DE102013001989A1 - Hand-held hybrid diagnostic and low energy irradiation system used for treatment of benign and malignant tumors, has low-energy radiation source that is provided with diagnostic imaging system integrated with gamma camera - Google Patents

Hand-held hybrid diagnostic and low energy irradiation system used for treatment of benign and malignant tumors, has low-energy radiation source that is provided with diagnostic imaging system integrated with gamma camera Download PDF

Info

Publication number
DE102013001989A1
DE102013001989A1 DE201310001989 DE102013001989A DE102013001989A1 DE 102013001989 A1 DE102013001989 A1 DE 102013001989A1 DE 201310001989 DE201310001989 DE 201310001989 DE 102013001989 A DE102013001989 A DE 102013001989A DE 102013001989 A1 DE102013001989 A1 DE 102013001989A1
Authority
DE
Germany
Prior art keywords
radiation source
low
diagnostic
radiation
systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE201310001989
Other languages
German (de)
Inventor
Michael Friebe
Philipp Matthies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE201310001989 priority Critical patent/DE102013001989A1/en
Publication of DE102013001989A1 publication Critical patent/DE102013001989A1/en
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computerised tomographs
    • A61B6/037—Emission tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4258—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1028—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy using radiation sources applied onto the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046—Tracking techniques
    • A61B2034/2051—Electromagnetic tracking systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046—Tracking techniques
    • A61B2034/2055—Optical tracking systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/12—Devices for detecting or locating foreign bodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/54—Control of apparatus or devices for radiation diagnosis
    • A61B6/547—Control of apparatus or devices for radiation diagnosis involving tracking of position of the device or parts of the device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1058—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using ultrasound imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1091—Kilovoltage or orthovoltage range photons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1094—Shielding, protecting against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam

Abstract

The system has radiation-shielded housing (1) that is vertically displaceable into human or animal bodies and around own axles. A rotatable low-energy radiation source (6) is provided with a diagnostic imaging system (3) integrated with a gamma camera. The endoscopic system (5) and a tool channel (7) are parallel to the radiation source. The camera system is provided for quality assurance or for additional optical diagnosation. The tracking sensor (2) is installed on the housing.

Description

Für die Anmeldung relevante SchriftenFor the registration relevant fonts

  • • US PATENT 8269197 , METHOD AND SYSTEM FOR ELECTRON BEAM APPLICATION• US PATENT 8269197 , METHOD AND SYSTEM FOR ELECTRON BEAM APPLICATION
  • • US PATENT 7120224 , X-RAY IMAGING APPARATUS ...• US PATENT 7120224 , X-RAY IMAGING APPARATUS ...
  • • US PATENT 6493421 , APPARATUS AND METHOD FOR GENERATING HIGH INTENSITY X-RAY• US PATENT 6493421 , APPARATUS AND METHOD FOR GENERATING HIGH INTENSITY X-RAY
  • • EP PATENT 1829437 , X-RAY NEEDLE APPARATUS AND METHOD FOR RADIATION TREATMENT• EP PATENT 1829437 , X-RAY NEEDLE APPARATUS AND METHOD FOR RADIATION TREATMENT
  • • US PATENT 6580940 , X-RAY SYSTEM WITH IMPLANTABLE NEEDLE FOR TREATMENT OF CANCER• US PATENT 6580940 , X-RAY SYSTEM WITH IMPLANTABLE NEEDLE FOR TREATMENT OF CANCER
  • • ORTHOVOLTAGE INTRAOPERATIVE RADIATION THERAPY FOR PANCREATIC ADENO CARCINOMA; BACHIDREDDY ET AL. RADIATION ONCOLOGY 2010, 5: 105 • ORTHOVOLTAGE INTRAOPERATIVE RADIATION THERAPY FOR PANCREATIC ADENO CARCINOMA; BACHIDREDDY ET AL. RADIATION ONCOLOGY 2010, 5:10
  • • TARGETED INTRAOPERATIVE RADIOTHERAPY (TARGIT) YIELDS VERY LOW RECURRENCE RATES WHEN GIVEN AS A BOOST; INT. J. RADIATION ONCOLOGY BIOL. PHYS., VOL. 66, NO. 5, PP. 1335–1338, 2006 • TARGETED INTRAOPERATIVE RADIOTHERAPY (TARGIT) YIELDS VERY LOW RECURRENCE COUNCIL WHEN GIVEN AS A BOOST; INT. J. RADIATION ONCOLOGY BIOL. PHYS., VOL. 66, NO. 5, PP. 1335-1338, 2006
  • • R EDUCING RADIOTHERAPY DOSE IN EARLY BREAST CANCER. THE CONCEPT OF CONFORMAL INTRAOPERATIVE BRACHYTHERAPY; THE BRITISH JOURNAL OF RADIOLOGY, 77 (2004), 279–284 • R EDUCING RADIOTHERAPY CAN IN EARLY BREAST CANCER. THE CONCEPT OF CONFORMAL INTRAOPERATIVE BRACHYTHERAPY; THE BRITISH JOURNAL OF RADIOLOGY, 77 (2004), 279-284
  • • X-RAY SCALPEL – A NEW DEVICE FOR TARGETED X-RAY BRACHYTHERAPY AND STEREOTACTIC RADIOSURGERY; GEORGE GUTMAN ET AL. 2007 PHYS. Med. BIOL. 52 1757–1770 • X-RAY SCALPEL - A NEW DEVICE FOR TARGETED X-RAY BRACHYTHERAPY AND STEREOTACTIC RADIOSURGERY; GEORGE GUTMAN ET AL. 2007 PHYS. Med. BIOL. 52 1757-1770
  • • A VACUUM SEALED MINIATURE X-RAY TUBE BASED ON CARBON NANOTUBE FIELD EMITTERS; HEO ET AL., NANOSCALE RES LETT. 2012; 7(1): 2 • A VACUUM SEALED MINIATURE X-RAY TUBE BASED ON CARBON NANOTUBE FIELD EMITTERS; HEO ET AL., NANOSCALE RES LETT. 2012; 7 (1): 2
  • • INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER; WENZ F., KRAUS-TIEFENBACHER U.; UNI-MED, 2011; 51 • INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER; WENZ F., KRAUS-TIEFENBACHER U .; UNI-MED, 2011; 51
  • • USE OF LOW-ENERGY X-RAYS IN THE TREATMENT OF SUPERFICIAL NONMELANOMATOUS SKIN CANCERS; BODNER WR, HILARIS BS, ALAGHEBAND M ET AL.; CANCER INVEST 2003; 21(3): 355–62 • USE OF LOW-ENERGY X-RAYS IN THE TREATMENT OF SUPERFICIAL NONMELANOMATOUS SKIN CANCERS; BODNER WR, HILARIS BS, ALAGHEBAND M ET AL .; CANCER INVEST 2003; 21 (3): 355-62
  • • INTRAOPERATIVE RADIOTHERAPY (IORT) WITH LOW-ENERGY PHOTONS AS A BOOST IN PATIENTS WITH EARLYSTAGE ORAL CANCER ...; RUTKOWSKI T, WYGODA A, HUTNIK M ET AL.; STRAHLENTHER ONKOL 2010; 86(9): 496–501 • INTRAOPERATIVE RADIO THERAPY (IORT) WITH LOW-ENERGY PHOTONS AS A BOOST IN PATIENTS WITH EARLYSTAGE ORAL CANCER ...; RUTKOWSKI T, WYGODA A, HUTNIK M ET AL .; STRAHLENTHER ONKOL 2010; 86 (9): 496-501
  • • ZEISS INTRABEAM -- http://meditec.zeiss.com/meditec/de_de/produkte/onkologie.html angesehen am 04.02.2013• ZEISS INTRABEAM - http://meditec.zeiss.com/meditec/de_de/produkte/onkologie.html viewed on 04/02/2013
  • • ARIANE MEDICAL SYSTEMS -- http://www.arianemedicalsystems.com angesehen am 05.02.2013• ARIANE MEDICAL SYSTEMS - http://www.arianemedicalsystems.com viewed on 05.02.2013

Für die Therapie von gut- und/oder bösartigen Tumoren stehen eine Vielzahl an Optionen zur Verfügung. Neben der operativen Entfernung (konventionell oder minimal-invasiv), gibt es dabei auch Möglichkeiten zur lokalen Tumorkontrolle und Eindämmung z. B. durch Implantation von radioaktiven Seed-Implantaten, Anwendung von hochenergetischer perkutaner Strahlentherapie (> 4 MeV), intra-operativer und perkutaner Anwendung von niederenergetischer Strahlentherapie (< 400 keV), lokaler oder Ganzkörper-Applikation von Pharmaka (Chemotherapie) und natürlich der Kombination der o. a. Verfahren. Neben diesen Verfahren gibt es noch eine Reihe anderer Optionen, auf die jedoch nicht explizit eingegangen wird. Alle diese Verfahren haben das Ziel die Tumorzellen nachhaltig zu zerstören und gleichzeitig die nicht-befallenen Zellen möglichst zu schützen. Zudem sollte die Belastung für den Patienten und für den medizinischen Anwender möglichst gering sein. Wobei gegenwärtig keines der Verfahren all diese Anforderungen (möglichst geringe Belastung, möglichst selektive und nachhaltige Zerstörung der befallenen Zellen) ideal erfüllt. Insbesondere ist es schwierig den Krankheitsherd diagnostisch genau zu erfassen und die gewonnen Bilddaten dann akkurat in Navigationsinformation umzuwandeln. Nur wenn dies möglich ist kann eine minimal-invasive (geringe Belastungen) Behandlung zielgesteuert und effektiv funktionieren. Hochenergetische Strahlentherapiesysteme können bis auf wenige Ausnahmen (siehe US PATENT 8269197 ) nicht für intra-operative Anwendungen benutzt werden, sondern applizieren die Strahlung durch die Haut zum Tumorherd. Damit besteht die Gefahr von Hautverbrennungen und von Strahlenablagerungen an Stellen mit gesundem Gewebe. Zudem sind selbst die intra-operativen Strahlentherapiesysteme, deren zerstörende Strahlung direkt an den Ort des Tumors gebracht wird, durch Ihr sehr grosses und starres Strahlenzugangssystem sehr limitiert im Einsatz. Das gleiche Problem gilt für ähnlich konstruierte Systeme mit niederenergetischen Strahlensystemen (ARIANE MEDICAL SYSTEMS und ZEISS), wobei hier die Strahlenbelastung für den Anwender und Patienten geringer ist. Den Nachteil eines grossen Systems und einer starren Zuführung lösen die Ansätze, wie in den US Patenten 8269197 , 7120224 , 6493421 , 6580940 und dem EP Patent 1829437 beschrieben. Dabei handelt es sich um in der Abmessung deutlich reduzierte Systeme, die teilweise auch über flexible und kleinste Zugangswege zum Tumorherd gebracht werden können. Möchte man diese Systeme minimal-invasiv einsetzen, muss man in der Lage sein den Tumor ohne direkte Sicht bzw. ohne klare Darstellung der Pathologie (bei Einsatz oder Kombination mit Endoskopiesystemen kann man zwar das Gewebe erkennen, aber nicht unterscheiden ob es Tumorgewebe ist) auf dem für den Patienten ungefährlichsten Zugangsweg zu finden und nachfolgend behandeln. Allen bisher beschriebenen Systemen fehlt jedoch eine integrierte diagnostische Bildgebung und damit eine genaue Navigationsmöglichkeit zum Ort der Strahlenapplikation. Eine Kombination mit pre-operativ erstellten Bildern ist dabei zwar möglich, aber aufgrund der Patientenbewegungen, geänderten Lage und dem zeitlichen und örtlichen Abstand zwischen der diagnostischen Untersuchung und der Therapie in der Regel nicht genau. Man kann dabei zwar die pre-operativ akquirierten Daten zur Navigation nutzen, müsste jedoch in der Lage sein diese Information mit intra-operativ aufgenommen Bilddaten zu korrigieren bzw. zu ergänzen. Ein weiteres Problem stellt die Tatsache dar, dass bei allen Anlagen eine intra-operative bildgebende Diagnostik, die operative Entfernung von Gewebe und die nachfolgende Strahlentherapie nicht in einem einzelnen System stattfinden, sondern in der Regel in drei unabhängige Systeme und zeitlich sequentiell (möglicherweise sogar örtlich sequentiell, d. h. mit Transport des Patienten) erfolgt. Ein weiterer Nachteil ist die ungenügende Strahlenabschirmung, die es bei den hochenergetischen Systemen sogar erfordert den teilweise zusätzlich abgeschirmten Bestrahlungsraum (in der Regel mit Blei) während der Anwendung zu verlassen. Wir schlagen deswegen ein abgeschirmtes niederenergetisches Bestrahlungssystem kombiniert mit diagnostischer und intra-operativen Bildgebung vor, mit der Möglichkeit zur weiteren Kombination mit einem Therapiewerkzeug. Die intra-operative Bildgebung funktioniert in Kombination mit der pre-operativen Bildgebung und einer Navigationselektronik zur Zieführung zum Tumor. Mit den Werkzeugen ist dann ein direkter operativer Eingriff möglich, gefolgt von einer Strahlenapplikation (bzw. ausschliesslich Strahlenapplikation ohne operativen Eingriff) und nachfolgender bildgebender Therapiekontrolle.There are a variety of options available for the treatment of benign and / or malignant tumors. In addition to the surgical removal (conventional or minimally invasive), there are also opportunities for local tumor control and containment z. By implantation of radioactive seed implants, use of high-energy percutaneous radiotherapy (> 4 MeV), intra-operative and percutaneous application of low-energy radiotherapy (<400 keV), local or full-body application of drugs (chemotherapy) and of course the combination the above procedure. In addition to these procedures, there are a number of other options that are not explicitly discussed. All of these methods have the goal of permanently destroying the tumor cells while at the same time protecting the non-affected cells as much as possible. In addition, the burden on the patient and for the medical user should be as low as possible. At the present time, none of the methods ideally fulfills all of these requirements (minimum stress, as selective and sustainable destruction of the affected cells as possible). In particular, it is difficult to diagnose the disease focus accurately and then accurately convert the acquired image data into navigation information. Only when this is possible can a minimally invasive (low stress) treatment be targeted and effective. High-energy radiotherapy systems can, with a few exceptions (see US PATENT 8269197 ) are not used for intra-operative applications, but apply the radiation through the skin to the tumor focus. There is thus the danger of skin burns and of radiation deposits in places with healthy tissue. In addition, even the intra-operative radiation therapy systems, whose destructive radiation is brought directly to the site of the tumor, very limited by their very large and rigid radiation access system in use. The same problem applies to similarly constructed systems with low-energy beam systems (ARIANE MEDICAL SYSTEMS and ZEISS), whereby the radiation exposure for the user and patient is lower here. The disadvantages of a large system and a rigid feeder solve the approaches, as in the U.S. Patents 8,269,197 . 7120224 . 6493421 . 6580940 and the EP patent 1829437 described. These are significantly reduced in size systems, which can be partially brought via flexible and smallest access to the tumor focus. If you want to use these systems minimally invasive, you have to be able to the tumor Without a direct view or without a clear presentation of the pathology (when using or in combination with endoscopy systems, one can indeed detect the tissue, but do not distinguish whether it is tumor tissue) on the most harmless pathway for the patient to find and subsequently treat. However, all systems described so far lack integrated diagnostic imaging and thus accurate navigation to the site of radiation application. A combination with pre-operative images is possible, but due to the patient's movements, changed situation and the temporal and spatial distance between the diagnostic examination and the therapy is usually not accurate. Although it is possible to use the pre-operatively acquired data for navigation, it would have to be able to correct or supplement this information with intra-operatively recorded image data. Another problem is the fact that intra-operative imaging diagnostics, tissue removal and subsequent radiotherapy are not performed in a single system in all systems, but typically in three independent systems and sequentially in time (possibly even locally) sequential, ie with transport of the patient) takes place. A further disadvantage is the insufficient radiation shielding, which even requires the highly energetic systems to leave the partially additionally shielded irradiation space (usually with lead) during use. We therefore propose a shielded low-energy radiation system combined with diagnostic and intra-operative imaging, with the option of further combination with a therapy tool. Intra-operative imaging works in combination with pre-operative imaging and navigation electronics to guide the tumor. With the tools, a direct surgical procedure is then possible, followed by a radiation application (or only radiation application without surgery) and subsequent imaging therapy control.

Erfindungsbeschreibunginvention description

Wir schlagen ein System vor, mit dem eine niederenergetische Strahlenquelle (6) perkutan oder intraoperativ eingesetzt werden kann. Diese Strahlenquelle ist in einem strahlentechnisch abgeschirmten Gehäuse (1) integriert und entsprechend bewegbar z. B. in vertikaler Richtung und zudem um diese Achse drehbar. Das Gesamtsystem ist aufgrund seiner Größe und seines Gewichts von einem Anwender händisch führbar und wegen der integrierten Abschirmung auch ungefährlich in der Anwendung. Es ist in einer weiteren Ausführungsform natürlich denkbar auch andere Bewegungsrichtungen und Winkel zu zulassen bzw. über eine Änderung des Strahlenwinkels am Kopf der Strahlenquelle (6) kegelförmige Strahlenbehandlungen zu ermöglichen. Die Strahlenquelle (6) ist dabei kombiniert mit Bildgebungsverfahren z. B. mit einer Gammakamera (3) zur Erstellung von 2D und 3D Aufnahmen (dann SPECT – single photon emission computed tomography) und/oder mit einem (oder zwei) Ultraschallsystem(en) (3). Ausführungsformen könnten es zulassen entweder nur mit einem System oder mit zwei gleichartigen oder mit zwei oder mehr verschiedenen Bildgebungsverfahren zu arbeiten. Weitere Möglichkeiten für (3) könnten ein Positron Emissions Tomography (PET) Detektor sein oder eine diagnostische Röntgenquelle. Zudem könnten die integrierte Strahlenquelle (6) für die Therapiebehandlung auch zeitweise als Diagnosesystem zur Erstellung von Röntgenaufnahmen benutzt werden. Über weitere vertikale Zugänge (4, 5, 7) können Kamerasysteme zur tatsächlichen Aufnahme der Operation und Strahlenbehandlung bzw. für zusätzliche optische Bildgebung (z. B. Fluoreszenz) integriert werden bzw. Werkzeuge (8) zur Operation/Therapie in den menschlichen oder tierischen Körper (9) eingeführt werden. Über die Anbindung von Detektoren oder Chips oder Markern (2) kann mit externen Systemen/Elektronik/Kamera eine zusätzliche Navigation/Tracking der Gesamtanlage oder der Einzelkomponenten erfolgen. Navigation/Tracking könnte dabei z. B. über ein elektromagnetisches oder optisches oder RFID gestütztes Verfahren durchgeführt werden. Die entsprechenden Bilddaten, Navigationsinformationen, Strahlendosisberechnungen und Strahlenverteilung, Qualitätssicherung, Patienteninformationen und andere Berechnungen/Darstellungen und Eingaben erfolgen über das angeschlossene Computersystem und die Systemelektronik, die nicht explizit und detailliert beschrieben werden soll.We propose a system with which a low-energy radiation source ( 6 ) can be used percutaneously or intraoperatively. This radiation source is in a radiation-shielded housing ( 1 ) and correspondingly movable z. B. in the vertical direction and also rotatable about this axis. Due to its size and weight, the entire system can be manually operated by a user, and because of the integrated shielding, it is also safe to use. In a further embodiment, it is of course also conceivable to allow other directions of movement and angle, or via a change of the beam angle at the head of the radiation source (FIG. 6 ) cone-shaped radiation treatments to enable. The radiation source ( 6 ) is combined with imaging z. B. with a gamma camera ( 3 ) for the production of 2D and 3D images (then SPECT - single photon emission computed tomography) and / or with one (or two) ultrasound system (s) ( 3 ). Embodiments could allow to work with either one system only, or two similar or two or more different imaging methods. Other possibilities for (3) could be a positron emission tomography (PET) detector or a diagnostic x-ray source. In addition, the integrated radiation source ( 6 ) for the therapy treatment also be used intermittently as a diagnostic system for the preparation of X-rays. Via further vertical accesses ( 4 . 5 . 7 ) camera systems can be integrated for the actual recording of the surgery and radiation treatment or for additional optical imaging (eg fluorescence) or tools ( 8th ) for surgery / therapy in the human or animal body ( 9 ). Via the connection of detectors or chips or markers ( 2 ) can be done with external systems / electronics / camera additional navigation / tracking of the entire system or the individual components. Navigation / tracking could be z. B. be carried out via an electromagnetic or optical or RFID-based method. The corresponding image data, navigation information, radiation dose calculations and radiation distribution, quality assurance, patient information and other calculations / representations and inputs are made via the connected computer system and the system electronics, which should not be described explicitly and in detail.

BezugszeichenlisteLIST OF REFERENCE NUMBERS

11
Abschirmung/Gehäuse (z. B. inkl. Pb oder vergleichbares Material)Shielding / housing (eg incl. Pb or similar material)
22
Tracking/Navigationshardware (Elektromagnetisch oder optisch oder RFID oder...)Tracking / navigation hardware (Electromagnetic or optical or RFID or ...)
33
Ultraschall und/oder Gammadetektor und/oder PET Detektor und/oder optisches BildgebungsverfahrenUltrasound and / or gamma detector and / or PET detector and / or optical imaging method
44
Kamerasystem (Fluoreszenz, normale Optik, Spektroskopie, Wärme, ...)Camera system (fluorescence, normal optics, spectroscopy, heat, ...)
55
Endoskopiesystem oder WerkzeugzugangEndoscopy system or tool access
66
Gamma oder Röntgenquelle < 400 keV - verschiebbar und drehbarGamma or X-ray source <400 keV - slidable and rotatable
77
Injektionskanal/Arbeitskanal -- verschiebbar und drehbarInjection channel / working channel - displaceable and rotatable
8 8th
Injektionssystem, z. B Nadel oder Biopsie u. U. auch mit abgewinkelter SpitzeInjection system, e.g. B Needle or biopsy u. U. also with angled tip
99
Menschlicher (oder tierischer) Körper oder anderes BildgebungsobjektHuman (or animal) body or other imaging object

Nicht detailliert zeichnerisch gezeigt sind die Verbindungsleitungen zum Systemcomputer, Navigations- und Trackingelektronik, Eingabesystem und anderer für die Bildgebung und Strahlentherapie notwendigen Komponenten, sowie eines für die Röntgendiagnostik eventuell notwendigen Detektor-/Aufnahmesystems.Not shown in detail are the connecting lines to the system computer, navigation and tracking electronics, input system and other necessary components for imaging and radiotherapy, and a possibly necessary for X-ray diagnostics detector / recording system.

Figuren und kurze Beschreibung:Figures and short description:

1: Systemkopf Querschnitt A-A' aus 2 1 : System head cross section AA 'off 2

2: Gesamtsystem Draufsicht -- nicht detailliert zeichnerisch gezeigt sind die Verbindungsleitungen zum Systemcomputer, Navigations- und Trackingelektronik, Eingabesystem und anderer für die Bildgebung und Strahlentherapie notwendigen Komponenten, sowie eines für die Röntgendiagnostik eventuell notwendigen Detektor-/Aufnahmesystems. 2 : Complete system top view - not shown in detail drawing are the connection cables to the system computer, navigation and tracking electronics, input system and other components necessary for imaging and radiotherapy, as well as a possibly necessary for X-ray diagnostics detector / recording system.

ZITATE ENTHALTEN IN DER BESCHREIBUNG QUOTES INCLUDE IN THE DESCRIPTION

Diese Liste der vom Anmelder aufgeführten Dokumente wurde automatisiert erzeugt und ist ausschließlich zur besseren Information des Lesers aufgenommen. Die Liste ist nicht Bestandteil der deutschen Patent- bzw. Gebrauchsmusteranmeldung. Das DPMA übernimmt keinerlei Haftung für etwaige Fehler oder Auslassungen.This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Zitierte PatentliteraturCited patent literature

  • US 8269197 [0001, 0002, 0002] US 8269197 [0001, 0002, 0002]
  • US 7120224 [0001, 0002] US 7120224 [0001, 0002]
  • US 6493421 [0001, 0002] US 6493421 [0001, 0002]
  • EP 1829437 [0001, 0002] EP 1829437 [0001, 0002]
  • US 6580940 [0001, 0002] US 6580940 [0001, 0002]

Zitierte Nicht-PatentliteraturCited non-patent literature

  • ORTHOVOLTAGE INTRAOPERATIVE RADIATION THERAPY FOR PANCREATIC ADENO CARCINOMA; BACHIDREDDY ET AL. RADIATION ONCOLOGY 2010, 5: 105 [0001] ORTHOVOLTAGE INTRAOPERATIVE RADIATION THERAPY FOR PANCREATIC ADENO CARCINOMA; BACHIDREDDY ET AL. RADIATION ONCOLOGY 2010, 5: 105 [0001]
  • TARGETED INTRAOPERATIVE RADIOTHERAPY (TARGIT) YIELDS VERY LOW RECURRENCE RATES WHEN GIVEN AS A BOOST; INT. J. RADIATION ONCOLOGY BIOL. PHYS., VOL. 66, NO. 5, PP. 1335–1338, 2006 [0001] TARGETED INTRAOPERATIVE RADIOTHERAPY (TARGIT) YIELDS VERY LOW RECURRENCE COUNCIL WHEN GIVEN AS A BOOST; INT. J. RADIATION ONCOLOGY BIOL. PHYS., VOL. 66, NO. 5, PP. 1335-1338, 2006 [0001]
  • EDUCING RADIOTHERAPY DOSE IN EARLY BREAST CANCER. THE CONCEPT OF CONFORMAL INTRAOPERATIVE BRACHYTHERAPY; THE BRITISH JOURNAL OF RADIOLOGY, 77 (2004), 279–284 [0001] EDUCING RADIOTHERAPY CAN IN EARLY BREAST CANCER. THE CONCEPT OF CONFORMAL INTRAOPERATIVE BRACHYTHERAPY; THE BRITISH JOURNAL OF RADIOLOGY, 77 (2004), 279-284 [0001]
  • X-RAY SCALPEL – A NEW DEVICE FOR TARGETED X-RAY BRACHYTHERAPY AND STEREOTACTIC RADIOSURGERY; GEORGE GUTMAN ET AL. 2007 PHYS. Med. BIOL. 52 1757–1770 [0001] X-RAY SCALPEL - A NEW DEVICE FOR TARGETED X-RAY BRACHYTHERAPY AND STEREOTACTIC RADIOSURGERY; GEORGE GUTMAN ET AL. 2007 PHYS. Med. BIOL. 52 1757-1770 [0001]
  • A VACUUM SEALED MINIATURE X-RAY TUBE BASED ON CARBON NANOTUBE FIELD EMITTERS; HEO ET AL., NANOSCALE RES LETT. 2012; 7(1): 2 [0001] A VACUUM SEALED MINIATURE X-RAY TUBE BASED ON CARBON NANOTUBE FIELD EMITTERS; HEO ET AL., NANOSCALE RES LETT. 2012; 7 (1): 2 [0001]
  • INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER; WENZ F., KRAUS-TIEFENBACHER U.; UNI-MED, 2011; 51 [0001] INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER; WENZ F., KRAUS-TIEFENBACHER U .; UNI-MED, 2011; 51 [0001]
  • USE OF LOW-ENERGY X-RAYS IN THE TREATMENT OF SUPERFICIAL NONMELANOMATOUS SKIN CANCERS; BODNER WR, HILARIS BS, ALAGHEBAND M ET AL.; CANCER INVEST 2003; 21(3): 355–62 [0001] USE OF LOW-ENERGY X-RAYS IN THE TREATMENT OF SUPERFICIAL NONMELANOMATOUS SKIN CANCERS; BODNER WR, HILARIS BS, ALAGHEBAND M ET AL .; CANCER INVEST 2003; 21 (3): 355-62 [0001]
  • INTRAOPERATIVE RADIOTHERAPY (IORT) WITH LOW-ENERGY PHOTONS AS A BOOST IN PATIENTS WITH EARLYSTAGE ORAL CANCER ...; RUTKOWSKI T, WYGODA A, HUTNIK M ET AL.; STRAHLENTHER ONKOL 2010; 86(9): 496–501 [0001] INTRAOPERATIVE RADIO THERAPY (IORT) WITH LOW-ENERGY PHOTONS AS A BOOST IN PATIENTS WITH EARLYSTAGE ORAL CANCER ...; RUTKOWSKI T, WYGODA A, HUTNIK M ET AL .; STRAHLENTHER ONKOL 2010; 86 (9): 496-501 [0001]
  • http://meditec.zeiss.com/meditec/de_de/produkte/onkologie.html [0001] http://meditec.zeiss.com/meditec/en_de/produkte/onkologie.html [0001]
  • http://www.arianemedicalsystems.com [0001] http://www.arianemedicalsystems.com [0001]

Claims (10)

Gesamtsystem in dem in einem strahlentechnisch abgeschirmten Gehäuse (1) eine vertikal verschiebbare (auch in einen menschlichen oder tierischen Körper (9)) und um die eigene Achse drehbare niederenergetische Strahlenquelle (6) mit mindestens einem diagnostischen Bildgebungssystem (3 – z. B. Ultraschall, Gammakamera, Röntgen, ...) integriert und kombiniert sind.Overall system in which in a radiation-shielded housing ( 1 ) a vertically displaceable (also in a human or animal body ( 9 )) and rotatable about its own axis low-energy radiation source ( 6 ) with at least one diagnostic imaging system ( 3 - z. B. ultrasound, gamma camera, X-ray, ...) are integrated and combined. System wie in Anspruch 1 beschrieben mit mehreren diagnostischen Bidgebungsystemen (3) kombiniert, wobei es sich dabei um gleiche Systeme oder unterschiedliche Systeme handeln kann.A system as claimed in claim 1 comprising a plurality of diagnostic imaging systems ( 3 ), which may be the same systems or different systems. System nach Anspruch 1 oder 2 dadurch gekennzeichnet, dass die integrierten Diagnosesysteme (3) das zu bestrahlende Gewebe und die Strahlenquelle (6) gleichzeitig abbilden können.System according to claim 1 or 2, characterized in that the integrated diagnostic systems ( 3 ) the tissue to be irradiated and the radiation source ( 6 ) at the same time. System nach Anspruch 1 bis 3 mit der Möglichkeit zusätzlich ein Endoskopiesystem (5) und einen Werkzeugkanal (7) parallel zur Strahlenquelle (6) zu integrieren.System according to claim 1 to 3 with the possibility additionally an endoscopy system ( 5 ) and a tool channel ( 7 ) parallel to the radiation source ( 6 ) to integrate. System nach Anspruch 1 bis 4 mit der Möglichkeit über einen Injektionskanal (7) parallel zur Strahlenquelle (6) ein oder mehrere Werkzeuge (8) in den menschlichen oder tierischen Körper (9) vorzuschieben.System according to claim 1 to 4 with the possibility of an injection channel ( 7 ) parallel to the radiation source ( 6 ) one or more tools ( 8th ) in the human or animal body ( 9 ) to advance. System nach Anspruch 1 bis 5 mit der Möglichkeit zusätzlich ein Kamerasystem (7) zur Qualitätssicherung oder zur zusätzlichen optischen Diagnose zu integrieren.System according to claim 1 to 5 with the possibility additionally a camera system ( 7 ) for quality assurance or for additional optical diagnosis. System nach Anspruch 1 bis 6, für die Kombination mit einem externen Tracking oder Navigationsverfahren, wobei auf dem Gehäuse (1), sowie an oder auf allen unabhängig vom Gehäuse bewegbaren, aber mit diesem direkt oder indirekt verbundenen Systeme (z. B. 5, 6, 8), Trackingsensoren (2) installiert werden (z. B. RFID Chip, infrarot reflektierende Marker, elektromagnetische Sensoren, QR Codes, ...), die einen Bezug zu einem Koordinatensystem herstellen und damit mit einem Bild registriert werden können.System according to claim 1 to 6, for combination with an external tracking or navigation method, wherein on the housing ( 1 ), as well as on or on all independently of the housing movable, but directly or indirectly connected with this system (eg. 5 . 6 . 8th ), Tracking sensors ( 2 ) are installed (eg RFID chip, infrared reflecting markers, electromagnetic sensors, QR codes, ...), which can be related to a coordinate system and thus registered with an image. System nach Anspruch 1 bis 7, wobei die Strahlenquelle (6) nicht nur vertikal, sondern auch in einem kegelförmigen Winkel von +45 Grad bis –45 Grad zum Gehäuse (1) bewegt werden kann.System according to claim 1 to 7, wherein the radiation source ( 6 ) not only vertically, but also in a conical angle of +45 degrees to -45 degrees to the housing ( 1 ) can be moved. System nach Anspruch 1 bis 8, wobei es die Strahlenquelle (6) zulässt über entsprechende Kollimatoren und Schnittflächen die Strahlen in unterschiedlichen Volumen und Richtungen zu applizieren.System according to claims 1 to 8, wherein it is the radiation source ( 6 ) allows to apply the beams in different volumes and directions via corresponding collimators and cut surfaces. System nach Anspruch 1 bis 9, wobei die Strahlenquelle (6) nicht nur zur Strahlentherapie sondern auch alternativ in Kombination mit einem Detektorsystem auch zur Röntgendiagnostik eingesetzt werden kann.System according to claims 1 to 9, wherein the radiation source ( 6 ) can be used not only for radiotherapy but also alternatively in combination with a detector system for X-ray diagnostics.
DE201310001989 2013-02-06 2013-02-06 Hand-held hybrid diagnostic and low energy irradiation system used for treatment of benign and malignant tumors, has low-energy radiation source that is provided with diagnostic imaging system integrated with gamma camera Ceased DE102013001989A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE201310001989 DE102013001989A1 (en) 2013-02-06 2013-02-06 Hand-held hybrid diagnostic and low energy irradiation system used for treatment of benign and malignant tumors, has low-energy radiation source that is provided with diagnostic imaging system integrated with gamma camera

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE201310001989 DE102013001989A1 (en) 2013-02-06 2013-02-06 Hand-held hybrid diagnostic and low energy irradiation system used for treatment of benign and malignant tumors, has low-energy radiation source that is provided with diagnostic imaging system integrated with gamma camera

Publications (1)

Publication Number Publication Date
DE102013001989A1 true DE102013001989A1 (en) 2014-08-07

Family

ID=51205855

Family Applications (1)

Application Number Title Priority Date Filing Date
DE201310001989 Ceased DE102013001989A1 (en) 2013-02-06 2013-02-06 Hand-held hybrid diagnostic and low energy irradiation system used for treatment of benign and malignant tumors, has low-energy radiation source that is provided with diagnostic imaging system integrated with gamma camera

Country Status (1)

Country Link
DE (1) DE102013001989A1 (en)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6217518B1 (en) * 1998-10-01 2001-04-17 Situs Corporation Medical instrument sheath comprising a flexible ultrasound transducer
US6416492B1 (en) * 2000-09-28 2002-07-09 Scimed Life Systems, Inc. Radiation delivery system utilizing intravascular ultrasound
US6493421B2 (en) 2000-10-16 2002-12-10 Advanced X-Ray Technology, Inc. Apparatus and method for generating a high intensity X-ray beam with a selectable shape and wavelength
US6580940B2 (en) 2000-02-02 2003-06-17 George Gutman X-ray system with implantable needle for treatment of cancer
US20060067467A1 (en) * 2004-09-28 2006-03-30 Minnesota Medical Physics Llc Apparatus and method for conformal radiation brachytherapy for breast and other tumors
US7120224B2 (en) 2004-11-02 2006-10-10 Advanced X-Ray Technology, Inc. X-ray imaging apparatus and method for mammography and computed tomography
US20070129593A1 (en) * 2005-12-05 2007-06-07 Hampton University Apparatus and method for brachytherapy radiation distribution mapping
EP1829437A2 (en) 2004-12-21 2007-09-05 Advanced X-Ray Technology, Inc. X-ray needle apparatus and method for radiation treatment
DE102010034101A1 (en) * 2010-08-12 2012-02-16 Siemens Ag Support arm for arrangement for radiation therapy, for detector or diagnostic radiation source attached at arm end, has radiation therapy system attached to arm in area of another arm end in radiator header section
US8269197B2 (en) 2009-07-22 2012-09-18 Intraop Medical Corporation Method and system for electron beam applications

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6217518B1 (en) * 1998-10-01 2001-04-17 Situs Corporation Medical instrument sheath comprising a flexible ultrasound transducer
US6580940B2 (en) 2000-02-02 2003-06-17 George Gutman X-ray system with implantable needle for treatment of cancer
US6416492B1 (en) * 2000-09-28 2002-07-09 Scimed Life Systems, Inc. Radiation delivery system utilizing intravascular ultrasound
US6493421B2 (en) 2000-10-16 2002-12-10 Advanced X-Ray Technology, Inc. Apparatus and method for generating a high intensity X-ray beam with a selectable shape and wavelength
US20060067467A1 (en) * 2004-09-28 2006-03-30 Minnesota Medical Physics Llc Apparatus and method for conformal radiation brachytherapy for breast and other tumors
US7120224B2 (en) 2004-11-02 2006-10-10 Advanced X-Ray Technology, Inc. X-ray imaging apparatus and method for mammography and computed tomography
EP1829437A2 (en) 2004-12-21 2007-09-05 Advanced X-Ray Technology, Inc. X-ray needle apparatus and method for radiation treatment
US20070129593A1 (en) * 2005-12-05 2007-06-07 Hampton University Apparatus and method for brachytherapy radiation distribution mapping
US8269197B2 (en) 2009-07-22 2012-09-18 Intraop Medical Corporation Method and system for electron beam applications
DE102010034101A1 (en) * 2010-08-12 2012-02-16 Siemens Ag Support arm for arrangement for radiation therapy, for detector or diagnostic radiation source attached at arm end, has radiation therapy system attached to arm in area of another arm end in radiator header section

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
A VACUUM SEALED MINIATURE X-RAY TUBE BASED ON CARBON NANOTUBE FIELD EMITTERS; HEO ET AL., NANOSCALE RES LETT. 2012; 7(1): 2
EDUCING RADIOTHERAPY DOSE IN EARLY BREAST CANCER. THE CONCEPT OF CONFORMAL INTRAOPERATIVE BRACHYTHERAPY; THE BRITISH JOURNAL OF RADIOLOGY, 77 (2004), 279-284
http://meditec.zeiss.com/meditec/de_de/produkte/onkologie.html
http://www.arianemedicalsystems.com
INTRAOPERATIVE RADIOTHERAPY (IORT) WITH LOW-ENERGY PHOTONS AS A BOOST IN PATIENTS WITH EARLYSTAGE ORAL CANCER ...; RUTKOWSKI T, WYGODA A, HUTNIK M ET AL.; STRAHLENTHER ONKOL 2010; 86(9): 496-501
INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER; WENZ F., KRAUS-TIEFENBACHER U.; UNI-MED, 2011; 51
ORTHOVOLTAGE INTRAOPERATIVE RADIATION THERAPY FOR PANCREATIC ADENO CARCINOMA; BACHIDREDDY ET AL. RADIATION ONCOLOGY 2010, 5: 105
TARGETED INTRAOPERATIVE RADIOTHERAPY (TARGIT) YIELDS VERY LOW RECURRENCE RATES WHEN GIVEN AS A BOOST; INT. J. RADIATION ONCOLOGY BIOL. PHYS., VOL. 66, NO. 5, PP. 1335-1338, 2006
USE OF LOW-ENERGY X-RAYS IN THE TREATMENT OF SUPERFICIAL NONMELANOMATOUS SKIN CANCERS; BODNER WR, HILARIS BS, ALAGHEBAND M ET AL.; CANCER INVEST 2003; 21(3): 355-62
X-RAY SCALPEL - A NEW DEVICE FOR TARGETED X-RAY BRACHYTHERAPY AND STEREOTACTIC RADIOSURGERY; GEORGE GUTMAN ET AL. 2007 PHYS. Med. BIOL. 52 1757-1770

Similar Documents

Publication Publication Date Title
US20150208994A1 (en) Ct/mri integrated system for the diagnosis of acute strokes and methods thereof
Moteabbed et al. Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy
DE102005059210B4 (en) Radiotherapeutic device
US7564945B2 (en) System including computed tomography device for image guided treatment
EP1898234B1 (en) Medical unit producing an image
DE102007037103B4 (en) Method and apparatus for visualizing functional and electrical activities of the brain
DE102005048853A1 (en) Medical imaging modality, e.g. for medical examination procedure of patient, has PET detector ring which records raw positron emission tomography image data of patient
DE102009021740A1 (en) Radiotherapy device with an imaging unit
DE102008041286A1 (en) Balloon catheter and X-ray applicator with a balloon catheter
DE102005056080B4 (en) Device for X-ray brachytherapy with a probe insertable into the interior of a body for X-ray brachytherapy
WO2010006722A1 (en) Contrast agent-reinforced radiotherapy having high-output tubes
CN105451816B (en) The Medical Devices of radiation therapy treatment
DE102007018102B4 (en) Device for the radiotherapeutic treatment of tissue by means of an X-ray CT system or a diagnostic or Orthovolt X-ray system
Nishio et al. Experimental verification of proton beam monitoring in a human body by use of activity image of positron-emitting nuclei generated by nuclear fragmentation reaction
Treuer et al. Accuracy and conformity of stereotactically guided interstitial brain tumour therapy using I-125 seeds
DE102005056067B3 (en) Device for X-ray brachytherapy
DE102012215170A1 (en) Apparatus, system and method for supporting brachytherapy
DE10139934B4 (en) Integrated 3D online imaging for radiotherapy positioning
DE102007060189A1 (en) Radiotherapy device for treating disease i.e. cancer such as tumor in stomach region of patient, has high intensity focused ultrasound-device radiating target volumes with ultrasound for increasing temperature in target volume
Cho et al. Feasibility of hydrogel fiducial markers for in vivo proton range verification using PET
DE102005056066B3 (en) Device for X-ray brachytherapy with a probe insertable into the interior of a body
DE102006049599A1 (en) Medical diagnostic system
US8295910B1 (en) Imaging method for monitoring delivery of high dose rate brachytherapy
DE102013001989A1 (en) Hand-held hybrid diagnostic and low energy irradiation system used for treatment of benign and malignant tumors, has low-energy radiation source that is provided with diagnostic imaging system integrated with gamma camera
DE102014218454A1 (en) Apparatus, medical instrument and method for obtaining a spatial image of a medical instrument with a magnetic resonance tomography apparatus

Legal Events

Date Code Title Description
R012 Request for examination validly filed
R002 Refusal decision in examination/registration proceedings
R003 Refusal decision now final