1998020166A3 (en) 1998-10-22
CA2270132A1 (en) 1998-05-14
US20070202514A1 (en) 2007-08-30
US20020042112A1 (en) 2002-04-11
DE69738206T2 (de) 2008-07-17
NO992168L (no) 1999-07-06
AU5106998A (en) 1998-05-29
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ATE375403T1 (de) 2007-10-15
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EP1164203A3 (de) 2002-03-13
NO992168D0 (no) 1999-05-04

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