DE10199055I1 - Stabile Mikroblasensuspensionen wie Verstaerkungagenzien fuer Ultraschall-Echographie - Google Patents

Stabile Mikroblasensuspensionen wie Verstaerkungagenzien fuer Ultraschall-Echographie

Info

Publication number
DE10199055I1
DE10199055I1 DE2001199055 DE10199055C DE10199055I1 DE 10199055 I1 DE10199055 I1 DE 10199055I1 DE 2001199055 DE2001199055 DE 2001199055 DE 10199055 C DE10199055 C DE 10199055C DE 10199055 I1 DE10199055 I1 DE 10199055I1
Authority
DE
Germany
Prior art keywords
suspensions
amplification agents
microbubble suspensions
disclosed
ultrasound echography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2001199055
Other languages
English (en)
Other versions
DE10199055I2 (de
Inventor
Michel Schneider
Jean Brochot
Jerome Puginier
Yan Feng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8212014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10199055(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco International BV filed Critical Bracco International BV
Publication of DE10199055I1 publication Critical patent/DE10199055I1/de
Application granted granted Critical
Publication of DE10199055I2 publication Critical patent/DE10199055I2/de
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
DE2001199055 1992-11-02 1993-10-21 Mikroblasensuspensionen wie verst{rkungagenzien f}r ultraschall-Echographie. Active DE10199055I2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92810837 1992-11-02
PCT/EP1993/002915 WO1994009829A1 (en) 1992-11-02 1993-10-21 Stable microbubble suspensions as enhancement agents for ultrasound echography

Publications (2)

Publication Number Publication Date
DE10199055I1 true DE10199055I1 (de) 2002-08-14
DE10199055I2 DE10199055I2 (de) 2005-09-29

Family

ID=8212014

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69307124T Expired - Lifetime DE69307124T2 (de) 1992-11-02 1993-10-21 Stabile mikroblasensuspensionen wie verstärkungagenzien für ultraschall-echographie
DE2001199055 Active DE10199055I2 (de) 1992-11-02 1993-10-21 Mikroblasensuspensionen wie verst{rkungagenzien f}r ultraschall-Echographie.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69307124T Expired - Lifetime DE69307124T2 (de) 1992-11-02 1993-10-21 Stabile mikroblasensuspensionen wie verstärkungagenzien für ultraschall-echographie

Country Status (22)

Country Link
US (7) US5445813A (de)
EP (1) EP0619743B1 (de)
JP (1) JP3135919B2 (de)
KR (1) KR100216138B1 (de)
CN (1) CN1069838C (de)
AT (1) ATE146972T1 (de)
AU (3) AU666238B2 (de)
CA (1) CA2125027C (de)
DE (2) DE69307124T2 (de)
DK (1) DK0619743T3 (de)
ES (1) ES2097548T3 (de)
FI (1) FI115953B (de)
GR (1) GR3022826T3 (de)
HU (1) HU227043B1 (de)
IL (1) IL107453A (de)
IS (1) IS1625B (de)
LU (1) LU90837I2 (de)
NL (1) NL300061I2 (de)
NO (1) NO308830B1 (de)
NZ (2) NZ257115A (de)
WO (1) WO1994009829A1 (de)
ZA (1) ZA938117B (de)

Families Citing this family (177)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (de) 1990-04-02 1993-05-01 Sint Sa
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
NZ262237A (en) * 1993-01-25 1997-06-24 Sonus Pharma Inc Ultrasound contrast agents comprising phase shift colloids having a boiling point below the body temperature of the animal it is used in
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
US5695740A (en) * 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
US5701899A (en) * 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
AU694135B2 (en) 1993-07-30 1998-07-16 Imcor Pharmaceutical Company Stabilized microbubble compositions for ultrasound
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
PT682530E (pt) * 1993-12-15 2003-06-30 Bracco Research Sa Misturas de gases uteis como meios de contraste para ultrassons
DE4406474A1 (de) 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
WO2004073750A1 (en) * 1995-06-07 2004-09-02 Harald Dugstad Improvements in or relating to contrast agents
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
DE69721235T2 (de) * 1996-02-19 2004-02-05 Amersham Health As Verbesserungen an (oder im bezug auf) kontrastmittel
AU721209B2 (en) * 1996-03-05 2000-06-29 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
ATE345682T1 (de) 1996-05-01 2006-12-15 Imarx Pharmaceutical Corp In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
US5849727A (en) * 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
KR100593873B1 (ko) * 1996-08-02 2006-07-03 지이 헬스케어 에이에스 조영제
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
ES2289188T3 (es) 1996-09-11 2008-02-01 Bristol-Myers Squibb Medical Imaging, Inc. Procedimiento para la obtencion de imagenes para el diagnostico usando un agente de contraste y un vasodilatador.
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US5962015A (en) * 1997-05-02 1999-10-05 Kobo Products S.A.R.L. Stabilized liposomes
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
ZA9811087B (en) * 1997-12-04 1999-06-03 Bracco Research Sa Automatic liquid injection system and method
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
NZ506051A (en) * 1998-02-09 2003-08-29 Bracco Res S Targeted delivery of biologically active media
DE19840532A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung
DE19840536A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung
US6187665B1 (en) * 1999-01-14 2001-02-13 Lucent Technologies, Inc. Process for deuterium passivation and hot carrier immunity
US6575930B1 (en) * 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
FR2791249B1 (fr) 1999-03-25 2001-06-15 Edap Technomed Milieu de couplage pour ultrasons de puissance
US6514209B1 (en) 1999-06-07 2003-02-04 Drexel University Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals
US6210611B1 (en) * 1999-11-30 2001-04-03 Duke University Methods for producing gas microbubbles having lipid-containing shells formed thereon
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
WO2002080774A2 (en) * 2001-04-06 2002-10-17 Bracco Research S.A. Method for improved measurement of local physical parameters in afluid-filled cavity
US6855561B2 (en) * 2001-09-10 2005-02-15 Quidel Corporation Method for adding an apparent non-signal line to a lateral flow assay
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
WO2003074005A2 (en) 2002-03-01 2003-09-12 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US20040126400A1 (en) * 2002-05-03 2004-07-01 Iversen Patrick L. Delivery of therapeutic compounds via microparticles or microbubbles
CA2532324A1 (en) * 2002-07-11 2004-01-22 Targeson, Llc Microbubble compositions, and methods for preparing and using same
KR20050072496A (ko) 2002-11-29 2005-07-11 아머샴 헬스 에이에스 초음파 촬영 방법
MXPA05007730A (es) * 2003-02-04 2006-01-31 Bracco Int Bv Agentes de contraste para ultrasonido y proceso para la preparacion de los mismos.
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
WO2004071535A1 (en) 2003-02-13 2004-08-26 Bracco Imaging S.P.A. Contrast enhanced x-ray phase imaging
DK2949658T3 (en) 2003-03-03 2018-10-01 Dyax Corp Peptides that specifically bind HGF receptor (cMet) and uses thereof
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
US8021303B2 (en) 2003-06-12 2011-09-20 Bracco Research Sa System for extracting morphological information through a perfusion assessment process
WO2004110279A1 (en) 2003-06-12 2004-12-23 Bracco Research Sa Blood flow estimates through replenishment curve fitting in ultrasound contrast imaging
CA2547024C (en) * 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
EP1696965B1 (de) * 2003-12-22 2014-12-10 Bracco Suisse SA Anordnung aus gasgefüllten mikrovesikeln mit wirkstoff für die kontrastdarstellung
US20080281205A1 (en) * 2004-01-16 2008-11-13 Morteza Naghavi Methods and Apparatuses For Medical Imaging
US8708909B2 (en) 2004-01-20 2014-04-29 Fujifilm Visualsonics, Inc. High frequency ultrasound imaging using contrast agents
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB2417080B (en) 2004-08-13 2008-05-21 Stichting Tech Wetenschapp Intravascular ultrasound techniques
AU2005273865B2 (en) 2004-08-18 2011-02-24 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
US20080045919A1 (en) * 2004-12-23 2008-02-21 Bracco Research S.A. Liquid Transfer Device for Medical Dispensing Containers
EP1833373B1 (de) 2004-12-23 2015-12-16 Bracco Suisse SA Perfusionsbeurteilungsverfahren und system auf basis einer bolus-verabreichung
EP1866663A1 (de) 2005-03-03 2007-12-19 Bracco Research S.A. Medizinisches bildgebungssystem auf der basis eines abgezielten kontrastmittels
EP1714642A1 (de) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung
US9198639B2 (en) 2005-11-10 2015-12-01 Bracco Suisse S.A. Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis
AU2006313706B2 (en) 2005-11-10 2011-09-22 Bracco Suisse S.A. Instantaneous visualization of contrast agent concentration in imaging applications
DK1966388T3 (da) 2005-12-09 2013-10-28 Bracco Suisse Sa Tilsigte vektor-fosfolipidkonjugater
EP1797919A1 (de) * 2005-12-16 2007-06-20 Bracco Research S.A. Vorrichtung zum Übertragen von Flüssigkeiten für Behälter zur Abgabe von Medikamenten
WO2008016992A1 (en) 2006-08-01 2008-02-07 Scimed Life Systems, Inc. Pulse inversion sequences for nonlinear imaging
ITBO20060593A1 (it) * 2006-08-04 2008-02-05 Francesca Cavalieri Microbolle realizzate in alcol polivinilico e relativo caricamento delle stesse con ossido di azoto
EP2061517B1 (de) 2006-09-05 2010-06-02 Bracco Research S.A. Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden
US8293214B2 (en) * 2006-12-19 2012-10-23 Bracco Suisse S.A. Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds
EP2099364B8 (de) 2006-12-21 2019-04-03 Bracco Suisse SA Detektion der ablösung eines immobilisierten kontrastmittels bei medizinischen bildgebungsanwendungen
WO2011110552A1 (en) 2010-03-09 2011-09-15 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
JP5524860B2 (ja) 2007-12-28 2014-06-18 ブラッコ・シュイス・ソシエテ・アノニム 医療画像用途における固定化された造影剤の定量分析
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
EP2090322A1 (de) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Verwendung von FSH-Rezeptorliganden zur Diagnose und Behandlung von Krebs
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
CA2748995C (en) 2008-10-07 2018-01-16 Bracco Suisse Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
EP2189112A1 (de) 2008-11-24 2010-05-26 Bracco Research S.A. Echzeit-Perfusionsbildgebung und -quantifizierung
KR101630190B1 (ko) 2008-12-16 2016-06-14 브라코 스위스 에스.에이. 조영제의 볼러스 투여를 위한 장치
EP2441044B8 (de) 2009-06-08 2019-03-27 Bracco Suisse SA Automatische Skalierung parametrischer Bilder
SG10201403566SA (en) * 2009-08-06 2014-10-30 Sunstar Engineering Inc Composition and process for production thereof
JP5628314B2 (ja) 2009-09-01 2014-11-19 ブラッコ・シュイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ 経時的な動的挙動に基づくパラメトリック画像
EP2335675B1 (de) 2009-12-10 2015-02-18 Neubourg Skin Care GmbH & Co. KG Emulgatorfreie, Polymer-stabilisierte Schaumformulierungen
EP2345732A1 (de) 2010-01-19 2011-07-20 Universite Paris Descartes Verfahren zur intrazellulären Abgabe von Nukleinsäuren
US9211348B2 (en) 2010-08-09 2015-12-15 Bracco Suisse S.A. Targeted gas-filled microvesicles
JP2013536187A (ja) 2010-08-09 2013-09-19 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 対象における眼疾患の処置の為の方法及び医薬組成物
WO2012085072A1 (en) 2010-12-24 2012-06-28 Bracco Suisse Sa Gas-filled microvesicles for use as vaccine
EP2474327A1 (de) 2011-01-07 2012-07-11 RWTH Aachen Mikrodosierung von Ultraschallkontrastmitteln
BR112013024863A2 (pt) 2011-03-28 2016-12-20 Yissum Res Dev Co formulação injetável de liberação sustentada
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
EP2545908A1 (de) 2011-07-11 2013-01-16 RWTH Aachen Medium für Mikrobläschen oder Mikropartikel und seine Herstellung
JP6333287B2 (ja) 2012-12-21 2018-05-30 ブラッコ・シュイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ 時間に対する統計的分析に基づく画像診断応用におけるセグメンテーション
WO2014096165A2 (en) 2012-12-21 2014-06-26 Bracco Suisse Sa Gas-filled microvesicles
WO2014140197A1 (en) 2013-03-15 2014-09-18 Westfaelische Wilhelms-Universitaet Muenster Detection of acute renal allograft rejection
CN105407968B (zh) 2013-07-03 2019-09-03 博莱科瑞士股份公司 用于对缺血性中风的超声处置的设备
BR112016022401B1 (pt) 2014-04-07 2023-04-04 Bracco Suisse S.A Método para uso com um scanner de ultrassom, meio de armazenamento legível por computador, e, sistema
CA2968478C (en) 2014-12-18 2021-10-12 Bracco Suisse Sa Targeted gas-filled microvesicles formulation
US10537622B2 (en) 2014-12-22 2020-01-21 Bracco Suisse S.A. Gas-filled microvesicles for use as vaccine
NZ733010A (en) 2014-12-31 2023-01-27 Lantheus Medical Imaging Inc Lipid-encapsulated gas microsphere compositions and related methods
EP3386589B1 (de) 2015-12-09 2022-02-09 Koninklijke Philips N.V. Verschachteltes strahlmuster für sonothrombolyse und andere, durch vaskulären akustischen resonator vermittelte therapien
CN108289654B (zh) 2015-12-10 2021-03-30 博莱科瑞士股份有限公司 通过动态阈值化来检测固定化造影剂
WO2017137477A1 (en) 2016-02-09 2017-08-17 Bracco Suisse Sa A recombinant chimeric protein for selectins targeting
CN107233582B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种基于叔丁醇/水混合溶剂制备超声造影剂的方法
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
CN109641068B (zh) 2016-05-04 2022-09-30 蓝瑟斯医学影像公司 用于制备超声波造影剂的方法及装置
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US10335502B1 (en) 2019-01-29 2019-07-02 Bracco Suisse Sa Freeze-dried formulation for gas-filled microvesicles
US10232061B1 (en) 2018-07-06 2019-03-19 Bracco Suisse Sa Freeze-dried formulation for gas-filled microvesicles
AU2019298652A1 (en) 2018-07-06 2020-11-26 Bracco Suisse Sa Freeze-dried formulation for gas-filled microvesicles
WO2020127816A1 (en) 2018-12-21 2020-06-25 Bracco Suisse Sa Gas-filled microvesicles with ligand
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
GB201908352D0 (en) 2019-06-11 2019-07-24 Innovation Ulster Ltd Sonodynamic therapy
KR20220140527A (ko) 2020-02-11 2022-10-18 브라코 스위스 에스.에이. 치료용 기체 충전 미세소포
GB202004629D0 (en) 2020-03-30 2020-05-13 Innovation Ulster Ltd Therapy
US11191888B1 (en) 2020-05-18 2021-12-07 Agitated Solutions Inc. Syringe-based microbubble generator
CN113440627B (zh) * 2021-07-30 2022-11-25 北京诺康达医药科技股份有限公司 一种冻干粉末及其制备方法与应用
CN114177317A (zh) * 2021-11-03 2022-03-15 深圳奥祺生物医药有限公司 一种用于超声造影的微泡冻干制剂、造影剂及制备方法
US11833224B1 (en) 2023-02-08 2023-12-05 Leuvian Llc Lyoprotectant compositions and uses thereof

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968203A (en) * 1965-10-01 1976-07-06 Jerome G. Spitzer Aerosol astringent composition
US3615972A (en) * 1967-04-28 1971-10-26 Dow Chemical Co Expansible thermoplastic polymer particles containing volatile fluid foaming agent and method of foaming the same
US3650831A (en) * 1969-03-10 1972-03-21 Armour Dial Inc Method of cleaning surfaces
US3900420A (en) * 1970-05-18 1975-08-19 Felix Sebba Microgas emulsions and method of forming same
US4027007A (en) * 1970-12-09 1977-05-31 Colgate-Palmolive Company Antiperspirants formulated with borax
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute
CH624011A5 (de) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4256251A (en) * 1978-04-24 1981-03-17 Lawrence M. Smith Surgical staplers and staple
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
US4587545A (en) * 1978-12-20 1986-05-06 At&T Bell Laboratories High voltage dielectrically isolated remote gate solid-state switch
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4316391A (en) * 1979-11-13 1982-02-23 Ultra Med, Inc. Flow rate measurement
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4442843A (en) * 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
GB2135647A (en) * 1983-02-15 1984-09-05 Squibb & Sons Inc Method of preparing liposomes and products produced thereby
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3313947A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
DE3324754A1 (de) * 1983-07-06 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen Ultraschallkontrastmittel sowie dessen herstellung
US5618514A (en) * 1983-12-21 1997-04-08 Nycomed Imaging As Diagnostic and contrast agent
GB8504916D0 (en) * 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
DE3637926C1 (de) * 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5283067A (en) * 1987-01-30 1994-02-01 Ciba-Geigy Corporation Parenteral suspensions
US5089181A (en) * 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
CH672733A5 (de) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
DE3741201A1 (de) * 1987-12-02 1989-06-15 Schering Ag Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
IE66912B1 (en) * 1988-02-05 1996-02-07 Schering Ag Ultrasonic contrast agents process for their preparation and their use as diagnostic and therapeutic agents
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
US5730954A (en) * 1988-08-23 1998-03-24 Schering Aktiengesellschaft Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
DE3934656A1 (de) * 1989-10-13 1991-04-18 Schering Ag Verfahren zur herstellung von waessrigen dispersionen
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
SE465300B (sv) * 1989-12-29 1991-08-26 Sjoeberg John Anitec Ab Anordning vid stickkniv foer urtagning av blod fraan slaktdjur
DE4004430A1 (de) * 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
JPH05506031A (ja) * 1990-03-30 1993-09-02 スミスクライン・ビーチャム・コーポレイション 免疫不全ウイルス感染に伴う疾病の抑制
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (de) * 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
DE4127442C2 (de) * 1991-08-17 1996-08-22 Udo Dr Gros Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
KR100191303B1 (ko) * 1991-09-17 1999-06-15 씨. 큐웨이 스티븐 기체상의 초음파 조영제 및 초음파 조영제로서 사용하기 위한 기체를 선택하는 방법
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
AU5457394A (en) * 1992-11-02 1994-05-24 Drexel University Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
CN1129910A (zh) * 1993-07-02 1996-08-28 分子生物系统研究所 蛋白质包囊不溶性气体的微球及其制备并用作超声显影剂
AU694135B2 (en) * 1993-07-30 1998-07-16 Imcor Pharmaceutical Company Stabilized microbubble compositions for ultrasound
US5601085A (en) * 1995-10-02 1997-02-11 Nycomed Imaging As Ultrasound imaging

Also Published As

Publication number Publication date
NO308830B1 (no) 2000-11-06
IS1625B (is) 1996-10-18
AU5336294A (en) 1994-05-24
AU3431795A (en) 1996-01-04
NZ280615A (en) 1997-02-24
IL107453A0 (en) 1994-02-27
EP0619743A1 (de) 1994-10-19
US5908610A (en) 1999-06-01
EP0619743B1 (de) 1997-01-02
NL300061I1 (nl) 2001-12-01
FI943167A (fi) 1994-07-01
DK0619743T3 (da) 1997-01-20
DE69307124T2 (de) 1997-07-17
ES2097548T3 (es) 1997-04-01
AU666238B2 (en) 1996-02-01
US5597549A (en) 1997-01-28
AU2618197A (en) 1997-12-18
US5686060A (en) 1997-11-11
KR940703691A (ko) 1994-12-12
AU681812B2 (en) 1997-09-04
CN1088456A (zh) 1994-06-29
AU704954B2 (en) 1999-05-13
LU90837I2 (fr) 2001-11-19
US20030129137A1 (en) 2003-07-10
NZ257115A (en) 1997-06-24
DE10199055I2 (de) 2005-09-29
IS4089A (is) 1994-05-03
CA2125027C (en) 1998-12-01
NO942476L (no) 1994-06-30
CA2125027A1 (en) 1994-05-11
US5445813A (en) 1995-08-29
US20010001279A1 (en) 2001-05-17
NL300061I2 (nl) 2002-02-01
JPH07503254A (ja) 1995-04-06
ZA938117B (en) 1994-06-23
FI943167A0 (fi) 1994-07-01
ATE146972T1 (de) 1997-01-15
HUT74561A (en) 1997-01-28
HU227043B1 (en) 2010-05-28
US6187288B1 (en) 2001-02-13
JP3135919B2 (ja) 2001-02-19
FI115953B (fi) 2005-08-31
HU9401409D0 (en) 1994-08-29
WO1994009829A1 (en) 1994-05-11
DE69307124D1 (de) 1997-02-13
GR3022826T3 (en) 1997-06-30
KR100216138B1 (ko) 1999-08-16
NO942476D0 (no) 1994-06-30
CN1069838C (zh) 2001-08-22
IL107453A (en) 1998-01-04

Similar Documents

Publication Publication Date Title
DE10199055I1 (de) Stabile Mikroblasensuspensionen wie Verstaerkungagenzien fuer Ultraschall-Echographie
NZ295744A (en) Frozen suspension of gas bubbles; the liquid suspension being used as an injectable contrast agent
EA199800745A1 (ru) Устовершенствования в области контрастных агентов
ES2192572T3 (es) Medios de contraste de ultrasonidos, agentes de contraste que contienen los medios, y metodo.
ATE318247T1 (de) Dekontaminierte fluide und biozide flüssigkeiten
NO953637D0 (no) Emulgert gass som ultralyd-kontrastmiddel
DK0744961T3 (da) Gasholdige mikropartikler, midler indeholdende disse, deres anvendelse i ultralydsdiagnostikken samt fremgangsmåder til fremstilling af partiklerne og midlerne