CN1357023A - 控释聚丙烯酸颗粒及其制备方法 - Google Patents
控释聚丙烯酸颗粒及其制备方法 Download PDFInfo
- Publication number
- CN1357023A CN1357023A CN99811880A CN99811880A CN1357023A CN 1357023 A CN1357023 A CN 1357023A CN 99811880 A CN99811880 A CN 99811880A CN 99811880 A CN99811880 A CN 99811880A CN 1357023 A CN1357023 A CN 1357023A
- Authority
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- Prior art keywords
- polyacrylic acid
- particle
- polyacrylic
- acid
- small pieces
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920002125 Sokalan® Polymers 0.000 title claims abstract description 76
- 239000004584 polyacrylic acid Substances 0.000 title claims abstract description 69
- 238000013270 controlled release Methods 0.000 title claims abstract description 25
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 239000008187 granular material Substances 0.000 title abstract description 20
- 239000002245 particle Substances 0.000 claims abstract description 69
- 238000000034 method Methods 0.000 claims abstract description 56
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
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- 239000000178 monomer Substances 0.000 claims description 9
- 150000008065 acid anhydrides Chemical class 0.000 claims description 8
- 230000006872 improvement Effects 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- 125000002843 carboxylic acid group Chemical group 0.000 claims description 6
- 229920000058 polyacrylate Polymers 0.000 claims description 6
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 5
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- -1 polypropylene Polymers 0.000 description 17
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000005054 agglomeration Methods 0.000 description 3
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- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 3
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- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 240000002853 Nelumbo nucifera Species 0.000 description 2
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
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- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 2
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- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000863032 Trieres Species 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B9/00—Making granules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B9/00—Making granules
- B29B9/08—Making granules by agglomerating smaller particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B9/00—Making granules
- B29B9/12—Making granules characterised by structure or composition
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B9/00—Making granules
- B29B9/16—Auxiliary treatment of granules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/16—Powdering or granulating by coagulating dispersions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2033/00—Use of polymers of unsaturated acids or derivatives thereof as moulding material
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
- C08J2333/02—Homopolymers or copolymers of acids; Metal or ammonium salts thereof
Abstract
Description
实施例1 | 实施例2 | |
加料(磅/小时) | 360 | 390 |
辊压(psig) | 800 | 1000 |
辊速(RPM) | 12 | 12 |
真空度(in.Hg.) | 7 | 7 |
制粒机速度(RPM) | 1250 | 1250 |
筛号/型号 | 0.079/Rasping | .079/Rasping |
筛眼孔径(目) | 10~84 | 10~84 |
%产品 | 82 | 85 |
wt%过大颗粒/wt%微粒 | 1.8/16 | 1.6/14 |
粉末 | 实施例1(得自表I) | 实施例2(得自表I) | |
T70SGF*(分钟) | 482 | 310 | 244 |
T70SIF*(分钟) | 627 | 347 | 274 |
粉末 | 实施例1(得自表I) | 实施例2(得自表I) | |
0.2% 树脂 | 3250 | 2930 | 2810 |
0.5% 树脂 | 6050 | 5750 | 5700 |
1.0% 树脂 | 9850 | 9300 | 9300 |
1.0% 树脂+1.0% NaCl | 3070 | 2700 | 2680 |
配方实施例# | 辊速/压力(RPM) | 流率-20目* | 流率20~80* |
1 | 5/1,000 | 22 | 18 |
2 | 10/700 | 32 | 24 |
3(对照粉末) | ---- | 34 | n/a |
4**(对比实施例) | n/a | 22 | 22 |
实施例1 | 实施例2 | 实施例3(粉末) | 实施例4 | |
茶碱 | 33.3 | 33.3 | 33.3 | 33.3 |
无水乳糖 | 45.7 | 45.7 | 45.7 | 45.7 |
Carbopol971P(直接用或粒化) | 20.0 | 20.0 | 20.0 | 20.0 |
Cab-O-Sil | 0.5 | 0.5 | 0.5 | 0.5 |
硬脂酸镁 | 0.5 | 0.5 | 0.5 | 0.5 |
实施例1 | 实施例2 | 实施例3(粉末) | 实施例4(对比) | |
Flodex(流动指数)(压片前) | 32 | 26 | 32 | >32 |
压缩指数(压片前) | 22.9 | 18.8 | 21.8 | 28.5 |
T70 **SGF/SIF*** | 100/573.58 | 162/623 | 466/1006 | 62/66 |
T90 **SGF/SIF***(分钟) | 122/663 | 210/725 | 673/1343 | 71.6/(<90) |
成分 | 实施例5 | 实施例6 | 实施例7 |
茶碱 | 32.9g | 32.9 | 32.9 |
无水乳糖 | 55.7 | 55.7 | 55.7 |
聚丙烯酸 | 10 | 10 | 10 |
聚丙烯酸的压实压力(巴) | 10 | 30 | 60 |
Cabosil(热解法二氧化硅) | 0.4 | 0.4 | 0.4 |
硬脂酸镁 | 1.0 | 1.0 | 1.0 |
特性 | 实施例5 | 实施例6 | 实施例7 |
堆积密度 | .0566 | 0.404 | 0.476 |
振实密度 | 0.765 | 0.475 | 0.560 |
Hausner比率 | 1.352 | 1.175 | 1.176 |
压缩指数% | 26.01 | 14.95 | 15.00 |
实施例5 | 实施例6 | 实施例7 | |
在SGF中的释放T20 | 60 | 52 | 39 |
T50 | 279 | 152 | 70 |
T70 | 445 | 196 | 81 |
T90 | 764 | 316 | 92 |
在SIF中的释放T20 | 174 | 184 | 153 |
T50 | 702 | 592 | 460 |
T70 | 1133 | 828 | 627 |
T90 | - | 1173 | 712 |
溶解时间(分钟) | 34.9 | 33.5 | 36.0 |
小片厚度(英寸) | 0.1748 | 0.1728 | 0.1755 |
Claims (17)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9517998P | 1998-08-02 | 1998-08-02 | |
US60/095,179 | 1998-08-02 | ||
US09/329,471 US6492488B1 (en) | 1998-08-02 | 1999-06-10 | Controlled release polyacrylic acid granules and a process for preparing the same |
US09/329,471 | 1999-06-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1357023A true CN1357023A (zh) | 2002-07-03 |
CN1197899C CN1197899C (zh) | 2005-04-20 |
Family
ID=26789936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB99811880XA Expired - Lifetime CN1197899C (zh) | 1998-08-02 | 1999-07-20 | 控释聚丙烯酸颗粒及其制备方法 |
Country Status (10)
Country | Link |
---|---|
US (3) | US6492488B1 (zh) |
EP (1) | EP1183302B1 (zh) |
JP (1) | JP4371394B2 (zh) |
CN (1) | CN1197899C (zh) |
AT (1) | ATE315605T1 (zh) |
AU (1) | AU5002499A (zh) |
BR (1) | BR9912846B1 (zh) |
DE (1) | DE69929439T2 (zh) |
MX (1) | MXPA01000894A (zh) |
WO (1) | WO2000008092A1 (zh) |
Cited By (4)
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CN103147325A (zh) * | 2013-03-19 | 2013-06-12 | 太仓市佳玲塑料制品有限公司 | 一种有色聚丙烯酸造粒的制备工艺 |
CN106422975A (zh) * | 2016-09-22 | 2017-02-22 | 张家港汇普光学材料有限公司 | 一种光学红外成像上用硫化锌的自动造粒设备 |
CN111497169A (zh) * | 2020-04-21 | 2020-08-07 | 广东技塑新材料股份有限公司 | 一种在线塑料造粒的颗粒次品回收循环自动输送系统 |
CN114904007A (zh) * | 2022-04-24 | 2022-08-16 | 南京紫鸿生物科技有限公司 | 一种提高卡波姆的堆积密度的方法 |
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US6623754B2 (en) | 2001-05-21 | 2003-09-23 | Noveon Ip Holdings Corp. | Dosage form of N-acetyl cysteine |
US20050126238A1 (en) * | 2003-12-11 | 2005-06-16 | Qc Corporation | Plant nutrient and method of making |
BRPI0516437A (pt) * | 2004-10-04 | 2008-09-02 | Oreal E Nestec S A L | utilização de uma quantidade eficaz de pelo menos um microorganismo, processo de tratamento cosmético, composição cosmética e/ou dermatológica e composição para absorção oral |
US20070048364A1 (en) * | 2005-08-04 | 2007-03-01 | Yingxu Peng | Free flowing granules containing carbomer |
WO2007022317A2 (en) * | 2005-08-17 | 2007-02-22 | Cadbury Adams Usa Llc | Dusting compositions for chewing gum products |
US9224303B2 (en) | 2006-01-13 | 2015-12-29 | Silvertree Media, Llc | Computer based system for training workers |
FI20080346A0 (fi) * | 2008-05-09 | 2008-05-09 | Atacama Labs Oy | Prosessi lisäaineita sisältävän tabletin valmistamiseksi |
FI20080353A0 (fi) * | 2008-05-09 | 2008-05-09 | Atacama Labs Oy | Prosessi erittäin korkean lääkepitoisuuden tabletin valmistamiseksi |
US8951562B2 (en) * | 2006-11-10 | 2015-02-10 | Atacama Labs Oy | Method and apparatus or dry granulation |
FI20080355A0 (fi) * | 2008-05-09 | 2008-05-09 | Atacama Labs Oy | Prosessi metforminia käsittävien tablettien valmistamiseksi |
FI20070521L (fi) * | 2006-11-10 | 2008-05-11 | Atacama Labs Oy | Rakeita, tabletteja ja rakeistusmenetelmä |
JP2009203419A (ja) * | 2008-02-29 | 2009-09-10 | Lion Chemical Kk | ジクロロイソシアヌル酸ナトリウム含有錠剤 |
EP2291233B1 (en) * | 2008-05-09 | 2019-09-04 | Atacama Labs Oy | Method for dry granulation |
IT1394597B1 (it) * | 2008-11-05 | 2012-07-05 | Politi | Granulazione a secco in flusso di gas. |
US8513378B2 (en) | 2009-09-16 | 2013-08-20 | Nippon Shokubai Co., Ltd. | Production method for water-absorbing resin powder |
KR101899175B1 (ko) | 2010-12-16 | 2018-09-14 | 메르크 파텐트 게엠베하 | 건조 과립화된 세포 배양 배지 |
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US4386120A (en) * | 1980-01-07 | 1983-05-31 | Nippon Kayaku Kabushiki Kaisha | Process for producing polyacrylic acid salt granules easily soluble in water |
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US4654039A (en) * | 1985-06-18 | 1987-03-31 | The Proctor & Gamble Company | Hydrogel-forming polymer compositions for use in absorbent structures |
US5122544A (en) | 1988-05-31 | 1992-06-16 | Nalco Chemical Company | Process for producing improved superabsorbent polymer aggregates from fines |
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GB9114095D0 (en) | 1991-06-29 | 1991-08-14 | Allstate Limited | Improvements in water-soluble polymers |
DE69331192D1 (de) | 1992-05-09 | 2002-01-03 | Surfachem Group Plc | Umwandlung von pulverförmigen polymeren |
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RU2084462C1 (ru) | 1994-04-12 | 1997-07-20 | Саратовский филиал Научно-исследовательского института химии и технологии полимеров им.акад.В.А.Каргина | Способ получения порошкообразных акриловых сополимеров |
DE19600324A1 (de) | 1996-01-08 | 1997-07-10 | Basf Ag | Granulate für kosmetische und pharmazeutische Zubereitungen |
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1999
- 1999-06-10 US US09/329,471 patent/US6492488B1/en not_active Expired - Lifetime
- 1999-07-20 BR BRPI9912846-2A patent/BR9912846B1/pt not_active IP Right Cessation
- 1999-07-20 CN CNB99811880XA patent/CN1197899C/zh not_active Expired - Lifetime
- 1999-07-20 AT AT99934124T patent/ATE315605T1/de not_active IP Right Cessation
- 1999-07-20 DE DE69929439T patent/DE69929439T2/de not_active Expired - Lifetime
- 1999-07-20 EP EP99934124A patent/EP1183302B1/en not_active Expired - Lifetime
- 1999-07-20 AU AU50024/99A patent/AU5002499A/en not_active Abandoned
- 1999-07-20 MX MXPA01000894A patent/MXPA01000894A/es not_active IP Right Cessation
- 1999-07-20 WO PCT/US1999/016227 patent/WO2000008092A1/en active IP Right Grant
- 1999-07-20 JP JP2000563720A patent/JP4371394B2/ja not_active Expired - Lifetime
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2001
- 2001-12-20 US US10/034,011 patent/US6596844B2/en not_active Expired - Lifetime
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2003
- 2003-03-31 US US10/403,721 patent/US6762267B2/en not_active Expired - Lifetime
Cited By (6)
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CN103147325A (zh) * | 2013-03-19 | 2013-06-12 | 太仓市佳玲塑料制品有限公司 | 一种有色聚丙烯酸造粒的制备工艺 |
CN106422975A (zh) * | 2016-09-22 | 2017-02-22 | 张家港汇普光学材料有限公司 | 一种光学红外成像上用硫化锌的自动造粒设备 |
CN106422975B (zh) * | 2016-09-22 | 2023-03-21 | 张家港汇普光学材料有限公司 | 一种光学红外成像上用硫化锌的自动造粒设备 |
CN111497169A (zh) * | 2020-04-21 | 2020-08-07 | 广东技塑新材料股份有限公司 | 一种在线塑料造粒的颗粒次品回收循环自动输送系统 |
CN114904007A (zh) * | 2022-04-24 | 2022-08-16 | 南京紫鸿生物科技有限公司 | 一种提高卡波姆的堆积密度的方法 |
CN114904007B (zh) * | 2022-04-24 | 2024-04-05 | 南京紫鸿生物科技有限公司 | 一种提高卡波姆的堆积密度的方法 |
Also Published As
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EP1183302A1 (en) | 2002-03-06 |
US6492488B1 (en) | 2002-12-10 |
ATE315605T1 (de) | 2006-02-15 |
JP4371394B2 (ja) | 2009-11-25 |
WO2000008092A1 (en) | 2000-02-17 |
BR9912846B1 (pt) | 2009-12-01 |
CN1197899C (zh) | 2005-04-20 |
US20030187167A1 (en) | 2003-10-02 |
DE69929439T2 (de) | 2006-09-21 |
US6762267B2 (en) | 2004-07-13 |
EP1183302B1 (en) | 2006-01-11 |
BR9912846A (pt) | 2002-07-09 |
DE69929439D1 (de) | 2006-04-06 |
AU5002499A (en) | 2000-02-28 |
MXPA01000894A (es) | 2002-06-04 |
US6596844B2 (en) | 2003-07-22 |
JP2002537410A (ja) | 2002-11-05 |
US20020086967A1 (en) | 2002-07-04 |
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