CN201230913Y - Human nerve conduit with amplified self-functionality - Google Patents
Human nerve conduit with amplified self-functionality Download PDFInfo
- Publication number
- CN201230913Y CN201230913Y CNU2007200947280U CN200720094728U CN201230913Y CN 201230913 Y CN201230913 Y CN 201230913Y CN U2007200947280 U CNU2007200947280 U CN U2007200947280U CN 200720094728 U CN200720094728 U CN 200720094728U CN 201230913 Y CN201230913 Y CN 201230913Y
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- inner sleeve
- nerve
- artificial
- sleeve support
- artificial nerve
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Abstract
The utility model discloses a self functional magnifying artificial nerve canula used for surgical operation in the medical science field, and aims to provide an artificial nerve canula which can meet the requirement of defect operation restoration for long section of nerve, crassitude nerve and multiple parts of peripheral nerves and can continuously position nerve segments at intervals to promote the nerve growth. The artificial nerve canula comprises an outer sleeve and an inner sleeve which are both made of biological degradable materials, wherein the outer sleeve and the inner sleeved are sleeved together coaxially; the inner sleeve can extend out or retract along the axes of the outer sleeve; a plurality of sets of inner sleeve brackets are positioned in the inner sleeve, and each set of inner sleeve brackets is a containing cavity formed by two single inner sleeve brackets; the distance between the two single inner sleeve brackets in the containing cavity is 0.3 cm to 0.5 cm, and the distance between two adjacent containing cavities is 0.5 cm; the outer sleeve and the inner sleeve are thin-wall tube bodies with elliptical ring shaped cross section in the appearance shape; and the plurality of sets of inner sleeve brackets in the inner sleeve are fixedly connected by three artificial matrix bridges.
Description
Technical field
This utility model relates to the artificial neuron product of medical domain surgical operation clinical practice, relates to a kind of artificial nerve catheter from the functional amplification of body or rather.
Background technology
Long section, reparation thick and the many places peripheral nerve defection are the still unsolved so far difficult problems of surgical field.Nerve autograft is repaired neurologic defect, be acknowledged as ideal method, but owing to can only repair the major function nerve with the tegumentary nerve of very thin secondary function, not only repairing effect is not good enough, and owing to the nerve disappearance for the district causes new dysfunction occurring for the district, so the autologous nerve source is greatly limited.
Allosome and xenogenesis neural transplantation because xenogenesis neural transplantation rejection is still unresolved, only limit to the animal experiment study stage.
Therefore, people begin the human nerve that the using artificial neural conduit comes repair deficiency.According to the difference of material therefor, artificial nerve catheter can be divided into three major types:
1. the biotype material mainly comprises vein, tremulous pulse, skeletal muscle, cord vessels etc.;
2. abiotic degradable synthetic material mainly contains silica gel tube;
3. the biodegradable synthetic material mainly comprises chitin, chitosan, polylactic acid etc.
Whether in addition, can be absorbed by human body according to artificial nerve catheter, the used material of artificial nerve catheter can be divided into absorbable material and absorbable material not; According to the situation of artificial nerve catheter to surrounding material permeability, the used material of artificial nerve catheter can be divided into half permeable materials and non-permeable materials etc.
Single artificial nerve catheter has certain effect in the reparation of short distance (less than 3 centimetres) neurologic defect, but lack active single non-nervous tissue can't repair in, a long section neurologic defect.
Promote nerve growth though there is the people in artificial nerve catheter, to place a neural segment abroad in the document, be only limited to short distance (less than 3 centimetres) neurologic defect situation.Continuously, the neural segment of spaced placement promote in, long section (greater than 10 a centimetres) nerve growth, yet there are no the pertinent literature report.
Summary of the invention
The technical problem that this utility model solves provides a kind of artificial nerve catheter, a kind of long section, thick and the requirement of many places peripheral nerve defection surgical repair that is specially adapted to especially is provided, and the neural segment of continuous, spaced placement promotes the artificial nerve catheter from the functional amplification of body of nerve growth.
Consult Fig. 1, for addressing the above problem, this utility model adopts following scheme to be achieved.Described artificial nerve catheter from the functional amplification of body is made up of trocar sheath and inner sleeve, array inner sleeve support and three artificial substratum bridges of adopting Biodegradable material to make; Trocar sheath is sleeved on the inner sleeve coaxial line, inner sleeve can stretch out in trocar sheath or indentation along coaxial line, in inner sleeve, be placed with array inner sleeve support along axis, every group of inner sleeve support is made up of two independent inner sleeve supports, formed space is called the storage chamber between two independent inner sleeve supports, the distance L between two single inner sleeve supports of storage intracavity
1Be 0.3 centimetre to 0.5 centimetre, the distance L between the adjacent two storage chambeies
2It is 0.5 centimetre.Array inner sleeve support is fixedly connected with three artificial substratum bridges that are parallel to the inner sleeve axis.
The width of the single inner sleeve support described in the technical scheme is 0.3 centimetre to 0.5 centimetre, the profile of single inner sleeve support is oval, the ellipsoid of inner sleeve support is processed into netted, and angle is 90 ° to 140 ° between horizontal netting twine parallel to each other and the vertical netting twine parallel to each other; The described array inner sleeve support that in inner sleeve, is placed with, be meant and determine in inner sleeve, to be placed with that to be one group at least be at most ten groups inner sleeve support according to the human nerve damage length, determine promptly in inner sleeve, to be built with that to be one at least be at most ten storage chamber; The face shaping of the trocar sheath of described artificial nerve catheter from the functional amplification of body is that cross section is the thin-walled body of oval ring, and inner sleeve is that cross section is that the thin-walled body and the centre of oval ring is that cross section is that the face shaping that the annular half thin-walled body of semiellipse is formed is the thin-walled body of U font by two ends; Described three artificial substratum bridges are to be two of centrosymmetry fixed and arranged along the long axis direction of inner sleeve support ellipsoid with the intersection point of major axis and minor axis on array inner sleeve support, and fixed and arranged is one on the intersection point of major axis and minor axis.
The beneficial effects of the utility model are:
1. the autologous nerve of using small size amplifies autologous nerve by the pipe support structure of new bio degradation material from function, for solve limited this difficult problem in autologous nerve source provide newly by way of.
2. the application of new bio degradation material pipe support structure has overcome abiotic degradable pipe and long term the chronic embedding of nerve has been pressed.
3. simple to operate, only need cut far-end in the operation between the default inner sleeve support in the artificial nerve catheter of the functional amplification of body that the new bio degradation material that the neural fragment and the fixed point of the very thin secondary function of body is positioned over it different size is made.
4. the degradable biological synthetic material of this utility model application all is to be applied to clinical biosynthesis material, and human body is not had any untoward reaction, does not therefore need to do any toxicity and immunological experiment, but can directly apply to clinical.
5. the artificial nerve catheter from the functional amplification of body made of new bio degradation material is cheap; The autologous nerve of the secondary function that the far-end of small size is very thin draws materials conveniently, safe and practical, do not need repeatedly, the many places operation, patient is easy to accept.
Description of drawings
Below in conjunction with accompanying drawing this utility model is further described:
Fig. 1 is the assembly structure sketch map along trocar sheath axis pinch in from the inner sleeve of the artificial nerve catheter of the functional amplification of body;
Fig. 2 is the assembly structure sketch map of stretching along the trocar sheath axis from the inner sleeve of the artificial nerve catheter of the functional amplification of body;
Fig. 3 is the structural representation from the inner sleeve of the artificial nerve catheter of the functional amplification of body;
Among the figure: 1. trocar sheath, 2. inner sleeve, 3. inner sleeve support, 4. artificial substratum bridge.
The specific embodiment
Below in conjunction with accompanying drawing this utility model is described in further detail:
Consult Fig. 1 to Fig. 3, adopting the cross section that new bio degradation material pla-pcl (PCL) or polylactic acid (PLA) copolymer are processed into artificial nerve catheter is trocar sheath 1, several single inner sleeve supports 3, the artificial substratum bridge 4 and inner sleeve 2 of the thin-walled body of oval ring.Inner sleeve 2 is that cross section is that the thin-walled body of oval ring and centre are to be that the face shaping that the annular half thin-walled body of semiellipse is formed is the thin-walled body of U font along oval ring long axis direction cross section by two ends, the width of single inner sleeve support 3 is 0.3 centimetre to 0.5 centimetre, the profile of single inner sleeve support 3 is oval, the ellipsoid of inner sleeve support 3 is processed into netted, and angle is 90 ° to 140 ° between horizontal netting twine parallel to each other and the vertical netting twine parallel to each other.Inner sleeve 2 can be determined with the storage chamber that makes up sufficient amount according to the thickness of the length of damaged nerve, damaged nerve with the length of trocar sheath 1 cross section oval ring major axis and minor axis with length, the inner sleeve 2 of trocar sheath 1.Inner sleeve 2 is packed within the trocar sheath 1, and inner sleeve 2 will reach two tubular axis line conllinear with the accuracy of manufacture of trocar sheath 1, and inner sleeve 2 can vertically be free to slide along axis within trocar sheath 1, and inner sleeve 2 can conveniently within the trocar sheath 1 take out and conveniently put into.Take out inner sleeve 2 for 1 li from trocar sheath, length according to the damaged nerve that will repair is placed corresponding array inner sleeve support for 2 li at inner sleeve, promptly make up the storage chamber of sufficient amount, the length in storage chamber is 0.3 centimetre to 0.5 centimetre, the distance in two storage chambeies is 0.5 centimetre, three artificial substratum bridges 4 of reuse are fixedly connected array inner sleeve support, and it is become one.Three artificial substratum bridges 4 are parallel to the axis of inner sleeve 2, three artificial substratum bridges 4 are that centrosymmetry is arranged two at the long axis direction of array inner sleeve support upper edge inner sleeve support ellipsoid with the intersection point of major axis and minor axis, and layout is one on the intersection point of major axis and minor axis; Between two inner sleeve supports 3 in storage chamber, place the autologous nerve segment that cuts, will place the pulsating inner sleeve 2 of autologous nerve then and put into trocar sheath 1, will make the human body that good whole artificial nerve catheter is positioned over needs repairing again.Use operation method at last artificial nerve trachea is connected in the neurologic defect position.The segmental work of autologous nerve of fixed point, interruption implantation small size is implemented to finish like this.
Manufacturing from the Biodegradable material that artificial nerve catheter adopted of the functional amplification of body except pla-pcl (PCL) or polylactic acid (PLA) copolymer, also adoptable Biodegradable material also has chitin and chitosan, can satisfy clinical requirement equally.
The required clinically artificial nerve catheter from the functional amplification of body may be various, so, in order to satisfy clinical needs, can be standby according to the artificial nerve catheter that the neural thickness of the human body breakage of clinical practice, damaged neural length are processed into different model from the functional amplification of body.
Artificial nerve trachea is connected in the operational approach at neurologic defect position:
At first anesthesia back is cut skin, is appeared from disconnected, damaged peripheral nerve, with scalpel, after distal nerve is trimmed to normal nervous tissue, measure the physical length of neurologic defect, selects the artificial nerve trachea of respective length for use nearly.Earlier artificial nerve trachea inner sleeve 2 is vertically pulled out, group number according to the default support of inner sleeve, cut the branchiess normal nervous tissue segment of far-end of a plurality of suitable lengths (0.3 centimetre-0.5 centimetre), and place it in default storage intracavity, with artificial nerve trachea inner sleeve withdrawal, artificial nerve trachea trocar sheath 1 and near, distal nerve broken ends of fractured bone adventitia are carried out interrupted suture with 5/0 no wound stitching thread.
The structure of artificial nerve trachea and experimental analysis:
Along with the development of polymer material science, adopt special process catalysis to synthesize new bio degradation material pla-pcl (PCL) and polylactic acid (PLA) copolymer.Can control molecular weight of product, paradigmatic structure and degradation time by the ratio of artificial adjustment response time, monomer and catalyst.Put into practice verified, this copolymer good biocompatibility, do not find toxicity and immunological rejection and mutagenesis the reaction, the termination product be carbon dioxide and water, human body is not had any untoward reaction.Thisly possess " bite the hand which has fed one ' Biodegradable material of performance, can remove general bridge pipe from and long term the chronic embedding of nerve be pressed, can become the ideal carrier that promotes autologous nerve regeneration activity material, have special superiority to repairing neurologic defect.
By the tissue engineering means, we organically combine the carcass Schwann cell of the pipe support structure of this Biodegradable material and purification, and the tissue engineered peripheral nerve of preparation has been repaired in the rat sciatic nerve, long section is damaged more satisfactoryly.The solution of the problems such as purification, preservation and graft-rejection of human carcass Schwann cell has also obtained progress.Recently, Ikuta etc. studies confirm that: the near-end nerve of fracture is connected in the silicone tube of opening of 10mm, does not find neuranagenesis after six weeks; And the distal nerve fragment of different volumes (the long whole cross section of 5mm, the long whole cross section of 1mm, the long half section of 1mm) is implanted the open silicone tube far-end of 10mm, regenerating nerve is successfully crossed over the quality no significant difference of regenerating between silicone tube and the neural slice groups of different volumes.This result repairs neurologic defect for the development and use autologous nerve new way is provided.On the basis of these work, the pipe support structure fixed point that the finishing of this utility model success used the new bio degradation material, be interrupted the autologous nerve fragment of implanting small size, to repair long section, thick peripheral nerve defection.
Select in the human limb, the case of long section peripheral nerve defection, the neuranagenesis that can farthest promote that the animal experiment study in applying clinical early stage is determined is repaired the autologous nerve of the amplification of neurologic defect, repair patient in, long section peripheral nerve defection.Respectively by two point discrimination, electromyogram and ninhydrin test,, all obtained satisfactory result to recovering to compare Journal of Sex Research with sensation, motion and the sympathetic nerve function of postoperative before the art.
Claims (5)
1. artificial nerve catheter from the functional amplification of body, it is characterized in that described artificial nerve catheter from the functional amplification of body is made up of the trocar sheath (1) that adopts Biodegradable material to make and inner sleeve (2), array inner sleeve support and three artificial substratum bridges (4); Trocar sheath (1) being sleeved on inner sleeve (2) coaxial line, inner sleeve (2) can stretch out or indentation in trocar sheath (1) along coaxial line, be placed with array inner sleeve support in inner sleeve (2) lining along axis, every group of inner sleeve support is made up of two independent inner sleeve supports (3), formed space is called the storage chamber between two independent inner sleeve supports (3), the distance L between two independent inner sleeve supports (3) in formation storage chamber
1Be 0.3 centimetre to 0.5 centimetre, the distance L between the adjacent two storage chambeies
2Be 0.5 centimetre, array inner sleeve support is fixedly connected with three artificial substratum bridges (4) that are parallel to inner sleeve (2) axis.
2. according to the described artificial nerve catheter of claim 1 from the functional amplification of body, it is characterized in that, the width of single inner sleeve support (3) is 0.3 centimetre to 0.5 centimetre, the profile of single inner sleeve support (3) is oval, the ellipsoid of inner sleeve support (3) is processed into that angle is 90 ° to 140 ° between netted, parallel to each other horizontal netting twine and the vertical netting twine parallel to each other.
3. according to the described artificial nerve catheter of claim 1 from the functional amplification of body, it is characterized in that, describedly be placed with array inner sleeve support in inner sleeve (2) lining, be meant and determine to be placed with that to be one group at least be at most ten groups inner sleeve support according to the human nerve damage length, determine promptly to be built with that to be one at least be at most ten storage chamber in inner sleeve (2) lining in inner sleeve (2) lining.
4. according to the described artificial nerve catheter of claim 1 from the functional amplification of body, it is characterized in that, the face shaping of the trocar sheath (1) of described artificial nerve catheter from the functional amplification of body is that cross section is the thin-walled body of oval ring, and inner sleeve (2) is that cross section is that the thin-walled body and the centre of oval ring is that cross section is that the face shaping that the annular half thin-walled body of semiellipse is formed is the thin-walled body of U font by two ends.
5. according to the described artificial nerve catheter of claim 1 from the functional amplification of body, it is characterized in that, described three artificial substratum bridges (4) are to be two of centrosymmetry fixed and arranged along the long axis direction of inner sleeve support (3) ellipsoid with the intersection point of major axis and minor axis on array inner sleeve support, and fixed and arranged is one on the intersection point of major axis and minor axis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200947280U CN201230913Y (en) | 2007-12-06 | 2007-12-06 | Human nerve conduit with amplified self-functionality |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200947280U CN201230913Y (en) | 2007-12-06 | 2007-12-06 | Human nerve conduit with amplified self-functionality |
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| CN201230913Y true CN201230913Y (en) | 2009-05-06 |
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| CNU2007200947280U Expired - Lifetime CN201230913Y (en) | 2007-12-06 | 2007-12-06 | Human nerve conduit with amplified self-functionality |
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Cited By (26)
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| CN100560037C (en) * | 2007-12-06 | 2009-11-18 | 崔树森 | Artificial nerve catheter from the functional amplification of body |
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- 2007-12-06 CN CNU2007200947280U patent/CN201230913Y/en not_active Expired - Lifetime
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