DE122006000012I1 - Lhrh antagonistische Peptide - Google Patents

Lhrh antagonistische Peptide

Info

Publication number
DE122006000012I1
DE122006000012I1 DE1996623254 DE69623254C DE122006000012I1 DE 122006000012 I1 DE122006000012 I1 DE 122006000012I1 DE 1996623254 DE1996623254 DE 1996623254 DE 69623254 C DE69623254 C DE 69623254C DE 122006000012 I1 DE122006000012 I1 DE 122006000012I1
Authority
DE
Germany
Prior art keywords
moiety
longer
peptide compound
antagonistic peptides
lhrh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE1996623254
Other languages
English (en)
Other versions
DE69623254D1 (de
DE69623254T2 (de
Inventor
W Roeske
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University Research and Technology Corp
Original Assignee
Indiana University Research and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Publication of DE122006000012I1 publication Critical patent/DE122006000012I1/de
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/23Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16Masculine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/13Luteinizing hormone-releasing hormone; related peptides
DE1996623254 1995-06-07 1996-06-07 Lhrh antagonistische Peptide Pending DE122006000012I1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/480,494 US5843901A (en) 1995-06-07 1995-06-07 LHRH antagonist peptides
PCT/US1996/009852 WO1996040757A2 (en) 1995-06-07 1996-06-07 Lhrh antagonist peptides

Publications (1)

Publication Number Publication Date
DE122006000012I1 true DE122006000012I1 (de) 2006-06-29

Family

ID=23908180

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69623254T Expired - Lifetime DE69623254T2 (de) 1995-06-07 1996-06-07 Lhrh antagonistische peptide
DE122006000012C Active DE122006000012I2 (de) 1995-06-07 1996-06-07 Lhrh antagonistische peptide
DE69535963T Expired - Lifetime DE69535963D1 (de) 1995-06-07 1996-06-07 LHRH antagonistische Peptide
DE1996623254 Pending DE122006000012I1 (de) 1995-06-07 1996-06-07 Lhrh antagonistische Peptide

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE69623254T Expired - Lifetime DE69623254T2 (de) 1995-06-07 1996-06-07 Lhrh antagonistische peptide
DE122006000012C Active DE122006000012I2 (de) 1995-06-07 1996-06-07 Lhrh antagonistische peptide
DE69535963T Expired - Lifetime DE69535963D1 (de) 1995-06-07 1996-06-07 LHRH antagonistische Peptide

Country Status (13)

Country Link
US (4) US5843901A (de)
EP (2) EP1188768B1 (de)
JP (3) JP4164125B2 (de)
AT (2) ATE432941T1 (de)
AU (1) AU715399B2 (de)
CA (1) CA2219460C (de)
DE (4) DE69623254T2 (de)
DK (2) DK1188768T3 (de)
ES (2) ES2326861T3 (de)
HK (1) HK1045161B (de)
LU (2) LU91225I2 (de)
PT (2) PT1188768E (de)
WO (1) WO1996040757A2 (de)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117175A (en) 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5780435A (en) 1995-12-15 1998-07-14 Praecis Pharmaceuticals Incorporated Methods for treating prostate cancer with LHRH-R antagonists
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
WO1998028424A2 (en) 1996-12-23 1998-07-02 Immunex Corporation Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily
US5925730A (en) 1997-04-11 1999-07-20 Ferring Bv GnRH antagonists
AU735355B2 (en) * 1997-04-15 2001-07-05 Daiichi Sankyo Company, Limited Novel protein and method for producing the protein
US6316408B1 (en) * 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
TR199902512T2 (xx) 1997-04-16 2000-06-21 Amgen Inc. Osteoprotegerin ba�lay�c� proteinler ve resept�rler.
AU770565B2 (en) * 1998-04-27 2004-02-26 Praecis Pharmaceuticals Incorporated Methods for treating hot flashes and gynaecomastia
US6217844B1 (en) * 1998-04-27 2001-04-17 Praecis Pharmaceuticals, Inc. Methods for detecting lesions in dense breast tissue using LHRH antagonists
US6191115B1 (en) * 1998-08-12 2001-02-20 Abbott Laboratories C-terminus modified heptapeptide LHRH analogs
US6455499B1 (en) * 1999-02-23 2002-09-24 Indiana University Foundation Methods for treating disorders associated with LHRH activity
US6703367B1 (en) * 1999-04-27 2004-03-09 Praecis Pharmaceuticals Inc. Methods for treating hot flashes and gynaecomastia
CZ2002421A3 (cs) * 1999-08-09 2002-09-11 Tripep Ab Prostředek pro potlačení aktivace transkripce, represe transkripce, sestavování bakteriálního holotoxinu, polymerizace aktinu, agregace beta-amyloidního peptidu, sestavování tubulínového komplexu, způsob potlačení, způsob léčby a prevence lidských chorob, Alzheimerovy choroby a rakoviny, způsob přípravy léčiva a léčivo
CA2349406C (en) * 1999-09-03 2011-01-11 Amgen Inc. Compositions and methods for the prevention or treatment of cancer and bone loss associated with cancer
US20030103978A1 (en) 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
US7109171B2 (en) 2000-02-28 2006-09-19 Praecis Pharmaceuticals Inc. Methods for treating FSH related conditions with GnRH antagonists
AU2001267872A1 (en) 2000-06-30 2002-01-14 Suntory Limited Novel gonadotropin-releasing hormone, precursor peptides thereof and genes encoding the same
US6598784B2 (en) * 2000-12-20 2003-07-29 Meadwestvaco Packaging Syatens, Llc Beverage carton with strap type carrying handle
AU2002235348A1 (en) * 2001-01-17 2002-07-30 Praecis Pharmaceuticals Inc. Methods for treating hormone associated conditions using a combination of lhrh antagonists and specific estrogen receptor modulators
SI3351246T1 (sl) 2001-02-19 2019-08-30 Novartis Pharma Ag Derivat rapamicina za zdravljenje trdnega tumorja, povezanega z deregulirano angiogenezo
NZ529145A (en) 2001-05-16 2005-07-29 Novartis Ag Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)- 2pyrimidine-amine and a chemotherapeutic agent
AU2002324447B2 (en) 2001-06-22 2006-06-29 Durect Corporation Zero-order prolonged release coaxial implants
ES2907826T3 (es) 2001-06-26 2022-04-26 Amgen Inc Anticuerpos para OPGL
US6593455B2 (en) * 2001-08-24 2003-07-15 Tripep Ab Tripeptide amides that block viral infectivity and methods of use thereof
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
US7718776B2 (en) 2002-04-05 2010-05-18 Amgen Inc. Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors
MXPA04011384A (es) 2002-05-16 2005-02-14 Novartis Ag Uso de agentes de union del receptor edg en cancer.
US6861236B2 (en) 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
NZ564694A (en) 2003-04-22 2009-11-27 Sod Conseils Rech Applic Peptide vectors
GB0320806D0 (en) 2003-09-05 2003-10-08 Astrazeneca Ab Therapeutic treatment
JP4407322B2 (ja) * 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
KR20080083220A (ko) 2004-04-07 2008-09-16 노파르티스 아게 Iap 억제제
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
WO2006077428A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
GT200600430A (es) 2005-09-27 2007-05-21 Compuestos de carboxiamina y metodos de uso de los mismos
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
GB0605120D0 (en) 2006-03-14 2006-04-26 Novartis Ag Organic Compounds
EP2272511A1 (de) 2006-05-09 2011-01-12 Novartis AG Kombination aus einem Eisenchelatbildner und einem anti-neoplastischen Mittel und ihre Verwendung
JP2010504933A (ja) 2006-09-29 2010-02-18 ノバルティス アーゲー Pi3k脂質キナーゼ阻害剤としてのピラゾロピリミジン
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
KR20090110913A (ko) 2007-02-15 2009-10-23 노파르티스 아게 Lbh589와 암을 치료하기 위한 다른 치료제와의 조합물
WO2009118292A1 (en) 2008-03-24 2009-10-01 Novartis Ag Arylsulfonamide-based matrix metalloprotease inhibitors
NZ588069A (en) 2008-03-26 2012-06-29 Novartis Ag Hydroxamate-based inhibitors of deacetylases b
EP2370076B1 (de) * 2008-11-28 2017-01-04 Novartis AG Pharmazeutische Zusammensetzung enthaltend einen Hsp 90-Inhibitor und einen mTOR-Inhibitor
WO2010083617A1 (en) 2009-01-21 2010-07-29 Oncalis Ag Pyrazolopyrimidines as protein kinase inhibitors
WO2010085145A1 (en) 2009-01-22 2010-07-29 Maatschap Interne Geneeskunde Rijnstate Method for the prophylaxis or treatment of flushing
EP2391366B1 (de) 2009-01-29 2012-11-28 Novartis AG Substituierte benzimidazole zur behandlung von astrozytomen
AU2010264698C1 (en) 2009-06-26 2013-05-16 Novartis Ag 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of CYP 17
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
BR112012003262A8 (pt) 2009-08-12 2016-05-17 Novartis Ag compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação
EP2467383A1 (de) 2009-08-20 2012-06-27 Novartis AG Heterocyclische oximverbindungen
US20120149661A1 (en) 2009-08-26 2012-06-14 Novartis Ag Tetra-substituted heteroaryl compounds and their use as mdm2 and/or mdm4 modulators
JP2013504543A (ja) 2009-09-10 2013-02-07 ノバルティス アーゲー 二環ヘテロアリール類のエーテル誘導体
JP5466767B2 (ja) 2009-11-04 2014-04-09 ノバルティス アーゲー Mek阻害剤として有用なヘテロ環式スルホンアミド誘導体
JP2013512215A (ja) 2009-11-25 2013-04-11 ノバルティス アーゲー 二環式ヘテロアリールのベンゼン縮合6員酸素含有ヘテロ環誘導体
US8614239B2 (en) 2009-12-08 2013-12-24 Novartis Ag Heterocyclic sulfonamide derivatives
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
CU24130B1 (es) 2009-12-22 2015-09-29 Novartis Ag Isoquinolinonas y quinazolinonas sustituidas
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
SG177783A1 (en) 2010-07-09 2012-02-28 Smart Communications Inc Content provision system and method
US8946260B2 (en) 2010-09-16 2015-02-03 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
US20130324526A1 (en) 2011-02-10 2013-12-05 Novartis Ag [1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
US20130338152A1 (en) 2011-03-08 2013-12-19 Irm Llc Fluorophenyl bicyclic heteroaryl compounds
AU2012249421B9 (en) 2011-04-28 2015-10-22 Novartis Ag 17alpha-hydroxylase/C17,20-lyase inhibitors
KR20140034898A (ko) 2011-06-09 2014-03-20 노파르티스 아게 헤테로시클릭 술폰아미드 유도체
EP2721008B1 (de) 2011-06-20 2015-04-29 Novartis AG Hydroxy substituierte isochinolinone als p53 (mdm2 or mdm4) inhibitoren
US8859586B2 (en) 2011-06-20 2014-10-14 Novartis Ag Cyclohexyl isoquinolinone compounds
MX2013015001A (es) 2011-06-27 2014-03-31 Novartis Ag Formas solidas y sales de derivados de tetrahidro-pirido-pirimidin a.
JP5957526B2 (ja) 2011-09-15 2016-07-27 ノバルティス アーゲー チロシンキナーゼとしての6−置換3−(キノリン−6−イルチオ)−[1,2,4]トリアゾロ[4,3−a]ピラジン
US8969341B2 (en) 2011-11-29 2015-03-03 Novartis Ag Pyrazolopyrrolidine compounds
LT2794600T (lt) 2011-12-22 2018-02-26 Novartis Ag 2,3-dihidro-benzo[1,4]oksazino dariniai ir giminingi junginiai kaip fosfoinozitido-3 kinazės (pi3k) inhibitoriai, skirti gydymui, pavyzdžiui, reumatoidinio artrito
WO2013093850A1 (en) 2011-12-22 2013-06-27 Novartis Ag Quinoline derivatives
KR20140107574A (ko) 2011-12-23 2014-09-04 노파르티스 아게 Bcl2와 결합 파트너의 상호작용을 억제하기 위한 화합물
US9126980B2 (en) 2011-12-23 2015-09-08 Novartis Ag Compounds for inhibiting the interaction of BCL2 with binding partners
BR112014015322A2 (pt) 2011-12-23 2017-06-13 Novartis Ag compostos e composições para inibir a interação de bcl2 com parceiros de ligação
WO2013096055A1 (en) 2011-12-23 2013-06-27 Novartis Ag Compounds for inhibiting the interaction of bcl2 with binding partners
US20140350014A1 (en) 2011-12-23 2014-11-27 Novartis Ag Compounds for inhibiting the interaction of bcl2 with binding partners
JO3357B1 (ar) 2012-01-26 2019-03-13 Novartis Ag مركبات إيميدازوبيروليدينون
US9365576B2 (en) 2012-05-24 2016-06-14 Novartis Ag Pyrrolopyrrolidinone compounds
JP6427097B2 (ja) 2012-06-15 2018-11-21 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. 癌を処置するための組成物および該組成物を製造するための方法
PL2903968T3 (pl) 2012-10-02 2017-05-31 Gilead Sciences, Inc. Inhibitory demetylaz histonowych
TW201422625A (zh) 2012-11-26 2014-06-16 Novartis Ag 二氫-吡啶并-□衍生物之固體形式
US9403827B2 (en) 2013-01-22 2016-08-02 Novartis Ag Substituted purinone compounds
EP2948453B1 (de) 2013-01-22 2017-08-02 Novartis AG Pyrazolo[3,4-d]pyrimidinonverbindungen als inhibitoren der p53/mdm2-interaktion
WO2014128612A1 (en) 2013-02-20 2014-08-28 Novartis Ag Quinazolin-4-one derivatives
WO2014131777A1 (en) 2013-02-27 2014-09-04 Epitherapeutics Aps Inhibitors of histone demethylases
US20150018376A1 (en) 2013-05-17 2015-01-15 Novartis Ag Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof
UY35675A (es) 2013-07-24 2015-02-27 Novartis Ag Derivados sustituidos de quinazolin-4-ona
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
WO2015022664A1 (en) 2013-08-14 2015-02-19 Novartis Ag Compounds and compositions as inhibitors of mek
WO2015022663A1 (en) 2013-08-14 2015-02-19 Novartis Ag Compounds and compositions as inhibitors of mek
EP3046563B1 (de) 2013-09-22 2019-05-29 Calitor Sciences, LLC Substituierte aminopyrimidinverbindungen als pi3-kinase inhibitoren
RU2016133285A (ru) 2014-01-15 2018-02-20 Новартис Аг Фармацевтические комбинации
JP6538148B2 (ja) 2014-03-28 2019-07-03 キャリター・サイエンシーズ・リミテッド・ライアビリティ・カンパニーCalitor Sciences, Llc 置換されたヘテロアリール化合物および使用方法
EP3126345A1 (de) 2014-03-31 2017-02-08 Gilead Sciences, Inc. Inhibitoren von histondemethylasen
RU2016140160A (ru) 2014-04-03 2018-05-07 Инвиктус Онколоджи Пвт. Лтд. Супрамолекулярные комбинаторные лекарственные средства
SG11201701182VA (en) 2014-08-27 2017-03-30 Gilead Sciences Inc Compounds and methods for inhibiting histone demethylases
US10351591B2 (en) 2015-03-20 2019-07-16 The Regents Of The University Of California Polypeptides, peptides, and proteins functionalized by alkylation of thioether groups via ring-opening reactions
EP3124495A1 (de) 2015-07-31 2017-02-01 Centre National de la Recherche Scientifique (C.N.R.S.) Derivate von elastin-ähnlichen polypeptiden und verwendungen davon
US9938257B2 (en) 2015-09-11 2018-04-10 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
US11732008B2 (en) 2016-04-27 2023-08-22 The Regents Of The University Of California Preparation of functional homocysteine residues in polypeptides and peptides
JP7254076B2 (ja) 2017-11-19 2023-04-07 サンシャイン・レイク・ファーマ・カンパニー・リミテッド 置換ヘテロアリール化合物及び使用方法
US11602534B2 (en) 2017-12-21 2023-03-14 Hefei Institutes Of Physical Science, Chinese Academy Of Sciences Pyrimidine derivative kinase inhibitors
US10751339B2 (en) 2018-01-20 2020-08-25 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
CN109926430A (zh) * 2018-11-19 2019-06-25 云南省环境科学研究院(中国昆明高原湖泊国际研究中心) 一种重金属废渣还原造锍熔炼处置的方法

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3787385A (en) * 1971-05-17 1974-01-22 K Folkers Synthetically produced tetrapeptide having the activity of the luteinizing hormone releasing hormone
US3974135A (en) * 1971-06-24 1976-08-10 Karl Folkers Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for producing the same
US3953416A (en) * 1971-12-20 1976-04-27 Karl Folkers Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same
GB1541733A (en) * 1975-10-29 1979-03-07 Parke Davis & Co Octapeptides and methods for their production
BE847762A (fr) 1975-10-29 1977-02-14 Nouveaux nonapeptides et procedes pour les preparer,
DE2617646C2 (de) * 1976-04-22 1986-07-31 Hoechst Ag, 6230 Frankfurt Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
US4215038A (en) * 1978-10-16 1980-07-29 The Salk Institute For Biological Studies Peptides which inhibit gonadal function
US4307083A (en) * 1978-10-16 1981-12-22 The Salk Institute For Biological Studies LRF Antagonists
US4244946A (en) * 1979-06-11 1981-01-13 The Salk Institute For Biological Studies Water-soluble peptides affecting gonadal function
US4409208A (en) * 1980-04-15 1983-10-11 The Salk Institute For Biological Studies GnRH antagonists
US4292313A (en) * 1980-04-15 1981-09-29 The Salk Institute For Biological Studies LRF Antagonists
US4377574A (en) * 1980-06-26 1983-03-22 The Salk Institute For Biological Studies Contraceptive treatment of male mammals
US4386074A (en) * 1980-08-29 1983-05-31 The Salk Institute For Biological Studies LRF Antagonists
US4341767A (en) * 1980-10-06 1982-07-27 Syntex Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4419347A (en) * 1980-10-06 1983-12-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4489061A (en) * 1981-06-12 1984-12-18 The Salk Institute For Biological Studies Treatment of male mammals
US4481190A (en) * 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4667014A (en) * 1983-03-07 1987-05-19 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4581169A (en) * 1982-12-21 1986-04-08 Syntex (U.S.A.) Inc. Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
US4444759A (en) * 1982-07-26 1984-04-24 The Salk Institute For Biological Studies GnRH Antagonists II
US4619914A (en) * 1983-03-10 1986-10-28 The Salk Institute For Biological Studies GNRH antagonists IIIB
US4504414A (en) * 1983-03-28 1985-03-12 Board Of Regents, The University Of Texas System Synthetic pyridyl-alanyl decapeptides having antiovulatory activity
DE3467173D1 (en) * 1983-08-16 1987-12-10 Akzo Nv Lh- rh antagonists
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4569927A (en) * 1984-02-23 1986-02-11 The Salk Institute For Biological Studies GnRH Antagonists IV
US4652550A (en) * 1984-05-21 1987-03-24 The Salk Institute For Biological Studies GnRH antagonists VII
US4647653A (en) * 1984-08-23 1987-03-03 Tulane Educational Fund Therapeutic peptides
US4565804A (en) * 1984-09-07 1986-01-21 The Salk Institute For Biological Studies GnRH Antagonists VI
US4690916A (en) * 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
US4740500A (en) * 1985-01-31 1988-04-26 The Salk Institute For Biological Studies GnRH antagonists VIII
US4659691A (en) * 1985-02-08 1987-04-21 Merck & Co., Inc. Novel cyclic Hexapeptide LHRH antagonists
US4677193A (en) * 1985-02-22 1987-06-30 The Salk Institute For Biological Studies Peptides containing an aliphatic-aromatic ketone side chain
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US5003011A (en) * 1985-04-09 1991-03-26 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US5073624A (en) * 1985-04-09 1991-12-17 Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US4642332A (en) * 1985-04-26 1987-02-10 The Board Of Regents, The University Of Texas System Effective hormonal peptides: D-3-Pal6 -LHRH
US4656247A (en) * 1985-04-26 1987-04-07 Board Of Regents, The University Of Texas System Effective hormonal peptides: D-3-QA1 6-LHRH
US4661472A (en) * 1985-05-09 1987-04-28 The Salk Institute For Biological Studies GnRH antagonists IX
US4721775A (en) * 1985-08-26 1988-01-26 Board Of Regents, The University Of Texas System Effective peptides related to the luteinizing hormone releasing hormone from L-amino acids
US4705778A (en) * 1985-10-22 1987-11-10 Sri International Orally active LHRH analogs
US5182205A (en) * 1986-11-27 1993-01-26 Hoffmann-La Roche Inc. Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4851385A (en) * 1987-07-15 1989-07-25 Indiana University Foundation LHRH antagonist analogs having low histamine-release activity
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
EP0400065B1 (de) * 1988-02-10 1997-08-27 TAP Pharmaceuticals Inc. Lhrh-analog
US5300492A (en) * 1988-02-10 1994-04-05 Tap Pharmaceuticals LHRH analogs
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
DK163689A (da) * 1988-04-08 1989-10-30 Sandoz Ag Peptidderivater
US4992421A (en) * 1988-04-19 1991-02-12 Abbott Laboratories Luteinizing hormone releasing hormone antagonist
US5258492A (en) * 1988-10-21 1993-11-02 The Administrators Of The Tulane Educational Fund LHRH analogues with cytotoxic moieties at the sixth position
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
US5296468A (en) * 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
US5352796A (en) * 1989-10-30 1994-10-04 The Salk Institute For Biological Studies Amino acids useful in making GnRH analogs
US5169932A (en) * 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
US5064939A (en) * 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
US5180711A (en) * 1990-06-14 1993-01-19 Applied Research Systems Ars Holding N.V. Combined treatment with gnrh antagonist and gnrh to control gonadotropin levels in mammals
CN1036343C (zh) * 1990-11-10 1997-11-05 天津市计划生育研究所 新促黄体生成素释放激素拮抗类似物的制备方法
IL101074A (en) * 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
US5340585A (en) * 1991-04-12 1994-08-23 University Of Southern California Method and formulations for use in treating benign gynecological disorders
DK0593491T3 (da) * 1991-04-25 1997-03-17 Romano Deghenghi Luteiniseringshormonfrigørende hormonantagonistpeptider
DE4117507A1 (de) * 1991-05-24 1992-11-26 Schering Ag Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
US5480969A (en) * 1992-09-15 1996-01-02 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US5371070A (en) * 1992-11-09 1994-12-06 The Salk Institute For Biological Studies Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
EP0673254A4 (de) * 1992-12-04 1998-11-18 Abbott Lab Lhrh antagonistische decapeptide in position 6 modifiziert.
EP0683792B1 (de) * 1992-12-18 2001-09-26 Abbott Laboratories Lhrh antagonisten mit modifizierten aminoacylresten an den positionen 5 und 6
RU2130464C1 (ru) * 1993-05-20 1999-05-20 Биотек Аустралиа Пти, Лимитед Антагонист лг-рилизинг-фактора (lhrh), комплекс, способ химической кастрации и/или лечения гонадотропинзависимых расстройств
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
US5502035A (en) * 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
US5508383A (en) * 1994-03-09 1996-04-16 Tap Holdings Inc. Cyclic peptide LHRH antagonists
US5506207A (en) * 1994-03-18 1996-04-09 The Salk Institute For Biological Studies GNRH antagonists XIII
US5516759A (en) * 1994-12-08 1996-05-14 Tap Holdings Inc. LHRH antagonists having lactam groups at the N-terminus
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5780435A (en) * 1995-12-15 1998-07-14 Praecis Pharmaceuticals Incorporated Methods for treating prostate cancer with LHRH-R antagonists

Also Published As

Publication number Publication date
DE69623254D1 (de) 2002-10-02
JPH11507374A (ja) 1999-06-29
AU715399B2 (en) 2000-02-03
JP4164125B2 (ja) 2008-10-08
PT1188768E (pt) 2009-08-13
EP1188768A3 (de) 2002-10-23
US5843901A (en) 1998-12-01
DE69623254T2 (de) 2002-12-19
HK1045161B (zh) 2009-12-24
EP0794961A2 (de) 1997-09-17
DE69535963D1 (de) 2009-07-16
US20030040482A1 (en) 2003-02-27
HK1045161A1 (en) 2002-11-15
PT794961E (pt) 2003-01-31
LU91857I2 (fr) 2011-10-24
ES2177789T3 (es) 2002-12-16
EP1188768A2 (de) 2002-03-20
JP2009040793A (ja) 2009-02-26
ES2326861T3 (es) 2009-10-21
WO1996040757A3 (en) 1997-02-20
EP0794961B1 (de) 2002-08-28
US7071165B2 (en) 2006-07-04
US6423686B1 (en) 2002-07-23
US20030181385A1 (en) 2003-09-25
AU6168096A (en) 1996-12-30
LU91225I2 (fr) 2006-05-03
DK1188768T3 (da) 2009-09-21
DE122006000012I2 (de) 2010-02-04
EP1188768B1 (de) 2009-06-03
CA2219460C (en) 2009-04-14
WO1996040757A2 (en) 1996-12-19
ATE432941T1 (de) 2009-06-15
ATE222924T1 (de) 2002-09-15
DK0794961T3 (da) 2002-10-21
CA2219460A1 (en) 1996-12-19
US20020115615A1 (en) 2002-08-22
JP2007302695A (ja) 2007-11-22

Similar Documents

Publication Publication Date Title
DE122006000012I1 (de) Lhrh antagonistische Peptide
ES2103857T3 (es) Peptidos ciclicos y su uso.
PT1288223E (pt) Derivados de peptidos terapeuticos
DK0966297T4 (da) Regulering af gastrointestinal motilitet
SE8903042L (sv) Pharmaceutical compositions comprising cyklosporins
LV10720A (lv) Peptidi un farmaceitiska kompozicija uz to bazes
DE69801369T2 (de) Peptidanaloge des lh-rh, ihre verwendungen und die sie enthaltenden pharmazeutischen zusammensetzungen
ATE196296T1 (de) Dolastatin analog
FI903971A0 (fi) Peptid med bradykinin antagonistverkan.
DE60044945D1 (de) Auf scf peptid basiertes basolaterales sortiersignal und inhibitoren dafür
ATE69556T1 (de) Cyclopeptide als resorptionsfoerderer bei applikation auf die schleimhaeute.
NZ231636A (en) Anticoagulant peptides analogus to hirudins' active site
BR9714376A (pt) Antagonistas de somatostatina
ATE46347T1 (de) Immunostimulierende peptide.
FR2717390B1 (fr) Compositions thérapeutiques à base de peptides capables d'inhiber la libération de pepsine.
IT8719949A0 (it) Composizioni farmaceutiche adattivita' immunomodulante.
IT8720701A0 (it) Composizioni farmaceutiche adattivita' immunomodulante.
TH17650EX (th) "อนุพันธ์เปปไทด์ที่ใช้รักษาโรค"(therapeutic peptide derivatives)
IT8847610A0 (it) Composizioni farmaceutiche adattivita' antiprolattinica
IT8622051A0 (it) Composizioni farmaceutiche adattivita' cicatrizzante.
IT8820026A0 (it) Composizioni farmaceutiche adattivita' antineoplastica.