DE102006062568A1 - Stabilizing the color and/or odor of a water-containing cosmetic or pharmaceutical composition comprises adding a mixture of a phenolic antioxidant and a complexing agent - Google Patents

Abstract

Stabilizing the color and/or odor of a water-containing cosmetic or pharmaceutical composition comprises adding a mixture of a phenolic antioxidant and a complexing agent, provided that the antioxidant is added in an amount of less than 0.02 wt.% of the. Independent claims are also included for: (1) water-containing cosmetic or pharmaceutical composition comprising a color-stabilizing mixture of a phenolic antioxidant and a complexing agent, provided that the composition contains less than 0.02 wt.% of the antioxidant; (2) product comprising a composition as above and a transparent or semitransparent container.

Description

The The present application relates to improvements in color stabilization aqueous cosmetic and pharmaceutical agent. The products are particularly storage-stable by a special stabilizer mixture and are characterized by improved color and odor stability, especially against the action of light, from.

State of the art

cosmetic and also pharmaceutical agents are often with low Quantities of an approved food or cosmetic dye colored to increase the product attractiveness or one by certain raw materials, such as plant extracts, to compensate for registered unattractive color. hydrous Cosmetic and pharmaceutical agents show during the Storage a certain tendency to decomposition. This can happen for example, a phase separation in emulsion preparations act to change the viscosity behavior or to color and smell changes. In particular, color and odor stability play for acceptance of the product by the end user a significant role. colour and smell of hydrous preparations may change, if the preparations have elevated temperatures or Are exposed to light, for example in shop windows, in the Shelf or the end user himself. To the light-related Minimizing changes will be cosmetic and pharmaceutical Medium therefore usually in non-transparent, opaque Bottled container. Transparent or semitransparent Product containers are often used to improve light stability made of materials that UV filter substances, such as Benzotriazole be added. In addition, you can the cosmetic agents themselves to protect the product UV filter substances contain. The amounts of UV filter substances are low and the Color and odor stabilization sufficient, but sufficient not to give the user a sunscreen over the To provide UV rays of sunlight. However, more expensive an addition of such stabilizers the production cost, without to give the consumer a real cosmetic benefit. In addition, many consumers avoid appropriate UV filter-containing Products, as they consider these additives unnecessary reject.

From the DE 197 50 906 and the DE 197 39 797 The use of triazine derivatives for stabilizing organic materials against UV light, oxygen and elevated temperatures is known. The EP 0 714 880 relates to bismethylenephenylene derivatives which find use not only as sun protection factors for the protection of the skin and hair, but also serve to improve the storage stability of cosmetic compositions. From the publications JP 09078085 A and JP 10237488 A Skin and hair cleansers are known, which are added to improve the storage stability at elevated temperature complexing agents and antioxidants. Stabilizer mixtures of antioxidants and complexing agents are also often used to stabilize retinoid-containing cosmetic preparations, such as in the EP 0 440 398 . WO 96/07396 . EP 0 549 592 and EP 0 586 106 described. Out WO 02/02058 A1 For example, a stabilizer mixture of tocopherols, chelating agents, and selected glyceride citrate esters is known.

task

Of the current consumer trend goes to cosmetic products in transparent and semitransparent containers. A The task was therefore to develop a stabilizer system that cosmetic products in transparent or semitransparent containers against the light-related color and odor changes stabilized. The known means are not in this regard sufficiently effective. A special aspect of the task was therefore in it, the cosmetic means in such containers to stabilize more strongly against light-induced changes as this is achieved by added UV filter substances. Another Part of the task was to provide a particularly skin-friendly Stabilizer system to develop, which with a variety of cosmetic Formulations is compatible and in particular surfactant-containing formulations in transparent or semitransparent containers too stabilized against the effects of light without the use of UV filters. Another object of the present application was to use the amount Further reducing stabilizers in order to a) reduce raw material costs, b) Do not use the user with substances without additional cosmetic or pharmaceutical use and c) the Making the means easier. Usual stabilizers are oil-soluble, but not water-soluble, and therefore require an entry of additional mixing energy or the addition of solubilizers.

It has now surprisingly been found that water-containing cosmetic and pharmaceutical compositions can be stabilized by a novel, compared to the prior art further optimized stabilizer combination against light-induced color and odor changes and for a long time constant Have product properties, at the same time the other tasks set, in particular with regard to the reduction of manufacturing costs, are solved.

One The first object of the invention is a hydrous cosmetic or pharmaceutical agent containing a color-stabilizing Active ingredient mixture of a) less than 0.02 wt .-%, based on the weight the agent, at least one phenolic antioxidant and b) at least a complexing agent.

One Another object of the invention is the use of a combination from a) less than 0.02% by weight, based on the weight of the composition, at least one phenolic antioxidant and b) at least one Complexing agent, for color and odor stabilization hydrous cosmetic or pharmaceutical agent, especially against the action of light.

One Another object of the invention is a process for color and Odor stabilization hydrous cosmetic or pharmaceutical Means characterized by giving the agent a Stabilizer mixture of a) less than 0.02 wt .-%, based on the weight of the agent, at least one phenolic antioxidant and b) at least one complexing agent added.

For The expert surprising is that even and straight excellent color stabilization results with very low levels of antioxidant be achieved. Usually the expert finally expects that only more active ingredient leads to a better result.

The Combination of at least one phenolic antioxidant in one very small amount of less than 0.02 wt .-%, based on the Weight of the entire agent according to the invention, with at least one complexing agent, allows an extraordinary Color and odor stabilization of hydrous cosmetic Means. Storage tests have shown that the stabilizer mixture the odor and color stability when exposed to light (simulated sunlight) with lower concentrations of phenolic Antioxidant more improved than at higher Concentrations.

The Stabilizer combination can be used for cosmetic cleansing products such as bubble baths, shower baths, cleaning foams, Shampoos, for hair care products as well as for Cosmetic or dermatological products and skin care, such as creams, lotions, deodorants, etc. are used. The products can be watery, aqueous-alcoholic or aqueous-glycolic base, and For example, perfume, facial and Aftershaves include. Basically lie here - too with regard to pharmaceutical or dermatological products - none Limitations.

When Component (A) of the stabilizer mixture is phenolic antioxidants in an amount of less than 0.02% by weight, by weight of the entire agent according to the invention. According to the invention preferred phenolic antioxidants are selected from the esters the para-hydroxyhydrocinnamic acid, furthermore from oleuropein, ligustroside, the tocopherols, biochinones, gallic acid esters, 2,6-di-tert-butyl-4-methylphenol (BHT, butylhydroxytoluene), as well as mixtures thereof.

A particularly preferred ester of para-hydroxyhydrocinnamic acid according to the present invention is pentaerythrityltetra-di-t-butyl-hydroxyhydrocinnamate (see the formula below). This substance is commercially available under the trade names Tinogard TT, Tinogard TTDD or Irganox 1010.

Oleuropein occurs in the fruits and leaves of the olive tree (olive tree, Olea europaea, Oleaceae) and can be extracted therefrom, for example with ethanol.

Tocopherole

Tocotrienole

Tocopherolchinone

Tocopherolhydrochinone Tabelle: Struktur und Daten von Tocopherolen. R¹ R² R³ Konfiguratio n Summenforme I CAS α CH₃ CH₃ CH₃ 2R,4'R,8'R C₂₉H₅₀O₂ 10191-41-0 59-02-9 β CH₃ H CH₃ 2R,4'R,8'R C₂₈H₄₈O₂ 148-03-8 16698-35-4 γ H CH₃ CH₃ 2R,4'R,8'R (±)-Form C₂₈H₄₈O₂ 7616-22-0 54-28-4 7540-59-2 δ H H CH₃ 2R,4'R,8'R C₂₇H₄₈O₂ 119-13-1 5488-58-4 ζ₂ CH₃ CH₃ H 2R,4'R,8'R C₂₈H₄₈O₂ 493-35-6 17976-95-3 η H CH₃ H 2R,4'R,8'R C₂₇H₁₆O₂ 91-86-1 78656-16-3 α CH₃ CH₃ CH₃ (E,E) R-(E,E) C₂₉H₄₄O₂ 1721-51-3 47686-42-0 58864-81-6 β^-(ε-Tocopherol) CH₃ H CH₃ R-(E,E) C₂₆H₄₂O₂ 490-23-3 γ H CH₃ CH₃ R-(E,E) (E,E) C₂₆H₄₂O₂ 14101-61-2 135970-12-6 α CH₃ CH₃ CH₃ 3'R,7'R,11'R C₂₉H₅₀O₃ 7559-04-8 α CH₃ CH₃ CH₃ 3'R,7'R,11'R C₂₉H₅₂O₃ 14745-36-9 Tocopherols have the following general formula. The tocopherol quinones, oxidation products of tocopherols, are among the biochinones.

tocopherols

tocotrienols

tocopherol quinones

Tocopherolhydrochinone Table: Structure and data of tocopherols. R ¹ R ² R ³ Configuration Sumforme I CAS α CH ₃ CH ₃ CH ₃ 2 R, 4 'R, 8'r C ₂₉ H ₅₀ O ₂ 10191-41-0 59-02-9 β CH ₃ H CH ₃ 2 R, 4 'R, 8'r C ₂₈ H ₄₈ O ₂ 16698-35-4 148-03-8 γ H CH ₃ CH ₃ 2R, 4'R, 8'R (±) -form C ₂₈ H ₄₈ O ₂ 7616-22-0 54-28-4 7540-59-2 δ H H CH ₃ 2 R, 4 'R, 8'r C ₂₇ H ₄₈ O ₂ 119-13-1 5488-58-4 ζ ₂ CH ₃ CH ₃ H 2 R, 4 'R, 8'r C ₂₈ H ₄₈ O ₂ 493-35-6 17976-95-3 η H CH ₃ H 2 R, 4 'R, 8'r C ₂₇ H ₁₆ O ₂ 91-86-1 78656-16-3 α CH ₃ CH ₃ CH ₃ (E, E) R- (E, E) C ₂₉ H ₄₄ O ₂ 1721-51-3 47686-42-0 58864-81-6 β ^- (ε-tocopherol) CH ₃ H CH ₃ R- (E, E) C ₂₆ H ₄₂ O ₂ 490-23-3 γ H CH ₃ CH ₃ R- (E, E) (E, E) C ₂₆ H ₄₂ O ₂ 14101-61-2 135970-12-6 α CH ₃ CH ₃ CH ₃ 3'R, 7'R, 11'R C ₂₉ H ₅₀ O ₃ 7559-04-8 α CH ₃ CH ₃ CH ₃ 3'R, 7'R, 11'R C ₂₉ H ₅₂ O ₃ 14745-36-9

tocopherols chemically consist of a chroman ring and a phytol side chain. Natural usable according to the invention or synthetic tocopherol, wherein natural tocopherol is preferred. Natural tocopherol is a mixture of four isomers, which differ only in the substitution on the chroman ring, however, their phytol side chain always has the RRR configuration. These include α-, β-, γ-, δ- and ε-tocopherol. Synthetically produced tocopherol on the other hand, also has a mixture of isomers in the phytol side chain on. Particularly preferred according to the invention Tocopherol mixtures with a high content of γ- and δ-isomers. Natural tocopherol mixtures can come from many Vegetable oils are obtained. Especially rich in tocopherols are the seed oils of soy, wheat, corn, rice, cotton, alfalfa and nuts. Usable according to the invention are also the esters of tocopherol, such as tocopheryl acetate, succinate, nicotinate and poly (oxyethylene) succinate.

The preferred tocopherol component (a) or the preferred mixture from tocopherols is in the inventive Agents in concentrations of less than 0.02 wt .-%, preferably 0.0001-0.01 wt%, and more preferably 0.0005-0.006 Wt .-%, each based on the weight of the composition.

bioquinones

To The biochinones according to the invention include the Plastoquinones, ubiquinones and the tocopherol quinones shown above.

Plastoquinones have the following formula:

Under Plastoquinones are the quinones isolated from chloroplasts the above general structure used as redox substrates play a role in photosynthesis, being reversible in pass over the corresponding hydroquinones (plastoquinol). Multiprenyl side chains of plastoquinone and closely related Ubiquinones are derived biosynthetically from farnesyl diphosphate. Several plastoquinones are known, which are in the number n of isoprene residues distinguish, for. B. Plastoquinone-9 (n = 9) or those with different Substituents on the quinone ring.

(UBI-I) mit n = 6, 7, 8, 9 oder 10.Cosmetic or pharmaceutical agents used particularly preferably according to the invention are characterized in that they contain as phenolic antioxidant at least one active substance which is selected from at least one ubiquinone or a ubiquinol or derivatives thereof. Ubiquinols are the reduced form of ubiquinones. The preferred ubiquinones according to the invention have the formula (UBI-I):

(UBI-I) with n = 6, 7, 8, 9 or 10.

Especially preferred is the ubiquinone of the formula (UBI-I) with n = 10, also known as coenzyme Q10.

According to the invention preferred are the ubiquinones, ubiquinols or their derivatives in total of less than 0.02% by weight, preferably 0.0001-0.01% by weight and particularly preferably 0.0005-0.006 wt .-%, each based on the weight of the agent according to the invention, used.

Gallussäureester

Gallussäureester, in particular the propyl ester, but also the dodecyl ester and the Octyl esters are approved as antioxidants in cosmetics. According to the invention preferred the gallic acid esters are in total amounts of less as 0.02 wt .-%, preferably 0.0001-0.01 wt .-% and especially preferably 0.0005-0.001 wt .-%, each based on the Weight of the agent according to the invention used.

Also 2,6-di-tert-butyl-4-methylphenol (BHT, butylhydroxytoluene) is a known, approved for cosmetics and medicines phenolic antioxidant. According to the invention preferred BHT is in an amount of less than 0.02 wt .-%, preferably 0.0001-0.01 Wt .-% and particularly preferably 0.0005-0.001 wt .-%, respectively based on the weight of the invention By means of, used.

Component (b) contains at least one complexing agent. According to the invention, these are understood to mean compounds which chelate-like complex metal cations, in particular calcium, iron, Ni ckel and copper ions. The skilled worker is aware of a large number of such compounds from the relevant literature. Particularly suitable for cosmetic purposes are polycarboxylic acids and their water-soluble sodium, potassium, magnesium and ammonium salts, various fruit acids, derivatives of amino acids, aminopolycarboxylic acids, in particular ethylenediaminetetraacetic acid, and phosphonic acids, in particular etidronic acid.

Suitable according to the invention are also hydroxycarboxylic acids and their salts, such as Citric acid, tartaric acid, malic acid, Gluconic acid, glucuronic acid, galactaric acid, Phytic acid, polycarboxylic acids such. Succinic acid, 1,2,3-propanetricarboxylic acid, cyclodextrins, β-alaninediacetic acid and their salts, dihydroxyethylglycinates, dicarboxymethylalaninates, Iminodisuccinates, tetrahydroxyethyl- and tetrahydroxypropylethylenediamine.

Preferably suitable as complexing agent (b) are the water-soluble salts of aminopolycarboxylic acids, in particular the sodium, potassium, ammonium, magnesium, calcium and triethanolamine salts. These include preferably ethylenediaminetetraacetic acid (EDTA) and its salts, eg. Calcium disodium EDTA, diammonium EDTA, disodium and dipotassium EDTA, triethanolamine EDTA, trisodium and tripotassium EDTA, tetrasodium and tetrapotassium EDTA, and nitrilotriacetic acid, hydroxyethylethylenediaminetriacetic acid, cyclohexanediaminetetraacetic acid, diethylenetriaminepentaacetic acid, lauroylethylenediaminetriacetic acid and ethylenediamine disuccinic acid and the corresponding salts. According to the invention particularly preferred as component B is tetrasodium EDTA and trisodium EDTA, which are, for example, under the name Trilon B ^® and Trilon ^® A commercially.

Of the Complexing agent or the mixture of complexing agents (b) is in the agents according to the invention preferably in a total concentration from 0.01-2% by weight, more preferably 0.02-1 Wt%, most preferably 0.05-0.1 wt%, in each case based on the weight of the invention By means of, included.

Agents preferred according to the invention are characterized in that they contain at least one ester of a hydroxy-substituted bi- or tricarboxylic acid and a C ₁₂ -C ₂₄ -fatty acid mono- and / or -diglyceride. Particular preference according to the invention as hydroxy-substituted di- or tricarboxylic acids of these esters are, in particular, fruit acids such as, for example, tartaric acid, citric acid, malic acid, fumaric acid and succinic acid. Particularly preferred according to the invention are the citric acid esters (citrates) of C ₁₂ -C ₂₄ fatty acid mono- and diglycerides.

The fatty acid mono- and diglyceride components of the aforementioned esters are known substances which can be prepared by relevant processes of preparative organic chemistry. For example, the citrates of the mono- and diglycerides are obtained by transesterification of the corresponding triglycerides with glycerol and citric acid or by targeted esterification of fatty acids and citric acid with glycerol. The separation of unreacted starting materials and the accumulation of certain components in the mixtures is usually carried out via a molecular distillation. Suitable ester components are preferably the citrates of unbranched, saturated C ₁₂ -C ₂₀ fatty acid mono- and diglycerides, and among these in particular the C ₁₂ -C ₁₈ fatty acid mono- and diglycerides. Explicit examples of such are Glycerylmonostearatcitrat Citrate, Glyceryldistearatcitrat, Glycerylmonopalmitatcitrat, Glyceryldipalmitatcitrat, Glycerylmonomyristatcitrat, Glyceryldimyristatcitrat, Glycerylmonolauratcitrat, Glyceryldilauratcitrat and mixtures of these Glyceridcitrate, especially mixtures of Glycerylmonostearatcitrat, Glyceryldistearatcitrat, Glycerylmonopalmitatcitrat and Glyceryldipalmitatcitrat. Such Citrate are available, for example under the name IMWITOR ^® 370 as a pure substance or in the form of product mixtures as Controx ^® KS and Controx ^® VP.

The at least one ester of a hydroxy-substituted bi- or tricarboxylic acid and a C ₁₂ -C ₂₄ -fatty acid mono- and / or -diglyceride is preferred in the preferred compositions according to the invention in total amounts of 0.0001 to less than 0.02 wt .-%, more preferably 0.0005-0.01 wt .-% and most preferably 0.001-0.008 wt .-%, each based on the weight of the inventive composition.

Particularly suitable as a preferred stabilizer mixture is a combination of at least one tocopherol and / or tocopherol derivative (a) in a concentration of less than 0.02 wt .-%, a salt of ethylenediaminetetraacetic acid (b) and a citric acid ester of a C ₁₂ C ₁₈ fatty acid mono- and / or diglycerides (c). Combinations of Trilon ^® B and Controx ^® KS can be particularly preferred.

When Another preferred stabilizer mixture is particularly suitable a combination of pentaerythrityltetra-di-t-butyl-hydroxyhydrocinnamate (a) at a concentration of less than 0.02% by weight and a salt an ethylenediaminetetraacetic acid (b).

Further preferred agents according to the invention are characterized in that they contain at least one active ingredient selected from ascorbic acid, the esters and the salts of ascorbic acid (see the formulas below). It has surprisingly been observed that ascorbic acid and its esters, in particular sodium ascorbyl phosphate, enhance the action of the phenolic antioxidants. A particularly preferred combination are mixtures of salts of ascorbyl phosphate with tocopherols and / or tocopherol esters, in particular mixtures in a weight ratio of 1: 1.

According to the invention preferred or preferably used are the ascorbic acid itself, in particular L-ascorbic acid, furthermore dehydroascorbic acid. Ascorbic acid derivatives preferred according to the invention In particular, the salts of ascorbic acid, d. H. Hydroascorbate or ascorbates, among them the alkali and alkaline earth salts are preferred. Particularly preferred salts of ascorbic acid are sodium hydroascorbate, sodium ascorbate, potassium hydroascorbate, Potassium ascorbate, ammonium ascorbate, ammonium hydroascorbate, calcium ascorbate, Calcium hydroascorbate, magnesium ascorbate and magnesium hydroascorbate.

Further Inventively preferred ascorbic acid derivatives are selected from the esters of ascorbic acid with at least one organic and / or inorganic acid (R ≠ H in the above formula). Among the esters of ascorbic acid are in particular ascorbyl methanoate, Ascorbyl ethanoate, ascorbyl n-propanoate, ascorbyl iso-propanoate, Ascorbyl n-butanoate, etc. preferred. With special preference According to the invention, the esters of ascorbic acid with fatty acids, in particular ascorbyl linoleate, ascorbyl oleate, Ascorbyloleinate, ascorbyl palmitate, ascorbyl stearate, ascorbyl oleate (6-palmitoyl-L-ascorbic acid) and ascorbyl tetraisopalmitate, used.

Also Inorganic acids can be treated with ascorbic acid be esterified. Among the esters of ascorbic acid with Inorganic acids is in particular the ascorbyl phosphate preferably, in the form of the sodium salt, sodium ascorbyl phosphate, or the magnesium salt, magnesium ascorbyl phosphate.

Further Inventively preferred ascorbic acid derivatives are selected from the ethers of ascorbic acid with at least one organic polyhydroxy compound, in particular with at least one (glycosidically bonded) saccharide, in particular Ascorbyl.

Especially preferred agents according to the invention are characterized characterized in that they, based on their weight, a total of maximum 0.01 wt .-%, preferably at most 0.001 wt .-%, ascorbic acid and / or ascorbic acid salts and / or ascorbic acid esters and / or ascorbic acid ethers.

Further inventively preferred agents are characterized in that they contain at least one triarylmethane dye, in particular selected from the triarylmethane dyes approved for cosmetics. From this class, the acid dyes, in particular the diaminotriarylmethane dyes, and in particular the patent blue dyes, are particularly preferred. Such dyes are in preferred compositions of the invention in a total amount of 0.00001-0.0001 wt .-%, based on the Weight of the total agent, included.

When another obligatory component contains the cosmetic Means water, preferably in amounts of 5-90% by weight, more preferably 10-80% by weight and extraordinarily preferably 20-70 wt .-%, each based on the weight of the agent according to the invention is contained.

The Inventive agent preferably contains at least one surfactant from the group of anionic surfactants, nonionic surfactants, the amphoteric, the zwitterionic surfactants and / or the cationic surfactants.

The Surfactants are preferred in total amounts of from 5 to 40% by weight, especially preferably 5 to 20 wt .-%, each based on the weight of the inventive By means of, included.

• – lineare Fettsäuren mit 10 bis 22 C-Atomen (Seifen),
• – Ethercarbonsäuren der Formel R¹-O-(CH₂-CH₂O)_x-CH₂-COOH, in der R¹ eine lineare Alkylgruppe mit 10 bis 22 C-Atomen und x = 0 oder 1 bis 16 ist,
• – Amidethercarboxylate der Formel [R²-NH(-CH₂-CH₂-O)_nCH₂-COO]_mZ, in der R² für einen linearen oder verzweigten, gesättigten oder ungesättigten Acylrest mit 2 bis 29 C-Atomen, n für ganze Zahlen von 1 bis 10, m für die Zahlen 1 oder 2 und Z für ein Kation aus der Gruppe der Alkali- oder Erdalkalimetalle steht,
• – Acylsarcoside mit 10 bis 18 C-Atomen in der Acylgruppe,
• – Acyltauride mit 10 bis 18 C-Atomen in der Acylgruppe,
• – Acylisethionate mit 10 bis 18 C-Atomen in der Acylgruppe,
• – Sulfobernsteinsäuremono- und dialkylester mit 8 bis 18 C-Atomen in der Alkylgruppe und Sulfobernsteinsäuremonoalkylpolyoxyethylester mit 8 bis 18 C-Atomen in der Alkylgruppe und 1 bis 6 Oxyethylgruppen,
• – lineare Alkansulfonate mit 12 bis 18 C-Atomen,
• – lineare Alpha-Olefinsulfonate mit 12 bis 18 C-Atomen,
• – Alpha-Sulfofettsäuremethylester von Fettsäuren mit 12 bis 18 C-Atomen,
• – Alkylsulfate und Alkylpolyglycolethersulfate der Formel R³-O(-CH₂-CH₂O)_x-SO₃H, in der R³ eine bevorzugt lineare Alkylgruppe mit 10 bis 18 C-Atomen und x = 0 oder 1 bis 12 ist,
• – Gemische oberflächenaktiver Hydroxysulfonate gemäß DE-A-37 25 030 ,
• – sulfatierte Hydroxyalkylpolyethylen- und/oder Hydroxyalkylenpropylenglycolether gemäß DE-A-37 23 354 ,
• – Sulfonate ungesättigter Fettsäuren mit 12 bis 24 C-Atomen und 1 bis 6 Doppelbindungen gemäß DE-A-39 26 344 ,
• – Ester der Weinsäure und Zitronensäure mit Alkoholen, die Anlagerungsprodukte von etwa 2–15 Molekülen Ethylenoxid und/oder Propylenoxid an Fettalkohole mit 8 bis 22 Kohlenstoffatomen darstellen,
• – Kokosmonoglyceridsulfate.

Suitable anionic surfactants in compositions according to the invention are all anionic surfactants suitable for use on the human body. These are characterized by a water-solubilizing, anionic group such as. Example, a carboxylate, sulfate, sulfonate or phosphate group and a lipophilic alkyl group having about 10 to 22 carbon atoms. In addition, glycol or polyglycol ether groups, ester, ether and amide groups and hydroxyl groups may be present in the molecule. Examples of suitable anionic surfactants are, in each case in the form of the sodium, potassium, magnesium and ammonium as well as the mono-, di- and trialkanolammonium salts with 2 or 3 C atoms in the alkanol group,

• - linear fatty acids with 10 to 22 carbon atoms (soaps),
• Ether carboxylic acids of the formula R ¹ -O- (CH ₂ -CH ₂ O) _x -CH ₂ -COOH, in which R ^{1 is} a linear alkyl group having 10 to 22 C atoms and x = 0 or 1 to 16,
• Amide ether carboxylates of the formula [R ² -NH (-CH ₂ -CH ₂ -O) _n CH ₂ -COO] _m Z in which R ^{2 is} a linear or branched, saturated or unsaturated acyl radical having 2 to 29 C atoms, n is an integer from 1 to 10, m is the number 1 or 2 and Z is a cation from the group of the alkali or alkaline earth metals,
• Acylsarcosides having 10 to 18 C atoms in the acyl group,
• Acyltaurides having 10 to 18 C atoms in the acyl group,
• Acyl isethionates having 10 to 18 C atoms in the acyl group,
• Sulfosuccinic acid mono- and dialkyl esters having 8 to 18 C atoms in the alkyl group and sulfosuccinic monoalkylpolyoxyethyl esters having 8 to 18 C atoms in the alkyl group and 1 to 6 oxyethyl groups,
• Linear alkanesulfonates having 12 to 18 C atoms,
• - linear alpha-olefin sulfonates having 12 to 18 C atoms,
• Alpha-sulfofatty acid methyl esters of fatty acids containing 12 to 18 carbon atoms,
• Alkyl sulfates and alkyl polyglycol ether sulfates of the formula R ³ -O (-CH ₂ -CH ₂ O) _x -SO ₃ H in which R ^{3 is} a preferably linear alkyl group having 10 to 18 C atoms and x = 0 or 1 to 12,
• Mixtures of surface active hydroxysulfonates according to DE-A-37 25 030 .
• - Sulfated Hydroxyalkylpolyethylen- and / or Hydroxyalkylenpropylenglycolether according to DE-A-37 23 354 .
• - Sulfonates of unsaturated fatty acids having 12 to 24 carbon atoms and 1 to 6 double bonds according to DE-A-39 26 344 .
• Esters of tartaric acid and citric acid with alcohols which are adducts of about 2-15 molecules of ethylene oxide and / or propylene oxide with fatty alcohols containing 8 to 22 carbon atoms,
• - Coconut monoglyceride sulfates.

preferred Anionic surfactants are alkyl sulfates, alkyl polyglycol ether sulfates and ether carboxylic acids having 10 to 18 C atoms in the alkyl group and up to 12 glycol ether groups in the molecule, as well as sulfosuccinic acid mono- and -dialkylester having 8 to 18 C-atoms in the alkyl group and sulfosuccinic monoalkylpolyoxyethylester with 8 to 18 C atoms in the alkyl group and 1 to 6 oxyethyl groups.

• – Anlagerungsprodukte von 2 bis 30 Mol Ethylenoxid und/oder 0 bis 5 Mol Propylenoxid an lineare Fettalkohole mit 8 bis 22 C-Atomen, an Fettsäuren mit 12 bis 22 C-Atomen und an Alkylphenole mit 8 bis 15 C-Atomen in der Alkylgruppe,
• – C₁₂-C₂₂-Fettsäuremono- und -diester von Anlagerungsprodukten von 1 bis 30 Mol Ethylenoxid an Glycerin,
• – C₈-C₂₂-Alkylmono- und -oligoglycoside und deren ethoxylierte Analoga sowie
• – Anlagerungsprodukte von 5 bis 60 Mol Ethylenoxid an Rizinusöl und gehärtetes Rizinusöl.

Nonionic surfactants contain as hydrophilic group z. A polyol group, a polyalkylene glycol ether group or a combination of polyol and polyglycol ether groups. Such compounds are, for example

• Addition products of 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide onto linear fatty alcohols having 8 to 22 carbon atoms, to fatty acids containing 12 to 22 carbon atoms and to alkylphenols having 8 to 15 carbon atoms in the alkyl group,
• C ₁₂ -C ₂₂ -fatty acid mono- and diesters of addition products of 1 to 30 mol of ethylene oxide with glycerol,
• C ₈ -C ₂₂ alkyl mono- and oligoglycosides and their ethoxylated analogs, and
• - Addition products of 5 to 60 moles of ethylene oxide with castor oil and hydrogenated castor oil.

Preferred nonionic surfactants are alkylpolyglycosides of the general formula R ⁴ O- (S) _x . These un support the mildness of the agents according to the invention, have a thickening effect and contribute to an improved solubility of the antioxidants and of the optionally contained fatty acid partial glycerides. They are identified by the following parameters:
The alkyl radical R ⁴ contains 6 to 22 carbon atoms and may be both linear and branched. Preference is given to primary linear and methyl-branched in the 2-position aliphatic radicals. Such alkyl radicals are, for example, 1-octyl, 1-decyl, 1-lauryl, 1-myristyl, 1-cetyl and 1-stearyl.

Especially preferred are 1-octyl, 1-decyl, 1-lauryl, 1-myristyl. Using so-called "oxo-alcohols" as starting materials predominate Compounds with an odd number of carbon atoms in the alkyl chain.

The alkylpolyglycosides which can be used according to the invention can contain, for example, only one particular alkyl radical R ⁴ . Usually, however, these compounds are prepared starting from natural fats and oils or mineral oils. In this case, the alkyl radicals R ^{4 are} mixtures corresponding to the starting compounds or corresponding to the particular work-up of these compounds.

• – im wesentlichen aus C₈- und C₁₀-Alkylgruppen,
• – im wesentlichen aus C₁₂- und C₁₄-Alkylgruppen,
• – im wesentlichen aus C₈- bis C₁₆-Alkylgruppen oder
• – im wesentlichen aus C₁₂- bis C₁₆-Alkylgruppen besteht.

Particular preference is given to those alkylpolyglycosides in which R ⁴

• Consisting essentially of C ₈ and C ₁₀ -alkyl groups,
• Essentially of C ₁₂ and C ₁₄ alkyl groups,
• - Essentially from C ₈ - to C ₁₆ alkyl groups or
• - Consists essentially of C ₁₂ - to C ₁₆ -alkyl groups.

When Sugar component S can be any mono- or oligosaccharides be used. Usually, sugars with 5 or 6 carbon atoms and the corresponding oligosaccharides used. Such sugars are, for example, glucose, fructose, galactose, Arabinose, ribose, xylose, lyxose, allose, altrose, mannose, gulose, Idose, talose and sucrose. Preferred sugar building blocks are glucose, Fructose, xylose, galactose, arabinose and sucrose; Glucose and Xylose are particularly preferred.

The According to the invention preferred alkylpolyglycosides contain on average 1.1 to 5 sugar units. alkylpolyglycosides with x values of 1.1 to 1.6 are preferred. Very particularly preferred are alkyl glycosides in which x is 1.1 to 1.4.

The Alkyl glycosides can also be added to their surfactant effect serve to fix the fragrance components on the hair and skin to improve.

Also the alkoxylated homologs of said alkylpolyglycosides can used according to the invention. These homologs can average up to 10 ethylene oxide and / or Contain propylene oxide per alkyl glycoside unit.

at the compounds used as surfactants with alkyl groups each are uniform substances. However, it is usually preferred in the preparation of these substances of native to go out with vegetable or animal raw materials, so that one Substance mixtures with different, from the respective raw material receives dependent alkyl chain lengths.

at the surfactants, the adducts of ethylene and / or propylene oxide represent fatty alcohols or derivatives of these addition products, can both products with a "normal" homolog distribution as well as those with a narrow homolog distribution become. Under "normal" homolog distribution are mixtures understood by homologues who are involved in the reaction of fatty alcohol and alkylene oxide using alkali metals, alkali metal hydroxides or alkali metal alcoholates as catalysts. Narrowed homolog distributions are obtained when, for example Hydrotalcites, alkaline earth metal salts of ether carboxylic acids, Alkaline earth metal oxides, hydroxides or alcoholates as catalysts be used. The use of products with narrow homolog distribution may be preferred.

Furthermore, zwitterionic surfactants can be used, in particular as cosurfactants. Zwitterionic surfactants are surface-active compounds which contain at least one quaternary ammonium group and at least one -COO or -SO ₃ in the molecule ^- Wear group. Particularly suitable zwitterionic surfactants are the so-called betaines such as the N-alkyl-N, N-dimethylammoniumglycinate, for example Kokosalkyldimethylammoniumglycinat, N-acyl-aminopropyl-N, N-dimethylammoniumglycinate, for example Kokosacylaminopropyldimethylammoniumglycinat, and 2-alkyl-3-carboxylmethyl-3 -Hy droxyethylimidazolin having in each case 8 to 18 carbon atoms in the alkyl or acyl group and Kokosacylaminoethylhydroxyethylcarboxymethylglycinat. A preferred zwitterionic surfactant is the fatty acid amide derivative known by the INCI name Cocamidopropyl Betaine.

Also particularly suitable as co-surfactants are ampholytic surfactants. Ampholytic surfactants are understood as meaning those surface-active compounds which, apart from a C ₈ -C ₁₈ -alkyl or acyl group in the molecule, contain at least one free amino group and at least one -COOH or -SO ₃ H group and are capable of forming internal salts. Examples of suitable ampholytic surfactants are N-alkylglycines, N-alkylpropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having about 8 to 18 C Atoms in the alyl group. Particularly preferred ampholytic surfactants are N-cocoalkylaminopropionate, cocoacylaminoethyl aminopropionate and C _12-18 acyl sarcosine.

Examples of the cationic surfactants which are preferably used in hair treatment agents are, in particular, quaternary ammonium compounds. Preference is given to ammonium halides, in particular chlorides and bromides, such as alkyltrimethylammonium chlorides, dialkyldimethylammonium chlorides and trialkylmethylammonium chlorides, eg. Cetyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, lauryl dimethyl ammonium chloride, lauryl dimethyl benzyl ammonium chloride and tricetylmethyl ammonium chloride. Furthermore, the very readily biodegradable quaternary ester compounds, such as the sold under the trademark Stepantex ^® dialkyl ammonium methosulfates and Methylhydroxyalkyldialkoyloxyalkylammoniummethosulfate and the corresponding products of the Dehyquart ^® series, can be used as cationic surfactants. Further inventively preferred cationic surfactants are the quaternized protein hydrolysates.

In a preferred embodiment is a Cleaning foam with inventive stabilizer combination, as surfactant components a combination of a sulfosuccinic monoester salt, an ampho- or betaine surfactant and an alkylpolyglycoside.

Further According to the invention preferred means are characterized characterized in that they are transparent or semitransparent Container and form a product with it.

In a particularly preferred embodiment of the invention is a foam cleaning product for body care and facial care consisting of a surfactant-containing stabilizer mixture Detergent in a transparent or semi-transparent, propellant-free dispenser with foam valve.

Dispenser with foam nozzle are z. B. from the US 3,709,437 , of the US 3,937,364 , of the US 5,635,469 or WO 94/09345 A1 known. In these devices, the cleaning liquid is conveyed either by pressure on the flexible container wall (squeeze bottle) or via a manually operated pump to the foam valve. In the foam valve, the liquid is then mixed with air and discharged as a foam.

Further According to the invention preferred means are characterized characterized in that it comprises at least one nourishing agent, selected from the group of vitamins, provitamins or Vitamin precursors, included. These are in the inventive Means in an amount of 0.1-10 wt .-%, preferably 0.2-5 wt .-% and in particular 0.5-1 wt .-%, respectively based on the weight of the container-free cosmetic By means of, included. In this case, such according to the invention Vitamins, pro-vitamins and vitamin precursors are preferred, usually be assigned to the groups A, B, C, F and H.

The group of substances called vitamin A includes retinol (vitamin A ₁ ) and 3,4-didehydroretinol (vitamin A ₂ ). The β-carotene is the provitamin of retinol. As vitamin A component according to the invention, for example, vitamin A acid and its esters, vitamin A aldehyde and vitamin A alcohol and its esters such as the palmitate and the acetate into consideration.

• • Vitamin B₁ (Thiamin)
• • Vitamin B₂ (Riboflavin)
• • Vitamin B₃. Unter dieser Bezeichnung werden häufig die Verbindungen Nicotinsäure und Nicotinsäureamid (Niacinamid) geführt, unter denen insbesondere das Nicotinsäureamid erfindungsgemäß bevorzugt ist.
• • Vitamin B₅ (Pantothensäure und Panthenol). Im Rahmen dieser Gruppe wird bevorzugt das Panthenol eingesetzt. Erfindungsgemäß einsetzbare Derivate des Panthenols sind insbesondere die Ester und Ether des Panthenols, kationisch derivatisierte Panthenole sowie Pantolacton.
• • Vitamin B₆ (Pyridoxin sowie Pyridoxamin und Pyridoxal).
• • Vitamin B₉ (Folsäure und deren Salze).
• • Vitamin B₁₃ (Orotsäure und deren Salze).

The vitamin B group or vitamin B complex includes, among others

• • Vitamin B ₁ (thiamine)
• • Vitamin B ₂ (riboflavin)
• • Vitamin B ₃ . Under this name, the compounds nicotinic acid and nicotinamide (niacinamide) are often performed, among which in particular the nicotinic acid amide is preferred according to the invention.
• • Vitamin B ₅ (pantothenic acid and panthenol). Within this group the panthenol is preferred. Derivatives of panthenol which can be used according to the invention are, in particular, the esters and ethers of panthenol, cationically derivatized panthenols and pantolactone.
• • Vitamin B ₆ (pyridoxine and pyridoxamine and pyridoxal).
• • Vitamin B ₉ (folic acid and its salts).
• • Vitamin B ₁₃ (orotic acid and its salts).

According to the invention preferred are, as discussed above, vitamin C (ascorbic acid) and its esters, in particular ascorbyl palmitate.

vitamin F. The term "vitamin F" usually becomes essential Fatty acids, especially linoleic acid, linolenic acid and arachidonic acid, understood.

vitamin H. As vitamin H, the compound becomes (3aS, 4S, 6aR) -2-oxohexahydrothienol [3,4-d] imidazole-4-valeric acid but for the meantime the trivial name Biotin has prevailed.

In a further preferred embodiment the agent according to the invention at least one plant extract or a distillate of plant components. Plant extracts and Distillates often increase the other active ingredient properties of the agent. The plant extracts and distillates can according to the invention both in pure and in diluted Form are used. The invention Means can also be mixtures of several different ones Contains plant extracts and distillates. The plant extracts and distillates are preferably in a total amount of 0.01-5 Wt .-%, particularly preferably 0.1-3 wt .-% and in particular 0.1 to 2 wt .-% of active ingredient, each based on the weight of the agent according to the invention.

Usually These extracts and distillates are made by extracting the entire Plant or obtained by steam distillation. But it can in some cases also be preferred, the extracts and -Distillate exclusively from flowers and / or Leaves of the plant produce. According to the invention especially the extracts and distillates of green tea, oak bark, Stinging nettle, witch hazel, hops, chamomile, burdock root, horsetail, Hawthorn, lime blossom, almond, aloe vera, spruce needle, Horse chestnut, sandalwood, juniper, coconut, mango, apricot, Lime, Wheat, Kiwi, Melon, Orange, Grapefruit, Sage, Rosemary, Birch, Mallow, Meadowfoam, Quendel, Yarrow, Thyme, Melissa, Toadstool, coltsfoot, marshmallow, meristem, ginseng and ginger root prefers. Almond extracts and are preferred according to the invention Distillates of witch hazel and sage.

When Extraction agent for the preparation of said plant extracts may be used water, alcohols and mixtures thereof become. Among the alcohols are lower alcohols such as ethanol and isopropanol, but especially polyhydric alcohols such as ethylene glycol and propylene glycol, both as the sole extractant also in mixture with water, preferred. Plant extracts based of water / propylene glycol in the ratio 1:10 to 10: 1 proved to be particularly suitable.

The agents according to the invention preferably also contain at least one organic thickener. Such thickeners are, for example, thickeners such as agar-agar, guar gum, alginates, cellulose ethers, gelatin, pectins and / or xanthan gum. Ethoxylated fatty alcohols, in particular those with limited homolog distribution, such as, for example, as a commercial product under the name Arlypon ^® F (Henkel) in the market, alkoxylated methylglucoside esters, such as the commercial product Glucamate ^® DOE 120 (Amerchol), and ethoxylated propylene glycol esters, such as the commercial product Antil ^® 141 (Goldschmidt) may be preferred organic thickeners.

As conditioning agents suitable silicone oils and silicone gums are especially dialkyl and alkylaryl, such as dimethylpolysiloxane and methylphenylpolysiloxane, and their alkoxylated and quaternized analogs. Examples of such silicones are the DC 200 and DC 1401 products sold by Dow Corning under the names DC 190, and the commercial product Fancorsil ^® LIM first A suitable anionic silicone oil is the product Dow ^Corning® 1784.

Prefers contained vegetable oils and waxes are evening primrose oil, Jojoba oil, sunflower oil, orange oil, Almond oil, wheat germ oil and peach kernel oil. Evening primrose oil is particularly preferred.

In particular, for the formulation of very mild cosmetic preparations, it has furthermore proved to be advantageous if the amount of dissolved inorganic salts is preferably less than 2% by weight, in particular less than 0.5 wt .-% is limited. It should also be noted that such salts not only z. B. are added to adjust the viscosity, but also by other agents, especially surfactants, can be introduced.

• – nichtionische Polymere wie beispielsweise Vinylpyrrolidon/Vinylacrylat-Copolymere, Polyvinylpyrrolidon und Vinylpyrrolidon/Vinylacetat-Copolymere,
• – anionische Polymere, wie Polyacryl- und Polymethacrylsäuren, deren Salze, deren Copolymere mit Acrylsäure- und Methacrylsäureestern und -amiden und deren Derivate, die durch Kreuzvernetzung mit polyfunktionellen Agentien erhalten werden, Polyoxycarbonsäuren, wie Polyketo- und Polyaldehydocarbonsäuren und deren Salze, sowie Polymere und Copolymere der Crotonsäure mit Estern und Amiden der Acryl- und der Methacrylsäure, wie Vinylacetat-Crotonsäure- und Vinylacetat-Vinylpropionat-Crotonsäure-Copolymere,
• – Strukturanten wie Glucose und Maleinsäure,
• – haarkonditionierende Verbindungen wie Phospholipide, beispielsweise Sojalecithin, Ei-Lecithin und Kephaline,
• – Parfümöle, insbesondere solche mit der Duftnote einer Frucht, wie beispielsweise von Apfel, Birne, Erdbeere, Pfirsich, Aprikose, Ananas, Banane, Kirsche, Kiwi, Mango, Kokos, Mandel, Grapefruit, Maracuja, Mandarine und Melone, oder der Duftnote eines Genußmittels, wie beispielsweise von Tabak, Cola, Kaugummi, Guarana, Schokolade, Kakao, Vanille, Sarsaparilla, Pfefferminze und Rum.
• – Dimethylisosorbid und Cyclodextrine,
• – Lösungsvermittler, wie Ethanol, Isopropanol, Ethylenglycol, Propylenglycol, Glycerin, Diethylenglycol und ethoxylierte Triglyceride,
• – Farbstoffe,
• – Antischuppenwirkstoffe wie Climbazol, Piroctone Ölamine und Zink Omadine,
• – Wirkstoffe wie Bisabolol und Allantoin,
• – Lichtschutzmittel,
• – Konsistenzgeber wie Zuckerester, Polyolester oder Polyolalkylether,
• – Fette und Wachse, wie Walrat, Bienenwachs, Montanwachs, Paraffine, Ester, Glyceride und Fettalkohole,
• – Fettsäurealkanolamide,
• – Quell- und Penetrationsstoffe wie PCA, Glycerin, Propylenglycolmonoethylether, Carbonate, Hydrogencarbonate, Guanidine, Harnstoffe sowie primäre, sekundäre und tertiäre Phosphate,
• – Trübungsmittel wie Latex oder Styrol/Acrylamid-Copolymere,
• – Perlglanzmittel wie Ethylenglycolmono- und -distearat oder PEG-3-distearat,
• – direktziehende Farbstoffe
• – Treibmittel wie Propan-Butan-Gemische, N₂O, Dimethylether, CO₂ und Luft sowie
• – Bitterstoffe, wie beispielsweise Denatonium Benzoate,
• – Konservierungsmittel.

Further optional ingredients for the agents according to the invention are:

• Nonionic polymers such as vinyl pyrrolidone / vinyl acrylate copolymers, polyvinyl pyrrolidone and vinyl pyrrolidone / vinyl acetate copolymers,
• Anionic polymers, such as polyacrylic and polymethacrylic acids, their salts, their copolymers with acrylic and methacrylic acid esters and amides and their derivatives obtained by cross-linking with polyfunctional agents, polyoxycarboxylic acids, such as polyketo- and polyaldehydocarboxylic acids and their salts, and polymers and Copolymers of crotonic acid with esters and amides of acrylic and methacrylic acid, such as vinyl acetate-crotonic acid and vinyl acetate-vinyl propionate-crotonic acid copolymers,
• - structurants such as glucose and maleic acid,
• Hair conditioning compounds such as phospholipids, for example soya lecithin, egg lecithin and cephalins,
• - Perfume oils, especially those with the fragrance of a fruit, such as apple, pear, strawberry, peach, apricot, pineapple, banana, cherry, kiwi, mango, coconut, almond, grapefruit, passion fruit, mandarin and melon, or the fragrance of a Stimulants such as tobacco, cola, chewing gum, guarana, chocolate, cocoa, vanilla, sarsaparilla, peppermint and rum.
• Dimethylisosorbide and cyclodextrins,
• Solubilizers, such as ethanol, isopropanol, ethylene glycol, propylene glycol, glycerol, diethylene glycol and ethoxylated triglycerides,
• - dyes,
• Antidandruff active ingredients such as climbazole, piroctone oil amines and zinc omadine,
• - active substances such as bisabolol and allantoin,
• - sunscreen,
• Bodying agents such as sugar esters, polyol esters or polyol alkyl ethers,
• Fats and waxes, such as spermaceti, beeswax, montan wax, paraffins, esters, glycerides and fatty alcohols,
• Fatty acid alkanolamides,
• - swelling and penetrating substances such as PCA, glycerol, propylene glycol monoethyl ether, carbonates, bicarbonates, guanidines, ureas and primary, secondary and tertiary phosphates,
• Opacifiers such as latex or styrene / acrylamide copolymers,
• Pearlescing agents such as ethylene glycol mono- and distearate or PEG-3-distearate,
• - direct dyes
• - Propellants such as propane-butane mixtures, N ₂ O, dimethyl ether, CO ₂ and air and
• Bitter substances, such as Denatonium Benzoate,
• - preservative.

The The following examples are intended to illustrate the subject matter of the invention without limiting it to this.

Carrying out the Color stability tests

For the color stability tests became a cleaning composition, as listed below, made as a base. The base contained 0.1% by weight of tetrasodium ethylenediamine acetate as complexing agent. At the expense of water content were different concentrations different phenolic antioxidants added. The cleaning base was stained with 0.000060 wt% CI 42051 (ACID BLUE 3, Patent Blue).

each Sample was simulated for 20 or 40 hours in the Suntest XLS + apparatus Exposed to daylight. Subsequently, the color difference (ΔE) determined with a Minolta Spectrometer.

ΔE was determined according to the L * a * b * color system, a method familiar to the person skilled in the art. The ΔE values quantify the color loss as a dimensionless value. ΔE = 0 means no color loss, while ΔE = 10 for a complete color loss. Composition of the cleaning base (% by weight) DISODIUM LAURETH SULFOSUCCINATE 10.000000 PEG-7 GLYCERYL COCOATE 2.000000 COCAMIDOPROPYL BETAINE 1.520000 DECYL GLUCOSIDE 1.060000 GLYCERIN 0.860000 COCO-GLUCOSIDE 0.836750 GLYCERYL OLEATE 0.700000 SORBITOL 0.700000 SODIUM BENZOATE 0.400000 Panthenol 0.375000 SODIUM CHLORIDE 0.280000 LACTIC ACID 0.160000 CITRIC ACID 0.125000 SODIUM LACTATE 0.120000 CAMELLIA SINENSIS LEAF EXTRACT 0.060000 TETRASODIUM EDTA 0.100000 BENZOIC ACID 0.015000 POLYSORBATE 20 0.006000 CI 42051 (ACID BLUE 3) 0.000060 AQUA (WATER) ad 100

For each cleansing base, the following phenolic antioxidants were added: formula antioxidant Amount (wt%) 1A retinyl palmitate 0001 1B Sodium ascorbyl phosphate (NAP) 0001 1C Controx KS 12:05 1D Controx KS 12:01 1E Controx KS 0001 1F Tocopheryl acetate: NAP (1: 1) 0002 IG propyl gallate 0001 1H Olea Europea (olive leaf extract) 0005 1I BHT 0001 1y Tinogard TT 0001

The table below shows the results of the color stability test. As a control, a cleaning base without antioxidant was tested. formula % Antiox. ΔE after 20 hours. ΔE at 40 hours control 0 12:43 13.85 1A 0001 5.5 9.9 1B 0001 3.69 4:59 1C 12:05 3:52 7.1 1D 12:01 2:54 2.83 1E 0001 2.11 6.31 1F 0002 2:01 1.96 1G 0001 1.73 2:05 1H 0005 1.71 2:59 1I 0001 1.4 2.2 1y 0001 0.8 5.1

Example 2

This example demonstrates the optimization of the antioxidant content using the example of Tinogard TT (pentaerythrityltetra-di-t-butyl-hydroxyhydrocinnamate), a synthetic phenolic antioxidant preferred according to the invention. The cleaning base of Example 1 was prepared with various concentrations of Tinogard ™ TT (see table below). As in Example 1, the samples were each exposed to simulated sunlight for 20 or 40 hours; then the color loss (ΔE) was measured. Conc. Tinogard TT (% by weight) ΔE after 20 hours ΔE after 40 hours 0.0 12:43 13.8 0.0001 4.1 6.9 0.0005 2.4 4.2 0001 0.9 5.1 0005 2.0 3.9 12:01 1.7 4.4 12:05 3.8 6.5 0.1 12.6 12.8

example 2 shows that the color stabilization is dependent on the concentration of phenolic antioxidant in the concentration range from 0 to 0.1 wt .-% passes through an optimum.

It be noted that the presence of a complexing agent absolutely necessary.

In Absence of a complexing agent succeeds with no antioxidant, to prevent a strong color loss.

List of raw materials used:

• 1) Controx KS ^® INCI: Tocopherol (56 wt .-%), Hydrogenated Palm Glycerides Citrate (44 wt .-%), manufacturer: Cognis Germany GmbH (Grunau)
• 2) Tinogard TT (active substance content at least 98% by weight) INCI: Pentaerythrityl tetra-di-t-butyl-hydroxyhydrocinnamate
• 3) Olea europaea Fol. Extr. S. sicc. (Oleuropein content 18-26 Wt .-%) INCI: OLEA EUROPAEA (OLIVE) LEAF EXTRACT Manufacturer: Frutarom

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited patent literature

• - DE 19750906 [0003]
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• WO 96/07396 [0003]
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• US 3709437 [0064]
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Claims (13)

Hydrous cosmetic or pharmaceutical Agent comprising a color-stabilizing active ingredient mixture a) less than 0.02% by weight, based on the weight of the composition, at least a phenolic antioxidant and b) at least one complexing agent. Composition according to Claim 1, characterized in that, furthermore, less than 0.02% by weight, based on the weight of the total composition, of at least one ester of a hydroxy-substituted bi- or tricarboxylic acid and a C ₁₂ -C ₂₄ fatty acid mono- and / or or diglyceride are included. Means according to one of the preceding Claims, characterized in that the complexing agent selected is from the water-soluble salts of aminopolycarboxylic acids. Means according to one of the claims 2 or 3, characterized in that the hydroxy-substituted tricarboxylic acid of the ester is citric acid. Means according to one of the preceding Claims, characterized in that the complexing agent selected is from the salts of ethylenediaminetetraacetic acid. Means according to one of the preceding Claims, characterized in that the phenolic Antioxidant is selected from esters of para-hydroxyhydrocinnamic acid, from oleuropein, ligustroside, tocopherols, biochinones, gallic acid esters, 2,6-di-tert-butyl-4-methylphenol (BHT), as well as mixtures thereof. Means according to one of the preceding Claims, characterized in that at least one Active ingredient selected from ascorbic acid, the esters and the salts of ascorbic acid. Agent according to claim 7, characterized in that the at least one active ingredient is selected from ascorbic acid, the esters and the salts of ascorbic acid, in a total amount of at most 0.01% by weight, preferably at most 0.001 wt .-%, each based on the weight of the composition is. Means according to one of the preceding Claims, characterized in that at least one Triarylmethane dye is included. Means according to one of the preceding Claims, characterized in that at least one Surfactant from the group of anionic surfactants, the nonionic surfactants, the amphoteric and zwitterionic surfactants or cationic surfactants. Product consisting of an aqueous agent according to any one of the preceding claims and a transparent or semi-transparent container. Using a combination of a) less as 0.02 wt .-%, based on the weight of the composition, at least a phenolic antioxidant and b) at least one complexing agent, to Color and / or odor stabilization hydrous cosmetic or pharmaceutical agents, in particular to the Action of light. Method for color and / or odor stabilization aqueous cosmetic or pharmaceutical agent, thereby characterized in that the agent is a stabilizer mixture a) less than 0.02% by weight, based on the weight of the composition, at least a phenolic antioxidant and b) at least one complexing agent, added.