CN1154450C - 眼内透镜 - Google Patents
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- A61F2/02—Prostheses implantable into the body
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- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1602—Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/16905—Having means on lens to reduce overall dimension of lens for insertion into small incision
- A61F2002/169051—Segmented zones
- A61F2002/169053—Segments fold
Abstract
一种眼内屈光透镜(20),包括一具有一外周边(24)的视力部(22)和在病人眼睛(10)中支撑该视力部(22)的至少两个触觉件(26),每一触觉件包括一内部(28)和一外端(30),触觉件(26)的内部(28)与该视力部(22)的外周边(24)连接。每一触觉件(26)包括该外端(30)上的至少一个脚板(32)和伸展在该脚板(32)与该内部(28)之间的一中心部(38)。每一触觉件(26)的中心部(38)在与病人眼睛(10)的光轴(OA-OA)平行的一平面(40-40)中的抗弯性大于在与该光轴(OA-OA)垂直的一平面(36-36)中的抗弯性。该视力部(22)和触觉件(26)最好用可折叠或可压缩材料制成。
Description
技术领域
本发明涉及眼内透镜(IOL),特别涉及主要用来对保留有完整的天然透镜的有晶状体眼睛进行屈光矫正的眼内透镜,尽管本发明眼内透镜也可用于天然透镜因白内障手术而摘除的无晶状体眼睛中。
现有技术
近视眼和远视眼之类眼疾一般使用眼镜或隐形眼镜之类屈光透镜矫正。尽管这类眼镜可有效矫正视力,但由于必须定位、戴一段时间后会磨损、定期取下、容易失落或错放等缺点,因此许多配戴者感到不方便。此外在进行体育运动时显得不方便,眼睛受到撞击时很危险。
用眼内透镜永久性地矫正视力日益受到欢迎。眼内透镜多年来在无晶状体眼睛中用来代替因白内障手术而被摘除的天然晶状体。已成功开发出各种用于无晶状体眼睛中的眼内透镜。它们主要包括一视力部和称为触觉件的支撑件,该触觉件与视力部圆周的至少一部分连接,从而把眼内透镜支撑在眼睛的前室或后室中。
眼内透镜用各种生物相容材料制成,从聚甲基丙烯酸甲酯(PMMA)之类刚性材料到可折叠或可压缩的软性材料,例如硅酮、某些丙烯酸树脂和水凝胶。触觉件与视力部分开制造,然后用热或机械压凹接合或化学粘合之类工艺连接。在所谓的整体式眼内透镜中它们与视力部制成一体。
软性眼内透镜受欢迎的原因是,由于它们可压缩、折叠、卷起或其他变形,因此插入角膜中时所经的切口比刚性透镜的切口小得多,刚性透镜必须经一稍小于视力部直径的切口插入角膜。植入眼睛中后,软透镜由于软材料的记忆特性而展开成原状。
不管是软性眼内透镜还是刚性眼内透镜,植入后一般在人斜视或擦眼时都会受到作用在眼内透镜外端上的压缩力。压缩力会造成沿光轴的平动,从而造成视力部偏心和视象扭曲。这一平动会使眼内透镜碰到、从而损坏精细的角膜内皮层。此外,由于不管是用软性材料还是刚性材料制成的现有眼内透镜,在触觉件受到压缩时都会在光轴方向上偏移,因此眼内透镜制造商必须提供各种大小的眼内透镜专人专用才能减小这一平动,以便使屈光矫正更准确。
由于眼内透镜的设计存在这些缺点,因此需要有一种新触觉件,其外端受到压缩力时能减小视力部在光轴方向上的平动。
发明概述
本发明眼内透镜包括一具有一外周边的视力部和在病人眼睛中支撑该视力部的至少两个触觉件,该眼内透镜用可折叠或可压缩材料制成。每一触觉件包括一内部和一外端,该内部与该视力部的外周边连接。每一触觉件包括该外端上的至少一个脚板和伸展在该脚板与该内部之间的中心部。这些脚板可接合病人眼睛的内表面。
触觉件在与眼睛光轴大致平行的一平面中的抗弯性大于在与该光轴大致垂直的一平面中的抗弯性。由于触觉件具有这种柔性,因此触觉件在受到压缩力时会相对视力部挠曲而不造成视力部在光轴方向上发生无法接受的平动,从而本发明眼内透镜可与各种大小的眼睛相配。
附图的简要说明
从结合附图对例示性实施例的下述详细说明中可更清楚理解本发明,附图中:
图1简示出人眼内部,包括天然晶状体和植入前室的一屈光眼内透镜;
图2为本发明眼内透镜的俯视图;
图3为图2眼内透镜的端视图;
图4为图2眼内透镜的侧视图;
图5为沿图2中5-5线剖取的图2眼内透镜的视力部、触觉件之一和脚板的局部侧视剖面图;
图6为本发明另一眼内透镜的俯视图;
图7为图6眼内透镜的端视图;
图8为图6眼内透镜的侧视图;
图9为沿图6中9-9线剖取的图6眼内透镜的视力部和触觉件之一的局部侧视剖面图;
图10为本发明另一眼内透镜的俯视图;
图11为图10眼内透镜的端视图;
图12为图10眼内透镜的侧视图;
图13为埋置有一加强件的一触觉件和脚板的俯视图;以及
图14为图13触觉件和脚板的侧视剖面图。
本发明的最佳实施方式和工业实用性
图1为植入有本发明眼内透镜的眼睛10的结构简图。眼睛10包括一透光角膜12和一虹膜14。虹膜14后方有一天然晶状体16和一视网膜18。眼睛10还包括虹膜14前方的一前室6和虹膜14与天然晶状体16之间的一后室8。本发明眼内透镜在保留天然晶状体16时最好植入在前室6中矫正屈光错误。本发明眼内透镜也可植入在后室8中,在无晶状体眼睛中用来代替施行白内障手术所摘除的天然晶状体16。眼睛10还包括一光轴OA-OA,它为一穿过一透镜两表面的光学中心的假想直线,在人眼中一般与眼睛10的角膜12、天然晶状体16和视网膜18垂直。
本发明的眼内透镜具有柔性,从而使得支撑件或触觉件在其外端受到压缩力而向视力部移动时在光轴方向上的平动最小,从而防止眼内透镜偏心、视象扭曲和接触角膜内皮层。这些柔性还使得每一种样式只须一种或若干种标准透镜尺寸即可适合多数人眼的尺寸。由于这种透镜的通用性,因此减小了植入大小不合适透镜的危险性,这对病人有利,因为解决了瞳孔不圆、角膜内皮层受损、固定不佳等临床问题。此外,每一种样式无需各种尺寸的眼内透镜,从而投资成本下降。本发明眼内透镜从大小上说更为有利,眼科医生无需测量病人眼室后选择合适大小的眼内透镜,从而节省时间。
尽管本发明最好用于由可折叠或可压缩材料制成的软眼内透镜,但也可用于其视力部由聚甲基丙烯酸甲酯(PMMA)之类较硬材料制成、其柔性触觉件用相同材料(″整件式眼内透镜″)或不同材料(″多件式眼内透镜″)制成的所谓的硬透镜。
本发明的透镜的优选软材料为称为赫菲尔康A(hefilcon A)的水凝胶,它的含水量和屈光率比眼睛的水状液高(+1.33),从而赋予屈光透镜所需放大率。该材料的机械强度在眼内透镜植入时也能承受手工操作,其良好的记忆特性使得眼内透镜可在眼睛中展开成预定形状,且在眼睛中尺寸稳定。但是,也可使用其他合适的可折叠或可压缩材料,例如硅酮聚合物、碳氢和碳氟聚合物、其他水凝胶、软丙烯酸聚合物、聚酯、聚酰胺、聚氨基甲酸乙酯、具有亲水单体的硅酮聚合物、含氟聚硅氧烷弹性体和上述材料的组合。
用作屈光透镜时,视力部可为屈光度约为0-+20的正放大率透镜或为屈光度约为0--20的负放大率透镜。视力部可为双凸、平凸、平凹、双凹或凹凸透镜,视获得合适的中心和圆周厚度所需的放大率而定。
在图2-5所示本发明的一实施例中,眼内透镜20设计成最好植入眼睛的前室中。眼内透镜20包括一具有外周边24的视力部22。在该实施例中,各有一内部28和一外端30的4个独立的触觉件26经其内部28与视力部22的外周边24连接。每一触觉件26还包括一可经弧形外端30接合眼睛内表面的较扁平的脚板32。触觉件可与视力部制成一体,也可用压凹接合、化学聚合或其他公知方法与视力部连接。
视力部22在外周边24旁可有一眩光减小区34,以便在透镜边缘受从瞳孔射入的光的照射时或在强光下或在瞳孔扩大时减小眩光。眩光减小区34一般用与视力部22相同的材料制成,但也可不透明、着色或呈图案,以便堵塞或散射光学平面中的光。
按照本发明,触觉件26设计成:眼内透镜20植入病人眼睛中、受作用在触觉件26外端30上的压缩力而就位后,触觉件26在一般与眼内透镜20的光轴OA-OA垂直的一平面36-36(图4)中以箭头A(图2)所示方向挠曲。由于触觉件26设计成具有这种柔性,因此一种或若干种标准尺寸的眼内透镜20即可适合病人眼睛的大多数尺寸,因为在大小不同的压缩力(即由大小不同的眼睛所引起)作用在触觉件26的外端30上时在与光轴OA-OA平行的方向上不发生平动或只发生很小平动。按本发明设计的眼内透镜的另一个优点是,在压缩力作用于眼睛时保护角膜内皮层不受眼内透镜的接触,因为眼内透镜不会移动到接触角膜内皮层的位置。
可用若干不同方法实现这一柔性。在图2-5所示眼内透镜20中,触觉件26在视力部22旁有一中心部38,中心部38在平面40-40(一般与光轴OA-OA平行(图4))中的尺寸等于或大于在平面42-42(图3)(一般与光轴OA-OA垂直)中的尺寸。在平面40-40中其尺寸递减的一过渡部44从中心部38伸展到脚板32。脚板32较扁平(见图3、4)。
这种眼内透镜的一般尺寸如下:视力部22的直径为5.5mm、其周边厚约0.7mm;触觉件26从其内部28到外端30长约3.5mm;中心部38长约1.5mm、在平面40-40中厚约0.7mm、在平面42-42中宽约0.7mm;过渡部长约0.5mm;脚板32宽约3.0mm、长约2.0mm、厚约0.3mm。
因此,触觉件26从脚板32处较薄(在平面40-40中)渐渐变为在内部28与视力部22的连接处较厚,中心部38的尺寸在平面40-40中与在平面42-42中相同。在图2中箭头A方向上具有这种形状的触觉件在压缩力作用在外端30上时向视力部22挠曲,而在光轴OA-OA方向上的平动最小。眼内透镜20用作屈光透镜时,可稳定、可靠地矫正视力。
在图6-9所示本发明的另一眼内透镜20A中,视力部的一边有两个触觉件26A,另一边有一个触觉件26。眼内透镜20A的柔性实现方式与上述眼内透镜20不同。它没有过渡部44,但触觉件26在平面42-42中比在平面40-40中厚。从图8和9中可看得特别清楚,脚板32的厚度从外端30到中心部38递增,中心部的宽度大大大于在平面40-40中的尺寸。这种形状使得触觉件26A在压缩力作用在外端30上时如图6中箭头B所示向视力部挠曲。
图10-12示出本发明的透镜的另一实施例20B。眼内透镜20B有两个触觉件26B,每一触觉件26B的外端有一对脚板32B。或者,也可只在一个触觉件26B上有一对脚板32B,视力部28的另一边为另一种合适触觉件。
眼内透镜20B也包括一内部28和一外端30。触觉件26B经薄内部28与视力部22的外周边24连接。脚板32B可经弧形外端30接合眼睛内表面。
与眼内透镜20一样,触觉件26B设计成:眼内透镜20B植入病人眼睛中、受作用在触觉件26B外端30上的压缩力而就位后,触觉件26B在一般与眼内透镜20B的光轴OA-OA垂直的一平面36-36(图12)中以箭头C所示方向(图10)挠曲。
为实现眼内透镜20B的柔性,触觉件26B的中心部38在平面40-40(一般与光轴OA-OA平行(图12))中的尺寸等于或大于在平面42-42(一般与光轴OA-OA垂直)(图10和12)中的尺寸。在平面40-40中其尺寸递减的一过渡部44从中心部38伸展到脚板32B。脚板32B较扁平(图11和12)。这种形状的脚板32B在压缩力作用在外端30上时会向视力部22挠曲,从而在光轴OA-OA方向上的平动最小。
实现本发明的眼内透镜的柔性的另一种方法是如图13和14所示在一个或多个触觉件26中增加一带状加强件46。带状加强件46用较强材料制成。它可配合上述触觉件形状使用,也可与现有触觉件一起使用而实现所需柔性。
带状加强件46在插入触觉件中时可如图14所示其扁平面与平面40-40平行,也可如图13所示与触觉件26的边缘的弧度一致。带状加强件46的制作材料的刚性比触觉件的制作材料好。合适的材料包括聚酰亚胺、聚烯烃、高密度聚乙烯(HDPE)、聚酯、尼龙、金属或任何其他具有合适刚性的材料。如全部包在眼内透镜中,该材料不必与生物相容。带状加强件46起到“I”形梁的作用,在压缩力作用在触觉件26上时防止在光轴OA-OA方向上的平动。
本发明的眼内透镜用作屈光透镜可制成各种适用于眼睛前室中的样式。本发明眼内透镜的触觉件具有柔性,从而在光轴OA-OA方向上的平动最小,从而防止透镜偏心、视象扭曲、角膜内皮层受损。本发明具有柔性的眼内透镜的优点还在于每种样式只须一种或若干种尺寸的透镜即可适用于大多数病人的眼睛。由于这种透镜的通用性,消除了病人由于透镜大小不合适造成的不适;由于无需为每一种样式生产各种尺寸的透镜,因此投资成本降低。
尽管以上详细说明了本发明的例示性实施例,但可在由权利要求限定的本发明精神和范围内作出种种修正。
Claims (19)
1、一种眼内透镜(20),它植入病人眼睛(10)中时放置成与眼睛(10)的光轴(OA-OA)垂直,其特征在于,该透镜(20)包括:
(a)一具有一外周边(24)的视力部(22);
(b)在病人眼睛(10)中支撑视力部(22)的至少两个触觉件(26),每一触觉件有一内部(28)和一外端(30),触觉件(26)的内部(28)与视力部(22)的外周边(24)连接;
(c)每一触觉件(26)包括外端(30)上的至少一个脚板(32),并进一步包括伸展在脚板(32)与内部(28)之间的一中心部(38);以及
(d)每一触觉件(26)的中心部(38)在与病人眼睛(10)的光轴(OA-OA)平行的一平面(40-40)中的抗弯性大于在与该光轴(OA-OA)垂直的一平面(36-36)中的抗弯性。
2、根据权利要求1所述的眼内透镜(20),其特征在于,该视力部(22)和触觉件(26)用可折叠或可压缩材料制成。
3、根据权利要求2所述的眼内透镜(20),其特征在于,该可折叠或可压缩材料选自:硅酮聚合物、碳氢和碳氟聚合物、水凝胶、软丙烯酸聚合物、聚酯、聚酰胺、聚氨基甲酸乙酯、具有亲水单体的硅酮聚合物、含氟聚硅氧烷弹性体和上述材料的组合。
4、根据权利要求3所述的眼内透镜(20),其特征在于,该水凝胶材料为赫菲尔康A。
5、根据权利要求1所述的眼内透镜(20),其特征在于,脚板(32)在与光轴(OA-OA)垂直的平面(36-36)中较扁平。
6、根据权利要求1所述的眼内透镜(20),其特征在于,至少一个触觉件(26)的中心部(38)在与光轴(OA-OA)平行的平面(40-40)中的尺寸等于或大于在与光轴(OA-OA)垂直的平面(42-42)中的尺寸。
7、根据权利要求6所述的眼内透镜(20),其特征在于,所有触觉件(26)的中心部(38)在与光轴(OA-OA)平行的平面(40-40)中的尺寸等于或大于在与光轴(OA-OA)垂直的平面(42-42)中的尺寸。
8、根据权利要求1所述的眼内透镜(20),其特征在于,一触觉件(26)的中心部(38)在与光轴(OA-OA)垂直的平面(42-42)中的尺寸等于或大于脚板(32)在同一平面(42-42)中的尺寸。
9、根据权利要求7或8所述的眼内透镜(20),其特征在于,触觉件(26)包括一过渡区(44),其在与光轴(OA-OA)平行的平面(40-40)中的厚度递增,该过渡区(44)从脚板(32)伸展到中心部(38)。
10、根据权利要求6所述的眼内透镜(20),其特征在于,该至少一个触觉件(26)的内部(28)在与光轴(OA-OA)平行的平面(40-40)中的尺寸与中心部(38)和视力部(22)在同一平面(40-40)中的尺寸大致相同。
11、根据权利要求1所述的眼内透镜(20),其特征在于,该至少两个触觉件(26)包括视力部(22)第一边上的两个触觉件(26)和视力部(22)另一边上的至少一个触觉件(26)。
12、根据权利要求1所述的眼内透镜(20),其特征在于,该至少两个触觉件(26)包括视力部(22)第一边上的两个触觉件(26)和视力部(22)另一边上的两个触觉件(26)。
13、根据权利要求1所述的眼内透镜(20),其特征在于,该至少两个触觉件(26)包括视力部(22)第一边上的一个触觉件(26)和视力部(22)另一边上的第二触觉件(26),至少一个触觉件(26)的外端(30)上连接有一对脚板(32)。
14、根据权利要求1所述的眼内透镜(20),其特征在于,视力部(22)的外周边(24)旁有一眩光减小(34)。
15、根据权利要求1所述的眼内透镜(20),其特征在于,进一步包括插入在至少一个触觉件(26)中的加强件(46),该加强件(46)在与光轴(OA-OA)平行的平面(40-40)中的抗弯性大于在与光轴(OA-OA)垂直的平面(36-36)中的抗弯性。
16、根据权利要求15所述的眼内透镜(20),其特征在于,该加强件(46)由细长形材料制成,其在与光轴(OA-OA)平行的平面(40-40)中的尺寸大于在与光轴(OA-OA)垂直的平面(42-42)中的尺寸。
17、根据权利要求15所述的眼内透镜(20),其特征在于,该加强件(46)伸入脚板(32)中。
18、根据权利要求15所述的眼内透镜(20),其特征在于,该加强件(46)的制作材料选自:聚酰亚胺、聚烯烃、高密度聚乙烯、聚酯、尼龙或金属。
19、根据权利要求15所述的眼内透镜(20),其特征在于,所有触觉件(26)中都有加强件(46)。
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US08/874,753 | 1997-06-13 | ||
US08/874,753 US5928282A (en) | 1997-06-13 | 1997-06-13 | Intraocular lens |
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-
1997
- 1997-06-13 US US08/874,753 patent/US5928282A/en not_active Expired - Lifetime
-
1998
- 1998-06-12 CA CA002263124A patent/CA2263124C/en not_active Expired - Fee Related
- 1998-06-12 ES ES98930177T patent/ES2187978T5/es not_active Expired - Lifetime
- 1998-06-12 EP EP98930177A patent/EP0925044B2/en not_active Expired - Lifetime
- 1998-06-12 WO PCT/US1998/012259 patent/WO1998056315A1/en active IP Right Grant
- 1998-06-12 CN CNB988010984A patent/CN1154450C/zh not_active Expired - Fee Related
- 1998-06-12 DE DE69809697T patent/DE69809697T3/de not_active Expired - Lifetime
- 1998-06-12 AU AU79634/98A patent/AU727825B2/en not_active Ceased
- 1998-06-12 BR BR9805988-2A patent/BR9805988A/pt active Search and Examination
- 1998-06-12 JP JP50325799A patent/JP4358310B2/ja not_active Expired - Fee Related
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AU7963498A (en) | 1998-12-30 |
CA2263124A1 (en) | 1998-12-17 |
EP0925044B1 (en) | 2002-11-27 |
CA2263124C (en) | 2003-04-15 |
AU727825B2 (en) | 2000-12-21 |
JP4358310B2 (ja) | 2009-11-04 |
ES2187978T5 (es) | 2010-12-30 |
EP0925044A1 (en) | 1999-06-30 |
US5928282A (en) | 1999-07-27 |
ES2187978T3 (es) | 2003-06-16 |
WO1998056315A1 (en) | 1998-12-17 |
JP2001508692A (ja) | 2001-07-03 |
BR9805988A (pt) | 2000-11-07 |
DE69809697T3 (de) | 2011-05-05 |
DE69809697T2 (de) | 2003-04-10 |
CN1236310A (zh) | 1999-11-24 |
DE69809697D1 (de) | 2003-01-09 |
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