DE102007005323A1 - Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source - Google Patents
Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source Download PDFInfo
- Publication number
- DE102007005323A1 DE102007005323A1 DE102007005323A DE102007005323A DE102007005323A1 DE 102007005323 A1 DE102007005323 A1 DE 102007005323A1 DE 102007005323 A DE102007005323 A DE 102007005323A DE 102007005323 A DE102007005323 A DE 102007005323A DE 102007005323 A1 DE102007005323 A1 DE 102007005323A1
- Authority
- DE
- Germany
- Prior art keywords
- suction
- diffuser
- needles
- vacuum chamber
- connection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L13/00—Cleaning or rinsing apparatus
- B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00367—Pipettes capillary
- B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
- B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
Abstract
Description
Die Erfindung betrifft eine Absaugeinrichtung und ein Verfahren zum Entleeren von Probenbehältern mit einer Vielzahl von Absaugnadeln.The The invention relates to a suction device and a method for Emptying sample containers with a variety of suction needles.
Es ist bekannt, dass man Probenbehälter mithilfe von Absaugnadeln entleeren kann, die in die Behälter abgesenkt werden und in denen Unterdruck erzeugt wird. Es ist auch bekannt, dies maschinell so zu gestalten, dass eine Vielzahl von insbesondere parallelen Absaugnadeln gleichzeitig abgesenkt und in einer Unterdruckkammer mit Unterdruck beaufschlagt wird. Dabei hat sich herausgestellt, dass der Unterdruck in der Unterdruckkammer ungleichmäßig verteilt ist, was dazu führt, dass die Absaugnadeln an den Stellen, wo der Unterdruck größer ist, schneller arbeiten. Dies bedeutet u. a., dass bei bestimmten Probenbehältern die Flüssigkeit schon entnommen wurde, während die Absaugnadeln an anderen Stellen noch mit Flüssigkeit gefüllt sind. Dann entsteht in den Probenbehältern ein Luftzug, der zum Austrocknen führen kann.It is known to use sample containers of suction needles, which are lowered into the containers and in which negative pressure is generated. It is also known by machine so that a lot of in particular parallel Suction needles simultaneously lowered and in a vacuum chamber is subjected to negative pressure. It turned out that the negative pressure in the vacuum chamber is distributed unevenly is what causes that the suction needles in the places where the negative pressure is greater, work faster. This means u. a. that for certain sample containers the liquid was already taken while the suction needles are still filled with liquid elsewhere. Then arises in the sample containers a breeze that can lead to dehydration.
Der Erfindung liegt die Aufgabe zu Grunde, eine Absaugeinrichtung und ein Verfahren zu schaffen, mit dessen Hilfe ein gleichmäßiges Entleeren der Probenbehälter bewirkt werden kann, so dass das Entleeren insgesamt schneller von sich gehen kann.Of the Invention is based on the object, a suction device and To provide a method by which causes a uniform emptying of the sample container can be, so the emptying altogether faster by itself can go.
Zur Lösung dieser Aufgabe schlägt die Erfindung eine Absaugeinrichtung mit den im Anspruch 1 genannten Merkmalen vor.to solution this task strikes the invention, a suction device with the mentioned in claim 1 Characteristics.
Die Erfindung schlägt ebenfalls ein Verfahren mit den im Anspruch 9 genannten Merkmalen vor. Weiterbildungen der Erfindung sind Gegenstand von Unteransprüchen.The Invention proposes also a method with the features mentioned in claim 9 in front. Further developments of the invention are the subject of dependent claims.
Durch die Anordnung des Diffusors zwischen der Unterdruckkammer und dem Anschluss für die Unterdruckquelle wird erreicht, dass die Strömung innerhalb der Unterdruckkammer vergleichmäßigt wird, was dazu führt, dass der Unterdruck an dem in der Unterdruckkammer angeordneten Ende der Absaugnadeln bei allen Absaugnadeln gleich ist. Alle Absaugnadeln arbeiten daher mit der gleichen Geschwindigkeit und sind zum gleichen Zeitpunkt fertig. Man muss mit dem Beenden des Absaugvorgangs nicht mehr auf die langsamste Absaugnadel Rücksicht nehmen.By the arrangement of the diffuser between the vacuum chamber and the Connection for The vacuum source is achieved that the flow within the vacuum chamber is evened out, which leads to, that the negative pressure at the arranged in the vacuum chamber End of the suction needles is the same for all suction needles. All suction needles therefore work at the same speed and are the same Time ready. One does not have to stop the suction process pay more attention to the slowest suction needle.
Zusätzlich zu der Verringerung der zum Absaugen benötigten Zeit insgesamt entsteht aber noch der Vorteil, dass nicht unnötig Luft angesaugt wird. Dies könnte bei einer weniger gleichmäßigen Absaugung dann auftreten, wenn beispielsweise ein Probenbehälter schon leer ist, der andere aber noch nicht. Da dieser Fall nach der Erfindung nicht mehr auftritt, wird der verbleibende Inhalt der Probenbehälter vor Austrocknung geschützt, und empfindliche Wandbeschichtungen werden gegenüber einer Ablösung durch eine anhaltende Luftströmung geschützt.In addition to the reduction of the time required for aspiration overall arises but still the advantage that not unnecessarily air is sucked. This could with less uniform suction occur when, for example, a sample container already is empty, the other is not yet. As this case according to the invention no longer occurs, the remaining contents of the sample container before Dehydration protected, and sensitive wall coatings will resist detachment a persistent airflow protected.
Beispielsweise kann man einen Diffusor verwenden, der eine Vielzahl von gleichmäßig verteilten Öffnungen aufweist. Je größer die Zahl der Öffnungen ist, desto gleichmäßiger kann man die Strömungsgeschwin digkeit über die Unterdruckkammer verteilen. Durch die Größe der Öffnungen kann man den Druckabfall bestimmen, der durch den Diffusor erzeugt wird.For example you can use a diffuser that has a variety of evenly spaced openings having. The bigger the Number of openings is, the more even can the flow velocity over the Distribute vacuum chamber. Due to the size of the openings you can see the pressure drop determine that is generated by the diffuser.
Beispielsweise kann der Diffusor aus porösem Material bestehen, das von sich aus eine Vielzahl von gleichmäßig verteilten Öffnungen bildet.For example the diffuser can be made of porous Material consist of a number of evenly spaced openings forms.
In Weiterbildung der Erfindung kann vorgesehen sein, dass der Anschluss für die Unterdruckquelle in eine Vorkammer führt, und dass die Trennwand zwischen der zweiten Kammer, nämlich der Vorkammer, und der Unterdruckkammer von dem Diffusor gebildet wird. Der Diffusor ist daher in der einen Dimension genauso groß wie die Vorkammer und die Unterdruckkammer.In Further development of the invention can be provided that the connection for the Low pressure source leads into an antechamber, and that the dividing wall between the second chamber, namely the prechamber, and the vacuum chamber formed by the diffuser becomes. The diffuser is therefore just as big in one dimension as the Prechamber and the vacuum chamber.
In Weiterbildung der Erfindung kann vorgesehen sein, dass die Vorkammer unterhalb der Unterdruckkammer angeordnet ist. Unten ist dort, wohin die Spitzen der Absaugnadeln zeigen.In Further development of the invention can be provided that the antechamber is arranged below the vacuum chamber. Below is where the Pointing tips of the suction needles.
Da mithilfe der Unterdruckquelle nicht nur Gas, sondern auch Fluide und eine Mischung aus Luft und Fluid abgesaugt wird, kann das Fluid dann nach unten aus der Vorkammer hinaus fließen.There using the vacuum source not only gas, but also fluids and a mixture of air and fluid is drawn off, the fluid then flow down out of the antechamber.
In Weiterbildung der Erfindung kann vorgesehen sein, dass die Absaugnadeln durch den Diffusor hindurchragen. Insbesondere können sie mit einem radialen Spiel durch Öffnungen in dem Diffusor hindurchragen. Dieses radiale Spiel bildet dadurch Öffnungen um die Absaugnadeln herum, durch die der Unterdruck an die geräteseitigen Enden der Absaugnadeln gelangen kann. Das heraus gesaugte Fluid kann dann unmittelbar an der Absaugnadel durch diesen ringförmigen Zwischenraum abgesaugt werden. Dies hat auch den Vorteil, dass Fluide, die sich nur schwierig von der Wand der Absaugnadeln lösen lassen, die Absaugnadeln entlang abgesaugt werden.In Development of the invention can be provided that the suction needles protrude through the diffuser. In particular, they can with a radial Play through openings protrude through the diffuser. This radial clearance thereby forms openings around the suction needles, through which the vacuum to the device side Ends of the suction needles can get. The sucked out fluid can then directly on the suction needle through this annular space be sucked off. This also has the advantage of fluids that are difficult to remove from the wall of the suction needles, the suction needles be sucked along.
Erfindungsgemäß kann in Weiterbildung vorgesehen sein, dass die Absaugnadeln, die untereinander parallel sind, die Diffusorplatte quer durchdringen.According to the invention, in Continuing to be provided that the suction needles to each other parallel, penetrate the diffuser plate across.
Weitere Merkmale, Einzelheiten und Vorzüge der Erfindung ergeben sich aus den Ansprüchen und der Zusammenfassung, deren beider Wortlaut durch Bezugnahme zum Inhalt der Beschreibung gemacht wird, der folgenden Beschreibung bevorzugter Ausführungsformen der Erfindung sowie anhand der Zeichnung. Hierbei zeigen:Further features, details and advantages of the invention will become apparent from the claims and abstract, the wording of which by reference to the content of the description ge makes, the following description of preferred embodiments of the invention and from the drawing. Hereby show:
Nähere Einzelheiten gehen aus der Figur zwei hervor, die schematisch zu verstehen ist.Further details will be apparent from the figure two, which is to be understood schematically.
Das
Gehäuse
Die
Absaugeinrichtung enthält
eine Vielzahl von Absaugnadeln
Anstelle
einer Diffusorplatte
Claims (13)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007005323A DE102007005323A1 (en) | 2007-01-29 | 2007-01-29 | Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source |
PCT/EP2008/000317 WO2008092570A1 (en) | 2007-01-29 | 2008-01-17 | Suction device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007005323A DE102007005323A1 (en) | 2007-01-29 | 2007-01-29 | Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source |
Publications (1)
Publication Number | Publication Date |
---|---|
DE102007005323A1 true DE102007005323A1 (en) | 2008-07-31 |
Family
ID=39367143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE102007005323A Withdrawn DE102007005323A1 (en) | 2007-01-29 | 2007-01-29 | Suction device has multiple suction needles and vacuum chamber, in which suction needles empty and connection is provided for vacuum source |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE102007005323A1 (en) |
WO (1) | WO2008092570A1 (en) |
Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US3572552A (en) * | 1969-07-25 | 1971-03-30 | Perry W Guinn | Diaphragm dispenser |
US3982438A (en) * | 1975-06-23 | 1976-09-28 | The Salk Institute For Biological Studies | Multiple sample pipetting apparatus |
US4302338A (en) * | 1978-07-28 | 1981-11-24 | Metallgesellschaft Aktiengesellschaft | Apparatus for metering and/or distributing liquid media |
DE3220444A1 (en) * | 1981-10-02 | 1983-04-21 | Culture Tek Corp., Granada Hills, Calif. | PIPETTE SAMPLER |
US4537231A (en) * | 1983-08-29 | 1985-08-27 | Becton, Dickinson And Company | Dispenser apparatus for simultaneously dispensing predetermined equal volumes of liquid including a disposable dispenser module |
US4565100A (en) * | 1981-10-02 | 1986-01-21 | Culture-Tek | Pipette device |
DE29603462U1 (en) * | 1995-02-27 | 1996-04-25 | Slt Labinstruments Gmbh | Device for aspirating a liquid from the cavities of a microtiter plate |
US6165417A (en) * | 1998-10-26 | 2000-12-26 | The Regents Of The University Of California | Integrated titer plate-injector head for microdrop array preparation, storage and transfer |
US6326212B1 (en) * | 1999-10-12 | 2001-12-04 | Arden Systems, Inc. | Membrane dispensing head apparatus and method for dispensing liquid |
US20020025582A1 (en) * | 2000-04-05 | 2002-02-28 | Allyn Hubbard | Methods and devices for storing and dispensing liquids |
WO2002049763A2 (en) * | 2000-12-18 | 2002-06-27 | Institut für Physikalische Hochtechnologie e.V. | Device for receiving and discharging liquid substances |
US20020114740A1 (en) * | 2001-01-31 | 2002-08-22 | Shimadzu Corporation | Liquid transfer apparatus and reaction vessel |
WO2002092228A2 (en) * | 2001-05-11 | 2002-11-21 | Allegro Research Limited | A method and device for dispensing of droplets |
DE69621608T2 (en) * | 1995-03-21 | 2003-02-06 | Aclara Biosciences Inc | DEVICE AND METHOD FOR CAPILLARY ELECTROPHORESIS |
US20030228241A1 (en) * | 1999-08-13 | 2003-12-11 | Legge Coulton Heath | Apparatus for liquid sample handling |
US20040018119A1 (en) * | 2002-07-23 | 2004-01-29 | Peter Massaro | Liquid handling tool having porous plunger |
US6841130B2 (en) * | 2000-12-15 | 2005-01-11 | Wallac Oy | Pipetting method and multichannel pipetting apparatus |
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DE3138176C2 (en) * | 1981-09-25 | 1984-06-07 | Mathias 4815 Schloss Holte Mitter | Serving as an applicator roller for the treatment of flat structures such. B. webs |
US4649967A (en) * | 1983-09-08 | 1987-03-17 | University Of Cincinnati | Multiple efflux apparatuses for transferring fluid |
DK492788D0 (en) * | 1988-09-02 | 1988-09-05 | Morten Meldal | Peptide Synthesizer |
US5334352A (en) * | 1992-09-23 | 1994-08-02 | Icn Biomedicals, Inc. | Manifold construction |
WO2006031311A2 (en) * | 2004-08-04 | 2006-03-23 | Irm, Llc | Multi-well container processing systems, system components, and related methods |
-
2007
- 2007-01-29 DE DE102007005323A patent/DE102007005323A1/en not_active Withdrawn
-
2008
- 2008-01-17 WO PCT/EP2008/000317 patent/WO2008092570A1/en active Application Filing
Patent Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3572552A (en) * | 1969-07-25 | 1971-03-30 | Perry W Guinn | Diaphragm dispenser |
US3982438A (en) * | 1975-06-23 | 1976-09-28 | The Salk Institute For Biological Studies | Multiple sample pipetting apparatus |
US4302338A (en) * | 1978-07-28 | 1981-11-24 | Metallgesellschaft Aktiengesellschaft | Apparatus for metering and/or distributing liquid media |
DE3220444A1 (en) * | 1981-10-02 | 1983-04-21 | Culture Tek Corp., Granada Hills, Calif. | PIPETTE SAMPLER |
US4565100A (en) * | 1981-10-02 | 1986-01-21 | Culture-Tek | Pipette device |
US4537231A (en) * | 1983-08-29 | 1985-08-27 | Becton, Dickinson And Company | Dispenser apparatus for simultaneously dispensing predetermined equal volumes of liquid including a disposable dispenser module |
DE29603462U1 (en) * | 1995-02-27 | 1996-04-25 | Slt Labinstruments Gmbh | Device for aspirating a liquid from the cavities of a microtiter plate |
DE69621608T2 (en) * | 1995-03-21 | 2003-02-06 | Aclara Biosciences Inc | DEVICE AND METHOD FOR CAPILLARY ELECTROPHORESIS |
US6165417A (en) * | 1998-10-26 | 2000-12-26 | The Regents Of The University Of California | Integrated titer plate-injector head for microdrop array preparation, storage and transfer |
US20030228241A1 (en) * | 1999-08-13 | 2003-12-11 | Legge Coulton Heath | Apparatus for liquid sample handling |
US6326212B1 (en) * | 1999-10-12 | 2001-12-04 | Arden Systems, Inc. | Membrane dispensing head apparatus and method for dispensing liquid |
US20020025582A1 (en) * | 2000-04-05 | 2002-02-28 | Allyn Hubbard | Methods and devices for storing and dispensing liquids |
US6905657B2 (en) * | 2000-04-05 | 2005-06-14 | Bioprocessors Corp. | Methods and devices for storing and dispensing liquids |
US6841130B2 (en) * | 2000-12-15 | 2005-01-11 | Wallac Oy | Pipetting method and multichannel pipetting apparatus |
WO2002049763A2 (en) * | 2000-12-18 | 2002-06-27 | Institut für Physikalische Hochtechnologie e.V. | Device for receiving and discharging liquid substances |
US20020114740A1 (en) * | 2001-01-31 | 2002-08-22 | Shimadzu Corporation | Liquid transfer apparatus and reaction vessel |
WO2002092228A2 (en) * | 2001-05-11 | 2002-11-21 | Allegro Research Limited | A method and device for dispensing of droplets |
US20040018119A1 (en) * | 2002-07-23 | 2004-01-29 | Peter Massaro | Liquid handling tool having porous plunger |
Also Published As
Publication number | Publication date |
---|---|
WO2008092570A1 (en) | 2008-08-07 |
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