CN1313166C - Dislysate preparing apparatus - Google Patents
Dislysate preparing apparatus Download PDFInfo
- Publication number
- CN1313166C CN1313166C CNB031215238A CN03121523A CN1313166C CN 1313166 C CN1313166 C CN 1313166C CN B031215238 A CNB031215238 A CN B031215238A CN 03121523 A CN03121523 A CN 03121523A CN 1313166 C CN1313166 C CN 1313166C
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- Prior art keywords
- dialysis solution
- concentration
- stock solution
- solution
- dialysis
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Abstract
The invention provides a dialysis solution preparation apparatus for stopping the feed of the dialysis stock solution by detecting an abnormality in the dialysis stock solution and stopping the feed of prepared dialysis solution to a patient. The dialysis solution preparation apparatus has constant flow valves 311 and 321 mounted in the upstream side of a connection part of the dialysis stock solution. Generally, the flow rate of the dialysis stock solution fed to dilution water feed lines 31 and 32 is not controlled to be constant, and therefore, it is preferable that flow meters 314 and 324 are disposed in downstream side from the connection part of the dialysis stock solution and in upstream side of densitometers 312 and 323. In the figure, the flow meters 314 and 324 are disposed between buffer tanks 312 and 322 and the densitometers for the sake of simpler explanation.
Description
Technical field
The present invention relates to the dialysis solution modulating device.Relate in more detail when the concentration of dialysis solution stock solution is unstable, during the perhaps mistaken container that dialysis solution stock solution is housed etc., the dialysis solution stock solution of supply takes place when unusual, detect that this is unusual and stop the supply of dialysis solution stock solution, and then stop to supply with the dialysis solution modulating device of the dialysis solution that modulates to the patient.
Background technology
The modulation of dialysis solution, be with a plurality of dialysis solution stock solutions respectively with dilution water dilution, these dialysis solution stock solutions of having diluted carry out by mixing.
As the dilution process of dialysis solution stock solution (adopting A stock solution and B stock solution usually), be with delivering to the dilution water supply pipeline behind the hopper metering dilution water in the past, supply with the method for A stock solution and B stock solution to the dilution water supply pipeline with being directly proportional with the flow of dilution water.In the method, between the feeding part of the feeding of A stock solution part and B stock solution and the downstream sidepiece of the feeding part of A stock solution concentration sensor is set, the concentration of the B stock solution that mensuration has been diluted and, the mixing of the B stock solution of having diluted and A stock solution and the concentration of the liquid that modulates can detect the normal and unusual of dialysis solution stock solution by the concentration of measuring.
; this method exists owing to use hopper on the feed pump; so there are the abrasion of piston fast, the shortcoming that the life-span is short, in addition; during the concentration change of the A stock solution that the downstream is supplied with; the flow of A stock solution also changes, and its result also changes at the flow of the B stock solution that upstream side is supplied with, and is any former thereby when causing the concentration change of the A stock solution of supplying with in the downstream; all need to calibrate concentration, this is very loaded down with trivial details.
Supplied to quantitative mixer as the dilution process of dialysis solution stock solution by also have A stock solution and B stock solution known to the people, with they blended methods with dilution water and ormal weight.
This method, owing to concentration sensor is not set at quantitative mixer with between the feeding part of the dilution water supply pipeline of A, B stock solution, so can not confirm the normal and unusual of A, B stock solution.And when the concentration of dialysis solution stock solution is unstable or during the mistaken container that dialysis solution stock solution is housed etc., the danger of will unusual liquid using as dialysis solution is normally arranged directly.
Summary of the invention
The present invention is in view of the above fact, and its purpose is to provide a kind of dialysis solution modulating device, and this device can be after detecting dialysis solution stock solution unusual, stops the supply of dialysis solution stock solution and then stops to supply with the dialysis solution that modulates to the patient.
Present inventors have carried out result of study discovery with keen determination in order to solve above-mentioned problem, on the dilution water supply pipeline, in downstream concentration sensor is set with the connecting portion of dialysis solution stock solution supply pipeline, concentration and the flow of dilution water and the flow of dialysis solution stock solution from the dialysis solution measured by this concentration sensor, can calculate the concentration of effective supply to the dialysis solution of above-mentioned dashpot, and, comparison from the concentration of the dialysis solution stock solution of such calculating and actual concentration with the dialysis solution stock solution supplied with, can find concentration unusual of the dialysis solution stock solution of effective supply, thereby finish the present invention.
Promptly, the present invention relates to the dialysis solution modulating device, the mixer that comprises a constant volume, dilution water supply pipeline that is connected with this mixer and the dialysis solution stock solution supply pipeline that is connected with this dilution water supply pipeline, and the dilution water supply pipeline with the downstream of the connecting portion of dialysis solution stock solution supply pipeline in order, possess dashpot and concentration sensor, concentration and the flow of dilution water and the flow of dialysis solution stock solution from the dialysis solution measured by this concentration sensor, calculate the concentration of effective supply to the dialysis solution of above-mentioned dashpot, at the predetermined concentration of this calculating concentration and the dialysis solution stock solution that should supply with not simultaneously, do not stop the supply of dialysis solution stock solution.
At this, the dilution water supply pipeline can be branched off into the pipeline more than 2, its branch each dilution water supply pipeline on also can connect different dialysis solution stock solution supply pipelines.
In addition, can supply to per 1 batch amount of electrolyte of mixer from the flow rate calculation of the flow of the concentration of dialysis solution and dilution water and dialysis solution stock solution, calculate the concentration of dialysis solution stock solution from this amount of electrolyte and the former liquid measure of the dialysis solution that supplies to mixer, mean concentration when also the concentration of the dialysis solution that can measure by concentration sensor becomes steady statue is the basis, calculates the concentration of the dialysis solution stock solution that supplies to dashpot.
In addition, preferably the upstream side at concentration sensor is provided with constant flow rate valve, and then this constant flow rate valve preferably is set in the downstream of the connecting portion of the upstream side of concentration sensor and dialysis solution stock solution supply pipeline.
Mixer preferably is separated into the closed quantitative container of Room 2 by moveable bulkhead.
In addition, dialysis solution modulating device of the present invention also can be by pressing the dialysis solution stock solution that the supply button replenishes necessary amount.
Show as mentioned above,, detect dialysis solution stock solution and stop to supply with dialysis solution stock solution after unusual, and then can stop to supply with synthetic dialysis solution, so can prevent the malpractice that causes unusually because of dialysis solution in advance for the patient according to the present invention.
Description of drawings
Fig. 1 is the diagrammatic illustration figure of expression one embodiment of the present of invention.
Fig. 2 is the diagrammatic illustration figure of expression an alternative embodiment of the invention.
Fig. 3 is the diagrammatic illustration figure of expression another embodiment of the present invention.
Fig. 4 is illustrated in the dialysis solution modulating device of the present invention, according to the flow chart of the controlling organization of the mensuration of dialysate concentration.
The specific embodiment
Then, according to figure explanation embodiments of the invention.
Fig. 1 is that diagrammatic illustration figure, Fig. 2 and Fig. 3 of expression one embodiment of the present of invention is diagrammatic illustration figure of expression an alternative embodiment of the invention.In addition, Fig. 4 is in dialysis solution modulating device of the present invention, according to the flow chart of the controlling organization of the mensuration of the concentration of dialysis solution.
Dilution water supply pipeline 3 shown in Figure 1 is 1,, Fig. 2, dilution water supply pipeline the 31, the 32nd shown in Figure 3, a plurality of (2).And shown in Figure 2 be the connecting portion upstream side that the constant flow rate valve 311,321 of dilution water supply pipeline 31,32 is arranged on dialysis solution stock solution, in the connecting portion downstream of dialysis solution stock solution and the upstream side of concentration sensor 313,323, effusion meter 314,324 is set preferably.In addition, shown in Figure 3 is connecting portion downstream and concentration sensor 313,323 upstream sides that the constant flow rate valve 311,321 of dilution water supply pipeline 31,32 is arranged on dialysis solution stock solution.
Dialysis solution modulating device shown in Figure 2, its constant flow rate valve 311,321 is arranged on the connecting portion upstream side of dialysis solution stock solution, generally, the dialysis solution stock solution that supplies to dilution water supply pipeline 31,32 is not the control of constant flow ground, so in the connecting portion downstream of dialysis solution stock solution and the upstream side of concentration sensor 313,323, effusion meter 314,324 is set preferably.In the drawings, for simple declaration, effusion meter 314,324 is arranged between dashpot 312,322 and the concentration sensor.
If opening open and close valve V1～V4, V6, V7, V9, close the status triggering dosing pump 12,22 o'clock of open and close valve V5, V8, V10, the dilution water that supplies to dilution water supply pipeline 31 is controlled with constant flow rate valve 311 constant flow ground, supplies in the dashpot 312.In addition, the dialysis solution stock solution A of stock solution A container 11 (below, be called stock solution A) quantitatively controls with dosing pump 12, supplies to the dashpot 312 by dilution water supply pipeline 31 from dialysis solution stock solution supply pipeline 1.Stock solution A mixes the back with the dilution water that supplies to this dashpot 312 diluted, supplies in the chamber 42 of mixer 4.At this moment, the flow of the stock solution A that has diluted and concentration are measured with effusion meter 314 that is arranged on dashpot 312 downstreams and concentration sensor 313 respectively.
On the other hand, the dilution water that supplies to dilution water supply pipeline 32 is controlled and is supplied in the dashpot 322 with constant flow rate valve 321 constant flow ground.In addition, the dialysis solution stock solution B of stock solution B container 21 (below, be called stock solution B) quantitatively controls with dosing pump 22, supplies to the dashpot 322 by dilution water supply pipeline 32 from dialysis solution stock solution supply pipeline 2.Stock solution B and the dilution water mixed diluting that supplies to this dashpot 322 supply in the chamber 42 of mixer 4.
At this moment, the flow of the stock solution B that has diluted and concentration are measured with effusion meter 324 that is arranged on dashpot 322 downstreams and concentration sensor 323 respectively.
In addition, under the situation for the mixer (being divided into the closed quantitative container of 2 chambers with moveable bulkhead) of the type of Fig. 1～shown in Figure 3 is natural, but if when dialysis solution is supplied with in chamber 42, the liquid (dilution water that is used to wash) of the same amount in the chamber 41 is discharged from by the pipeline of open and close valve V7 and the pipeline of V9.
At this, from the dilution of the stock solution A (stock solution B) that measures with concentration sensor 313 (323) concentration and the concentration of the flow of dilution water and stock solution A (stock solution B) concentration that can calculate the stock solution A (stock solution B) that supplies to dashpot 312 (322) practically, the concentration of this calculating compares with the predetermined concentration that is prior-entered in the device that should supply with stock solution A (stock solution B), at both not simultaneously, detect stock solution A (stock solution B) unusual (concentration abnormality of the mistaken or dialysis solution stock solution of the former liquid container of dialysis solution), stop the supply of stock solution A (stock solution B).
Supply to the calculating concentration of the dialysis solution stock solution of dashpot, can supply to per 1 batch amount of electrolyte of mixer 4 from the flow rate calculation of the flow of the concentration of dialysis solution (dilute dialysis solution stock solution) and dilution water and dialysis solution stock solution, calculate from this amount of electrolyte and the amount that supplies to the dialysis solution stock solution of mixer 4.In addition, can be the basis also from the concentration of the dialysis solution measured by the concentration sensor mean concentration when the steady statue, calculating supplies to the concentration of the dialysis solution stock solution of dashpot.
Calculating supplies to per 1 batch amount of electrolyte of mixer 4, the method of calculating the concentration of dialysis solution stock solution from this amount of electrolyte and the amount that supplies to the dialysis solution stock solution of mixer 4 is correctly to obtain the method for calculating concentration, by the long-pending integration that carries out of the flow of concentration and dialysis solution can be obtained per 1 batch amount of electrolyte.
Promptly, with per 1 batch amount of electrolyte as D, from the concentration that begins to supply with the dialysis solution of dilution water behind elapsed time t as the dialysate flow in the downstream of Ct, dashpot as the total amount of the dialysis solution stock solution of Vt, supply as the concentration of V, dialysis solution stock solution during as C
D＝∑C
t·V
t
C＝D/V＝∑C
t·V
t/V
Wherein, from the downstream of the connecting portion of dialysis solution stock solution and the upstream side of concentration sensor 313 (323) when constant flow rate valve 311 (321) is set, V
tBe certain (V
o), so,
C＝V
o∑C
t/V
In addition, the mean concentration of the concentration of measuring with concentration sensor when steady statue is the basis, the method of concentration that calculating supplies to the dialysis solution stock solution of dashpot is easy, and the feed speed of feed speed of dilution water certain (constant flow) and dialysis solution stock solution must be precondition generally.For the method, because the amount of the initial dialysis solution stock solution of supplying with is few, so concentration is low, but concentration uprises and becomes stable status (when the feed speed of dialysis solution was unstable, last end had vibration, but comprised the state of stable vibration at this moment) soon.If obtain the mean concentration of this moment and the relation of the concentration of dialysis solution stock solution in advance, then can from the mean concentration of dialysis solution obtain dialysis solution stock solution concentration.In addition, for the method, if with dialysis solution stock solution feed speed make necessarily (constant flow), owing to there is no need to obtain mean concentration, so can more correctly obtain the concentration of dialysis solution stock solution.
The dialysis solution modulating device is to control by the control device (not shown) according to the mensuration of dialysate concentration.Fig. 4 has represented the flow chart of this concentration controlling organization.
The concentration that calculates with concentration sensor 313 (323) with as the concentration (predetermined concentration) of the dialysis solution stock solution that will supply with when equating (S1), open and close valve V6, V7, V9 close, open and close valve V5, V8, V10 open (S2), supply with dialysis solution in the chamber 41 of mixer 4.At this, mixer 4 is because be the closed quantitative container that is divided into 2 chambers by moveable bulkhead 43 (softish barrier film etc.), so can be from the chamber 42 discharge with the dialysis solution of the dialysis solution equal quantities that supplies to chamber 41, the pipeline by open and close valve V10 supplies to (not shown) in the dialysis apparatus in downstream.
At calculating concentration and predetermined concentration (S1) not simultaneously, stop to supply with dialysis solution stock solution (S3).At this moment, also can report unusually by alarm buzzer or alarm lamp etc.The operator confirms whether dialysis solution stock solution has connection error, connects in dialysis solution stock solution and staggers the time, and presses discarded button (S4).So, close open and close valve V1, V2, open the liquid in the discarded chamber 42 of open and close valve V8 (S8), simultaneously, washing dilution water supply pipeline 31,32 and chamber 42.Connect when correct in dialysis solution stock solution, press replenishment pump button (S5).So, than predetermined concentration hour (S6), carry out supply stock solution (S7) at calculating concentration.In addition, when calculating concentration is bigger than predetermined concentration (S6), close open and close valve V1, V2, open the liquid in the discarded chamber 42 of open and close valve V8 (S8), simultaneously, dilution water supply pipeline 31,32 and chamber 42 are washed.
Shown in Figure 3 is the dialysis solution modulating device, because constant flow rate valve 311,321 is arranged on the downstream of connecting portion of dialysis solution stock solution and the upstream side of concentration sensor 313,323, and the flow that makes the dialysis solution by concentration sensor 313,323 is for certain, so different during with Fig. 2, without effusion meter.Because the running operation of device is identical during with Fig. 1, so the omission explanation.
In addition, dialysis solution modulating device shown in Figure 1 is 1 at dilution water supply pipeline 3 only, during beginning, opening open and close valve V1, V3, V6, V7, V9, closing driving dosing pump 12,22 under the state of open and close valve V2, V5, V8, V10, stock solution A is flow through, then, close open and close valve V1, open V2, stock solution B is flow through on this aspect difference, and for its concentration controlling organization, with Fig. 2 and shown in Figure 3 identical.
Claims (8)
1. dialysis solution modulating device, the mixer that comprises a constant volume, dilution water supply pipeline that is connected with this mixer and the dialysis solution stock solution supply pipeline that is connected with this dilution water supply pipeline, and the dilution water supply pipeline in the downstream of the connecting portion of dialysis solution stock solution supply pipeline in order, possess dashpot and concentration sensor, concentration and the flow of dilution water and the flow of dialysis solution stock solution from the dialysis solution measured by this concentration sensor, calculate the concentration of effective supply to the dialysis solution of above-mentioned dashpot, at the predetermined concentration of this calculating concentration and the dialysis solution stock solution that should supply with not simultaneously, do not stop the supply of dialysis solution stock solution.
2. dialysis solution modulating device according to claim 1, wherein, the dilution water supply pipeline can be branched off into the pipeline more than 2, simultaneously branch each dilution water supply pipeline on connecting different dialysis solution stock solution supply pipelines.
3. dialysis solution modulating device according to claim 1 and 2, wherein, supply to per 1 batch amount of electrolyte of mixer from the flow rate calculation of the flow of the concentration of dialysis solution and dilution water and dialysis solution stock solution, calculate the concentration of dialysis solution stock solution from this amount of electrolyte and the former liquid measure of dialysis solution that supplies to mixer.
4. dialysis solution modulating device according to claim 1 and 2, wherein, the mean concentration when becoming steady statue based on the concentration of the dialysis solution measured by concentration sensor, calculating supplies to the concentration of the dialysis solution of dashpot.
5. dialysis solution modulating device according to claim 1 wherein, is provided with constant flow rate valve at the upstream side of concentration sensor.
6. dialysis solution modulating device according to claim 5 wherein, is provided with constant flow rate valve in the downstream of the connecting portion of dialysis solution stock solution supply pipeline.
7. dialysis solution modulating device according to claim 1, wherein, mixer is the closed quantitative container that is separated into Room 2 by moveable bulkhead.
8. dialysis solution modulating device according to claim 1 by pressing the supply button, replenishes the dialysis solution stock solution of necessary amount.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002104052A JP4129721B2 (en) | 2002-04-05 | 2002-04-05 | Dialysate preparation device |
| JP104052/2002 | 2002-04-05 | ||
| JP104052/02 | 2002-04-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1453046A CN1453046A (en) | 2003-11-05 |
| CN1313166C true CN1313166C (en) | 2007-05-02 |
Family
ID=29242827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031215238A Expired - Fee Related CN1313166C (en) | 2002-04-05 | 2003-04-01 | Dislysate preparing apparatus |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP4129721B2 (en) |
| CN (1) | CN1313166C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5560539B2 (en) * | 2008-06-13 | 2014-07-30 | ニプロ株式会社 | Dialysate preparation device |
| JP5448867B2 (en) * | 2010-01-19 | 2014-03-19 | 旭化成メディカル株式会社 | Dialysis fluid generator, hemodialyzer, and dialysate generation method |
| JP2011182927A (en) * | 2010-03-08 | 2011-09-22 | Asahi Kasei Kuraray Medical Co Ltd | Hemodialyzer, liquid replenishment method for blood circuit, method for operating hemodialyzer |
| WO2013022024A1 (en) * | 2011-08-09 | 2013-02-14 | 川澄化学工業株式会社 | Blood purifying system |
| CN103830788B (en) * | 2012-11-27 | 2016-02-24 | 深圳先进技术研究院 | Liquid-supplying system of hemodialysis center |
| US10076735B2 (en) * | 2013-04-25 | 2018-09-18 | Gambro Lundia Ab | System and method for preparation of a medical fluid |
| DE102016006887A1 (en) * | 2016-06-03 | 2017-12-07 | Fresenius Medical Care Deutschland Gmbh | Dialysis machine and constant flow restrictor |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4922975A (en) * | 1986-01-24 | 1990-05-08 | Fresenius Ag | Apparatus for making mixtures of pharmaceutical liquids |
| US5318750A (en) * | 1992-02-14 | 1994-06-07 | Lascombes Jean Jacques | Device for the preparation of a solution for medical use |
| JPH06169987A (en) * | 1992-12-03 | 1994-06-21 | Sanyo Electric Works Ltd | Detector for acid rinsing finish in blood dialyzer |
| EP0648508A1 (en) * | 1993-10-15 | 1995-04-19 | Hospal Industrie | Servicing apparatus for dialysis machine |
| US5624551A (en) * | 1993-04-28 | 1997-04-29 | Fresenius Ag | Hydraulic safety circuit for a hemodialysis apparatus |
| JPH09149935A (en) * | 1995-11-30 | 1997-06-10 | Nissho Corp | Dehydration quantity monitoring device for dialyzer |
| US5808181A (en) * | 1995-09-16 | 1998-09-15 | Fresenius Ag | Method for testing a filter in a dialysis system |
| CN2374187Y (en) * | 1999-01-29 | 2000-04-19 | 暨南大学 | Blood dialyser |
| CN1275065A (en) * | 1998-08-14 | 2000-11-29 | 巴克斯特国际公司 | Compounding assembly for nutritional fluids |
| WO2001095955A1 (en) * | 2000-06-15 | 2001-12-20 | Jms Co., Ltd. | Automatic dialyzer and dialyzing method |
-
2002
- 2002-04-05 JP JP2002104052A patent/JP4129721B2/en not_active Expired - Fee Related
-
2003
- 2003-04-01 CN CNB031215238A patent/CN1313166C/en not_active Expired - Fee Related
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4922975A (en) * | 1986-01-24 | 1990-05-08 | Fresenius Ag | Apparatus for making mixtures of pharmaceutical liquids |
| US5318750A (en) * | 1992-02-14 | 1994-06-07 | Lascombes Jean Jacques | Device for the preparation of a solution for medical use |
| JPH06169987A (en) * | 1992-12-03 | 1994-06-21 | Sanyo Electric Works Ltd | Detector for acid rinsing finish in blood dialyzer |
| US5624551A (en) * | 1993-04-28 | 1997-04-29 | Fresenius Ag | Hydraulic safety circuit for a hemodialysis apparatus |
| EP0648508A1 (en) * | 1993-10-15 | 1995-04-19 | Hospal Industrie | Servicing apparatus for dialysis machine |
| US5808181A (en) * | 1995-09-16 | 1998-09-15 | Fresenius Ag | Method for testing a filter in a dialysis system |
| JPH09149935A (en) * | 1995-11-30 | 1997-06-10 | Nissho Corp | Dehydration quantity monitoring device for dialyzer |
| CN1275065A (en) * | 1998-08-14 | 2000-11-29 | 巴克斯特国际公司 | Compounding assembly for nutritional fluids |
| CN2374187Y (en) * | 1999-01-29 | 2000-04-19 | 暨南大学 | Blood dialyser |
| WO2001095955A1 (en) * | 2000-06-15 | 2001-12-20 | Jms Co., Ltd. | Automatic dialyzer and dialyzing method |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4129721B2 (en) | 2008-08-06 |
| JP2003290338A (en) | 2003-10-14 |
| CN1453046A (en) | 2003-11-05 |
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