CN1802147A - 包含两种聚合物的协同组合的眼用组合物 - Google Patents
包含两种聚合物的协同组合的眼用组合物 Download PDFInfo
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- CN1802147A CN1802147A CNA2004800159648A CN200480015964A CN1802147A CN 1802147 A CN1802147 A CN 1802147A CN A2004800159648 A CNA2004800159648 A CN A2004800159648A CN 200480015964 A CN200480015964 A CN 200480015964A CN 1802147 A CN1802147 A CN 1802147A
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- polymer
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- guar gum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
Description
成分 | 浓度(%w/v) |
Carbopol 974P | 0.1 |
HP-Guar | 0.1 |
甘露醇 | 4.0 |
NaOH/HCl | 适量至pH 7.0 |
纯化水 | 适量至100 |
组合物(%w/v) | |||||||
成分 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
甘露醇 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 |
HPMC 2910 | --- | 0.3 | --- | --- | 0.3 | 0.3 | --- |
Carbopol 974P | --- | --- | 0.1 | --- | 0.1 | --- | 0.1 |
HP-Guar | --- | --- | --- | 0.1 | --- | 0.1 | 0.1 |
NaOH/HCl | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 |
纯化水 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 |
粘度(cps) | 1.1 | 8.2 | 488.1 | 5.3 | 1339.5 | 32.3 | 1273.0 |
Subst.Synergy@ | --- | --- | --- | --- | 是 | 是 | 是 |
组合物(%w/v) | ||||||||
成分 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
甘露醇 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 |
HPMC 2910 | --- | 0.3 | --- | --- | --- | 0.3 | --- | --- |
HP-Guar | --- | --- | 0.1 | --- | --- | --- | 0.1 | --- |
Carbopol 974P | --- | --- | --- | 0.1 | --- | --- | --- | 0.1 |
Natrasol 250HR | --- | --- | --- | --- | 0.1 | 0.1 | 0.1 | 0.1 |
NaOH/HCl | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 |
纯化水 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 |
粘度(cps) | 1.0 | 8.0 | 5.2 | 465.9 | 3.0 | 27.7 | 10.9 | 642.0 |
Subst.Synergy@ | --- | --- | --- | --- | --- | 是 | 否 | 否 |
组合物(%w/v) | |||||||
成分 | 16 | 17 | 18 | 19 | 20 | 21 | 22 |
甘露醇 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 |
PVA(Airvol 523S) | --- | 0.2 | --- | --- | 0.2 | 0.2 | --- |
硫酸软骨素 | --- | --- | 0.2 | --- | 0.2 | --- | 0.2 |
PVP(K90) | --- | --- | --- | 0.2 | --- | 0.2 | 0.2 |
NaOH/HCl | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 |
纯化水 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 |
粘度(cps) | 1.0 | 1.5 | 1.3 | 1.4 | 1.7 | 1.9 | 1.8 |
Subst.Synergy@ | --- | --- | --- | --- | 否 | 否 | 否 |
组合物(%w/v) | |||||||
成分 | 17 | 18 | 19 | 23 | 24 | 25 | 26 |
甘露醇 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 |
PVA(Airvol 523S) | 0.2 | --- | --- | --- | 0.2 | --- | --- |
硫酸软骨素 | --- | 0.2 | --- | --- | --- | 0.2 | --- |
PVP(K90) | --- | --- | 0.2 | --- | --- | --- | 0.2 |
Carbopol 974P | --- | --- | --- | 0.1 | 0.1 | 0.1 | 0.1 |
NaOH/HCl | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 |
纯化水 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 |
粘度(cps) | 1.5 | 1.3 | 1.4 | 441.6 | 323.8 | 12.7 | N/A* |
Subst.Synergy@ | --- | --- | --- | --- | 否 | 否 | 否 |
组合物(%w/v) | ||||||||
成分 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
甘露醇 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 |
HPMC 2910 | --- | 0.3 | --- | --- | --- | 0.3 | --- | --- |
HP-Guar | --- | --- | 0.1 | --- | --- | --- | 0.1 | --- |
Carbopol 974P | --- | --- | --- | 0.1 | --- | --- | --- | 0.1 |
葡聚糖70 | --- | --- | --- | --- | 0.1 | 0.1 | 0.1 | 0.1 |
NaOH/HCl | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 | 适量至pH7.0 |
纯化水 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 |
粘度(cps) | 1.1 | 7.9 | 5.2 | 461.6 | 1.4 | 8.4 | 5.2 | 379.3 |
Subst.Synergy@ | --- | --- | --- | --- | --- | 否 | 否 | 否 |
组合物(%w/v) | |||||
成分 | 35 | 36 | 37 | 38 | 39 |
甘露醇 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 |
HPMC 2910 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
Carbopol 974P | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
NaCl | 0 | 0.001 | 0.005 | 0.01 | 0.05 |
NaOH/HCl | 适量至pH 7.0 | 适量至pH 7.0 | 适量至pH 7.0 | 适量至pH 7.0 | 适量至pH 7.0 |
纯化水 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 |
粘度(cps) | 737 | 430 | 359 | 212 | 49 |
组合物(%w/v) | |||||
成分 | 40 | 41 | 42 | 43 | 44 |
甘露醇 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 |
HPMC 2910 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
Carbopol 974P | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
硼酸 | 0 | 0.001 | 0.005 | 0.01 | 0.05 |
NaOH/HCl | 适量至pH 7.0 | 适量至pH 7.0 | 适量至pH 7.0 | 适量至pH 7.0 | 适量至pH 7.0 |
纯化水 | 适量至100 | 适量至100 | 适量至100 | 适量至100 | 适量至100 |
粘度(cps) | 657 | 534 | 362 | 233 | 65 |
Claims (14)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47825303P | 2003-06-13 | 2003-06-13 | |
US60/478,253 | 2003-06-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1802147A true CN1802147A (zh) | 2006-07-12 |
CN100475192C CN100475192C (zh) | 2009-04-08 |
Family
ID=33539082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004800159648A Active CN100475192C (zh) | 2003-06-13 | 2004-06-06 | 包含两种聚合物的协同组合的眼用组合物 |
Country Status (16)
Country | Link |
---|---|
US (1) | US7709012B2 (zh) |
EP (5) | EP3028692B1 (zh) |
JP (4) | JP4860475B2 (zh) |
KR (5) | KR101147046B1 (zh) |
CN (1) | CN100475192C (zh) |
AU (2) | AU2004249137B2 (zh) |
BR (1) | BRPI0411361B1 (zh) |
CA (6) | CA2527712C (zh) |
DK (1) | DK2116227T3 (zh) |
ES (3) | ES2415738T3 (zh) |
MX (1) | MXPA05013290A (zh) |
PL (1) | PL2116227T3 (zh) |
PT (1) | PT2116227E (zh) |
SI (1) | SI2116227T1 (zh) |
WO (1) | WO2004112836A2 (zh) |
ZA (1) | ZA200509440B (zh) |
Cited By (3)
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CN104039307A (zh) * | 2011-04-22 | 2014-09-10 | 爱尔康研究有限公司 | 具有包含两种不同粘度增强剂的粘度增强体系的眼用组合物 |
CN108367026A (zh) * | 2015-06-18 | 2018-08-03 | 常规制药股份公司 | 抗微生物配制品 |
CN113518646A (zh) * | 2019-02-27 | 2021-10-19 | 参天制药株式会社 | 含有地夸磷索或其盐,乙烯基系高分子及纤维素系高分子的眼科用组合物 |
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US20080057022A1 (en) * | 2006-08-30 | 2008-03-06 | Erning Xia | Ophthalmic Pharmaceutical Compositions and Uses Thereof |
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CN101605531B (zh) * | 2007-02-09 | 2012-10-10 | 爱尔康公司 | 含有三种聚合物的协同组合的眼用组合物 |
US8759321B2 (en) * | 2007-06-13 | 2014-06-24 | Bausch & Lomb Incorporated | Ophthalmic composition with hyaluronic acid and polymeric biguanide |
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US8629099B2 (en) * | 2008-03-25 | 2014-01-14 | Bausch & Lomb Incorporated | Ophthalmic compositions comprising a dipeptide |
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US8324171B1 (en) | 2012-02-06 | 2012-12-04 | Bausch & Lomb Incorporated | Ophthalmic compositions containing diglycine |
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UA113434C2 (uk) * | 2012-05-04 | 2017-01-25 | Алкон Рісерч, Лтд. | Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням |
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