CN1138828A - 中空微胶囊的制备 - Google Patents
中空微胶囊的制备 Download PDFInfo
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- CN1138828A CN1138828A CN95191282A CN95191282A CN1138828A CN 1138828 A CN1138828 A CN 1138828A CN 95191282 A CN95191282 A CN 95191282A CN 95191282 A CN95191282 A CN 95191282A CN 1138828 A CN1138828 A CN 1138828A
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- microcapsule
- solution
- protein
- above arbitrary
- liquid
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- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
- 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- KFEVDPWXEVUUMW-UHFFFAOYSA-N docosanoic acid Natural products CCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 KFEVDPWXEVUUMW-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000008344 egg yolk phospholipid Substances 0.000 description 1
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- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
- IZOOGPBRAOKZFK-UHFFFAOYSA-K gadopentetate Chemical compound [Gd+3].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O IZOOGPBRAOKZFK-UHFFFAOYSA-K 0.000 description 1
- 229960003460 gadopentetic acid Drugs 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
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- 238000009434 installation Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 229960001025 iohexol Drugs 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 description 1
- 229960004647 iopamidol Drugs 0.000 description 1
- 229960004537 ioversol Drugs 0.000 description 1
- 229960001707 ioxaglic acid Drugs 0.000 description 1
- TYYBFXNZMFNZJT-UHFFFAOYSA-N ioxaglic acid Chemical compound CNC(=O)C1=C(I)C(N(C)C(C)=O)=C(I)C(C(=O)NCC(=O)NC=2C(=C(C(=O)NCCO)C(I)=C(C(O)=O)C=2I)I)=C1I TYYBFXNZMFNZJT-UHFFFAOYSA-N 0.000 description 1
- 230000003137 locomotive effect Effects 0.000 description 1
- 235000018977 lysine Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N methyl undecanoic acid Natural products CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011490 mineral wool Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 150000003077 polyols Chemical group 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 210000004777 protein coat Anatomy 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 210000003492 pulmonary vein Anatomy 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 1
- 229940066675 ricinoleate Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
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- 230000002792 vascular Effects 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
干燥空气 | 内部气温 | 外部气温 | 蒸发量 |
85kg/h | 150℃ | 80℃ | 1,3kg/h |
85kg/h | 170℃ | 85℃ | 1,7kg/h |
80kg/h | 200℃ | 90℃ | 2,5kg/h |
80kg/h | 240℃ | 90℃ | 3,4kg/h |
75kg/h | 350℃ | 90℃ | 7,0kg/h |
雾化压力(×105Pa) | %大于10μm的频率 |
6.0 | 0.8 |
5.0 | 3.0 |
3.5 | 6.6 |
2.5 | 8.6 |
2.0 | 13.1 |
批号 | 回声特性(VDU) | 加入微胶囊的浓度(μg/ml) | 总VDU,μg/ml微胶囊 |
AIP101/941 | 26 | 13.23 | 1.97 |
AIP101/942 | 26 | 12.29 | 2.11 |
AIP101/943 | 25 | 13.80 | 1.92 |
AIP101/944 | 26 | 12.47 | 2.09 |
平均结果 | - | - | 2.023±0.09 |
批号 | 回声特性(dB) | 加入微胶囊的Wt(μg/ml) | dB/μg/ml微胶囊 |
AIP101/941 | -7.4 | 13.23 | -0.56 |
AIP101/942 | -7.4 | 12.29 | -0.6 |
AIP101/943 | -7.3 | 13.80 | -0.53 |
AIP101/944 | -7.4 | 12.47 | -0.59 |
平均结果 | - | - | 0.57±0.04 |
流动速率(ml/min) | 4 | 8 | 12 | 16 |
平均尺寸(μm) | 3.08 | 3.04 | 3.13 | 3.07 |
回声特性(图像 密度 单位) | 22 | 21 | 14 | 10 |
受压后的回声特性(图像 密度 单位) | 20 | 18 | 10 | 8 |
Claims (19)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9423419.2 | 1994-11-19 | ||
GB9423419A GB9423419D0 (en) | 1994-11-19 | 1994-11-19 | Preparation of hollow microcapsules |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1138828A true CN1138828A (zh) | 1996-12-25 |
CN1072966C CN1072966C (zh) | 2001-10-17 |
Family
ID=10764705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95191282A Expired - Fee Related CN1072966C (zh) | 1994-11-19 | 1995-11-15 | 中空微胶囊的制备 |
Country Status (19)
Country | Link |
---|---|
US (2) | US5741478A (zh) |
EP (1) | EP0743860B2 (zh) |
JP (1) | JP4592831B2 (zh) |
KR (1) | KR100188356B1 (zh) |
CN (1) | CN1072966C (zh) |
AT (1) | ATE216595T1 (zh) |
AU (1) | AU681815B2 (zh) |
CA (1) | CA2177492C (zh) |
DE (1) | DE69526491T3 (zh) |
DK (1) | DK0743860T3 (zh) |
ES (1) | ES2174968T3 (zh) |
GB (2) | GB9423419D0 (zh) |
HK (1) | HK1013405A1 (zh) |
NO (1) | NO313491B1 (zh) |
PT (1) | PT743860E (zh) |
RU (1) | RU2193397C2 (zh) |
SG (1) | SG81230A1 (zh) |
WO (1) | WO1996015814A1 (zh) |
ZA (1) | ZA959801B (zh) |
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-
1994
- 1994-11-19 GB GB9423419A patent/GB9423419D0/en active Pending
-
1995
- 1995-11-15 AU AU38533/95A patent/AU681815B2/en not_active Ceased
- 1995-11-15 RU RU96116133/14A patent/RU2193397C2/ru not_active IP Right Cessation
- 1995-11-15 ES ES95936688T patent/ES2174968T3/es not_active Expired - Lifetime
- 1995-11-15 GB GB9610968A patent/GB2298628B/en not_active Expired - Fee Related
- 1995-11-15 WO PCT/GB1995/002673 patent/WO1996015814A1/en active IP Right Grant
- 1995-11-15 AT AT95936688T patent/ATE216595T1/de not_active IP Right Cessation
- 1995-11-15 JP JP51665396A patent/JP4592831B2/ja not_active Expired - Fee Related
- 1995-11-15 US US08/676,344 patent/US5741478A/en not_active Expired - Lifetime
- 1995-11-15 CN CN95191282A patent/CN1072966C/zh not_active Expired - Fee Related
- 1995-11-15 EP EP95936688A patent/EP0743860B2/en not_active Expired - Lifetime
- 1995-11-15 KR KR1019960703464A patent/KR100188356B1/ko not_active IP Right Cessation
- 1995-11-15 SG SG9800856A patent/SG81230A1/en unknown
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- 1995-11-15 DE DE69526491T patent/DE69526491T3/de not_active Expired - Lifetime
- 1995-11-15 PT PT95936688T patent/PT743860E/pt unknown
- 1995-11-15 DK DK95936688T patent/DK0743860T3/da active
- 1995-11-17 ZA ZA959801A patent/ZA959801B/xx unknown
-
1996
- 1996-07-18 NO NO19962994A patent/NO313491B1/no not_active IP Right Cessation
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1998
- 1998-02-13 US US09/023,696 patent/US6623722B1/en not_active Expired - Fee Related
- 1998-12-22 HK HK98114794A patent/HK1013405A1/xx not_active IP Right Cessation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN100500275C (zh) * | 2002-12-19 | 2009-06-17 | 阿库斯菲尔公司 | 使用喷雾干燥器和内连气流粉碎机制备粒子的方法和设备 |
CN104288793A (zh) * | 2014-10-31 | 2015-01-21 | 苏州大学 | 纳米超声/荧光双模态造影剂、其制备方法与应用 |
CN111389315A (zh) * | 2020-03-27 | 2020-07-10 | 南京芬之怡生物科技有限公司 | 一种绿色除异净化剂及其制备方法 |
CN114265256A (zh) * | 2021-12-30 | 2022-04-01 | 广东志慧芯屏科技有限公司 | 一种电子纸显示设备的制造方法及电子纸显示设备 |
Also Published As
Publication number | Publication date |
---|---|
PT743860E (pt) | 2002-10-31 |
US5741478A (en) | 1998-04-21 |
DE69526491T3 (de) | 2009-07-30 |
EP0743860A1 (en) | 1996-11-27 |
RU2193397C2 (ru) | 2002-11-27 |
NO313491B1 (no) | 2002-10-14 |
WO1996015814A1 (en) | 1996-05-30 |
EP0743860B2 (en) | 2008-12-31 |
CA2177492C (en) | 2003-03-25 |
ATE216595T1 (de) | 2002-05-15 |
AU3853395A (en) | 1996-06-17 |
AU681815B2 (en) | 1997-09-04 |
GB2298628B (en) | 1998-08-05 |
HK1013405A1 (en) | 1999-08-27 |
ES2174968T3 (es) | 2002-11-16 |
US6623722B1 (en) | 2003-09-23 |
CA2177492A1 (en) | 1996-05-30 |
GB2298628A (en) | 1996-09-11 |
EP0743860B1 (en) | 2002-04-24 |
SG81230A1 (en) | 2001-06-19 |
DK0743860T3 (da) | 2002-08-12 |
NO962994D0 (no) | 1996-07-18 |
JPH09508067A (ja) | 1997-08-19 |
NO962994L (no) | 1996-07-18 |
CN1072966C (zh) | 2001-10-17 |
KR100188356B1 (ko) | 1999-06-01 |
DE69526491T2 (de) | 2002-10-31 |
MX9602851A (es) | 1997-12-31 |
GB9423419D0 (en) | 1995-01-11 |
DE69526491D1 (de) | 2002-05-29 |
ZA959801B (en) | 1996-08-28 |
JP4592831B2 (ja) | 2010-12-08 |
GB9610968D0 (en) | 1996-07-31 |
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