CN1691929B - Dental filling material - Google Patents
Dental filling material Download PDFInfo
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- CN1691929B CN1691929B CN03824381.4A CN03824381A CN1691929B CN 1691929 B CN1691929 B CN 1691929B CN 03824381 A CN03824381 A CN 03824381A CN 1691929 B CN1691929 B CN 1691929B
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Abstract
An dental filling material comprising a thermoplastic polymer. The thermoplastic polymer may be biodegradable. A bioactive substance may also be included in the filling material. The thermoplastic polymer acts as a matrix for the bioactive substance. The composition may include other polymeric resins, fillers, plasticizers and other additives typically used in dental materials. The filling material is used for the filing of root canals.
Description
Invention field
The present invention relates to a kind of packing material, this packing material is used for teeth cavity and root canal treatment.
Background technology
Endodontic and root canal treatment are the branches of dentistry, and they can treat the dental tissue disease.An aspect in the endodontic comprises the treatment that root canal is infected, and ill pulp tissue dispels, along with the development of the filling of biomechanics and pulp cavity afterwards (root canal).The treatment of root canal, even indicating the tooth that external structures is arranged, also may ill, downright bad or pressure myeloid tissue necrosis.Such tooth have and or do not have complete enamel and dentine, and these teeth are used for osseous tissue.In such tooth, press the stripped part of myeloid tissue and root to be substituted by acceptable substitute on the biology.
The technique of making tooth heel conduit comprises with conventional dental drill opens a crown path.A kind of instrument for remove the medullary substance material from crown opening.The formation of cavity is to enlarge to form a full cavity that hollows out with borer and/or file.Fragment is removed by flushing from cavity, and this cavity also becomes clean because having removed all illing tissues.This method, its essence has caused tooth heel conduit to become fragile and easily pulverizing.After the ensuing chemical disinfection, the conduit that hollows out is filled easily.
A basic method comprises that the taperer with a filling is inserted in the root canal, and it is sticked on the conduit of sealing.Common root canal is filled the material of taperer and is made with gutta-percha.The method of lateral condensation has several filling taperers therein, and a main taperer and several auxiliary taperer insert in the root canal.Main taperer is inserted into firm bonding on the heel conduit.By using a tapered spreader, this main taperer can be squeezed into the side of heel conduit, and second taperer can be inserted into and be bonded to suitable position.This method can be by continuous until the heel conduit be sealed completely, and the heel conduit can hold the filling taperer more than 10 to 15.Another method sealing root conduit of concentrated usefulness of vertical gutta-percha warm or heat.A main conduit is being sticked on the root canal, and the application of heating can be by change using less implant, knows that gutta-percha is by from top removal.When little implant arrives 3 to 5 millimeters on tooth top.The space is filled.The conduit of side is filled and is closed, and seals because of the lateral expansion of heated gutta-percha.
In addition, the gutta-percha of small pieces can be used to this method, and these materials can be inserted in the root canal, and heating is for they can be attached to one and each implant at one time, until root canal is filled.All these three kinds of methods, independent filling taperer, lateral condensation and vertical condensation can be applied to the adhesive of root canal or be enclosed in independent taperer or between fragment, because cohere the existence of reagent.
Another method is to use a kind of filling gun, injection gutta-percha warm or heat in the implant of root canal.Syringe at first is positioned at the gutta-percha of heat the apex region of root canal, by a needle-like catheter tip, and fills gutta-percha around in the environment, and under the pressure of root canal, these can concentrate with the implant that is filled in the root top.Syringe can be filled root canal by to wherein injecting extra gutta-percha until it is filled.A kind of similar method, comprise the heating gutta-percha one on a flexible metal or plastic carrier, this carrier is used for gutta-percha is inserted into root canal.Carrier can solid rod be arranged in main cone shape thing in the heart.Described bar is connected on the handle, and described handle can be by marking perforated pipe and place to go or excision with it.
The method of most is in the conduit that is applied to seal, and uses gutta-percha material, is inserted in the natural fabric, and can not be absorbed by biological tissue or degrade, if root canal is crossed slow and exceeded the top.Challenge to the dentist is accurately to control the quantity of material to avoid root canal excessively to fill.The coolant core of gutta-percha is not extending, to such an extent as to it can not be cast into catheter wall, causes cohering not firm.In addition, when the gutta-percha of heating was cooled to body temperature, a unified contraction will occur, and can further reduce cohering catheter wall.In addition, the material of gutta-percha is the polyisoprene rubber material, and this material has the ability of binding most of dental materialss, and especially the fluid sealant when root canal is polymer material.Because bad adhering to and adhesion, can adhere to or breed a lot of antibacterials in root canal, cause that antibacterial enters conduit from the oral cavity, these can cause the infection that continues or other complication.The intensity of gutta-percha and fragility are all very poor.The dental gutta-percha can be broken under mal-condition, such as the root canal of sharp bend, in root of the tooth duct portion narrow space and similar situation.
Wish to provide a kind of root canal implant material to cohere with sealant easily.Preferably tooth heel packing material can have suitable intensity and toughness.Advantage is that tooth heel packing material can be to hold facile and be soluble.If tooth heel packing material can reduce or eliminate antibacterial, this will be very large progress.Cavity packing material and root canal packing material are bioactive.If the root canal packing material can be strengthened heel.
Summary of the invention
Other purposes of the present invention and advantage realize that by packing material of the present invention packing material of the present invention comprises a kind of thermoplastic polymer.The preferred biodegradable polymer of this thermoplastic polymer.A kind of bioactive substance can combine with this degradable thermoplastic polymer.This thermoplastic polymer can be used as the substrate of bioactive substance.Compositions can comprise other polymer based resin, implant, plasticizer and other the additive that is used for dental filling material.
Packing material is used for filling the hole of root canal.Material can be positioned at root canal, and these root canal are with the endodontic file certain size that is opened, to reach the purpose of apical end.If necessary, packing material is to most advanced and sophisticated compact, but it is still at very soft state, to guarantee that the tip is sealed fully.If packing material is pushed through the tip or oozes out from the tip or contact liquid the oral cavity by slight, this biodegradable material will be decomposed or by around biological tissue absorb and partially absorb.If biodegradable material appears in the packing material, it will react with the tissue in the oral cavity, repairs and/or make tissue growth to fill any gully or opening.
Description of drawings
Feature of the present invention is open by following accompanying drawing, wherein the same characteristic features of identical numeral in different accompanying drawings:
Fig. 1. illustrate the leakage of bacteria of test specimen after 30 days;
Fig. 2. represented the leakage of bacteria of test specimen after 30 days;
Fig. 3. front view, a sample is positioned at the mensuration of tension test instrument;
Fig. 4. the front view of sample as shown in Figure 3;
Fig. 5. have the front view of packing material equipment;
Fig. 6. the front view in a site, the alternately carrier in a site according to the present invention;
Fig. 7. front view, according to a switching implementation example of exchange carrier of the present invention.
Fig. 8. front view, another switching implementation example of the present invention.
Detailed Description Of The Invention
The invention provides a kind of packing material for tooth heel conduit and cave, described packing material comprises a kind of thermoplastic polymer.This polymer can be biodegradable.A kind of have bioactive material and can combine with this biodegradable thermoplastic polymer.This thermoplastic polymer can be used as the substrate of bioactive substance.Compositions comprises other thermoplastic resin, implant, plastotype agent and other additives for dental filling material, these comprise antibiotic, end dental caries material, antibiotics or other anti-inflammatory drug, bioactive substance, therapeutant, pigment or stain.Compositions can also be used for the sealant of tooth heel conduit and/or inculcate material.
Importantly, thermoplastic polymer is with the good adhesion of tooth heel conduit sealant.The adhesion intensity for tooth heel conduit sealant of thermoplastic polymer is equal to, or greater than 3Mpa, preferably is equal to, or greater than 4Mpa, most preferably is equal to, or greater than 5Mpa.
The thermoplastic resin that is fit to that is used for substrate is pharmaceutically acceptable.Preferably, polymer is can be by cellular activity and/or biodegradable by body fluid.The example of the thermoplastic polymer that is fit to is polyactide, PVOH ester (polyglycolides), polycaprolactone, poly-anhydride, polyamide, the poly-inferior ester of pressing, poly-alkyl ester (polyorthoesters), poly-dioxane, bunching copper, polyacetals, Merlon, poly-orthocarbonic ester, poly-diazonium phosphide, poly butyric ester, poly-hydroxyl valerate, poly-alkylene oxalate, polyethylene oxide, polyacrylate/methacrylate, poly-alkylene succinate, amino acid polymer, chitin, chitosan and copolymer, terpolymer, the perhaps combination material of above chemical compound.
Preferably polyactide, PVOH ester (polyglycolides), polycaprolactone and copolymer thereof.These polymers can be used for polymer system, and a part is because they have fabulous biocompatibility.Can reduce like this tissue rejection, inflammation, necrosis or toxicity phenomenon.If have in the situation of water, these polymers produce lactic acid, glycolic, hydroxycaproic acid, and these materials are easy to be fallen by the health biological metabolism.Polyactide and polycaprolactone can also be in conjunction with the acetas monomer to strengthen the polymeric degraded of product.Biodegradable thermoplastic polymer can be 10%-100% (weight).
Bioactive materials can comprise any material or metabolic precursor thereof, and these materials can promote to grow and the survival of cell, tissue, skeleton.The bone growth that is fit to promotes material, comprise bio-vitric, calcium phosphate, portland cement, hydroxyapatite, tricalcium phosphate, Diphosphonate, irritation element, sodium fluoride reagent, a kind of material, the ratio of its phosphate and calcium is similar to the skeleton of nature, the material of calcium hydroxide, other calcic components that are fit to.Bone growth promotes that material can microgranule or the form of optical fiber implant, with the form of microcosmic or macroscopic view, and the Ore fragment of skeleton bar, skeleton crystal, skeleton or tooth, a kind of synthetic hydroxyl rock phosphate in powder, perhaps other forms that are fit to.The content of biological activity filler can be at more than 90% of percentage by weight.
Biodegradable thermoplastic polymer should have the melting temperature at 50-300 ℃, preferably at 60-250 ℃, and most preferably 70-200 ℃.Polymeric melting temperature in above-mentioned scope is applied to the method for thermoplastic polymer, with having bioactive organic fine particles and other additives.In addition, polymeric melting temperature scope also can promote the application of filler, and these implants are in tooth heel conduit, with conventional heating means.
The example that is used for the extra resin of filling mixture, comprise polyamide, polyester, polyimides, polyurethane, vinyl esters, or epoxy material, styrene, styrene-acrylonitrile, the ABS polymer, polyacetals, Merlon, polyphenylene sulfides, acrylonitrile-butadiene-styrene copolymer, polyurethane dimethylacrylate (representing with phrase " UDMA " herein), trietbhlene glycol dimethylacrylate (after this representing with phrase TEGDMA), polyethylene glycol dimethacrylate (after this representing with PEGDMA), carbamate dimethylacrylate (after this representing with UDMA), hexane diol dimethylacrylate (after this using 1,6HDDMA to represent) and Merlon dimethylacrylate (after this representing with PCDMA) and similar substance.In the above-mentioned example that provides, resin comprises surface functional group, preferred such as acrylates/methacrylate, epoxy hydroxyl and other materials, because they are not only as the plastotype agent of mixture, also as cohering composition for the connection that promotes between mixture and sealant.Preferred polymer matrix material comprises these acrylic monomerss, for example at United States Patent (USP) the 3rd, 066, in 112 and disclosed in 3,179,623 and 3,194,784; United States Patent (USP) 3,751, and is disclosed in the disclosed and United States Patent (USP) 5,276,068 in 399 and 3,926,906.All particularly preferred methacrylate monomer are bisphenol-A and (+)-2,3-Epoxy-1-propanol methacrylate, 2,2-[4-(3-methacrylate-2-hydroxyl)-propyl group]-propane (representing with " BIS-GMA " herein).
Other implants that can be used for bioactive materials comprise organic or inorganic microgranule and prior art fibrefill, comprise silicon, silicate glass, quartz, zinc oxide, barium disilicate, strontium silicate, barium borosilicate, strontium borosilicate, borosilicate, lithium silicates, unformed carbon dioxide silicate, pyrrole mixture such as BIOCI, the calcium phosphate that ammonification is closed, aluminium oxide, zirconium oxide, stannum oxide, in other conventional filler, as at United States Patent (USP) 4,544,359 and 4, disclosed in 547,531.Some implants as radiopacity/high-refraction material, such as sulfate, ytterbium oxide, ytterbium fluoride, ytterbium iodine, bismuth oxide, bismuth fluoride, Barium monoxide, oxidation load.The fibre-bearing implant, comprise glass, pottery, metal, carbon, graphite, polymer such as cellulose polyamide, polyester, acrylic acid, vinyl and artificial cellulose, polyolefin, teflon mixture, perhaps other optical fiber of the prior art.These optical fiber can be unified, random lengths, unidirectional or multinomial or unplanned, can be probably at 3 to 4 millimeters, or shorter.Light can be fabric mechanism as at United States Patent (USP) 6,186,791 or the optical fiber of possible enhancing, and disclosed in 341 and 4,894,102 such as United States Patent (USP) 4,717, and in conjunction with all related reference papers herein.
Be used in the plastotype agent of filling mixture, comprise polyol.It is as many as 40% (weight) that the plastotype agent is attached to the weight ratio of going in the mixture, as many as 30% (weight) preferably, most preferred as many as 20% (weight).
In the method for recovering root canal, tooth heel conduit is prepared by odontologist.This can comprise and inserts endodontic frustrate or borer one side in the middle of the conduit removes dental pulp, slough, organic fragment and other potential stimulus object.After this, be used for the filing of root canals wall with etchant.The example of etchant comprises, organic acid or its derivatives are such as EDTA solution, aminoacid, acrylic acid, maleic acid, citric acid, tartaric acid, itaconic acid, lactic acid and similarly acid; Mineral acid is such as phosphoric acid, hydrochloric acid, sulphuric acid, nitric acid and similarly acid.The etchant that is used for this method at United States Patent (USP) 6,537, is disclosed in 563.
Generally speaking, the etchant that is used for the economy of dentin surface is suitable for the etching purpose of filing of root canals.Commercial available etching gel uses this purpose, and by Pentron Clinical Technologies, LLC obtains, 10% phosphate etching gel and 37% phosphate etching gel.Preferably, the etchant self etching coheres in the document that is combined in this patent described in reagent such as the Application No. 20020019456.Here can with self etching be that trade mark is NANOBOND, by Pentron Clinical Technologies, LLC produces.The example that other commercial available self etchings bind reagent is that trade mark is that SE Bond company produces.
Alternatively, if etchant does not comprise adhesive, also to use a kind of bonding reagent on the filing of root canals wall.The example of bonding material comprises dental acrylate/methacrylate or resin binder.Commercially available adhesive comprises, the adhesive of BOND-LE and BOND-1, and by Pentron Clinical Technologies, LLC company produces, all Bond 2 and One STEP
TM, Bisco produces again.After this, sealant is used for filing of root canals.The example of sealant comprises that acrylate/methacrylic resin is the filing of root canals sealant on basis, epoxy encapsulant, and similar sealant.These materials are by United States Patent (USP) 6,455, and 608 is open.Commercial available sealant comprises the FiberFill sealant that Pentron company produces, the AH-26 that Caulk/Dentsply company produces
TMSealant.After using sealant, packing material is inserted in the middle of the conduit.Can make in all sorts of ways, comprise that the side is concentrated, the vertical condensation of flexible material, and the independent site of material be inserted separately or inserted together with carrier.Conduit fills with packing material, can add for the remaining structure of tooth and support.A kind of artificial crown, directly or indirectly repair, repair local tooth bridge, can be positioned on the tooth to finish the reparation to tooth.
Described materials and methods provides good sealing and has filled filing of root canals herein.These materials are used for sealing and fill filing of root canals and be connected to the root canal wall, to alleviate or to remove and degerm to the leakage in the conduit.In addition, packing material described herein is easy to be dispelled.One removes the example of packing material from tooth root, is that the dentistry solvent can be chloroform by dentistry dissolution with solvents dissolving packing material again.
Leakage is carried out in testing during 30, filler in the samples of teeth use is individual, the microorganism of a cracking is revealed model and is used for mutant S. or reveals S. (as follows), and wherein these samples are positioned at palate, only has the conduit contact lower tooth thorax by obturation.Lower tooth thorax is by basal medium and the phenolphthalein indicator of 15ml, adds take 1% as standard.Sample inspection in per 24 hours in 30 days once detects the variation from red to Huang (bio-metabolic process of acid) for culture medium in the Corii Caprae seu Ovis and PH indicator, and these are indicating the leakage of antibacterial.The average ratio of leakage of bacteria and mutually comparing between all cohorts, these cohorts have been used 30 days and have been processed and counting statistics.
During 30 days, leakage phenomenon is assessed every day.Tested cohort is as follows.Group 1 is comprised of 10 teeth of filling with gutta-percha, but does not use fluid sealant (anodal control).Group 2 is by 1 10 teeth preparing on the same group, but this system's sealant sealing, the ability (negative pole control) that prevents that to test it antibacterial from therefrom overflowing.Group 3 is comprised of 15 teeth, and these teeth have used the AH26 sealant, and the side uses gutta-percha to fill and concentrated (LT-AH26).Group 4 is comprised of 15 teeth, and these teeth have used the AH26 sealant, and vertical uses gutta-percha to fill and concentrated (VT-AH26).Group 5 is comprised of 15 teeth, and these teeth have used soft seal gutta-percha (Obtura-AH26).Group 6 is comprised of 15 teeth, and these teeth are with self etching equipment vegetation and etching, and next with using the tooth root sealant, the side direction of (LT resin Percha) resin material is inserted (resin Percha) then according to the present invention.Group 7 is comprised of 15 teeth, and these teeth are with the preparation of self etching equipment and etching, next with using tooth root sealant, the vertical insertion (resin Percha) of (LT resin Percha) resin material then according to the present invention.Group 8 and group 9 respectively on the same group 6 group 7 identical, but and be different from group 1 and use S. variation antibacterials to group 7, group 8 and group 9 use coccuses.Result of the test is as shown in table 1:
As described in Table 1, inventive example 6-9 material therefor, during 30 days in, with respect to used conventional material among the routine 3-5, only have 1 or 2 tooth leakage phenomenon to occur in 15 teeth, and among the routine 3-5 conventional material during 30 days in, leakage phenomenon has all appearred in most of teeth.
Fig. 1 and 2 has represented diagram variation, enterococcal, coccus, for for detection of 15 teeth.In Fig. 1, PC, NC, L-GP, V-GP, L-RP and L-RP represent respectively positive pole, negative pole, side direction gutta-percha, vertical gutta-percha, side direction resin PERCHA and vertical resin PERCHA.Comprise that with resin PERCHA herein compositions 3 is in lower tabulation 3.Consistent with above-mentioned table 1, the graphical presentation among Fig. 1 the tooth of anodal control, these teeth have packing material, in the absence of adhesive (PC), revealing appears in all teeth.In normal tooth, negative pole control, tooth after 30 days, not occurring and reveal, gutta-percha inserts from both sides and vertical direction, after 30 days, the high leakage rate of 13 to 14 teeth occurred.Resin PRCHA of the present invention has expressed low-down leakage rate, after 30 days, only has 2 teeth to occur revealing.
Pictorialization enterococcal leakage among Fig. 2, coccus in the test cohort of 15 teeth and Fig. 1 table 1 consistent.As was expected, and leakage has all appearred in 15 teeth of group of anodal control, and the group of negative pole control does not then have leakage phenomenon.The resin PRCHA of side and vertical placement has expressed low leakage ratio, and 1 and 2 teeth are only arranged respectively.
Following example can be explained the present invention.
Example 1.
The front tooth selected is adapted to the size of standard with root canal files, so so that the remaining tooth wall of tooth has similar size.Tooth root is resumed as follows.Group 1 (15 tooth)-positive pole-do not have tooth root implant.Group 2 (15 tooth)-tooth roots are filled with gutta-percha and the AH26 sealant of lateral condensation.Group 3 (15 tooth)-Ya heel conduits are filled with vertical condensation gutta-percha and AH26 tooth root sealant.Group 4 (15 tooth)-filing of root canals walls and self etching equipment put together, and fill with the filing of root canals sealant, fill with resin RESIN on the vertical direction according to the present invention.All roots are with preserving for 2 weeks under 100% humidity, until carry out strength test, tooth is installed in the plastic hoop after two weeks, keeps the surplus of 8MM around resin.This ring is installed in the middle of the Instron equipment, in this equipment, a spherical auxiliary equipment is arranged, in order to produce the power of a wedge shape at the tooth major axis.Be incorporated into the reference paper of Fig. 3 and Fig. 4, represented the position of sample in the middle of Instron equipment.When the correct position of ball when tooth is determined, the Instron device activation is so that have a dynamics that slowly increases on tooth root, until cracked phenomenon occurs.The cracked resistance power of every tooth in each group, all note down, and the average cracked numerical value of organizing is listed in the middle of the following table 2.
Table 2.
Such as the result that can see at table 2, as broad as long with group (group 2 and group 3) and the control group (organizing 1) of gutta-percha, there is not equally the filling of filing of root canals.Resin PERHCA group (group 4) has demonstrated and has surpassed 22% dynamics in control force.
Example 2.
A kind of compositions, comprise polycaprolactone, buy from Union Carbide company, content is 40%, a kind of bioactivity glass has compositions, is similar to bio-vitric (buying from U.S. BIOMATERIALS), and content is probably 30%, the zinc oxide approximate content of USP grade be 20% and Barium monoxide as the spoke opacifier, content is greatly about 10%.The method for preparing compositions comprises that the heating polycaprolactone probably arrives soft condition to 70 ℃.The composition that keeps is added into and mixes under the kneading state, pushes or be mixed into the dough/pasta that polycaprolactone is completed into pure lines.The composition that forms will be prepared for vehicle equipment.
Example 3.
A kind of compositions comprises polycaprolactone, and content is 30%, CMEE content is approximately 10%, CAPROLACTONE 2-(METHACRYLOYLOXY) ETHYLESTER (CMEE), and content is approximately 10%, tricalcium phosphate, content are 30%, zirconia content 10%.The method for preparing compositions comprises that the heating polycaprolactone probably arrives soft condition to 70 ℃.The composition that keeps is added into and mixes under the kneading state, pushes or be mixed into the dough/pasta that polycaprolactone is completed into pure lines.The composition that forms will be prepared for vehicle equipment.
Following 3 the implant mixture of tabulating is similar to above-mentioned example 2 and 3 described methods:
These components will be done the bond strength test:
In the baking oven of routine, the component in the table 3 will be 80 ℃ of lower deliquescing.When these materials arrive available concordance, they will be placed between 15 millimeters to 1.2 millimeters the firm model, and the both sides at glass are cooled to room temperature.Sample is formed with glass slides and model and will be removed.Some trimming are necessary to remove reflection from the edge.Five dishes have been prepared in each test material.
Some specimen discs can be installed in a kind of cooling cures on acrylic acid gasket material, and the mould of column type has 20 to 30 millimeters diameter, and the one side of specimen disc exposes.The dark-coloured adhesive that a kind of two composition autonomies are healed, It C﹠amp; (Pentron Corp., Wallingford, CT) buys in B Universal Cement company, and these are methacrylic resin bonding agent, and this composition is used to make a compound button, and directly binds the exposed surface at sample.No. 5 gel capsules (Torpac Inc.NJ) are used to the load bonding agent and directly place the surface, in the power of 500 grams, on the Bencor test instrunment (Denville Engineering, CA), until the adhesive hardening.After composition mixed, adhesive had an about setup times of 4 minutes, and after one hour placement, sample is discongested with promoting Pruning model, on the BENCOR testing equipment, under the 0.02in/min speed.Under the ultimate load, cement cylinders is smashed from sample surfaces, and bonding strength can be cut apart contact surface with the load of cement cylinders and cut apart load, and calculates bonding strength.
Represented the bond strength of filling mixture such as following table 4, with using the mixture of gutta-percha to compare in the table 3:
Table 4.
The control of dentistry gutta-percha material is from Endodent, and Inc company buys.
The lateral deviation test
The toughness of specimen herein, testing equipment for the lateral deviation test as in the ADA description numeral 12 for the polymeric employing of tooth base, for this test.Specimen is made into clavate, and the size of size 50 * 3 * 3 is in the model of politef, in the time of the state of material a softness.A kind of 500 grammes per square metres in the centre of specimen by the load front end.Span between two supporters is 30 millimeters.These loads can be removed (if sample is not broken) in steady statue after 1 minute, and maximum deflection distance is with measured and record.Three test sample books will be to each test material operation.Test result is listed in table 5:
Table 5.
The result of material of the present invention expresses the result who is better than gutta-percha material.
Bioactive materials can mix in polymer, and the mixture of homogeneous is provided, with polymer or the insoluble matter in polymer, to form for polymeric suspension or dispersion liquid.Implant can be inserted in the conduit with the form of taperer and go.Taperer can be inserted in the conduit with file or similar instrument, is inserted in the conduit with taperer together.After inserting, carrier is removed or the tapering part that surpasses is cut down because the application of conventional gutta-percha taperer in filing of root canals.
Alternatively, material can be softened and compression apicad.When it still is in soft condition, guaranteed that the top is fully sealed.These can be finished by a kind of backfill technology, and for example material can be heated and be expelled in the conduit and go, with the handled equipment of tool, and such as ObturaII equipment, from Obtura/Spartan, Fenton, Missouri buys.
If, packing material is by the slight top of pushing to, perhaps ooze out the top, perhaps contact the liquid in the oral cavity, Biodegradable material will decompose, absorb or partially absorb by the liquid in the surrounding and biological tissue, and bioactive substance appears in the packing material and will react with the tissue in the oral cavity, repairs or the promotion tissue growth, to fill gully or opening.
United States Patent (USP) 6,455,628 directly disclose dental composition, and said composition comprises polymer, as the filing of root canals sealant, inculcates material, when with the Ben Wenben combination time.Compositions is used for polymerization or degraded, forms biodegradable and biological acceptable precursor to provide, and in chemical reaction, its advantage can allow tissue regeneration.
Optional as another, packing material can cylindricality of integrated formation, and the cylindricality site that one of them is independent comprises the site of dental pulp of an associating and the tip of packing material.The use of cylindrical unit, the tip of equipment is softened, by be placed on the baking oven or be heated to softening packing material or chemical heat with softening packing material.Equipment will be placed to filing of root canals, and the size that pre-establishes to such an extent as to it can be opened is by using endodontic file, with apical end.If necessary, packing material can be rung the top compression, when it also is in soft condition, to guarantee that the top is fully sealed.Cylindricality can be connect and be adhered on the catheter wall, by cohering the contact surface of reagent and filling cylindricality and catheter wall, same resinoid bond, such as two-sided bonding agent or spontaneous recovery bonding agent, such as FIBERFILL RCS root canal bonding agent or CEMENT-IT@Universal bonding agent, the two can Pentron Clinical Technologies, LLC in Wallingford, and CT obtains.These will cause one to the crown sealing of conduit, and the end sealing by resin demobilization material and conduit is by the mode of encapsulant and bonding agent.Remaining cylindrical section, forward expansion will be for building one around the core around it.Any part that surpasses will be sheared.Equipment will extend to adapt to the very long root of anterior teeth.Another one length will be shortened, to adapt to the different size of filing of root canals.The conduit of the flexible that coheres can be strengthened tooth to stop later tooth broken.
Fig. 3 has represented to have the carrier of packing material to Fig. 6, and packing material is applied to the carrier tip.Fig. 3 illustrates equipment 10 and has handle 12 and an axis of elongation 14.The axis of elongation 14 has a proximal end 14P and a tip 14D, and tip 14D is applicable to filing of root canals.A sliding support 16 is positioned at axle 14 and handle 12, is used for the indicator of a catheter length, and helps the position that kept carrier.After equipment was inserted into conduit, sliding support 14 was moved to the top of conduit.Packing material 18 has comprised a biodegradable thermoplastic polymer and a biological activity optical fiber, is positioned on the axle, begins at near-end, and comprises continuous downward tip with making progress.Reference document herein is United States Patent (USP) 6,447,297 and 6,428,319, and United States Patent (USP) 10/164,512, the applying date is on June 6th, 2002, and each direct site or sealing device have the packing material of integration, and these are all herein in conjunction with document.
Fig. 4, shown site 20 comprises a site part 21 and taperer or head portion 24.Head portion 24 comprises a toughness bar or taper, comprises a biodegradable thermoplastic polymer, combines with bioactive substance, in order to fill the top of conduit.Packing material can be included in the additive of dental field, such as plastotype agent, antibiotic, cariostatic agent, antibacterial or other anti-inflammatory drug, and biological activity or treatment material.
Site part 21 comprises a main housing or endodontic's part 22 and carrier or head portion 23, and these are positioned at the top of cylindrical unit 20.Main housing 22 can be solid bar or other cross sections that is fit to, and comprises the surface that xenogenesis is smooth in fact or comprises large numbers of bullet parts, is distributed in the y direction of housing 22.Preferably, housing 22 has a consistent width on its longitudinal axis, and bullet partly has identical bullet width and bullet length.Possible is various width or the housing of length 22 and/or different taper length or the taper truncation part of width are along the longitudinal axis part of housing 22.
Carrier 23 preferably has 21 1 housings that spread 22 of cylindrical section, and these are very meticulous diameters with the head portion 24 of the thermoplastic that cooperates cylindrical unit 20.Therein in a kind of production method, what be discussed later is, cylindrical section 21 is produced as the clavate material, and it will be sheared or be processed as the top, have very little width or diameter with the carrier 23 that forms, when comparing with housing 22.Carrier 23 very little diameters allow it that enough zones part 24 that tapers off to a point is arranged, and there also can have enough intensity and integrity to adapt to packing material to be as discussed above.As mentioned above, carrier 23 preferably has the stretching, extension 22 of a housing, and they have represented the conforming diameter that has, but can be any shape or size, to help head portion 24.
Head portion 21 can be made into any material, divides with toughness and harder endodontic's partial crown shaped part that head portion is provided, is suitable for being placed on material in the oral cavity such as metal, plastics, pottery, polymer, compo or other.Compo comprises that implant is strengthened composite material and optical fiber is strengthened composite material, comprise that the component of reinforcement in the polymer matrix material, lists in following United States Patent (USP) such as these composite materials: the people such as Goldberg the 4th, 717, No. 341 and the 4th, 894, No. 012, the 6th of the people such as Prasad, 039, No. 569, the 6th, 030 of the people such as Karmaker, No. 220,5,564, No. 929 of the people such as Alpert, the 5th of the people such as Sicurelli, 919, No. 044, these United States Patent (USP)s all comprise in the document of this patent.Optical fiber is strengthened composite material can comprise microscler, unidirectional, continuous filament, and these are with preferred least part, and diameter is arranged or guiding along the longitudinal, all is possible together with the normal or vertical dimension of formation.These optical fiber can be identical or length arbitrarily, and are unidirectional or multidirectional, or disperse arbitrarily, length can be 3 to 4 millimeters or shorter.Optical fiber can be form of fabric, and such as the 09/280th, No. 760 United States Patent (USP) of submitting on March 29th, 1999, the patent No. is 6,186,191 at present, and can comprise the cylindricality of any attribute described herein, and all the elements here can be in conjunction with document.Because the integrated structure that improves, the number of fibers in structural composition preferably equal at least 20 (weight) % and preferred 20% (weight) to 70% (weight).Possible reinforcement optical fiber, these are the United States Patent (USP)s 4 that preferably are used for the people such as goldberg, 717,341 and 4,894,012, comprise glass, pottery, metal, carbon, graphite, polymer, such as vitamin, polyamide, polyester, acrylic acid, vinyl and artificial cellulose, polyolefin, politef or above mixture, and other optical fiber well known in the prior art.A kind of preferred equipment is comprised of the individual event microfilament glass fiber bundle in resinous substrates.
In order to improve the tack of optical fiber and polymer matrix, in order to strengthen the effect of reinforcement, optical fiber can be silylated or use other processing methods, such as the pairing of portability function monomer to obtain to be fit to, between optical fiber and resinous substrates.Silanization can make optical fiber be difficult for getting wet, and has reduced the absorption of water and has improved hydrolytic stability, and optical fiber is attached on the polymer matrix.Typical silane is A-174 (P-methacrylic acid propane-trimethoxy silane), and by OSI Specialties, New York produces.
Polymer matrix is selected from dental materials well known in the prior art, polyamide, polyester, polyolefin, polyimides, polyarylate, polyurethane, vinyl acetate or epoxy material, styrene, acrylonitrile, abs polymer, Merlon, polyphenylene sulfate, acrylonitrile-butadiene-styrene copolymer, polyurethane, PUDMA, and similar substance.Preferred polymer matrix material comprises acrylic acid and methacrylic acid monomer, and for example, those are at United States Patent (USP) 3,066,112,3,179,623 and 3,194, and 784 patent; United States Patent (USP) 3,751,399 and 3,926,906 and United States Patent (USP) 5,276,068.A kind of particularly preferred methacrylic acid monomer is the enriched product to phenol A and (+)-2,3-Epoxy-1-propanol methacrylate, and two [4-(3-methacryl-2-hydroxyl propoxyl group)-the phenyl]-propane of 2,2`-are (herein hereinafter referred to as " BIS-GMA ").
For polymer matrix, these are particularly including the initial son of polymerization, polymerization accelerators, ultra-violet light absorbers, antioxidant, fluorescent agent, activation factor and/or other additives, known in the prior art, these are with visible light, from what cure, two processing or vacuum cleaner, heating or pressure synthetic comprise the initial son that a heating is cured, such as the benzoxy compound, the initial son that 1-1`-cyclohexylamine carbon nitrile or other freely activate.Preferred polymer matrix is photo-thermal substrate, and photo effect is wherein partly cured and is aggregated body substrate, however last healing heating under pressure control control.
Implant appears at, and is additional or replace optical fiber greater than 80% (weight), is preferably greater than 70% (weight).If optical fiber occurs, the quantity of optical fiber is greater than one or more optical fiber well known in the prior art of 30% (weight), and is used for dental prosthetic material.The optical fiber that is fit to comprises that those have and itself have the optical fiber that polymer matrix is had adhesive ability, or the coupling preparation, and the two is adhered to mutually.Optical fiber comprises silicon, silex glass, quartz, barium silicate, strontium silicate, amorphous silica, silicic-boric acid barium, silicic-boric acid strontium, borosilicate, lithiumation silicon, amorphous silica, ammonification alloy/calcium orthophosphate, zirconium oxide, aluminium oxide, stannum oxide, in other optical fiber routinely, such as United States Patent (USP) 4,544,359 and 4,547,531 is disclosed, yet possible coupling reagent comprises silane, zirconates, titanate.If the site produces from synthetic material, preferably cure fully or hardened condition.
With the example of metal for cylindrical section 21, include, but are not limited to this, metal or alloy Pd, Pt, Rh, Ir, Au, Ag, Ti, Co, Mo and their mixture, AgPd, AuPtPd, TiAlFe, TiAlV, CoCrMo, rustless steel and pyrite, ceramic material is used for Processing position part 21, comprise aluminium oxide, zirconium oxide, many laterite soils, spinelle, titanium dioxide, two silicons acid lithium salts, leucite, unformed glass, lithium phosphate and their mixture, or high strength ceramic material, these can resist the pressure that forms in the chamber of shutting up.
Carrier 23 preferably comprises a smooth surface, even it can not limit the application that a such surface cooperates packing material.The site can provide opaque color of teeth or color that can similar dental pulp to reach aesthetic.The site can comprise the material of a large amount of radiopacities, such as titanium oxide, barium sulfate, and known various similar materials in dentistry industry, the X-ray joins in the material of site to avoid in process of production.After site part 21 was produced, the carrier 23 of site part 21 had been filled the material parcel, can obtain so as mentioned above a tapering part 24.Packing material can be applied in the middle of any known method, for example floods, injection, grinding tool manual polishing and similar method.
The application of site unit, equipment can use, and perhaps can be heated by being placed into the place near baking oven or thermal source, with heating and softening packing material, perhaps is immersed in the chemical solution, and for example chloroform softens packing material.Equipment will be placed in the filing of root canals, and its predetermined size that has been opened is by using endodontic file, to seal the tip.If necessary, this packing material can be compressed to the top, yet it still keeps soft condition to guarantee that the top is sealed fully.The top is binded to enter conduit by lining and cohere preparation to be filled between site and the catheter wall with the space between the resin binder, such as dual cure cement.These crown sealings that will cause catheter wall are by the resin repair materials, and a catheter tip sealing, by the form of packing material and sealant.Remaining site part, be made into by its around core, and if necessary, replace the crown structure on it.Any structure that surpasses the site will be sheared.A kind of length of equipment will be longer, to cooperate the root of long nipper.It is shorter that other length will become, to cooperate less root in the zone of grinding one's teeth in sleep.
Fig. 5 has represented site unit 30, comprises that a site part 32 makes the optical fiber reinforced composite.Site part 32 comprises housing 34 and carrier 36.Carrier 36 is filled the material parcel, to obtain the tapering part 38 on it.As shown in FIG., housing 34 be taper so that the frictional force that is placed in the conduit to be provided.The cross section of site unit 30 can be less of to adapt to thinner less subsidiary conduit than the cross section of standard post, and it is filled with thermoplastic usually.
Therefore, site unit 30 can be used as an obturator.As an obturator, better support force will be provided, because fiber is strengthened composite material 34 tapering part 38 thereon, be applied to only relatively treating material, and as a locking device.In addition, locking device can be easy to join to the position of conduit.Site unit 30 can comprise handle 40, can be any polymer material that fills or do not fill, such as the material for the preparation of the site of mentioning above those.
Composite of the present invention is to have the impenetrable character of radiation, is similar to gutta-percha.
Yet the present invention's middle narration as above, what should state is that various technical characterictics can use separately or be used in combination.Being understandable that, to herein change or the variation of described embodiment of the present invention, will be it will be apparent to those skilled in the art that.Such variation or modification can not depart from purport of the present invention and protection domain.
Claims (23)
1. dental filling material that is used for depression and filing of root canals comprises:
A kind of biodegradable thermoplasticity polycaprolactone polymer matrix and adhesive, and contain optionally a kind of bioactive filler; Wherein described polymer has bond strength when being attached to the filing of root canals sealant, and this intensity is equal to or greater than 3Mpa; Wherein by heating energy that described packing material is softening.
2. dental filling material as claimed in claim 1, the percentage by weight of the content of wherein said thermoplastic polymer substrate is at least 10%.
3. dental filling material as claimed in claim 1, the percentage by weight of wherein said bioactive filler content is at the most 90%.
4. dental filling material as claimed in claim 1, described bioactive filler comprises the mixing of bio-vitric, calcium phosphate, portland cement, hydroxyapatite, tricalcium phosphate, Jiao or polyphosphoric acid, estrogen antagonist, sodium fluoride reagent or above material.
5. dental filling material as claimed in claim 1, wherein said bioactive filler matter comprises the Ore fragment of skeleton bar, skeleton crystal, skeleton or tooth or the mixture of above material.
6. dental filling material as claimed in claim 1, wherein said bioactive filler matter comprises microgranule or fiberfill or its combination.
7. dental filling material as claimed in claim 1 also comprises plasticizer.
8. dental filling material as claimed in claim 7, the percentage by weight of wherein said plasticizer loading is for the highest by 90%.
9. dental filling material as claimed in claim 7, wherein said plasticizer comprises polyol, polyolefin or their mixture.
10. dental filling material as claimed in claim 1, described adhesive comprises acrylate, methacrylate or its mixture.
11. dental filling material as claimed in claim 1 also comprises the material of polymer resin, additional filler, pigment, dyestuff, bioactive or therapeutic properties.
12. dental filling material as claimed in claim 11, wherein said polymer resin comprises polyamide, polyester, polyolefin, polyarylate, polyimides, polyurethane, styrene, styrene-acrylonitrile, the ABS polymer, polysulfone resin, polyacetals, Merlon, polyphenylene sulfides, acrylonitrile-butadiene-styrene copolymer, the polyurethane dimethylacrylate, polyethylene glycol dimethacrylate, the Merlon dimethylacrylate, the condensation product of bisphenol-A and glycidyl methacrylate, 2,2-[4-(3-methacrylate-2-hydroxyl)-propyl group]-propane, and the combination of above-claimed cpd.
13. dental filling material as claimed in claim 11, wherein said additional filler comprises a kind of implant of radiopacity.
14. dental filling material as claimed in claim 11, wherein said additional filler comprises the mixing of silicon, silex glass, quartz, zinc oxide, barium sulfate, barium silicate, strontium silicate, borosilicate, lithiumation silicon, bismuth compound, ammonification alloy/calcium orthophosphate, zirconium oxide, aluminium oxide, stannum oxide, titanium dioxide, apatite, silicic acid calcio implant or above material.
15. dental filling material as claimed in claim 11, wherein said additional filler comprises the fibroid implant.
16. dental filling material as claimed in claim 15, wherein said fibroid implant comprises glass, pottery, metal, carbon or polymer optical fiber.
17. dental filling material as claimed in claim 16, wherein said polymer optical fiber comprise the mixture of cellulose, polyamide, aramid, polyester, poly-aramid, polyolefin, politef or above material.
18. an equipment is used for packing material is applied among the filing of root canals, comprising:
One handles;
An axle; With
Be placed on the packing material on the axle, wherein said packing material, comprise: a kind of thermoplasticity polycaprolactone polymer matrix and adhesive, wherein this polymer has bond strength when being attached to the filing of root canals sealant, and this intensity is equal to or greater than 3Mpa; Also contain optionally a kind of bioactive filler; Wherein by heating energy that described packing material is softening.
19. equipment as claimed in claim 18, described bioactive filler comprises the mixing of bio-vitric, calcium phosphate, portland cement, hydroxyapatite, tricalcium phosphate, Jiao or polyphosphoric acid, estrogen antagonist, sodium fluoride reagent or above material.
20. an endodontic column construction comprises:
A cylindrical section; With
A tip portion, wherein tip portion comprises: a kind of packing material, wherein said packing material comprises a kind of thermoplasticity polycaprolactone polymer matrix and adhesive, this polymer has adhesive strength when being attached to the filing of root canals sealant, and this intensity is equal to or greater than 3Mpa; Also contain optionally a kind of bioactive filler; Wherein by heating energy that described packing material is softening.
21. endodontic's column construction as claimed in claim 20, wherein tip portion and cylindrical section are an integral body.
22. endodontic's column construction as claimed in claim 20, wherein said cylindrical section is made with metal, composite, pottery, glass or polymeric material.
23. endodontic's column construction as claimed in claim 20, described bioactive filler comprises the mixture of bio-vitric, calcium phosphate, portland cement, hydroxyapatite, tricalcium phosphate, Jiao or polyphosphoric acid, estrogen antagonist, sodium fluoride reagent or above material.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/279,609 | 2002-10-24 | ||
| US10/279,609 US7204874B2 (en) | 2001-10-24 | 2002-10-24 | Root canal filling material |
| US10/304,371 | 2002-11-26 | ||
| US10/304,371 US7204875B2 (en) | 2001-10-24 | 2002-11-26 | Dental filling material |
| US10/465,416 US7211136B2 (en) | 2001-10-24 | 2003-06-18 | Dental filling material |
| US10/465,416 | 2003-06-18 | ||
| PCT/US2003/019277 WO2004037214A1 (en) | 2002-10-24 | 2003-06-19 | Dental filling material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1691929A CN1691929A (en) | 2005-11-02 |
| CN1691929B true CN1691929B (en) | 2013-03-13 |
Family
ID=35346919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN03824381.4A Expired - Fee Related CN1691929B (en) | 2002-10-24 | 2003-06-19 | Dental filling material |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1691929B (en) |
| AT (1) | ATE479417T1 (en) |
| DE (1) | DE60334018D1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009025293A1 (en) * | 2009-06-15 | 2010-12-16 | Adolf Pfaff & Dr. Karl-Friedrich Reichenbach GbR (vertretungsberechtigter Gesellschafter: Adolf Pfaff, 79183 Waldkirch) | Radioopaque shape memory polymers |
| KR101359073B1 (en) * | 2012-03-20 | 2014-02-05 | 장성욱 | Dental filling composition comprising zirconia powder |
| EP4023203A1 (en) | 2013-03-15 | 2022-07-06 | Ultradent Products, Inc. | Stable dental varnish compositions and methods of manufacture and use |
| CN104803673B (en) * | 2015-03-31 | 2017-03-08 | 佛山市三水宝力高无机材料有限公司 | A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and preparation method thereof |
| CN104905981A (en) * | 2015-05-29 | 2015-09-16 | 苏州博利迈新材料科技有限公司 | Composite resin used for dental filling and preparation method thereof |
| CN106435816B (en) * | 2016-09-21 | 2018-04-17 | 东华大学 | A kind of preparation method of cellulose/bio-vitric composite fibre |
| CN108113893B (en) * | 2017-12-28 | 2020-02-14 | 吴秉民 | Suspension-stable premixed magnesium phosphate-based dental filling material and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4740245A (en) * | 1985-09-12 | 1988-04-26 | G-C Dental Industrial Corp. | Thermoplastic dental filling composition |
| EP0539751A1 (en) * | 1991-10-28 | 1993-05-05 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
-
2003
- 2003-06-19 AT AT03739200T patent/ATE479417T1/en not_active IP Right Cessation
- 2003-06-19 DE DE60334018T patent/DE60334018D1/en not_active Expired - Lifetime
- 2003-06-19 CN CN03824381.4A patent/CN1691929B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4740245A (en) * | 1985-09-12 | 1988-04-26 | G-C Dental Industrial Corp. | Thermoplastic dental filling composition |
| EP0539751A1 (en) * | 1991-10-28 | 1993-05-05 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE479417T1 (en) | 2010-09-15 |
| DE60334018D1 (en) | 2010-10-14 |
| CN1691929A (en) | 2005-11-02 |
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