DE1667926A1 - Process for the production of salt solutions containing radioactive gases - Google Patents

Process for the production of salt solutions containing radioactive gases

Info

Publication number
DE1667926A1
DE1667926A1 DE19681667926 DE1667926A DE1667926A1 DE 1667926 A1 DE1667926 A1 DE 1667926A1 DE 19681667926 DE19681667926 DE 19681667926 DE 1667926 A DE1667926 A DE 1667926A DE 1667926 A1 DE1667926 A1 DE 1667926A1
Authority
DE
Germany
Prior art keywords
solution
zone
radioactive gas
gas
radioactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19681667926
Other languages
German (de)
Inventor
Kramer Henry Herman
Tilbury Roy Sidney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Union Carbide Corp
Original Assignee
Union Carbide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US607894A priority Critical patent/US3509919A/en
Application filed by Union Carbide Corp filed Critical Union Carbide Corp
Priority to BE710530D priority patent/BE710530A/xx
Priority to DE19681667926 priority patent/DE1667926A1/en
Priority to NL6802467A priority patent/NL6802467A/xx
Publication of DE1667926A1 publication Critical patent/DE1667926A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47L—DOMESTIC WASHING OR CLEANING; SUCTION CLEANERS IN GENERAL
    • A47L9/00—Details or accessories of suction cleaners, e.g. mechanical means for controlling the suction or for effecting pulsating action; Storing devices specially adapted to suction cleaners or parts thereof; Carrying-vehicles specially adapted for suction cleaners
    • A47L9/20—Means for cleaning filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1206—Administration of radioactive gases, aerosols or breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Atmospheric Sciences (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (7)

PatentansprücheClaims 1. Verfahren zur Herstellung einer pharmakologisch unbedenklichen Salzlösung mit einem Gehalt eines radioaktiven Gases konstanter Konzentration, dadurch gekennzeichnet , daß man 1. Process for the preparation of a pharmacologically acceptable salt solution with a content of a radioactive one Gas of constant concentration, characterized in that one (a) ein radioaktives Gas in eine sterile, geschlossene, evakuierte Lösungszone bringt,(a) brings a radioactive gas into a sterile, closed, evacuated solution zone, (b) das radioaktive Gas in der Lösungszone in Gegenwart einer für die Herstellung einer isotonischen Salzlösung, ausreichenden Menge Natriumchlorid kondensiert,(b) the radioactive gas in the solution zone in the presence condenses an amount of sodium chloride sufficient for the production of an isotonic salt solution, (c) in die Lösungszone entgastes pharmakologisch unbedenkliches Wasser einleitet bis die Zone völlig gefüllt ist und die entstandene isotonische Lösung mit darin gelöstem radioaktiven Gas(c) introduces degassed pharmacologically safe water into the solution zone until the zone is completely filled and the resulting isotonic solution with radioactive gas dissolved in it (d) durch Einbringen eines unlöslichen, nicht toxischen und nicht pyrogenen Silikonöls niedriger Dichte aus der Lösungszone verdrängt und(d) by incorporating an insoluble, non-toxic and non-pyrogenic, low-density silicone oil displaced from the solution zone and (e) die Lösung in verschließbare sterile Patronen abfüllt, bis kein Luftraum zurückbleibt.(e) Dispense the solution into sealable sterile cartridges until no head space is left. 2. Verfahren nach Anspruch 1, dadurch gekennzeichnet , daß das radioaktive Gas Xenon 133 ist. 2. The method according to claim 1, characterized in that the radioactive gas is xenon 133. 3. Verfahren nach Anspruch 1, dadurch g e k e η η zeichnet, daß das radioaktive Gas Krypton 85 ist.3. The method according to claim 1, characterized in that g e k e η η, that the radioactive gas is krypton 85. 4. Verfahren nach Anspruch 1 bis 3, dadurch gekennzeichnet , daß die das radioaktive Gas enthaltende Salzlösung steril ist.4. The method according to claim 1 to 3, characterized in that the containing the radioactive gas Saline solution is sterile. Vom Deutschen Patentamt ohne jede Gewahr hei';':-1;'.'-'-;) Al <'..:Kt YOB Unterlagen, iUa zur iotc-iicchdnUdMB Wiedergebe nidit geeignet »lad. _ ρ _From the German Patent Office without any guarantee called ';': - 1 ; '.'-'-;) Al <' ..: Kt YOB documents, iUa not suitable for iotc-iicchdnUdMB reproduction »lad. _ ρ _ 109845/1731109845/1731 5. Verfahren nach Anspruch 1 bis 4, dadurch gekennzeichnet , daß man die Patronen in einen Aspirator einbringt, eine mit Salzlösung gespülte Injektionsspritze in die Trennwand der Patrone einführt und mit der das radioaktive Gas enthaltenden Salzlösung füllt, ohne daß eine Gasblase in die Patrone oder die Injektionsspritze eingeschleppt wird.5. The method according to claim 1 to 4, characterized in that the cartridges in an aspirator brings in, a hypodermic syringe rinsed with saline into the septum of the cartridge and with which the radioactive Gas-containing saline solution fills without a gas bubble being dragged into the cartridge or the injection syringe will. 6. Verfahren nach Anspruch 5» dadurch gekennzeichnet , daß mehr als eine Injektionsspritze bei der Abfüllung verwendet wird.6. The method according to claim 5 »characterized in that more than one injection syringe used for bottling. 7. Verfahren nach Anspruch 1, dadurch gekennzeichnet , daß man anstelle des Wassers eine entgaste pharmakologisch unbedenkliche Salzlösung in Abwesenheit von Natriumchlorid in der Lösungszone verwendet.7. The method according to claim 1, characterized in that one degassed instead of the water pharmacologically safe saline solution in the absence of sodium chloride used in the dissolution zone. Vom Deutschen Patentamt ohne Jede
Gewähr hergestellte Abcdirift τοη
Unterlagen, die zur fotomechanischen
Wiedergabe nicht geeignet «Ind. From the German Patent Office without anyone
Guarantee produced abcdirift τοη
Documents necessary for the photomechanical
Playback not suitable «Ind. F.d.R.d.A.:F.d.R.d.A .: 109845/1731109845/1731
DE19681667926 1967-01-09 1968-02-08 Process for the production of salt solutions containing radioactive gases Pending DE1667926A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US607894A US3509919A (en) 1967-01-09 1967-01-09 Production of a pharmaceutically acceptable saline solution containing a radioactive gas and use thereof
BE710530D BE710530A (en) 1967-01-09 1968-02-08
DE19681667926 DE1667926A1 (en) 1967-01-09 1968-02-08 Process for the production of salt solutions containing radioactive gases
NL6802467A NL6802467A (en) 1967-01-09 1968-02-21

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60789467A 1967-01-09 1967-01-09
DE19681667926 DE1667926A1 (en) 1967-01-09 1968-02-08 Process for the production of salt solutions containing radioactive gases
NL6802467A NL6802467A (en) 1967-01-09 1968-02-21

Publications (1)

Publication Number Publication Date
DE1667926A1 true DE1667926A1 (en) 1971-11-04

Family

ID=40445256

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19681667926 Pending DE1667926A1 (en) 1967-01-09 1968-02-08 Process for the production of salt solutions containing radioactive gases

Country Status (4)

Country Link
US (1) US3509919A (en)
BE (1) BE710530A (en)
DE (1) DE1667926A1 (en)
NL (2) NL6802467A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0864329A1 (en) * 1997-03-10 1998-09-16 Michael Dr. Georgieff Medical preparations containing a lipophile noble gas

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3190321A (en) * 1961-07-03 1965-06-22 North American Aviation Inc Process and apparatus for filling and for removing contaminants from the flotation chamber of a flotation instrument

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0864329A1 (en) * 1997-03-10 1998-09-16 Michael Dr. Georgieff Medical preparations containing a lipophile noble gas
EP0864328A1 (en) * 1997-03-10 1998-09-16 Michael Dr. Georgieff Apparatus for controlled anaesthesia, analgesia and/or sedation
WO1998040084A1 (en) * 1997-03-10 1998-09-17 Michael Georgieff Device for controlled anaesthesia, analgesia and/or sedation
WO1998040083A1 (en) * 1997-03-10 1998-09-17 Michael Georgieff Medicinal preparation containing a lipophilic inert gas
US6511453B2 (en) 1997-03-10 2003-01-28 Michael Georgieff Device for controlled anaesthesia, analgesia and/or sedation

Also Published As

Publication number Publication date
US3509919A (en) 1970-05-05
BE710530A (en) 1968-08-08
NL139241B (en)
NL6802467A (en) 1969-08-25

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