CN1305535C - Medical high oxygen liquid, human blood oxygenating method and its instrument - Google Patents
Medical high oxygen liquid, human blood oxygenating method and its instrument Download PDFInfo
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- CN1305535C CN1305535C CNB200310122210XA CN200310122210A CN1305535C CN 1305535 C CN1305535 C CN 1305535C CN B200310122210X A CNB200310122210X A CN B200310122210XA CN 200310122210 A CN200310122210 A CN 200310122210A CN 1305535 C CN1305535 C CN 1305535C
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Abstract
The present invention discloses a method and a device for the oxygenation of medical high oxygen liquid and human blood. The method has the steps: first, the medical liquid is arranged in a liquid oxygenator, medical oxygen is sufficiently merged with the medical liquid, or the medical oxygen passes through a medical ozone generator, and parts of the medical oxygen is converted into ozone, so mixed gas of the medical oxygen and the ozone is sufficiently merged with the medical liquid to prepare high oxygen liquid of 22 Kpa to 150 Kpa; then, the human blood with an oxygen partial pressure value between 3 Kpa and 13.5 Kpa is transfused into the liquid oxygenator, in the liquid oxygenator, the high oxygen liquid is completely merged with the human blood, and dissolved oxygen is dispersed from the high oxygen partial pressure to the low oxygen partial pressure to accomplish the liquid oxygenation; the oxygen partial pressure value of oxygenation liquid which flows out of the liquid oxygenator is higher than a value of blood which is not oxygenated. The device prepared by the method has the advantages of long service life, low cost (each device costs 50 to 100 Yuan RMB), simple operation, infinitely large oxygenation area, high oxygenation efficiency, small contact surface of the blood and foreign matter and small damage on blood cells, and can be used in grass-roots hospitals.
Description
Technical field
The invention belongs to armarium, relate to a kind of Medical Instruments, specifically, is the method and the instrument thereof of a kind of medical oxygen-enriched liquid and blood of human body oxygenate, medically is being also referred to as artificial lung.
Background technology
Patient in hospital causes gas interchange disturbance because of pulmonary lesion, clinical manifestation hypoxemia, acid base imbalance.Clinical common method is:
1. through the respiratory tract oxygen supply, as inhaling pure oxygen, mechanical ventilation, hyperbaric oxygen chamber, but the serious patient of pulmonary lesion, as atypical pneumonia (SARS), inhalation injury etc., conventional oxygen supply effect is bad, even invalid.
2. another kind of effectively oxygen supply mode uses artificial lung to carry out external gas exchange, and its method is with blood of human body (PO
2=4Kpa～10Kpa) presses 30mlmin
-1～7000mlmin
-1Outside the lead body, be input to artificial lung----in the membrane oxygenator, charge into oxygen simultaneously in membrane oxygenator, the oxygenate process of blood is: oxygen and blood carry out gas exchange by the blood film, and the blood behind the oxygenate is oxygenated solution (PO
2=11Kpa---50Kpa) feed back to again in the human body, to reach purpose to supplying oxygen to body.The shortcoming of its existence is: (1) heart-lung machine cost an arm and a leg, and must be by professional perfusionist's operation; 1200 yuan-5000 yuan of every artificial lung (being membrane oxygenator) prices are used after 3 hours～6 hours and must be changed; (2) the QI and blood contact area of blood and oxygen is limited, and oxygenate efficient is low; (3) artificial lung---membrane oxygenator can cause injury of blood cell equally.Owing to this artificial lung treatment of above reason can only be carried out at large hospital, many patients lose valuable life because of no treatment condition.
Summary of the invention
Defective or deficiency at above-mentioned prior art exists the objective of the invention is to, and propose a kind ofly without membrane type or steep the formula oxygenator, but blood of human body and medical oxygen-enriched liquid are carried out instrument----the novel artificial lung of oxygenate in the liquid oxygenator.
The technical scheme that realizes the foregoing invention purpose is respectively that the instrument of a kind of hyperoxia solution and blood oxygenation comprises a medical oxygen, dissolved oxygen groove, blood of human body induction system and blood of human body acquisition system and moisture filter thereof; It is characterized in that also having an ozonator, the liquid oxygenator that has venthole and a medical use liquid source in the instrument;
Medical oxygen is connected with ozonator by oxygen catheter, the mist of oxygen and ozone enters the liquid oxygenator by pipeline, the liquid oxygenator is connected with the medical use liquid source, and the outlet of liquid oxygenator is connected with the dissolved oxygen groove by pipeline, is connected with the blood of human body acquisition system on the dissolved oxygen groove; The outlet of dissolved oxygen groove is connected with moisture filter, and the separating medium after the separation of moisture filter is communicated with the medical use liquid source by pipeline; Oxygenated blood after moisture filter separates enters the blood of human body induction system.
Some other characteristics of the present invention are; The venthole of described liquid oxygenator is used for the adjustments of gas flow.
Described blood of human body acquisition system and blood of human body induction system comprise the partial pressure of oxygen pick off that is provided with on pipeline, blood pump, filter and the pipeline of pumping blood.
Connected by pipeline between described medical use liquid source, dissolved oxygen groove, the liquid oxygenator, pipeline is provided with partial pressure of oxygen pick off, effusion meter.
Described moisture filter also is connected with reservoir.
The pipeline that described medical oxygen is connected with ozonator is provided with effusion meter.
Method of the present invention and by the advantage of the prepared novel artificial lung of this method: 1. long service life is not subjected to time restriction; 2. cost is low, and every liquid oxygenator only is 50～100 yuans; 3. simple to operate, can use at basic hospital; 4. its oxygenate process is variable concentrations solute (O in liquid
2) between carry out the infinity of oxygenate area, oxygenate efficient height; 5. blood and foreign body contact surface are little, and be little to injury of blood cell.
Description of drawings
Fig. 1 is a kind of block diagram that method of the present invention realizes, also is structured flowchart of the present invention;
Fig. 2 is the another kind of block diagram that method of the present invention realizes, also is another kind of structured flowchart of the present invention;
Fig. 3 is the structured flowchart of a kind of embodiment of instrument of the present invention;
Fig. 4 is the structured flowchart of another embodiment of instrument of the present invention.
The specific embodiment
The present invention is described in further detail below in conjunction with embodiment that accompanying drawing and inventor provide.
It below is the specific embodiment that the inventor provides by technique scheme.
The present invention is achieved in that referring to Fig. 1, at first the medical use liquid in the medical use liquid source is inserted in the dissolved oxygen groove, use medical oxygen and medical use liquid in the dissolved oxygen groove, fully to merge, be prepared into the hyperoxia solution that oxygen partial pressure value is 22Kpa～150Kpa, again hyperoxia solution is inserted the liquid oxygenator; And then be that in the liquid oxygenator, hyperoxia solution and blood of human body merge fully in the blood of human body input liquid oxygenator of 3Kpa～13.5Kpa with oxygen partial pressure value, dissolved oxygen to the low oxygen partial pressure disperse, is finished the liquid oxygenate from high keto sectional pressure; From the oxygen partial pressure value of the effusive oxygenated solution of liquid oxygenator than non-oxygenation blood value height.
Referring to Fig. 2, the said liquid oxygenate of the present invention method can realize again like this: at first the medical use liquid in the medical use liquid source is inserted in the oxygenator, and with medical oxygen (O
2) partly be converted into ozone (O by the medical ozone generator
3), make medical oxygen (O
2) and ozone (O
3) mist and medical use liquid fully merge, be prepared into the hyperoxia solution that oxygen partial pressure value is 22Kpa～150Kpa; And then be that in the liquid oxygenator, hyperoxia solution and blood of human body merge fully, dissolved oxygen (O in the blood of human body input liquid oxygenator of 3Kpa～13.5Kpa with oxygen partial pressure value
2) from high keto sectional pressure to the low oxygen partial pressure disperse, finish the liquid oxygenate; From the oxygen partial pressure value of the effusive oxygenated solution of liquid oxygenator than non-oxygenation blood value height.
In the aforesaid liquid oxygenate method: medical use liquid and hyperoxia solution are venoclysis liquid, and the flow of the hyperoxia solution of influent oxygenator is 5ml/min～7000ml/min; The blood of human body flow of influent oxygenator is 5ml/min～7000ml/min, and the oxygenated solution flow of trickle oxygenator is: 10ml/min～14000ml/min.
From the oxygen partial pressure value of the effusive oxygenated solution of liquid oxygenator is 5Kpa～140Kpa.
The separating medium flow is 5ml/min～7000ml/min.
1. method embodiment
Method embodiment 1:
Blood of human body: oxygen partial pressure value: PO
2=3kpa, input flow rate: 5ml/min;
Hyperoxia solution: oxygen partial pressure value: PO
2=22kpa～40kpa, input flow rate: 20ml/min;
Oxygenated solution: oxygen partial pressure value: PO
2=6kpa～23kpa, output flow: 25ml/min;
Method embodiment 2:
Blood of human body: oxygen partial pressure value: PO
2=6kpa, input flow rate: 50ml/min;
Hyperoxia solution: oxygen partial pressure value: PO
2=30kpa～60kpa, input flow rate: 100ml/min;
Oxygenated solution: oxygen partial pressure value: PO
2=10kpa～33kpa, output flow: 150ml/min;
Separating medium: output flow: 100ml/min.
Method embodiment 3:
Blood of human body: oxygen partial pressure value: PO
2=8kpa, input flow rate: 500ml/min;
Hyperoxia solution: oxygen partial pressure value: PO
2=30kpa～80kpa, input flow rate: 500ml/min;
Oxygenated solution: oxygen partial pressure value: PO
2=15kpa～43kpa, output flow: 1000ml/min.
Method embodiment 4:
Blood of human body: oxygen partial pressure value: PO
2=10kpa, input flow rate: 3000ml/min;
Hyperoxia solution: oxygen partial pressure value: PO
2=40kpa～100kpa, input flow rate: 3000ml/min;
Oxygenated solution: PO
2=15kpa～53kpa, output flow: 6000ml/min;
Method embodiment 5:
Blood of human body: oxygen partial pressure value: PO
2=6kpa～13.3kpa, input flow rate: 7000ml/min;
Hyperoxia solution: oxygen partial pressure value: PO
2=50kpa～150kpa, input flow rate: 7000ml/min;
Oxygenated solution: oxygen partial pressure value: PO
2=20kpa～140kpa, output flow: 14000ml/min;
Separating medium: output flow: 7000ml/min.
Method embodiment 6:
Blood of human body: oxygen partial pressure value: PO
2=3kpa, input flow rate: 10ml/min;
Hyperoxia solution: oxygen partial pressure value: PO
2=50kpa～150kpa, input flow rate: 30ml/min;
Oxygenated solution: oxygen partial pressure value: PO
2=20kpa～140kpa, output flow: 40ml/min.
2. instrument embodiment
Instrument embodiment 1:
Referring to Fig. 1, the instrument of a kind of hyperoxia solution and blood oxygenation comprises that a medical oxygen 1-1, has dissolved oxygen groove 1-3 and blood of human body induction system 1-6 and the blood of human body acquisition system 1-5 of venthole 1-3A according to a kind of instrument of method of the present invention preparation; Also include a liquid oxygenator 1-4 and a medical use liquid source 1-2;
Medical oxygen 1-1 is connected with dissolved oxygen groove 1-3 by oxygen catheter, medical use liquid source 1-2 is connected with dissolved oxygen groove 1-3 by pipeline, dissolved oxygen groove 1-3 is connected with liquid oxygenator 1-4 by pipeline, blood of human body acquisition system 1-5 is connected on the liquid oxygenator 1-4 by pipeline, and liquid oxygenator 1-4 links to each other with blood of human body induction system 1-6 by pipeline.
Blood of human body acquisition system 1-5 comprises effusion meter, filter and blood pump thereof and the partial pressure of oxygen pick off that is provided with on the pipeline of gathering blood of human body and the pipeline.
Dissolved oxygen groove 1-3 and liquid oxygenator 1-4 can unite two into one.
Novel artificial lung work process of the present invention:
From medical fluid supply 1-2, charge into 200ml～9000ml medical use liquid among the dissolved oxygen groove 1-3 in advance; Medical oxygen (O
2) by 2L/min～20L/min flow enter in the dissolved oxygen groove with groove in the medical use liquid oxygenate and the influent oxygenator in, in the liquid oxygenator, blood of human body acquisition system 1-5 adds the blood of human body that inbound traffics are 5ml/min～7000ml/min, hyperoxia solution and blood of human body merge fully, dissolved oxygen (O
2) from high keto sectional pressure to the low oxygen partial pressure disperse, finish the liquid oxygenate; The partial pressure of oxygen of the effusive oxygenated solution of liquid oxygenator is than the height of blood of human body; Flow by effusive medical use liquid in the medical use liquid source is 5ml/min～7000ml/min; The flow of the hyperoxia solution of influent oxygenator is 5ml/min～7000ml/min; The blood of human body flow of influent oxygenator is 5ml/min～7000ml/min, the oxygenated solution flow of trickle oxygenator: be 10ml/min～14000ml/min.Venthole 1-3A is used for the size of adjustments of gas gas output.
Above flow is all adjustable.
Instrument embodiment 2:
The said novel artificial lung of the present invention can also be made up of hyperoxia solution preparation system, blood of human body acquisition system, liquid oxygenator, ingress filter separator.
Referring to Fig. 2, the instrument of hyperoxia solution and blood oxygenation comprises a medical oxygen 2-1, an ozonator 2-1A and blood of human body induction system 2-6 and blood of human body acquisition system 2-5 and moisture filter 2-7 thereof; Also comprise the oxygenator 2-4 and the medical use liquid source 2-2 that have venthole 2-3;
Medical oxygen 2-1 is connected with ozonator 2-1A by oxygen catheter, oxygen (O
2) and the mist of ozone enter oxygenator 2-4 by pipeline, also be connected with blood of human body acquisition system 2-5 and medical use liquid source 2-2 on the oxygenator 2-4; The outlet of oxygenator 2-4 is connected with moisture filter 2-7, and the separating medium after the separation of moisture filter 2-7 is communicated with medical use liquid source 2-2 by pipeline 2-8; Oxygenated blood after moisture filter 2-7 separates enters blood of human body induction system 2-6, and venthole 2-3 is used for the adjustments of gas flow.
Its work process is:
Charge into 200ml～7000ml medical use liquid among the oxygenator 2-4 in advance; Medical oxygen (O
2) enter the medical ozone generator by 2L/min～20L/min flow, medical oxygen (O
2) partly be converted into ozone (O by the medical ozone generator
3), make medical oxygen (O
2) and ozone (O
3) mist and medical use liquid fully merge, be prepared into the hyperoxia solution that oxygen partial pressure value is 22Kpa～150Kpa; And then be that in the liquid oxygenator, hyperoxia solution and blood of human body merge fully, dissolved oxygen (O in the blood of human body input liquid oxygenator of 3Kpa～13.5Kpa with oxygen partial pressure value
2) from high keto sectional pressure to the low oxygen partial pressure disperse, finish the liquid oxygenate; From the oxygen partial pressure value of the effusive oxygenated solution of liquid oxygenator than non-oxygenation blood value height.
In the aforesaid liquid oxygenate method: medical use liquid and hyperoxia solution are venoclysis liquid, are 5ml/min～7000ml/min by the flow of effusive medical use liquid in the medical use liquid source; The flow of the hyperoxia solution of influent oxygenator is 5ml/min～7000ml/min; The blood of human body flow of influent oxygenator is 5ml/min～7000ml/min, the oxygenated solution flow of trickle oxygenator: be 10ml/min～14000ml/min.
Above flow is all adjustable.
Instrument embodiment 3:
Referring to Fig. 3, according to the instrument of the inventive method preparation------novel artificial lung comprises:
1. hyperoxia solution preparation system: by medical oxygen source of the gas 4-1, oxygen hose 4-2,4-4, oxygen filter 4-5, medical ozone generator 4-3, fluid supply effusion meter 4-10, dissolved oxygen groove 4-10a, partial pressure of oxygen pick off 4-8 forms.Dissolved oxygen groove 4-10a is a container of being made by medical macromolecular materials or all-metal material or pottery, and volume is 0.2L～10L, can be made into not co-content; As, 50ml is for baby, 500ml, 1500ml, 300ml, different sizes such as 6000ml extracorporeal circulation usefulness.
2. blood of human body acquisition system: by blood taking needle and blood vessel road 4-11, blood pump flow meter 4-12 forms.Take arterial blood or venous blood by blood taking needle from patient body, blood is transported to the liquid oxygenator by blood pump.Also can be with the aerobic venoclysis liquid that closes by blood pump input liquid oxygenator.
3. liquid oxygenator: be a container of making by medical macromolecular materials or all-metal material or pottery.Volume is 0.2L～10L, can be made into not isometric container.As, 50ml is for baby; 500ml, 1500ml, 300ml, 6L, 8L, 10L are that extracorporeal circulation such as uses at different size.The liquid oxygenator has two liquid inlets at least: 1. 2. liquid inlet B (4-17b) of liquid inlet A (4-16a).
4. ingress filter separator 4-27 is as required with part moisture (H in the oxygenated solution
2O) isolated by filtration is come out, separating rate 5ml/min～7000ml/min.
Ingress filter separator work process: oxygenated solution enters ingress filter separator (4-27), and ingress filter separator (4-27) leaches the separation of oxygenated solution part moisture content-separating medium, and separating medium is sent fluid supply effusion meter 4-10 or discharge back to through pipeline (4-23); Oxygenated solution is through pipeline 4-28, blood pump 4-29, transfusion (blood) pipeline 4-30, blood Micro-Bolt Filter 4-31, pipeline 4-32 input human body or reservoir 4-26a.
5. the work process of novel artificial lung
Charge into 200ml～7000ml medical use liquid in the dissolved oxygen groove in advance; Medical oxygen (O
2) enter the medical ozone generator by 2L/min～20L/min flow, medical oxygen (O
2) and ozone (O
3) mist enter in the dissolved oxygen groove with groove in the medical use liquid oxygenate, medical use liquid partial pressure of oxygen in the groove is risen, and the medical use liquid behind the oxygenate---hyperoxia solution does not stop to be entered in the liquid oxygenator by pipeline 4-11A, fluid flowmeter 4-17 by 5ml/min～7000ml/min flow; The medical use liquid source does not stop to charge into medical use liquid in dissolved oxygen groove 4-10a through pipeline 4-9 by 5ml/min～7000ml/min flow simultaneously, can be the separating medium that ingress filter separator 4-27 returns yet.
The blood of human body body provides flow by the blood of human body acquisition system by 5ml/min～7000ml/min, and that does not stop enters the liquid oxygenator.
Hyperoxia solution and blood of human body merge fully in the liquid oxygenator, dissolved oxygen (O
2) from high keto sectional pressure to the low oxygen partial pressure disperse, finish the liquid oxygenate, the partial pressure of oxygen of the effusive oxygenated solution of liquid oxygenator is than the height of blood of human body; Flow 10ml/min～the 14000ml/min of oxygenated solution; Oxygenated solution enters ingress filter separator 4-27 through pipeline 4-24, filter 4-25, pipeline 4-26, ingress filter separator 4-27 leaches separating medium with the separation of oxygenated solution part moisture content, medical use liquid source flux meter 4-10, separating medium flow 5ml/min～7000ml/min are discharged or returned to separating medium through pipeline; Oxygenated solution is through pipeline, blood pump, the defeated the Huis' body of transfusion (blood) pipeline or reservoir, oxygenated solution flow 5ml/min～7000ml/min.
Instrument embodiment 4:
The said novel artificial lung of the present invention again can be by source of oxygen, the blood of human body acquisition system, and the liquid oxygenator is formed.Equally referring to Fig. 3.The difference of present embodiment and embodiment 3 is, ingress filter separator 4-27 and medical ozone generator 4-2 are not set, but with oxygen (O
2) directly enter in the dissolved oxygen groove and medical use liquid oxygenate, the medical use liquid behind the oxygenate---hyperoxia solution.
1. source of oxygen adopts medical oxygen.
2. the blood of human body acquisition system is by blood taking needle, the blood vessel road, and blood pump is formed.Take arterial blood or venous blood by blood taking needle from patient body, by blood pump with blood transport to the liquid oxygenator.
3. the liquid oxygenator is a container of being made by medical macromolecular materials or all-metal material or pottery.Volume is 0.2L～10L, can be made into not isometric container.As, 200ml is for baby; 500ml, 1500ml, 3000ml is adult's usefulness, 6L～10L is different sizes such as extracorporeal circulation usefulness.The liquid oxygenator has two mouths at least: 1. 2. liquid outlet of liquid inlet.
4. the work process of novel artificial lung:
Charge into 200ml～6000ml medical use liquid among the dissolved oxygen groove 4-10a in advance; Medical oxygen (O
2) enter the medical ozone generator by 2L/min～20L/min flow, oxygen (O
2) enter among the dissolved oxygen groove 4-10a and the medical use liquid oxygenate, the medical use liquid source ceaselessly charges into medical use liquid by 10ml/min～6000ml/min flow in dissolved oxygen groove 4-10a.Medical use liquid behind the oxygenate---hyperoxia solution enters the liquid oxygenator.
The blood of human body body is provided by the blood of human body acquisition system, does not stop to enter the liquid oxygenator from feed tube by 10ml/min～6000ml/min flow.
Hyperoxia solution and blood of human body merge fully in the liquid oxygenator, and dissolved oxygen (O2) to the low oxygen partial pressure disperse, is finished the liquid oxygenate from high keto sectional pressure, and the partial pressure of oxygen of the effusive oxygenated solution of liquid oxygenator is than the height of blood of human body; Flow 20ml/min～the 12000ml/min of oxygenated solution.
Pore A (4-18), pore B (4-19) are used for regulating liquid oxygenator gas pressure.Liquid oxygen partial pressure sensor 4-8,4-15,4-20 measure hyperoxia solution respectively, blood of human body, the oxygen partial pressure value of oxygenated solution.Fluid supply effusion meter 4-10, blood pump flow meter 4-12, fluid flowmeter 4-17 measure hyperoxia solution respectively, blood of human body, the flow of oxygenated solution.
Instrument embodiment 5:
Present embodiment is identical with the device that embodiment 4 adopts, and ingress filter separator 4-27 and medical ozone generator 4-2 are not set yet, but with oxygen (O
2) directly enter in the dissolved oxygen groove and medical use liquid oxygenate, the medical use liquid behind the oxygenate---hyperoxia solution.The just variation of flow parameter of its difference.
Give among the dissolved oxygen groove 4-10a and charge into 1000ml medical use liquid 4-10b earlier; Source of oxygen 4-1 medical oxygen O
2By the 4-8L/min flow through pneumatic filter 4-5 enter among the dissolved oxygen groove 4-10a with groove in medical use liquid oxygenate 20min, make the medical use liquid partial pressure of oxygen rising 80-100kpa in the groove, medical use liquid behind the oxygenate is a hyperoxia solution, hyperoxia solution does not stop by pipeline 4-17a by the 50ml/min flow, and fluid flowmeter 4-17 enters liquid oxygenator 4-21; Unnecessary mist is discharged through exhaustor 4-7, and fluid supply effusion meter 4-10 does not stop to charge into medical use liquid in the dissolved oxygen groove by the 50ml/min flow through pipeline 4-9 simultaneously.
Blood of human body is gathered pipeline 4-11, blood pump flow meter 4-12 patient's arterial blood or venous blood is provided, and arterial blood or venous blood do not stop enter liquid oxygenator 4-21 from feed tube 4-16 by the 50ml/min flow through blood filter 4-14.
Hyperoxia solution and blood of human body merge fully in liquid oxygenator 4-21, dissolved oxygen (O
2) from high keto sectional pressure to the low oxygen partial pressure disperse, finish the liquid oxygenate; The partial pressure of oxygen of the effusive oxygenated solution of liquid oxygenator is than the height of blood of human body; The flow 100ml/min of oxygenated solution in pipeline 4-24.
Oxygenated solution is through oxygenated solution pipeline 4-26 input human body or reservoir 4-26a.
Instrument embodiment 6:
Present embodiment only is ingress filter separator 4-27 not to be set but with oxygen (O as different from Example 3
2) and ozone (O
3) mist enter in the dissolved oxygen groove and medical use liquid oxygenate, the medical use liquid behind the oxygenate---hyperoxia solution.
Among the dissolved oxygen groove 4-10a, charge into 2500ml medical use liquid 4-10b by fluid supply effusion meter 4-10 earlier; Source of oxygen 4-1 medical oxygen (O
2) enter medical ozone generator 4-3, oxygen (O by 6L/min～20L/min flow
2) and ozone (O
3) mist through pneumatic filter 4-5 enter among the dissolved oxygen groove 4-10a with groove in medical use liquid oxygenate 20min～30min, make the medical use liquid partial pressure of oxygen in the groove rise to 60kpa-100kpa, medical use liquid behind the oxygenate is a hyperoxia solution, and hyperoxia solution does not stop to enter liquid oxygenator 4-21 by pipeline 4-17a, fluid flowmeter 4-17 by the 3000ml/min flow; Unnecessary mist is discharged through exhaustor 4-7, and fluid supply effusion meter 4-10 does not stop to charge into medical use liquid in the dissolved oxygen groove by the 3000ml/min flow through pipeline 4-9 simultaneously, makes and remains 2500ml medical use liquid 4-10b among the dissolved oxygen groove 4-10a.
Blood of human body is gathered pipeline 4-11, blood pump flow meter 4-12 patient's arterial blood or venous blood is provided, and arterial blood or venous blood do not stop enter liquid oxygenator 4-21 from feed tube 4-16 by the 3000ml/min flow through blood filter 4-14.
Hyperoxia solution and blood of human body merge fully in liquid oxygenator 4-21, dissolved oxygen (O
2) from high keto sectional pressure to the low oxygen partial pressure disperse, finish the liquid oxygenate; The partial pressure of oxygen of the effusive oxygenated solution of liquid oxygenator is than the height of blood of human body; The flow 6000ml/min of oxygenated solution in pipeline 4-24.
Oxygenated solution is through oxygenated solution pipeline 4-26 input human body or reservoir 4-26a.
Pore A (4-18), pore B (4-19) use and regulate gas pressure in the liquid oxygenator.Liquid oxygen partial pressure sensor 4-8,4-15,4-20 measure hyperoxia solution respectively, blood of human body, the partial pressure of oxygen of oxygenated solution.Fluid supply effusion meter 4-10, blood pump flow meter 4-12, fluid flowmeter 4-17 measure hyperoxia solution respectively, blood of human body, the flow of oxygenated solution.
Instrument embodiment 7:
Referring to Fig. 4, charge into 1500ml medical use liquid 5-10b in liquid oxygenator 5-10a by fluid supply effusion meter 5-10 earlier; Medical oxygen (the O of source of oxygen 5-1
2) enter medical ozone generator 5-3, oxygen (O by 6L/min～20L/min flow
2) and ozone (O
3) mist enter among the liquid oxygenator 5-10a through pipeline 5-4 and pneumatic filter 5-5, the medical use liquid oxygenate 20min-30min with wherein makes the medical use liquid partial pressure of oxygen rise to 40kpa-120kpa, the medical use liquid behind the oxygenate becomes hyperoxia solution.Hyperoxia solution enters liquid oxygenator 5-10a with the flow of 500ml/min.
Blood of human body is gathered pipeline 5-11A, blood pump flow meter 5-12 patient's arterial blood or venous blood is provided, and arterial blood or venous blood do not stop enter liquid oxygenator 5-21 from feed tube 5-16 by the 500ml/min flow by pipeline 5-13 and by blood filter 5-14.
Hyperoxia solution and blood of human body merge fully in liquid oxygenator 5-10a, dissolved oxygen (O
2) from high keto sectional pressure to the low oxygen partial pressure disperse, finish the liquid oxygenate; The partial pressure of oxygen of the effusive oxygenated solution of liquid oxygenator is than the height of blood of human body.
The flow of oxygenated solution in pipeline 5-17 is 1000ml/min.Unnecessary mist is discharged through exhaustor 5-7; Fluid supply effusion meter 5-10 does not stop to charge into medical use liquid in the dissolved oxygen groove by the 500ml/min flow through pipeline 5-9 simultaneously, makes and remains 1500ml medical use liquid 5-10b among the liquid oxygenator 5-10a.
Oxygenated solution is through pipeline 5-17 input ingress filter separator 5-18, with 500ml/min separating medium (moisture content) through pipeline 5-11 rework solution body source effusion meter 5-10; 500ml/min oxygenated solution (blood) is through pipeline 5-19, oxygenated solution effusion meter 5-20, blood Micro-Bolt Filter 5-21, oxygenated solution blood pump 5-23, pipeline 5-25 input human body or reservoir 5-26.
Pore 5-7, pore 5-7a, pore 5-7b are used for regulating liquid oxygenator gas pressure.Liquid oxygen partial pressure sensor 5-8,5-15,5-24 measure the partial pressure of oxygen of hyperoxia solution, blood of human body, oxygenated solution respectively.Fluid supply effusion meter 5-10, blood pump flow meter 5-12, oxygenated solution effusion meter 5-20 measure hyperoxia solution respectively, blood of human body, the flow of oxygenated solution.
Instrument embodiment 8:
Different is for present embodiment and embodiment 7, has reduced ingress filter separator 5-18, in use, among the liquid oxygenator 5-10A, charges into 1500ml medical use liquid 5-10B by fluid supply effusion meter 5-10 earlier; Medical oxygen (the O that source of oxygen 5-1 provides
2) enter medical ozone generator 5-3, oxygen (O by 6L/min～20L/min flow
2) and ozone (O
3) mist by mist appendix 5-4 and behind pneumatic filter 5-5, enter among the liquid oxygenator 5-10a by appendix 5-6, with medical use liquid oxygenate 20min-30min wherein, make the medical use liquid partial pressure of oxygen rise to 30kpa～140kpa, medical use liquid behind the oxygenate promptly becomes hyperoxia solution, and hyperoxia solution is pressed 100ml/min flow influent oxygenator 5-10a.Blood of human body is gathered pipeline 5-11, blood pump flow meter 5-12 patient's arterial blood or venous blood is provided, and arterial blood or venous blood do not stop enter liquid oxygenator 5-10a from feed tube 5-16 by the 50ml/min flow through blood filter 5-14.
Hyperoxia solution and blood of human body merge fully in liquid oxygenator (5-10a), dissolved oxygen (O
2) from high keto sectional pressure to the low oxygen partial pressure disperse, finish the liquid oxygenate; The partial pressure of oxygen of the effusive oxygenated solution of liquid oxygenator is than the height of blood of human body.
Unnecessary mist is discharged through exhaustor 5-7; Fluid supply effusion meter 5-10 replenishes medical use liquid on demand through pipeline 5-9 in liquid oxygenator 5-10A simultaneously, makes and remains 1500ml medical use liquid 5-10B among the 5-10a.
The flow of oxygenated solution in pipeline 5-17 is 150ml/min.Oxygenated solution (blood) is through pipeline 5-19, oxygenated solution effusion meter 5-20, blood Micro-Bolt Filter 5-21, oxygenated solution blood pump 5-23, pipeline (5-25) input human body or reservoir 5-26.
Pore 5-7, pore 5-7a, pore 5-7b are used for regulating liquid oxygenator gas pressure.Liquid oxygen partial pressure sensor 5-8,5-15,5-24 measure the partial pressure of oxygen of hyperoxia solution, blood of human body, oxygenated solution respectively.Fluid supply effusion meter 5-10, blood pump flow meter 5-12, oxygenated solution effusion meter 5-20 measure the flow of hyperoxia solution, blood of human body, oxygenated solution respectively.
Certainly, medical ozone generator 5-3 is not set in the present embodiment also can realizes purpose of the present invention, just the time of dissolved oxygen is longer relatively.
The more excellent example that above-mentioned just inventor provides the invention is not restricted to the foregoing description, so long as increase or the replacement carried out all belong to protection scope of the present invention on the basis of technical scheme of the present invention.
Claims (6)
1. the instrument of hyperoxia solution and blood oxygenation comprises a medical oxygen, dissolved oxygen groove, blood of human body induction system and blood of human body acquisition system and moisture filter thereof; It is characterized in that also having an ozonator, the liquid oxygenator that has venthole and a medical use liquid source in the instrument;
Medical oxygen is connected with ozonator by oxygen catheter, the mist of oxygen and ozone enters the liquid oxygenator by pipeline, the liquid oxygenator is connected with the medical use liquid source, and the outlet of liquid oxygenator is connected with the dissolved oxygen groove by pipeline, is connected with the blood of human body acquisition system on the dissolved oxygen groove; The outlet of dissolved oxygen groove is connected with moisture filter, and the separating medium after the separation of moisture filter is communicated with the medical use liquid source by pipeline; Oxygenated blood after moisture filter separates enters the blood of human body induction system.
2. the instrument of hyperoxia solution as claimed in claim 1 and blood oxygenation is characterized in that the venthole of described liquid oxygenator is used for the adjustments of gas flow.
3. the instrument of hyperoxia solution as claimed in claim 1 and blood oxygenation is characterized in that, described blood of human body acquisition system and blood of human body induction system comprise the partial pressure of oxygen pick off that is provided with on pipeline, blood pump, filter and the pipeline of pumping blood.
4. the instrument of hyperoxia solution as claimed in claim 1 and blood oxygenation is characterized in that, is connected by pipeline between described medical use liquid source, dissolved oxygen groove, the liquid oxygenator, and pipeline is provided with partial pressure of oxygen pick off, effusion meter.
5. the instrument of hyperoxia solution as claimed in claim 1 and blood oxygenation is characterized in that described moisture filter also is connected with reservoir.
6. the instrument of hyperoxia solution as claimed in claim 1 and blood oxygenation is characterized in that the pipeline that described medical oxygen is connected with ozonator is provided with effusion meter.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB200310122210XA CN1305535C (en) | 2003-12-29 | 2003-12-29 | Medical high oxygen liquid, human blood oxygenating method and its instrument |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB200310122210XA CN1305535C (en) | 2003-12-29 | 2003-12-29 | Medical high oxygen liquid, human blood oxygenating method and its instrument |
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| CN1554451A CN1554451A (en) | 2004-12-15 |
| CN1305535C true CN1305535C (en) | 2007-03-21 |
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| CNB200310122210XA Expired - Fee Related CN1305535C (en) | 2003-12-29 | 2003-12-29 | Medical high oxygen liquid, human blood oxygenating method and its instrument |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101038283B (en) * | 2007-04-03 | 2011-04-06 | 西安交通大学 | Method for maintaining stabilization of perfusate pH value, oxygen partial pressure and carbon dioxide partial pressure |
| CN104147650A (en) * | 2014-08-27 | 2014-11-19 | 苏州承乐电子科技有限公司 | Blood transfusion and oxygen supplementation device |
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| US5366696A (en) * | 1993-01-07 | 1994-11-22 | 1077075 Ontario Inc. | Oxygenation apparatus for oxygenating a carrier liquid by spraying |
| US5569180A (en) * | 1991-02-14 | 1996-10-29 | Wayne State University | Method for delivering a gas-supersaturated fluid to a gas-depleted site and use thereof |
| CN2402332Y (en) * | 1999-12-03 | 2000-10-25 | 邢军 | Medical oxygen dissolving device for liquid contg. high oxygen |
| US6180059B1 (en) * | 1995-06-05 | 2001-01-30 | Therox, Inc. | Method for the preparation and delivery of gas-enriched fluids |
| US6582387B2 (en) * | 2001-03-20 | 2003-06-24 | Therox, Inc. | System for enriching a bodily fluid with a gas |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5569180A (en) * | 1991-02-14 | 1996-10-29 | Wayne State University | Method for delivering a gas-supersaturated fluid to a gas-depleted site and use thereof |
| US5366696A (en) * | 1993-01-07 | 1994-11-22 | 1077075 Ontario Inc. | Oxygenation apparatus for oxygenating a carrier liquid by spraying |
| US6180059B1 (en) * | 1995-06-05 | 2001-01-30 | Therox, Inc. | Method for the preparation and delivery of gas-enriched fluids |
| CN2402332Y (en) * | 1999-12-03 | 2000-10-25 | 邢军 | Medical oxygen dissolving device for liquid contg. high oxygen |
| US6582387B2 (en) * | 2001-03-20 | 2003-06-24 | Therox, Inc. | System for enriching a bodily fluid with a gas |
| CN2669868Y (en) * | 2003-12-29 | 2005-01-12 | 邢军 | Oxygenation equiment for medical pleonectic liquid and human body blood |
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| CN1554451A (en) | 2004-12-15 |
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