CN1893915B

CN1893915B - Oral care delivery system comprising a bleaching agent

Info

Publication number: CN1893915B
Application number: CN2004800376809A
Authority: CN
Inventors: C·K·高希; D·C·斯科特
Original assignee: Procter and Gamble Ltd
Current assignee: Procter and Gamble Ltd; Procter and Gamble Co
Priority date: 2003-12-17
Filing date: 2004-12-17
Publication date: 2011-06-29
Anticipated expiration: 2024-12-17
Also published as: CN1893917A; CN1893914A; CN1893917B; CN1893914B; CN1893915A

Abstract

Oral care delivery system comprising an integral carrier e.g. a strip material, dental tray or sponge material and a composition for whitening teeth of a subject in need comprising: a. a safe and effective amount of a bleaching agent; b. a safe and effective amount of a water insoluble solid phase; c. a safe and effective amount of a water soluble liquid phase; wherein the ratio of the water insoluble solid phase to the water soluble liquid phase is from about 1:4 to about 4:1. The composition is applied for a sufficient period of time to achieve whitening; the composition may have Whitening Index of from about 0.5 to about 4. The composition optionally comprises a hydrophobically modified polymer.

Description

The oral care delivery system that comprises bleach

The cross reference of related application

The priority of the U.S. Provisional Application 60/530,387 that the application requires to submit in 17th in December in 2003, the U.S. Provisional Application of submitting in 17th in December in 2003 60/530,217 and the U.S. Provisional Application 60/530,397 submitted in 17th in December in 2003.

Technical field

The method that the present invention relates to Lightening compositions and brighten the tooth of this individuality that needs.The invention still further relates to a kind of method that improves the effect of bleach in the oral cavity.Individuality is administered to compositions on a plurality of teeth and lasting long enough a period of time brightens with realization.Said composition comprises bleach, water insoluble solid phase and water soluble liquid phase; The ratio of wherein said water insoluble solid phase and described water soluble liquid phase is about 1: 4 to about 4: 1.In one embodiment, described compositions has about 0.5 to about 4 whitening index.

In one embodiment, the present invention relates to a kind of delivery system, this delivery system comprises this paper compositions and an integral carriers, as joint strip (strip of material), dens supporter (tray) and/or sponge material.

Background of invention

It is known being used for various beauty treatments and/or handling the dental articles that active component is delivered to tooth and oral cavity.The embodiment of this based article comprises: the dentifrice product of brush teeth auxiliary agent such as delivery of oral care active substance such as Quadrafos or fluoride; The collutory that comprises flavorants or antibacterial substance; And with the Tooth whitening strips of delivering bleaching agents to tooth.Specifically, utilize tooth to paste improve looks or to handle beneficial effect to be delivered to be considered on tooth and the oral mucosa surface a kind of not only having made things convenient for but also the method for economy.For example, Tooth whitening strips makes tooth and Lightening compositions continue to contact as you know, wherein at first Lightening compositions is coated on the joint strip, is administered on the tooth then.Referring to United States Patent (USP) 6,136,297,6,096,328,5,894,017,5,891,453 and 5,879,691, these patents are all authorized people such as Sagel, and United States Patent (USP) 5,989,569 and 6,045,811, these two patents are all authorized people such as Dirksing, and all transfer Procter﹠amp; Gamble Company.

Prior art has generally been attempted by the whole bag of tricks, especially improves whitening efficacy by the content that increases bleach in the compositions.Yet this method presents some problems.At first, individuality may feel that zest and/or sensitivity increase, and this zest and/or sensitivity increase relevant with the bleach consumption of use.In addition, some administrative organizations all over the world and law do not allow that content is exceeded certain density bleach and are used for product.

Therefore, although the method for above-mentioned known treatment oral condition, especially bleaching teeth is arranged, but still need provide product with improved bleaching effect.The present invention has overcome some limitation of present technology.

Summary of the invention

The present invention relates to be administered to the method for bleaching the tooth of the individuality that needs bleaching teeth on a plurality of teeth by the compositions with safe and effective amount, described compositions comprises:

A. the bleach of safe and effective amount;

B. the water insoluble solid phase of safe and effective amount;

C. the water soluble liquid phase of safe and effective amount;

The ratio of wherein said water insoluble solid phase and described water soluble liquid phase is about 1: 4 to about 4: 1; Wherein sufficiently long a period of time of applying said compositions brightens with realization; And wherein said compositions has about 0.5 to about 4 whitening index.In another embodiment, described compositions is single phase.

In one embodiment, the invention still further relates to a kind of oral care composition, described compositions comprises:

A. the bleach of safe and effective amount;

B. the water insoluble solid phase of safe and effective amount, it is selected from organic additive and their mixture;

C. the water soluble liquid phase of safe and effective amount; With

The ratio of wherein said water insoluble solid phase and described water soluble liquid phase is about 1: 4 to about 4: 1.

In another embodiment, the present invention relates to a kind of oral care composition, described compositions comprises:

A. the bleach of safe and effective amount;

B. the water insoluble solid phase of safe and effective amount;

C. the water soluble liquid phase of safe and effective amount; With

D. the associative thickeners of safe and effective amount;

In another embodiment, the invention still further relates to a kind of oral care delivery system, described system comprises:

A. integral carriers and

B. the compositions of safe and effective amount, described compositions comprises:

1. the bleach of safe and effective amount;

2. the water insoluble solid phase of safe and effective amount; With

3. the water soluble liquid phase of safe and effective amount;

The ratio of wherein said water insoluble solid phase and described water soluble liquid phase is about 1: 4 to about 4: 1; And wherein using sufficiently long a period of time of described compositions brightens realizing; And wherein said delivery system can stick on the hard or soft tissue in oral cavity.

In one embodiment, described delivery system comprises: the ground floor joint strip; The second layer that comprises above-mentioned composition, wherein said bleach combine with described joint strip releasedly.In one embodiment, the present invention is used for brightening beneficial effect by directly integral carriers being administered on the tooth to oral delivery.

Summary of drawings

Though this description it is believed that by the explanation of following embodiment and with reference to accompanying drawing to understand the present invention better by particularly pointing out and clearly claimed claim of the present invention is drawn a conclusion, the identical identical element of reference number representative among the figure.Integral carriers comprises joint strip, dens supporter, sponge material and their combination.In one embodiment of the invention, described integral carriers comprises joint strip.Joint strip is attached on the tooth by attachment members.Described attachment members can be this paper compositions, with the isolating adhesive composition of this paper compositions, perhaps by means of the attachment members that is the part of integral carriers, for example, integral carriers may optionally be enough sizes and/or width, and enough adhesivenesses are arranged so that once using, integral carriers and oral soft tissue crossover cause more dental surface to be bleached.

Be not intended to limit the present invention, the joint strip embodiment is more detailed description hereinafter:

Fig. 1 is the perspective view with flat substantially joint strip of fillet.

Fig. 2 is the perspective view of one embodiment of the invention, and this figure discloses the joint strip of above-mentioned Fig. 1, and second layer compositions is arranged on it, and said composition comprises compositions as herein described, but wherein combines bleach and integral carriers and/or this compositions release property.

Fig. 3 is along the profile of the intercepting of the hatching 3-3 among Fig. 2, the figure illustrates a kind of joint strip embodiment, the thickness of the little second layer that is coated with thereon of its thickness.

Fig. 4 is a profile, the figure illustrates an available embodiment of the present invention, and it has shown the scrobicula in the joint strip (shallow pocket), and this scrobicula is as the reservoir that is applied to the additional quantity of the second layer on the joint strip.

Fig. 5 is the cross section plane graph, the figure illustrates second layer compositions is applied to an available embodiment on the adjacent teeth, have joint strip of the present invention on the described tooth, it conforms to described tooth and sticks on the tooth by the second layer compositions between tooth and joint strip.

Fig. 6 is along the front view of the tooth cross section of the intercepting of the hatching 6-6 among Fig. 5, the figure illustrates joint strip of the present invention, and it conforms to tooth and sticks on the tooth by the second layer compositions between tooth and joint strip.

Fig. 7 is and the similar cross section plane graph of Fig. 5, the figure illustrates joint strip of the present invention, and it fits shape by the second layer compositions between tooth and joint strip and tooth and contiguous soft tissue, and sticks to the tooth both sides.

Fig. 8 is along the cross-sectional elevational view of Fig. 7 section line 8-8 intercepting, the figure illustrates joint strip of the present invention, and its soft tissue by the second layer compositions between tooth and joint strip and tooth and vicinity is fitted shape, and sticks to the tooth both sides.

Fig. 9 is the perspective view of the available embodiment of the present invention, and this figure discloses the joint strip with release liner, and the second layer compositions that this joint strip scribbles as shown in Figure 2 is used to nurse tooth and contiguous soft tissue.

Figure 10 is available embodiment of the present invention along the profile of the intercepting of the hatching 10-10 among Fig. 9, the figure illustrates by the second layer compositions on the joint strip and adheres to release liner on the joint strip.

Detailed Description Of The Invention

Definition

Term used herein " oral care composition " or " oral cavity composition " are meant a kind of like this product, this product is not intended to reach the purpose that inorganic agent is administered systemically by swallowing, thereby but stops time enough reach whitening efficacy with the contact dental surface in the oral cavity.

Term used herein " safe and effective amount " is meant in rational medical science/odontology determination range, the amount of active component is enough high to change disease that desire handles or the whitening efficacy that reaches expectation with significantly (clearly), but enough hang down with avoid serious side effects (with rational effect/danger than).The safe and effective amount of component depends on the order of severity, processing cycle, the character of associated treatment, the concrete form of use and the concrete carrier of applied component of pending concrete disease (for example realizing brightening), pending patient's age and physiological status, disease.

Phrase used herein " sufficiently long a period of time to realize brighten " be meant described compositions used by individuality consume or the individual frequency of using under guidance or consuming described compositions for use at every turn greater than about 2 minutes, be in another embodiment about 2.5 minutes to about 12 hours (as the processing of spending the night), be about 3 minutes to about 120 minutes in another embodiment, be about 5 minutes to about 40 minutes in another embodiment, but and use every day about 1 to about 7 times.In addition, for reaching desired beneficial effect (as teeth whitening), sustainable about one day to about six months of the time of processing, continue about one day to about 28 days in another embodiment, lasting about 7 days to about 28 days in another embodiment.Best persistent period of using and frequency depend on the order of severity of desired effect, all pending diseases, health status and the age and the similar factor of user.

Unit used herein " cm " is meant centimetre.Unit used herein " mm " is meant millimeter.

Except as otherwise noted, all hereinafter used percentage ratios and ratio are all by the weight of total composition.

Except as otherwise noted, all measurements of mentioning of this paper are all carried out under 25 ℃.

Except as otherwise noted, the percent of all the components that this paper mentions, ratio and content is all based on the actual content of this composition, and is not included in the commercially available prod solvent, filler or other material that can use with these compositions.

The patent of all publications, patent application and announcement that the present invention mentions is all introduced for your guidance in full.Quoting of any document is not to its approval as the availability of claimed prior art of the present invention.

Be not bound by theory, the present invention can increase " effectively " concentration of dental surface bleach by replace some water with water insoluble solid phase.In one embodiment, it is more hydrophobic that this can make described compositions.Therefore, even, also can make bleaching speed increase and/or the increase of bleach effect total use identical or lower bleach levels.Therefore, under given total bleach concentration, the number of times that the present invention may only use still less can obtain same bleaching degree, or may only need lower gel heap(ed) capacity to obtain same bleaching degree.

Bleach

Compositions in the inventive method and method comprise the bleach of safe and effective amount.Usually, the content of bleach depends on that respectively these molecules can provide available oxygen or the chlorine with the bleaching mottle.The content that bleach is generally used in the present composition counts about 0.1% to about 20% by described composition weight, be about 0.5 to about 9% in another embodiment, being about 3% to about 8% in another embodiment, is about 4% to about 6% bleach in another embodiment.In one embodiment, described bleach is shockingly more effective when using with low content, and described low content is generally about 0.5% to about 3% by the weight of described compositions, is about 0.5% to about 1.5% in another embodiment.

Bleach is included in the present composition.In one embodiment, bleach is selected from peroxide, metal chlorite, perborate, percarbonate, peroxy acid, persulfate, forms the chemical compound of aforesaid compound and their combination on the spot.Suitable peroxide comprises hydrogen peroxide, urea peroxide, calper calcium peroxide, carbamide peroxide, and their mixture.In one embodiment, bleach is a carbamide peroxide.Suitable metal chlorite comprises calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, potassium chlorite and their mixture.Other bleach also comprises hypochlorite and chlorine dioxide.In one embodiment, bleach is selected from sodium chlorite, peroxide, SODIUM PERCARBONATE, potassium hydrogen persulfate and their mixture.Initial bleach can be moisture or solid matter.

Water insoluble solid phase

The present invention comprises the water insoluble solid phase of safe and effective amount.Usually, described water insoluble solid phase comprises water-insoluble organic and/or inorganic (as granule) additive.Described water insoluble solid phase is generally water-insoluble, and is nontoxic to user, chemically stable, and with compositions in the bleach (decomposing substantially) that exists as not causing bleach compatible with other composition.Usually, in one embodiment, the present invention comprises by the weight of described compositions about 20% to about 80%, about in another embodiment 30% to about 75%, about in another embodiment 35% to about water insoluble solid phase of 65%, about in another embodiment 45% to about 60%.

Comprise polyolefin (for example, thermoplastic polymer, derived from the polymer and the copolymer thereof of simple olefins, polyethylene, polypropylene, polyisoprene, polybutene) and polyester and their mixture as the suitable material of water insoluble solid phase.For example, polyethylene can trade name

With Obtain, available from Honeywell Allied Signal.Other material that is used for water insoluble solid phase comprises water-insoluble cellulose (for example ethyl cellulose and cellulose ethanoate), silicon dioxide, Talcum, Muscovitum, magnesium carbonate, calcium carbonate, magnesium silicate, aluminium silicate magnesium salt, titanium dioxide, zinc oxide, nylon powder, methacrylate powder, polystyrene powder, silk powder, crystalline cellulose, titanation Muscovitum, calcium phosphate, calcium pyrophosphate, and their mixture.In one embodiment, described water insoluble solid phase is selected from polyethylene, polypropylene, polyisoprene, its copolymer, and their mixture.

In one embodiment, described water insoluble solid phase comprises by weight less than about 5%, less than about 2%, does not contain Tri-Compress, anhydrous dicalcium phosphate and/or calcium pyrophosphate in another embodiment substantially in another embodiment.

In one embodiment, various dyestuffs, coloring agent, pigment and their mixture can be chosen wantonly and add in this compositions or an optional part of mixing as water insoluble solid phase, so that this paper compositions has coloured appearance.Any consumer desired color all can be used, and comprising provides dyestuff or the pigment that is similar to nature tooth color color.An advantage of colored composition is that it makes user can see whether compositions evenly and fully covers their tooth, because if see with the level of coverage on the colored composition tooth is easier.

In one embodiment, described water insoluble solid phase is water-soluble substances (a for example water soluble starch material), and it joins in the compositions with sufficiently high content, surpasses its dissolubility in said composition, after this as the water-insoluble phase.

In one embodiment, if when especially compositions is used integral carriers (as joint strip), the particle mean size of described water insoluble solid phase is usually less than about 200 microns.In one embodiment, the particle mean size of described water insoluble solid phase is about 5 to about 100 microns, being about 5 to about 80 microns in another embodiment, is about 10 to about 60 microns in another embodiment, is about 10 to about 30 microns in another embodiment.

In one embodiment, described water insoluble solid phase and bleach-compatible, this is meant that described water insoluble solid phase will not cause that bleach significantly decomposes.In another embodiment, " with bleach-compatible " is meant that the stabilizing agent with safe and effective amount adds in the described water insoluble solid phase or the present composition.In another embodiment, the content of optional stabilizer counts about 0.001% to about 15% by the weight of described compositions, be about 0.01% to about 10% in another embodiment, being about 0.5% to about 5% in another embodiment, is about 1% to about 3% in another embodiment.

In one embodiment, suitable optional stabilizer known in the art such as chelating agen or non-chelating agen stabilizing agent can be selected from tartaric acid and officinal salt thereof; Citric acid and salt thereof such as alkali metal citrates; Pyrophosphate ion source; Quadrafos (as, tripolyphosphate, hexametaphosphate); Diphosphate (as, EHDP; AHP); EDTA; And their mixture; Can be selected from sodium citrate, potassium citrate, disodium tartrate, di-potassium tartrate, pyrophosphate ions source, potassium sodium tartrate, hydrogen tartrate disodium, potassium hydrogen tartrate, Sodium Acid Pyrophosphate, tetrasodium pyrophosphate, tetrapotassium pyrophosphate in another embodiment, and their mixture.

Water soluble liquid phase

The present invention comprises the water soluble liquid phase of safe and effective amount.Usually, the content of water soluble liquid phase counts about 15% to about 80% by the weight of described compositions, being about 20% to about 75% in another embodiment, is about 35% to about 70% in another embodiment, is about 45% to about 65% in another embodiment.In another embodiment, water soluble liquid phase is about 15% to less than about 50%.

It is about 200 to about 20,000 polyalkylene dihydroxylic alcohols, wetting agent that water soluble liquid phase is selected from water, molecular weight usually, and their mixture.Water soluble liquid phase can comprise the mixable component of water such as polyalkylene dihydroxylic alcohols, wetting agent and their mixture.Wetting agent generally includes edible polyhydric alcohol such as glycerol, sorbitol, xylitol, butanediol, Polyethylene Glycol and propylene glycol, and their mixture.In one embodiment, water soluble liquid phase is a water.In one embodiment, described compositions comprises by the weight of described compositions at least about 10% water, in another embodiment at least about 20% water.

The ratio of water insoluble solid phase and water soluble liquid phase

The ratio of water insoluble solid phase and water soluble liquid phase is about 1: 4 to about 4: 1, be about 1: 2.5 to about 2.5: 1 in another embodiment, being about 1: 1.5 to about 1.5: 1 in another embodiment, is about 1: 1.25 to about 1.25: 1 in another embodiment.

Whitening index

In one embodiment, whitening index of the present invention is about 0.5 to about 4, is about 1 to about 4 in another embodiment, is about 1.3 to about 3.5 in another embodiment, is about 1.5 to about 3 in another embodiment.Whitening index is calculated as follows:

1st, 2,3 or 4 Db (compositions A) that handle day deduct Db (compositions B), wherein compositions A has by the identical bleach concentration of described composition weight meter with compositions B, and compositions A is a compositions of the present invention, it has the water insoluble solid phase and the water soluble liquid phase of aequum, ratio be about 1: 4 to about 4: 1 or the like, and compositions B is quite different.

The Db of compositions A is calculated as follows: people's molar cleaning of 6 to 8 extractions is clean, be fixed on then In the piece, every molar positive labelled to discern every molar.Make molar in water or phosphate buffered solution once more hydration spend the night.Subsequently, molar takes out from solution, then 0.03g to 0.1g compositions A is coated in the front surface of every molar.In handling time-continuing process, molar is placed in 37 degrees centigrade of incubators then.Every molar twice usefulness compositions every day A handled 30 minutes in 4 days search time.After 30 minute processing time, molar is taken out from incubator, then with the distilled water rinsing to remove all residual compositionss.Between each the processing molar is placed in water or the buffer solution.The interval is two to four hours between each processing section.

Pretreatment (baseline) and all handle (total processing time every day is 1 hour) every day after obtain the digital picture of molar.Use Fuji, the high-resolution digital camera that Japan makes Catch the digital picture of molar.Analyzing these images derives to describe from the standard C IELAB of lightness/brightness of Lan Zhihuang ¹The average color of teeth numerical value (b) that three-dimensional color space is represented.Compare with processing effect b after handling every day (with the mean value calculation of each test molar b) and baseline b (with the mean value calculation of each test molar b), obtain being expressed as the color measured values b of Db.In one embodiment, the baseline b value of people's molar of extraction is about 10 to about 20, is about 12 to about 16 in another embodiment.

Whitening index can be calculated at the 1st or 2 or 3 or 4 day, and perhaps it can be the meansigma methods of the 1st to 4 day Db.

With with the Db of the same mode calculation composition B of compositions A, different compositions B rather than the compositions A of being to use.

¹The L*a*b* of international lighting association (Commission Internationale de l ' Eclairage) can represent all possible color by enough three variablees, and these three variablees are luninnce-L*; Color value a* on red-green axle; Color value-b* on the blue-yellow axle.

Optional thickeners

The optional thickening agent that comprises of this paper compositions.In one embodiment, thickening agent (or viscosity modifier) is used for increasing the retentivity of compositions on tooth.Viscosity modifier also can further be used for constituents for suppressing precipitate with separate or control precipitate, and the flowing property of may command compositions in the mode that helps redispersion.Viscosity modifier especially can be used for keeping granular bleach agent or other oral care active agents to be suspended in the present composition.The thickening agent of this paper also can be used as the adhesive means that hereinafter described reaches.

When existing, the content of thickening agent (viscosity modifier) counts about 0.01% to about 20% by the weight of described compositions, be about 0.1% to about 10% in one embodiment, be about 0.4% to about 5% in another embodiment, and be about 1% to about 3% in another embodiment.

The viscosity modifier that this paper is suitable comprises synthetic polymer such as cellulose derivative (methylcellulose for example, carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose etc.), carbomer polymer (for example crosslinked acrylic copolymer or homopolymer and with the crosslinked acrylic copolymer of polyalkenyl polyether), natural and paragutta, karaya, guar gum, gelatin, Algin, sodium alginate, tragacanth, chitosan, poly(ethylene oxide), acrylamide polymer, polyacrylic acid, polyvinyl alcohol, polyamine, poly-quaternary compound, ethylene oxide polymer, polyvinylpyrrolidone, cationic polyacrylamide polymer, and their mixture.

In one embodiment, thickening agent is selected from carbomer, as with pentaerythritol alkyl ether or the crosslinked acrylate homopolymer class of sucrose alkyl ether.Carbomer with The series city is sold by B.F.Goodrich.In one embodiment, acrylate copolymer is Carbopol 934,940,941,956, and their mixture.Polyacrylic homopolymer for example is described in the United States Patent (USP) 2,798,053.Other embodiment of available homopolymer comprises Ultrez 10, ETD 2050 and 974P polymer, and they are available from B.F.Goodrich Company.These polymer are the homopolymer of unsaturated, polymerisable carboxylic monomer such as acrylic acid, methacrylic acid, maleic acid, itaconic acid, maleic anhydride etc.

In another embodiment, thickening agent can be associative thickeners or stabilizing agent, as the alkali solubility acrylic emulsion of hydrophobically modified or the nonionic polyhydric alcohol polymer of hydrophobically modified, that is, and the urethane polymer of hydrophobically modified, the ethoxylation urethane polymer of hydrophobically modified or their combination.Associative thickeners can increase this paper compositions and/or retentivity or the adhesion of integral carriers on dental surface, can slow down the corrosion after compositions is administered to dental surface, and can improve the release of compositions on the optional release liner disclosed herein.

For example, the acrylic acid polymer of hydrophobically modified is described in United States Patent (USP) 3,915, in 921,4,421,902,4,509,949,4,923,940,4,996,274,5,004,598 and 5,349,030.These polymer have bigger happiness water hydrophilic segment (polyacrylic acid part) and less happiness oil hydrophobic part (its can derived from long carbon chain acrylate).Representational senior alkyl acrylate is decyl acrylate, lauryl acrylate, stearyl acrylate base ester, acrylic acid docosyl ester and acrylic acid Herba leucadis ciliatae ester and corresponding methacrylate.Should be appreciated that more than a kind of carboxylic monomer and more than a kind of acrylate or vinyl acetate or ether or styrene esters can be used for monomeric charge.Described polymer can be dispersed in the water and with the alkali neutralization so that the Aquo-composition thickening forms gel, or make and can use thing emulsifying or suspension.Available polymer with

1342 and 1382, and

ETD 2020, and TR-1, TR-2,1621 and 1622 sell, all available from B F Goodrich.Carbonyl bearing polymer is prepared by the monomer that comprises at least one activation vinyl and carboxyl, and will comprise the copolymer of polymerisable carboxylic monomer and acrylate, acrylamide, alkylation acrylamide, alkene, vinyl esters, vinyl ethers or polystyrene.The molecular weight of carbonyl bearing polymer is paramount to tens or higher greater than about 500, usually greater than about 10,000 to 900,000 or higher.

Same available is the copolymer of hydrophobically modified monomer and spatial arrangements stable polymer surfactant, and described surfactant has at least one hydrophilic segment and at least one hydrophobic part or straight chain block or random pectination configuration or its mixing.The stabilizing agent embodiment of spendable spatial stability is Hypermerl, and it is poly-(12-hydroxy stearic acid) polymer, available from ImperialChemical Industries Inc. and

It is methyl-3-polyethoxy propyl-siloxane Ω .-phosphate polymer, available from Phoenix Chemical, Somerville, N.J..These are by United States Patent (USP) 4,203, and 877 and 5,349,030 proposes.

Other associative thickeners comprise Rohm and Haas (as ICS-1 and 22 and 28 thickening agents, it is the alkali solubilized acrylic polymer emulsions of hydrophobically modified, and 44 and 46 thickening agents, it is a hydrophobically modified nonionic polyhydric alcohol).In one embodiment, associative thickeners is

And/or

Polymer.The concrete polymer that selection will be used will depend on the desired compositions rheology characteristic and the characteristic of other constituent.

Other associative thickeners discusses in more detail in US5, and 997,764, among the BF Goodrich.In one embodiment, can use the carbomer of hydrophobically modified and the mixture of carbomer.

The combination of integral carriers and compositions

In one embodiment, the present invention relates to comprise the delivery system of integral carriers and this paper compositions.In one embodiment, described delivery system comprises: the ground floor joint strip; The second layer that comprises above-mentioned composition, wherein bleach combines with compositions and/or joint strip releasedly.The present invention is brightened beneficial effect by directly integral carriers being administered on the tooth to oral delivery.

I. ground floor

Ground floor of the present invention comprises integral carriers, and it comprises joint strip, dens supporter, sponge material, and their mixture.In one embodiment, described integral carriers is a joint strip.

Referring now to accompanying drawing, more particularly be Fig. 1 and 2, they have shown first embodiment of the present invention, are typically expressed as 10, its expression is used for the bleaching activity component is delivered to the delivery system in tooth and oral cavity.Delivery system 10 has joint strip 12, and this joint strip is flat basically, preferably has fillet.

Be coated in releasedly on the described joint strip 12 is second layer compositions 14.In one embodiment, second layer compositions 14 for homogenization and can be evenly and be coated in continuously on the joint strip 12, as shown in Figure 3.Yet what second layer compositions 14 alternatively was a second layer compositions 14 along a part of joint strip 12 longitudinal axis is continuous coated.In addition, second layer compositions can be lamination or lamellated, and wherein said bleach and/or adhesive means may not be present in all layers or the laminated material.In addition, second layer compositions can be the amorphous mixture of compositions, and wherein said bleach and/or adhesive means may not be present in all phases of this amorphous mixture.In addition, second layer compositions can be painted strip, point-like and/or other pattern of identical or different compositions, and wherein said bleach and/or adhesive means may not be present in all strips, point-like and/or other pattern of compositions.

As shown in Figure 4, in an alternative embodiment, can have the scrobicula 18 that is formed at wherein on the joint strip 12.When second layer compositions 14 was coated on the joint strip 12, if present, additional second layer compositions 14 just was full of scrobicula 18 so that the reservoir of second layer compositions 14 to be provided.

Fig. 5 and Fig. 6 have shown and have been applied to tooth and the lip-deep delivery system 24 of the present invention of a plurality of adjacent teeth.A plurality of adjacent teeth 22 are embedded in the adjacent soft tissue 20.This paper adjacent soft tissue is defined as and is enclosed in tooth structure soft tissue surfaces on every side, it comprises: emulsus is outstanding, the gingiva viscosity structure on gingival edge, gingival sulcus, inner gingiva and tongue and oral surfaces top, and it comprises the viscosity gingiva that is connected with buccal.

In Fig. 5 and Fig. 6, delivery system 24 expression joint strip 12 and second layer compositionss 14, wherein second layer compositions 14 is in the side of joint strip 12 towards tooth 22.Second layer compositions 14 can be coated on the joint strip 12 in advance, perhaps can be coated in before being applied to tooth on the joint strip 12 by user.In an alternative embodiment, second layer compositions can directly apply to tooth 22 by user, and then above joint strip 12 covered.Under any circumstance, joint strip 12 has certain thickness and flexural stiffness, makes itself and tooth 22 contour surfaces and adjacent soft tissue 20 fit shapes.In one embodiment, joint strip has enough flexibilities to form the oral surfaces profile, and this surface is exactly a plurality of adjacent teeth.When using delivery system, joint strip also is easy to and the suitable shape of dental surface and tooth space, and does not have permanent deformation.Described delivery system can need not remarkable pressure and use.

Fig. 7 and Fig. 8 represent to be applied to the front and back surface of a plurality of adjacent teeth 22 and the delivery system of the present invention 24 of adjacent soft tissue 20.Delivery system 24 expression joint strip 12 and second layer compositionss 14, wherein second layer compositions 14 is in the side of joint strip 12 towards tooth 22.

Fig. 9 and Figure 10 represent the release liner 27 chosen wantonly.Release liner 27 sticks on the joint strip 12 by second layer compositions 14.Second layer compositions 14 is in the side of joint strip 12 towards release liner 27.After removing release liner 27, this side is applied to tooth and dental bed surface.

The ground floor of delivery system of the present invention is made of joint strip in one embodiment.This ground floor material is described in more detail in the following United States Patent (USP): 6,136,297,6,096,328,5,894,017,5,891,453 and 5,879,691, and these are all authorized people such as Sagel and all transfer Procter﹠amp; Gamble Company also is described in following United States Patent (USP) 5,989,569 and 6,045,811, all authorizes people such as Dirksing and all transfers Procter﹠amp; Gamble Company.

Joint strip is as the protection barrier of bleach.It prevents tongue, lip and saliva leaching and/or the corrosion second layer of user.This makes the active component on the second layer can contact the longer time with crust in the oral cavity, and promptly a few minutes are to several hrs.

Joint strip can comprise polymer, naturally and synthetic spin producing material material, non-producing material material, paper tinsel, paper, the rubber of spinning, and their combination.Joint strip can be that monolayer material also can be the laminated material of more than one deck.No matter how many numbers of plies is, in one embodiment, described joint strip is for water-insoluble substantially.Joint strip also can be water impervious.In one embodiment, this material can be the compositions of the polymer or the polymer of any kind, as long as it satisfies required flexural rigidity coefficient and compatible with oral care substance.Suitable polymers includes but not limited to polyethylene, acetic acid ethylethylene alcohol ester, polyester, ethyl vinyl alcohol, and compositions.The embodiment of polyester comprises With fluoroplastics as

Produce by E.I.Du Pont Company.This in one embodiment material is a polyethylene.Usually the thickness of joint strip in one embodiment less than about 0.05mm, is that about 0.001mm is to about 0.03mm less than about 1mm (millimeter) in another embodiment.The thickness of polyethylene joint strip is usually less than about 0.1mm, and is about 0.005mm about 0.02mm extremely in one embodiment.

The joint strip profile can be the Any shape and the size that can cover required oral surfaces.In one embodiment, joint strip has fillet to avoid stimulating the soft tissue in the oral cavity.Term " fillet " is meant without any wedge angle or cusp.In one embodiment the length of joint strip be about 2cm (centimetre) to about 12cm, it is about 4cm about 9cm extremely in another embodiment.The width of joint strip also depends on the oral surfaces that will cover.The width of joint strip is generally about 0.5cm to about 4cm, is that about 1cm is to about 2cm in one embodiment.In another embodiment, joint strip can be made patch and is attached on one or many teeth and pastes the zone to nurse this institute.

Joint strip can comprise scrobicula.When compositions was applied on the joint strip, bleach and/or oral care active were filled in the scrobicula, to be provided for storing the reservoir of extra bleach and/or oral care active.Scrobicula also helps to provide texture for described delivery system in addition.Described in one embodiment joint strip has row's scrobicula.It is wide that scrobicula is generally about 0.4mm, and about 0.1mm is dark.When comprising scrobicula on the joint strip, this paper compositions is coated on the joint strip with different thickness, but the gross thickness of delivery system is less than about 1mm.In one embodiment, gross thickness is less than about 0.5mm.

Flexural stiffness is the character of material, and it is the comprehensive function of joint strip thickness, width and elasticity of materials modulus.This test is to measure polyolefin film and the inflexible method of thin slice.This method is come the bending resistance of measuring samples by the deformeter that use is fixed on the horizontal gird end.Terminal horizontal being pressed on the sample of another of crossbeam forces the part ribbon to enter sample and puts perpendicular grooves on thereon the levelling bench.To be connected on the strain gauge with tinsel with the microammeter that angular force is calibrated.The stiffness coefficient of sample can directly read from microammeter, and it is wide that it is expressed as the gram per centimeter sample strip.In the present invention, the flexural stiffness of joint strip is less than about 5g/cm, and it is measured on the model #211-300 at Handle-O-Meter, this instrument is provided by the Thwing-Albert Instrument Company that is positioned at Philadelphia, and PA is as the method ASTMD2923-95 of each test.The flexural stiffness of joint strip in another embodiment less than about 2g/cm, is that about 0.1g/cm is to about 1g/cm less than about 3g/cm in another embodiment in one embodiment.Generally, the flexural stiffness of joint strip is constant basically, and can not change between the normal operating period.For example, joint strip does not need to combine with water the low flexural stiffness that just can reach in the declared range above.

This relatively low hardness makes joint strip just can cover the profile of oral surfaces under the situation of exerting oneself slightly.The concordance that can keep the oral surfaces profile of joint strip and user in other words, reason are that the residual stress in the joint strip is very little, and this stress makes joint strip reply the shape before using, for example flat basically shape.The pliability of joint strip makes it to contact for a long time and not with soft tissue can stimulate soft tissue.The pressure that joint strip does not need to continue yet makes it to be retained on the oral surfaces.

In one embodiment, the delivery system of this paper comprises the adhesion parts, and can stick to oral surfaces especially on the tooth.These adhesion parts can be provided by this paper compositions, the described adhesion parts that perhaps provide and the compositions of this paper have nothing to do (for example described adhesion parts be different from this paper compositions separation mutually, wherein said compositions can comprise or can not comprise adhesive means).In one embodiment, the adhesion that provides by this paper compositions of joint strip is placed in the appropriate location on the oral surfaces.The viscosity on the dried relatively surface of this compositions and general cohesiveness can stick on the oral surfaces joint strip, and basically can be when not drinking water in a minute etc. lip, tooth, tongue and other oral surfaces to the caused frictional force slippage of the friction of joint strip.Yet, this enough low with the adherent intensity of oral surfaces, make user can remove joint strip easily once scraping gently with finger.This delivery system is removed from oral surfaces with being easy to, and does not need to utilize instrument, chemical solvent or reagent or over-drastic friction.

In another embodiment, the adhesive means that provides by integral carriers self of joint strip and adhesion place the appropriate location on the oral surfaces.In one embodiment, joint strip can extend, adhere to and adhere on the oral soft tissue.Alternatively, binding agent can be applied to joint strip that delivery system is adhered on the part of oral soft tissue.In another embodiment, joint strip is fixed on suitable position by the adhesion parts that are independent of this paper present composition, and is disclosed among the WO03/015656 as the SmithKline Beecham that announced on February 27th, 2003.

The embodiment that is independent of the adhesion parts that this paper compositions provides comprise following these.

In one embodiment, compositions and jointing material can be deposited on respect on separating of the joint strip surface discontinuous position.In one embodiment, compositions and binding agent can be deposited on the joint strip surface, and deposition is distinguished on the isolating position, space from the teeth outwards.For example, binding agent can be deposited on the lip-deep appropriate location of joint strip, these positions are bonded near on the oral surfaces of dental surface the part joint strip, and as gum surfaces, another part joint strip that makes the compositions deposition be soaked with compositions thereon or wherein can contact dental surface.

Alternatively, binding agent can spatially separate with compositions, but the both can make binding agent contact same types of tissue such as tooth or gum surfaces with compositions, the less relatively difference discontinuity point or the position of sheet.For example, the parallel lines of binding agent and compositions, binding agent boundary member are connected or one or more compositions sheets of centering on fully, cover whole joint strip surface substantially, and by a binding agent partially or completely center on a sheet of.Binding agent can be deposited on by the compositions boundary member connect or center on fully one or more on.

In another embodiment, compositions and/or binding agent can be that capsule is sealed.For example to seal can be microcapsule or large capsule to capsule.The method of micro encapsulation is known, for example wherein in the liquid phase material droplet be encapsulated in one deck capsule encapsulation material, from liquid, separate then.These capsules can be deposited on the integral carriers surface or vicinity, but and for example physics or chemical disruption, for example pass through pressure, when being applied on the dental surface or action, break by the capsule wall under the effects such as the temperature in oral environment, humidity, pH, chemical substance or enzyme by stinging subsequently as joint strip.For example compositions and binding agent capsule separately can be attached on the joint strip surface, for example passes through the method for second binding agent, or capsule is embedded in the joint strip.For example, the skim binding agent can be deposited on the joint strip surface, and composition capsule can embed in this adhesive phase to small part (perhaps complete), perhaps can be positioned on the surface of this adhesive phase.

In another embodiment, binding agent can granule such as piller or micropill provide, it can be at oral environment, for example the influence of chemical substance in moisture, the oral cavity or enzyme discharges their content down, and can be coated to realize this release.The method of pelletize or pill is known, as the coating polymer such as known under specific pH dissolved Eudragit ^TMPolymer.These adhesive particles can be deposited on the joint strip surface or vicinity.For example, the capsule of binding agent and/or granule can be positioned evenly on the joint strip surface substantially, or alternatively binding agent capsule and/or granule separately can be positioned at isolating position separately on the joint strip surface.

In another embodiment, a layer composition can be close relatively, for example contiguous and contact surface deposition, and layer of adhesive can be far away relatively from the surface, for example contiguous and contact compositions lower floor deposition.In this structure, binding agent can be bonded at dental surface with joint strip, and compositions can be passed through adhesive phase, for example works as adhesive phase and becomes permeable under the influence of oral environment.Adhesive phase can be configured to have one or more holes that see through layer and pass through adhesive phase to help compositions.Alternatively, for example, layer of adhesive can be close relatively, for example contiguous and contact surface deposition, and a layer composition can be far away relatively from the surface, for example contiguous and contact adhesive lower floor deposition.In this structure, this layer composition may need one or more holes by this layer to pass through compositions to help binding agent.In above structure, the pressure when joint strip is applied to dental surface can promote that material passes through from lower floor.

The machinery adhesive means also can be used for providing adhesive function, can use separately or be used in combination with any other bonder disclosed herein.In another embodiment, machinery adhesion between joint strip and tooth or other oral surfaces is provided by the joint strip that comprises the plastically deformable material, this material can make its plastically deformable doing just joint strip and tooth or the suitable shape of other oral surfaces profile by user, thereby by mechanical engagement and adhered thereto.This engagement can strengthen as forming partial vacuum or surface tension effects by the surface action between for example joint strip and the surface.For example, joint strip can have anchoring agent in its surface, approximately is positioned at interdental gap length place, and these anchoring agents can be fitted in the slit between tooth.For example, the joint strip surface of contact dental surface can be provided by little siphon, and it is the lip-deep a plurality of little holes of stick, and it can be crushed on the dental surface air is wherein driven out of, thereby the partial vacuum of causing makes this joint strip be fixed on the dental surface by air pressure subsequently.These anchoring agents or little siphon can be positioned on the joint strip surface of contact dental surface.For example this joint strip can be extensile, makes it may be adjusted to the interdental gap length of each user.The form that another kind of " machinery " adheres to can be provided by a kind of joint strip, shrinks during this joint strip contact dental surface, but so its physics engages tooth surface.

When adhesive means was provided by binding agent, described binding agent can be any lip-deep binding agent that can be used for material is bonded at dental surface or oral surfaces.Suitable bonding comprises skin, gums and mucoadhesive, and should be able to keep out moisture in the oral environment, chemical substance and enzyme long enough time, so that oral care active and/or bleach onset, but follow by solubilized and/or biodegradable.For example suitable bonding can comprise the binding agent of water-soluble polymer, hydrophobic and/or non-soluble polymer, pressure and moisture-sensitive, as the contact oral environment, and the influence of moisture content, chemical substance or enzyme etc. the sticking dry adhesives that becomes in the oral cavity for example.Suitable bonding comprises natural gum, synthetic resin, natural or synthetic rubber, more than is listed as those natural gum and the polymer and various other stickums of this class that are used for known adhesive tape of " thickening agent ", and they are from US-A-2, and 835,628 learn.

The second layer

In one embodiment, the second layer comprises the compositions described herein of safe and effective amount.

Optional release liner

Release liner can be made with any following material, and the affinity between this material and second layer compositions is less than the affinity between the ground floor of second layer compositions itself and joint strip.Release liner comprises the rigidity flaky substance, for example polyethylene, paper, polyester or other material, and this material scribbles the non-stick material.The size of release liner is cut into size and the shape the same basically with joint strip with shape, and perhaps its size makes it to separate from joint strip easily than joint strip is big.Release liner is made of frangible material makes it can split when joint strip is crooked, and perhaps it constitutes by the multi-disc material or by the impressed material of a slice.Alternatively, release liner can be two doubling forms, for example typical adhesive bandage design.The description that is suitable as the releasing agent material is present in Kirk-Othmer, Encyclopedia of Chemical Technology (chemical technology encyclopaedia), and the 4th edition, the 21st volume, the 207th to 218 page, the document is incorporated herein by reference.

Softness/rigidity dens supporter combination

Dens supporter or sponge material (foam) and compositions

Delivery system can be united use with dens supporter.Dens supporter is that the field of brightening is known.The general process of preparation dens supporter is known in the art.For example, make alginate impression, it can write down all dental surfaces and gingival edge zone, and die can be made plaster mold rapidly thus.Reservoir if desired, it prepares by make one deck rigid material on the plaster mold on the pending concrete dental surface.Use routine techniques from the mould of modification, vacuum to form dens supporter then.In case form, dens supporter is preferably removed gingival edge on buccal surface and the lingual surface by pruning.Should stay enough denture base materials with guarantee all teeth be covered to completion with the dens supporter periphery of bevel on gingival edge about 1/4 to about 1/3mm.Dens supporter is cut into fan-shaped so that the dens supporter of finishing does not cover them along mastoid process between tooth in one embodiment.The shape of all dens supporter edge preferred smooth is so that the imperceptible edge of lip and tongue is outstanding.In one embodiment, resulting dens supporter provides the perfect stickiness of user tooth, and dens supporter is optional to be had reservoir or rigid material and place space on the plaster mold.Dens supporter can comprise the vinyl material of soft and transparent, and its preformed thickness is that about 1mm is to about 1.5mm (about 0.04 inch to 0.06 inch).Flexible material is worn more comfortable for user.The higher material (or thicker plastic material) of hardness also can be used to make dens supporter.

The dentist utilizes three kinds of dental instrument bleaching teeths traditionally.The first kind is mouthful rigidity utensil of user dental arch of accurately fitting.Second class rigidity customization tooth apparatus is a kind of " especially big " rigidity customization tooth apparatus.Make inflexible customization tooth apparatus and must make the plaster mold of user dental arch die, and heating and vacuum forming thermal plasticity slice are to meet the plaster mold of user dental arch.Thermoplastic film is sold with rigidity or semi-rigid form, has multiple size and thickness to use.The dental laboratory manufacturing technology of especially big rigidity tooth apparatus relates to the acrylic resin of using as punch die interval insulant or ripening (through ripening/little curing) and increase dental surface on plaster mold.Then the thermal plasticity slice is heated and centers on immediately the increase plaster mold vacuum forming of dental arch.The net effect of the method causes " super large " rigidity customization tooth apparatus.

The rigidity customization tooth apparatus that the 3rd class is seldom used is the double-deck customization of the rigidity tooth apparatus that is processed into by stratified material, the non-porous thin film from soft porous foam to rigidity.These are double-deck press tooth apparatus atresia, inflexible thermoplasticity shell encases and supports the internal layer of soft porous foam.

The 4th class dens supporter replaces rigidity customization tooth apparatus with the soft foam dens supporter of disposable U-shaped, and this disposable dens supporter can individual packaging, and can be saturated with the compositions of the present invention of having measured quantity in advance.Soft foamed materials is the plastic material of perforate normally.This device is by being positioned at Oxnard, and the Cadco Dental Products of Calif. is with trade name VitalWhite ^TMCommercially available.In one embodiment, these soft foam dens supporter comprise that back lining materials (as closed pore plasticity back lining materials) can reduce bleach and flow out in the oral cavity from this device, thereby reduce the absorption of user and/or to the stimulation of oral cavity tissue.Soft in another embodiment foam dens supporter is enclosed in the flexible polymer of atresia.Open celled foam is attached to the preceding inwall and/or the back inwall of tooth apparatus in another embodiment.

Those of ordinary skill in the art will be familiar with easily and recognize that this compositions is thickness enough, so that do not flow out easily between the foamy open-celled structure, and must be enough rare, so that slowly flow through open celled foam for a long time.In other words, open-cell foam materials has the internal structure interval with respect to the composition viscosity size, and compositions is flow through.

An embodiment of closed-cell materials is a closed cell polyolefin foam, is sold by Lawrence, the Sekisui America Corporation of Mass., and Voltek branch, commodity are called Volora, and thickness is 0.8mm (1/32 ") to 3mm (1/8 ").Closed-cell materials also comprises flexible polymeric material.

A polyethylene that embodiment is perforate of open-cell material is sold by Hyannis, the Packaging Industries Group of Mass., Inc., Sentinel Foam Products branch, commodity are called Opcell, and thickness is 1.6mm to 9.5mm (1/16 " to 3/8 ").Can be used for other open celled foam of the present invention and comprise that hydrophilic open-cell foam materials such as aquogel polymer are (as Medicell ^TMFoam, available from Hydromer, Inc.Branchburg, J.J.).Open celled foam also is to absorb to give the hydrophilic open-cell foam materials of fluid high-absorbable with reagent, for example uses the polyurethane or the polyvinylpyrrolidone of plurality of reagents chemical absorbing.

The device of the above-mentioned type is further described in the United States Patent (USP) 5,980,249 of M.G.Fontenot and the US5 of M.G.Fontenot, in 575,654.

Above-mentioned tooth apparatus can be designed as disposable or reusable.More dens supporter is disclosed in the United States Patent (USP) 6,368,576 of the Steven D.Jensen that announced on April 9th, 2002; The people's such as Jensen that announce October 30 calendar year 2001 United States Patent (USP) 6,309,625; The United States Patent (USP) 6,183,251 of the Dan E.Fischer that announce February 6 calendar year 2001; The United States Patent (USP) 6,036,943 of the Dan E.Fischer that on March 14th, 2000 announced; The United States Patent (USP) 5,985,249 of the Dan E.Fischer that on November 16th, 1999 announced; The United States Patent (USP) 5,846,058 of the Dan E.Fischer of December in 1998 announcement on the 8th; The United States Patent (USP) 6,382,979 of the Sherrill F.Lindquist that on May 7th, 2002 announced; The United States Patent (USP) 5,855,870 of the Dan E.Fischer of the Fischer United States Patent (USP) announcement on January 5th, 5,098,303 and 1999 of announcing on March 24th, 1992.

Optional oral care active agents

The present invention can randomly comprise the oral care active agents of safe and effective amount, described oral care active agents is selected from anti-calculus agent, fluorine ion source, antimicrobial, dentin desensitizer, anesthetis, antifungal, antiinflammatory, selectivity H-2 antagonist, caries preventive agent, nutrient substance, and their mixture.The orally active agent preferably comprises active substance with a kind of like this content: after active substance directly used, the beneficial effect that user is pursued was promoted and can not be damaged the oral surfaces of its application.The embodiment of the oral condition that these active components solve includes but not limited to: the change of tooth outward appearance and structure, brighten, mottle bleaching, mottle removal, dental plaque removal, tartar removal, the prevention of dental caries and processing, gums redness and/hemorrhage, mucosa injury, infringement and ulcer, aphthous ulcer, chilblain ulcer, the oral malodor that tooth abscess and elimination are caused by above-mentioned reason and other reason (for example microbial reproduction).

Suitable oral care active comprises and anyly is used for being considered to usually in the oral cavity safe, and oral cavity overall appearance and/or the healthy material that changes can be provided.Unless otherwise indicated, the content of oral care substance in the present composition is generally about 0.01% to about 50% by the weight of described compositions, be preferably about 0.1% to about 20%, more preferably about 0.5% to about 10%, even more preferably about 1% to about 7%.

Oral care composition of the present invention or material can comprise the previous disclosed many active substances in this area.Be the non-limiting tabulation that can be used for orally active material of the present invention below.

Caries preventive agent and fluorine ion source

This compositions can comprise the caries preventive agent of safe and effective amount and their mixture.In one embodiment, this caries preventive agent is selected from xylitol, fluorine ion source, and their mixture.Fluorine ion source provides the free fluorine ion during using compositions.In one embodiment, oral care active agents is a fluorine ion source, and it is selected from sodium fluoride, stannous fluoride, indium, organic fluoride, as amine fluoride and sodium monofluorophosphate.In another embodiment, sodium fluoride is a fluorion.The people's such as Widder that the people's such as Norris that announce July 26 nineteen sixty United States Patent (USP) 2,946,725 and on July 18th, 1972 announce United States Patent (USP) 3,678,154 discloses above-mentioned fluoride salt and other can be used as the material of fluorine ion source.These patents are incorporated herein by reference.

The fluorion that the preferred present composition provides in compositions is about 50ppm to 10,000ppm, and more preferably about 100 to 3000ppm.When using transfer system of the present invention, described compositions contacts with dental surface.

Anti-calculus agent

This compositions can comprise at least a anti-calculus agent of safe and effective amount.This content is generally about 0.01% to about 40% by the weight of described compositions, is about 0.1% to about 25% in another embodiment, is about 4.5% to about 20% in another embodiment, is about 5% to about 15% in another embodiment.Anti-calculus agent also should be compatible substantially with other composition of compositions.

The dental calculus preventing agent is selected from poly phosphate and salt thereof, poly-amino propane sulfonic acid (AMPS) and salt thereof, poly-sulfonic acid alkene ester and salt, polyphosphoric acid vinyl acetate and salt thereof, polyphosphoric acid alkene ester and salt, bisphosphonates and salt thereof, phosphonoalkane carboxylic acid and salt, polyphosphonates and salt thereof, polyphosphonic acid vinyl acetate and salt thereof, polyphosphonic acid alkene ester and salt thereof, polypeptide, and composition thereof.In one embodiment, salt is alkali metal salt.In another embodiment, anti-calculus agent is selected from poly phosphate and salt, bisphosphonates and salt thereof, and their mixture.In another embodiment, anti-calculus agent is selected from pyrophosphate, Quadrafos, and their mixture.

Quadrafos

In one embodiment of the invention, anti-calculus agent is a Quadrafos.Although there are some cyclic polyphosphates derivants, it has been generally acknowledged that Quadrafos is by mainly forming with two or more phosphate molecules of linear configuration arrangement.Straight-chain polyphosphate meets formula (X PO ₃) _n, wherein n is about 2 to about 125, wherein n is preferably greater than 4, and X is for example sodium, potassium etc.For

(X PO ₃) _n, when n at least 3 the time, Quadrafos has glass performance.These phosphatic counter ion counterionsl gegenions can be alkali metal, alkaline-earth metal, ammonium, C ₂-C ₆The mixture of alkanol ammonium and salt.Usually used Quadrafos is its all or part of neutral water-soluble alkali metal salts, as potassium salt, sodium salt, ammonium salt, and their mixture.Inorganic polyphosphate comprises that alkali metal (for example, sodium) tripolyphosphate, four Quadrafos, metal diaikyl are (for example, disodium) binary acid, trialkyl metal are (for example, trisodium) monoacid, potassium hydrogen phosphate, dibastic sodium phosphate and alkali metal are (for example, sodium) hexametaphosphate, and their mixture.The Quadrafos bigger than four Quadrafos occurs with the amorphous glass material usually.In one embodiment, Quadrafos is those that produced by FMCCorporation, and it is commercial to be called Sodaphos (n ≈ 6), Hexaphos (n ≈ 13) and Glass H (n ≈ 21), and their mixture.Typically, this compositions comprises the Quadrafos by the weight of described compositions about 0.5% to about 20%, and its content is about 4% to about 15% in one embodiment, and its content is about 6% to about 12% in another embodiment.

At Kirk﹠amp; The Encyclopedia of ChemicalTechnology of Othermer, the 4th edition, the 18th volume, Wiley-Interscience Publishers (1996) in the 685th to 707 page, has described the phosphate source in more detail, it is incorporated herein by reference, and comprises Kirk﹠amp; All lists of references that Othermer quotes.

In one embodiment, this Quadrafos is straight chain " nature of glass " Quadrafos with following chemical formula:

XO(XPO ₃) _nX

Wherein X is sodium or potassium; And n average out to about 6 to about 125.

In one embodiment, when n in above-mentioned arbitrary Quadrafos chemical formula at least 2 the time, the content of anti-calculus agent counts about 4.5% to about 40% by the weight of described compositions, is about 5% to about 25% in another embodiment, is about 8% to about 15% in another embodiment.Quadrafos is disclosed in US4, and 913,895, this patent is incorporated herein by reference.

Pyrophosphate

The pyrophosphate that is used for this compositions comprises alkali metal pyrophosphate salts, pyrophosphoric acid two, three and a potassium or sodium, pyrophosphoric acid two alkali metal salts, pyrophosphoric acid four alkali metal salts, and their mixture.In one embodiment, pyrophosphate is selected from Sodium phosphate (Na3HP2O7), Sodium Acid Pyrophosphate (Na ₂H ₂P ₂O ₇), Dipotassium pyrophosphate, tetrasodium pyrophosphate (Na ₄P ₂O ₇), tetrapotassium pyrophosphate (K ₄P ₂O ₇), and their mixture.Be described in the United States Patent (USP) 4,885,155 that the United States Patent (USP) 4,515,772 announced in 7 days Mays in 1985 of all authorizing people such as Parran and December in 1989 announced on the 5th pyrophosphate in full and wherein disclosed list of references be incorporated herein by reference.At Kirk﹠amp; The Encyclopedia of ChemicalTechnology of Othermer, the third edition, the 17th volume, Wiley-Interscience Publishers (1982) in the 685th to 707 page, has described pyrophosphate in more detail, it is incorporated herein by reference, and comprises Kirk﹠amp; All lists of references that Othermer quotes.

In one embodiment, compositions of the present invention comprises tetrasodium pyrophosphate.In this compositions, tetrasodium pyrophosphate can be anhydrous salt form or decahydrate form, or any other is stable at the kind of solid form.Salt is its solid particulate form, and this form can be its crystallization and/or amorphous state, and the particle diameter of salt is preferred enough little of can accept and easily dissolving in use on attractive in appearance.

The content of pyrophosphate is any safe and effective amount in the present composition, and is generally about 1.5% to about 15% by the weight of described compositions, is about 2% to about 10% in another embodiment, is about 3% to about 8% in another embodiment.

Other anti-calculus agent

Poly-sulfonic acid alkene ester comprises that olefin group wherein comprises those of 2 or a plurality of carbon atoms, and salt.Polyphosphonic acid alkene ester comprises that olefin group wherein comprises those of 2 a plurality of carbon atoms.The polyphosphonic acid vinyl acetate comprises polyvinylphosphonic acid.Bisphosphonates and salt thereof comprise azacycloalkyl-2,2-di 2 ethylhexyl phosphonic acid and salt thereof, azacycloalkyl-2, (for example paraffin section has five to the ion of 2-di 2 ethylhexyl phosphonic acid and salt thereof, those of six or seven carbon atoms, wherein nitrogen-atoms is unsubstituted or has a low alkyl substituent, as methyl), piperidine-2, the 2-di 2 ethylhexyl phosphonic acid, aza-cyclopentane-2, the 2-di 2 ethylhexyl phosphonic acid, N-methyl-aza-cyclopentane-2, the 3-di 2 ethylhexyl phosphonic acid, EHDP (ethane hydroxyl-1, the 1-di 2 ethylhexyl phosphonic acid), AHP (aza-cyclopentane-2,2-di 2 ethylhexyl phosphonic acid, a.k.a.1-azacyclo-heptadiene-2, the 2-di 2 ethylhexyl phosphonic acid), ethane-1-amino-1, the 1-bisphosphonates, dichloromethane-bisphosphonates or the like.Phosphonoalkyl carboxylic acid or their alkali metal salt comprise PPTA (phosphono tricarballylic acid), PBTA (phosphinylidyne butane-1,2,4-tricarboxylic acids), are respectively acid or alkali metal salt.Polyphosphoric acid alkene ester comprises that olefin group wherein comprises those of 2 or a plurality of carbon atoms.Polypeptide comprises poly-aspartate and polyglutamic acid.

Azacycloparaffin-2,2-di 2 ethylhexyl phosphonic acid are disclosed in the US3 that the people such as Ploger that announced on March 2nd, 1976 transfer Henkel, the people's such as Ploger that on October 26th, 941,772 and 1976 announced US3, and 988,443, it is incorporated herein by reference.

Be used to replace pyrophosphate or comprise those known substances with optional reagent that pyrophosphate is used in combination, as synthetic anionic polymer, it comprises the copolymer (for example Gantrez) of polyacrylate and maleic anhydride or maleic acid and methyl vinyl ether, these substance descriptions are in the United States Patent (USP) 4 of for example authorizing people such as Gaffar, 627, in 977, the disclosure of this patent is incorporated herein by reference, and for example poly-amino propane sulfonic acid (AMPS), Zinc citrate trihydrate., Quadrafos (tripolyphosphate for example; Hexametaphosphate), diphosphate (for example EHDP, AHP), polypeptide (as poly-aspartate and polyglutamic acid), and their mixture.

Antimicrobial

The antimicrobial antiplaque agent also can be chosen wantonly and be present in the present composition.These reagent can include but not limited to triclosan, 5-chloro-2-(2, the 4-dichlorophenoxy)-phenol, as The MerckIndex, the 11st edition (1989), 1529 pages (numbering 9573), United States Patent (USP) 3,506, the Beecham Group that on January 7th, 720 and 1988 announced, in the european patent application 0,251,591 of PLC; Chlohexidine (Merck Index, numbering 2090), Win-21904 (Merck Index, numbering 222); Hexatidine (Merck Index, numbering 4624); Sanguinarine (Merck Index, numbering 8320); Alkyl benzyl dimethyl ammonium chloride (MerckIndex, numbering 1066); Salicylamide (Merck Index, numbering 8299); Brominated phenododecinium bromide (Merek Index, numbering 3411); Cetylpyridinium chloride (CPC) (Merck Index, numbering 2024); TPC (TPC); Chlorination N-myristyl-4-ethylpyridine (TDEPC); Octenidine; Delmopinol, Octapinol and other sub-base derivatives of piperidine; The effectively quintessence oil of antimicrobial amount and their combination, for example citral, geranial, and the combination of menthol, eucalyptol, thymol and methyl salicylate; Antimicrobial metal and salt thereof for example can provide those of zinc ion, stannous ion, copper ion and/or their mixture; Bis-biguanide or phenol; Antibiotic such as augmentin, amoxicillin, tetracycline, doxycycline, minocycline and metronidazole; And the analog of above-mentioned antimicrobial antiplaque agent and salt; Antifungal is as being used to handle those of Candida albicans.If contain these reagent, then it exists with safe and effective amount usually, for example, counts about 0.1% to about 5% by the weight of compositions of the present invention.

Antiinflammatory

Antiinflammatory also can be present in the oral cavity composition of the present invention.This class reagent includes but not limited to non-steroidal anti-inflammatory agents, for example aspirin, ketorolac, flurbiprofen, ibuprofen, naproxen, indometacin, aspirin, ketoprofen, piroxicam and meclofenamic acid, cox 2 inhibitor such as valdecoxib, celecoxib and rofecoxib, and their mixture.If exist, the common content of antiinflammatory counts about 0.001% to about 5% by the weight of compositions of the present invention.Ketorolac is described in the United States Patent (USP) of announcing on May 6th, 1,997 5,626,838, and this full patent texts is incorporated herein by reference.

The H-2 antagonist

The present invention also can comprise the selectivity H-2 antagonist of safe and effective amount.Selectivity H-2 antagonist comprises following chemical compound, and they are disclosed in and are published on March 15th, 1994 and on November 15th, 1994 respectively and transfer Procter﹠amp; People's such as the Singer of Gamble United States Patent (USP) 5,294,433 and 5,364, in 616, wherein selectivity H-2 antagonist is selected from cimetidine, lupitidine, ranitidine, ICIA-5165, tiotidine, ORF-17578, Lu's skin is for fourth, the winter Buddhist nun is for fourth, famotidine, royal jelly, roxatidine, lamtidine, BL-6548, BMY-25271, zaltidine, nizatidine, mifentidine, BMY-25368 (SKF-94482), BL-6341A, ICI-162846, ramixotidine, Wy-45727, SR-58042, BMY-25405, loxtidine, DA-4634, bisfentidine, sufotidine, ebrotidine, HE-30-256, D-16637, FRG-8813, FRG-8701, impromidine, L-643728 and HB-408.Especially preferred is cimetidine (SKF-92334), N-cyano group-N '-methyl-N " (2-(((5-methyl isophthalic acid H-imidazol-4 yl) methyl) sulfenyl) ethyl) guanidine:

Cimetidine also is disclosed in Merck Index, and the 11st edition (1989) the 354th pages (numbering 2279), and Physicians ' Desk Reference are in the 46th edition (1992) the 2228th pages.Relevant preferred H-2 antagonist comprises burimamide and metiamide.

Nutrient substance

Nutrient substance can improve oral environment, and can be included in oral care composition of the present invention or the material of the present invention.Nutrient comprises mineral, vitamin, oral nutrient enriching substance, enteral nutrition enriching substance, and their mixture.

The mineral that can be included in the present composition comprises calcium, phosphorus, fluoride, zinc, manganese, potassium and composition thereof.These mineral are disclosed in Drug Facts and Comparisons (information service of loose-leaf pharmaceuticals), Wolters Kluer Company, and St.Louis, Mo.,

1997, the 10th to 17 page.

Vitamin can comprise or use separately with mineral.Vitamin comprises vitamin C and D, thiamine, riboflavin, calcium pantothenate, nicotinic acid, folic acid, nicotiamide, pyridoxin, cobalamin, Para-Aminobenzoic, bioflavonoids, and their mixture.These vitamin are disclosed in Drug Facts and Comparisons, Wolters Kluer Company, and St.Louis, Mo., 1997, the 3rd to 10 page.

The oral nutrient enriching substance comprises aminoacid, lipotropic, fish oil, and their mixture, as Drug Facts and Comparisons, and Wolters Kluer Company, St.Louis, Mo.,

1997, disclosed in the 54th to the 54e page or leaf.Aminoacid includes but not limited to L-tryptophan, L-lysine, methionine, threonine, levocarnitine or L-carnitine, and their mixture.Lipotropic includes but not limited to choline, inositol, betanin, linoleic acid, linolenic acid, and their mixture.Fish oil contains a large amount of ω-3 (N-3) polyunsaturated fatty acid, eicosapentaenoic acid and docosahexenoic acid.

The antioxidant that can be included in oral care composition of the present invention or the material includes but not limited to: vitamin E, ascorbic acid, uric acid, carotenoid, vitamin A, flavone compound and polyphenol, herbaceous plant antioxidant, melatonin, amino indole, thioctic acid, and their mixture.

The enteral nutrition enriching substance includes but not limited to protein product, glucose polymer, Semen Maydis oil, safflower oil, middle chain triglyceride, as at Drug Facts and Comparisons, and Wolters Kluer Company, St.Louis, Mo.,

1997, disclosed in the 55th to 57 page.

Desensitizer

Analgesic or go quick dose also can be present in oral care composition of the present invention or the material.These medicaments can include, but not limited to strontium chloride, potassium nitrate, natural herbal such as Galla Chinensis, Herba Asari, cubebin, Rhizoma Alpiniae Officinarum, Radix Scutellariae, Radix Zanthoxyli, the Radix Angelicae Dahuricae etc.

Optional colorants

Dyestuff, pigment, coloring agent and their mixture can be chosen wantonly and be included in the present composition so that this paper compositions has coloured appearance.Advantage in pigment and/or the coloring agent adding this paper compositions is: it makes user can see whether described compositions evenly and fully covers their tooth, because if see with the colored composition coverage rate is easier.In one embodiment, coloring agent provides the color that is similar to nature tooth color.To can be used for coloring agent of the present invention and bleach be stable together and to be known as be safe those.

The content of optional dyestuff, pigment and the coloring agent that is used for this paper about 0.05% to about 20% scope, is about 0.10% to about 15% by the weight of described compositions in another embodiment, is about 0.25% to about 5% in another embodiment.

Make method for compositions

Integral carriers such as joint strip can be made with several film-forming methods known in the art.In one embodiment, the polyethylene joint strip is made by the method for winding-up or casting.Other method also is feasible, comprises extrusion molding or can not influence the method for joint strip flexural rigidity.In addition, second layer compositions is added on the joint strip in joint strip manufacturing process.Second layer compositions on the joint strip can be a laminated material.

Use method for compositions

The present invention can be applied to also can be used at home by consumer on the tooth of consumer by the dental profession personage in dental clinic.

Put into practice when of the present invention, user is administered to compositions or the delivery system of this paper on one or more teeth.Described compositions can or be brushed sharp applicator, deer foot applicator etc. with painting device, syringe or unit-dose syringe, extruded tube, brush, pen, or even uses finger to apply.Described compositions also can at first make up with integral carriers such as joint strip, dens supporter and/or sponge material, and then is administered on the tooth.In one embodiment, when being applied to tooth, compositions and/or the delivery system of this paper almost be can't see.

Then, after the required time, the compositions of any remnants can be put on the skin, scrub by being coated with easily or the rinsing oral surfaces, or removes in the process of brushing teeth normally or in other mouth care action.

Needn't prepare to tooth before using compositions of the present invention or delivery system.For example, user can be selected to brush teeth or gargle before using the present invention, also can select not brush teeth or gargle.Oral surfaces had not both required and has dried up and needn't exceedingly get wet with saliva or water before using.Yet, it is believed that the adhesion on the dentium nitor surface will be enhanced if tooth is exsiccant before using.

When integral carriers was joint strip, second layer compositions can be coated on the joint strip, perhaps is applied on the joint strip by user, perhaps was applied on the tooth by user, joint strip was covered by on the tooth of second compositions parcel again.Be applied to size and capacity, the concentration of bleach and the beneficial effect that need obtain that second layer amount of composition on joint strip or the tooth can be depending on joint strip.Usually need need to use about 0.001 gram to about 0.0001 gram compositions in one embodiment, and need about 0.1 gram in another embodiment less than 1 gram compositions to about 0.4 gram compositions.The amount of composition of every square centimeter (cm) is less than about 1g/cm ², in another embodiment less than about 0.2g/cm ², be about 0.0001g/cm in another embodiment ²To about 0.1g/cm ², be about 0.01g/cm in another embodiment ²To about 0.04g/cm ²

Compositions of the present invention can be thick liquid, paste, gel, solution form or other suitable form.In one embodiment, described compositions low shear rate (less than 1/ second) down viscosity for about 0.2Pa.s extremely about 1000Pa.s (about 200 to about 1,000,000cps).In another embodiment, viscosity for about 100Pa.s to about 800Pa.s (about 100,000cps is to about 800,000cps), in another embodiment for about 400Pa.s extremely about 600Pa.s (about 400,000cps is extremely about 600,000cps).

In one embodiment, described compositions be non-ly clean the teeth, bubble-tight Lightening compositions, as whitening gel, wherein said Lightening compositions can for example not contain lathering surfactant or fluoride ion source not substantially substantially.

The present invention can allow frequency of administration to reduce.For example, usually the compositions of using 30 minutes 2 weeks of twice use (for example total time of application is 14 hours) to contain 6% peroxide can show with peroxide by using same amount but use as described herein that wherein said time of application is reduced to 6 to 10 hours essentially identical whitening efficacy every day.For example, when using as described herein, the bleach of same amount can obtain with use every day one 30 minutes 14 days or use 30 minutes twice 7 to 10 days identical or similar effects every day.

The dens supporter utensil can followingly use.User or dental profession personage be dispersed in this compositions soft or the rigidity dental instrument in, individual then utensil is placed on the individual dental arch (maybe is fitted in device on the his or her tooth to keep dens supporter to be in the appropriate location).Usually, the processing time of suggestion is identical with above-mentioned those.In the latter stage in processing time, remove dental instrument, the water cleaning is used to remove all remaining composition, to store then up to next time.

Above-mentioned composition and delivery system can be combined in the cover box, and described cover box comprises: 1. compositions and 2. operation instructions; Or comprise: 1. compositions, 2. operation instruction and 3. integral carriers.

The present composition can be used for the people and other animal (for example animal or the domestic animal in house pet, the zoo) is used.

Embodiment

Following non-limiting example is further narrated the preferred embodiment in the scope of the invention.In the case without departing from the scope of the present invention, a lot of variations of these embodiment are possible.

Example I

The compositions that below comprises bleach is prepared by following processing method:

	Embodiment 1	Embodiment 2	Embodiment 3
				Composition	Percentage by weight	Percentage by weight	Percentage by weight
Glycerol	10.0	10.0	10.0
				Water	20.3	17.3	21.5
Carbopol?956 ²	2.0	5.0	0.8
				Sodium acid pyrophosphate	0.4	0.4	0.4
Sodium stannate	0.2	0.2	0.2
				Saccharin sodium	0.1	0.1	0.1
Polyethylene	50.0	50.0	50.0
				Hydrogen peroxide (35% active substance)	17.0	17.0	17.0

²Available from BF Goodrich

	Embodiment 4	Embodiment 5	Embodiment 6
				Composition	Percentage by weight	Percentage by weight	Percentage by weight
Glycerol	10.0	10.0	10.0
				Water	28.5	3.3	45.3
Acrylate copolymer ETD 2020 ³	2.3
				Sodium Acid Pyrophosphate	0.4	0.4	0.4
Sodium stannate	0.2	0.2	0.2
				Saccharin sodium	0.1	0.1	0.1
Polyethylene	50.0	50.0	25.0
				Hydrogen peroxide (35% active substance)	8.5	34.0	17.0
Acrylate copolymer 1342 ⁴		2.0

Acrylate copolymer 1382 ⁵

2.0

³Available from BF Goodrich

⁴Available from BF Goodrich

⁵Available from BF Goodrich

	Embodiment 7	Embodiment 8
			Composition	Percentage by weight	Percentage by weight
Glycerol	10.0	10.0
			Water	20.3	20.3
Pemulen?TR?1 ⁶	2.0
			Sodium acid pyrophosphate	0.4	0.4
Sodium stannate	0.2	0.2
			Saccharin sodium	0.1	0.1
Polypropylene	50.0	50.0
			Hydrogen peroxide (35% active substance)	17.0	17.0
Pemulen?TR2 ⁷		2.0

^6.Available from BF Goodrich

^7.Available from BF Goodrich

Embodiment 1 to 8 prepares by the following method.Acrylate copolymer or Pemulen, glycerol, water, pyrophosphate, glucide, stannate and hydrogen peroxide at room temperature Yi @16 radian/s (150rpm) mixed 15 to 20 minutes.Add then 50/50 sodium hydroxide solution with the pH regulator of gained mixture to about 4.5 to 5.0.Then, with aequum half polyethylene and said mixture at room temperature Yi @16 radian/s (150rpm) mixed about 10 minutes.Add half remaining polyethylene then, and at room temperature Yi @16 radian/s (150rpm) remix 10 minutes to obtain final gel preparation.

Use any application process disclosed herein that about 0.1g to 0.2g above-mentioned composition is applied directly on the tooth.Alternatively, above-mentioned composition at first can be made up with integral carriers (as joint strip or dens supporter), and then be administered on the tooth.The above-mentioned composition of about 0.1g to 0.2g or about 1g to 3g is made up with joint strip or dens supporter respectively.An embodiment of joint strip is the thick polyethylene film sheet of 0.013mm.Joint strip can provide row's scrobicula, and it is wide dark with 0.1mm to be typically 0.4mm.When using available from Philadelphia, the Thwing-AlbertInstrument Co. model of PA is the Handle-O-Meter of #211-300, and when measuring according to method of testing ASTM D2923-95, the flexural stiffness of joint strip is about 0.6 gram per centimeter.

Any above-mentioned composition can be used for any integral carriers as herein described, as joint strip, dens supporter and/or foamed materials.In any the foregoing description, polyethylene can be white or natural tooth color, make user will be more all even continuous coating be administered on the tooth.The whitening index of the foregoing description is about 0.5 to about 4.

Claims

1. oral care delivery system, described oral care delivery system comprises:

A. integral carriers, it is selected from the group of being made up of joint strip, dens supporter or sponge material; With

B. compositions, described compositions comprises:

1. 0.1% to 20% safe and efficient bleach by weight, it is selected from by peroxide, metal chlorite, perborate, percarbonate, persulfate, and the group formed of their combination;

2. water insoluble solid phase, it is selected from by polyolefin, polyester, water-insoluble cellulose, silicon dioxide, Talcum, Muscovitum, magnesium carbonate, calcium carbonate, magnesium silicate, aluminium silicate magnesium salt, titanium dioxide, zinc oxide, nylon powder, methacrylate powder, polystyrene powder, silk powder, crystalline cellulose, titanation Muscovitum, calcium phosphate, calcium pyrophosphate, and the group of their mixture composition; With

3. water soluble liquid phase, it selects Free water, wetting agent, and the group formed of their mixture;

4. 0.01% to 20% associative thickeners by weight;

The ratio of wherein said water insoluble solid phase and described water soluble liquid phase is 1: 4 to 4: 1,

Wherein said compositions was suitable for consuming 3 minutes-120 minutes; And wherein said delivery system can adhere on the hard or soft tissue in oral cavity.

2. delivery system as claimed in claim 1, the ratio of wherein said water insoluble solid phase and described water soluble liquid phase are 1: 1.5 to 1.5: 1.

3. delivery system as claimed in claim 2, the ratio of wherein said water insoluble solid phase and described water soluble liquid phase are 1: 1.25 to 1.25: 1.

4. delivery system as claimed in claim 1, wherein said water insoluble solid phase are polyethylene.

5. delivery system as claimed in claim 1, wherein said compositions has 0.5 to 4 whitening index.

6. delivery system as claimed in claim 5, wherein said whitening index are 1.3 to 3.5.

7. delivery system as claimed in claim 1, wherein said integral carriers are joint strip.

8. gross thickness of coated compositions is less than 1mm on the delivery system as claimed in claim 7, wherein said joint strip and its.

9. delivery system as claimed in claim 7, wherein said joint strip has scrobicula on a side that scribbles compositions of described joint strip, and described scrobicula has to the described compositions of small part and is positioned at wherein.

10. delivery system as claimed in claim 7, wherein said joint strip are the polyethylene film that has less than the 0.1mm film thickness.

11. delivery system as claimed in claim 7, wherein said compositions is coated on the described joint strip with continuous coated.

12. it is fixing in position that delivery system as claimed in claim 7, wherein said joint strip are independent of the attachment members of described compositions.

13. delivery system as claimed in claim 11, wherein the amount of composition of every square centimeter of material is less than 1g/cm ²

14. delivery system as claimed in claim 1, wherein said integral carriers are dens supporter.

15. delivery system as claimed in claim 1, wherein said integral carriers are sponge material.

16. delivery system as claimed in claim 1, wherein said compositions also comprises dyestuff, coloring agent, pigment, or their mixture.

17. delivery system as claimed in claim 1, wherein said associative thickeners are acrylate/C10-C30 alkyl acrylate cross-linked polymer.

18. oral care delivery system as claimed in claim 1, wherein said polyolefin are selected from the group of being made up of polyethylene, polypropylene, polyisoprene and their mixture.

19. oral care delivery system as claimed in claim 1, the wherein said water-soluble wetting agent that comprises mutually, described wetting agent is selected from by glycerol, sorbitol, xylitol, butanediol.The group that Polyethylene Glycol, propylene glycol and their mixture are formed.

20. a method that strengthens bleach effect in the moisture oral care composition, described method comprises:

1. mix a kind of oral care delivery system, described delivery system comprises:

B. compositions, described compositions comprises:

2. water insoluble solid phase, it is selected from by polyolefin, polyester, water-insoluble cellulose, silicon dioxide, Talcum, Muscovitum, magnesium carbonate, calcium carbonate, magnesium silicate, aluminium silicate magnesium salt, titanium dioxide, zinc oxide, nylon powder, methacrylate powder, polystyrene powder, silk powder, crystalline cellulose, titanation Muscovitum, calcium phosphate, calcium pyrophosphate, and the group of their mixture composition;

3. water soluble liquid phase, it selects Free water, wetting agent, and the group formed of their mixture and

4. 0.01% to 20% associative thickeners by weight;

The ratio of wherein said water insoluble solid phase and described water soluble liquid phase is 1: 4 to 4: 1, and described compositions was suitable for consuming 3 minutes-120 minutes.

21. method as claimed in claim 20, the ratio of wherein said water insoluble solid phase and described water soluble liquid phase are 1: 1.5 to 1.5: 1.

22. method as claimed in claim 21, the ratio of wherein said water insoluble solid phase and described water soluble liquid phase are 1: 1.25 to 1.25: 1.

23. method as claimed in claim 20, the wherein said water-soluble wetting agent that comprises mutually, described wetting agent is selected from by glycerol, sorbitol, xylitol, butanediol.The group that Polyethylene Glycol, propylene glycol and their mixture are formed.