CN1132566C - 在胶囊中填充囊芯的方法和由该方法制得的固体剂型 - Google Patents
在胶囊中填充囊芯的方法和由该方法制得的固体剂型 Download PDFInfo
- Publication number
- CN1132566C CN1132566C CN95196811A CN95196811A CN1132566C CN 1132566 C CN1132566 C CN 1132566C CN 95196811 A CN95196811 A CN 95196811A CN 95196811 A CN95196811 A CN 95196811A CN 1132566 C CN1132566 C CN 1132566C
- Authority
- CN
- China
- Prior art keywords
- capsule
- dosage forms
- solid dosage
- core
- moisture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
Abstract
Description
Claims (52)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35813794A | 1994-12-16 | 1994-12-16 | |
US08/358,137 | 1994-12-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1170346A CN1170346A (zh) | 1998-01-14 |
CN1132566C true CN1132566C (zh) | 2003-12-31 |
Family
ID=23408454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95196811A Expired - Lifetime CN1132566C (zh) | 1994-12-16 | 1995-11-09 | 在胶囊中填充囊芯的方法和由该方法制得的固体剂型 |
Country Status (14)
Country | Link |
---|---|
US (1) | US6080426A (zh) |
EP (1) | EP0797424B1 (zh) |
JP (1) | JP3670016B2 (zh) |
KR (1) | KR100468335B1 (zh) |
CN (1) | CN1132566C (zh) |
AT (1) | ATE194486T1 (zh) |
CA (1) | CA2205553C (zh) |
DE (1) | DE69518006T2 (zh) |
DK (1) | DK0797424T3 (zh) |
ES (1) | ES2150017T3 (zh) |
GR (1) | GR3034491T3 (zh) |
MX (1) | MX9703773A (zh) |
PT (1) | PT797424E (zh) |
WO (1) | WO1996018370A1 (zh) |
Families Citing this family (64)
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US6245350B1 (en) * | 1994-12-16 | 2001-06-12 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
CA2205553C (en) * | 1994-12-16 | 2009-04-07 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
FR2757173A1 (fr) * | 1996-12-17 | 1998-06-19 | Warner Lambert Co | Compositions polymeres d'origine non-animale pour la formation de films |
US6428809B1 (en) * | 1999-08-18 | 2002-08-06 | Microdose Technologies, Inc. | Metering and packaging of controlled release medication |
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
US20030224047A1 (en) * | 2001-02-15 | 2003-12-04 | Franz G. Andrew | Levothyroxine compositions and methods |
US20030032675A1 (en) * | 2001-02-15 | 2003-02-13 | Franz G. Andrew | Manufacture of thyroid hormone tablets having consistent active moiety amounts |
JP2004525109A (ja) * | 2001-02-15 | 2004-08-19 | キング・ファーマシューティカルズ・インコーポレイティッド | 安定化された甲状腺ホルモン医薬組成物、及びその製法 |
US20030070584A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
AU4061702A (en) * | 2001-05-15 | 2003-04-03 | Mcneil-Ppc, Inc. | Dip coating compositions containing starch or dextrin |
US20030072731A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing starch or dextrin |
DE10125883A1 (de) | 2001-05-28 | 2002-12-12 | Serumwerk Bernburg Ag | Arzneimittel enthaltend einen Effektor des Glutathionmetabolismus zusammen mit alpha-Liponsäure im Rahmen der Nierenersatztherapie |
WO2002098403A1 (en) * | 2001-06-01 | 2002-12-12 | Georgetown University | Steroid hormone and non-steroidal anti-inflammatory drug combinations for inducing tumor cell apoptosis |
ITMI20011401A1 (it) * | 2001-07-02 | 2003-01-02 | Altergon Sa | Formulazioni farmaceutiche per ormoni tiroidei |
US20030198667A1 (en) * | 2001-08-10 | 2003-10-23 | Franz Andrew G. | Methods of producing dispersible pharmaceutical compositions |
US20030198671A1 (en) * | 2001-08-10 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique plasma AUC properties |
US20030190349A1 (en) * | 2001-08-10 | 2003-10-09 | Franz G. Andrew | Methods of stabilizing pharmaceutical compositions |
US20030180353A1 (en) * | 2001-08-10 | 2003-09-25 | Franz G. Andrew | Stabilized pharmaceutical compositions |
US20030198672A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique triidothyronine plasma AUC properties |
US20030199586A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Unique levothyroxine aqueous materials |
US20030195253A1 (en) * | 2001-08-14 | 2003-10-16 | Franz G. Andrew | Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration |
US20030199587A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique Cmax properties |
US20030203967A1 (en) * | 2001-08-14 | 2003-10-30 | Franz G. Andrew | Levothyroxine compositions having unique Tmax properties |
US20040253312A1 (en) | 2001-09-28 | 2004-12-16 | Sowden Harry S. | Immediate release dosage form comprising shell having openings therein |
US20040146559A1 (en) * | 2002-09-28 | 2004-07-29 | Sowden Harry S. | Dosage forms having an inner core and outer shell with different shapes |
US8309118B2 (en) * | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
US20030165564A1 (en) * | 2001-10-29 | 2003-09-04 | Franz G. Andrew | Levothyroxine compositions having unique triiodothyronine Tmax properties |
US20030166732A1 (en) * | 2002-02-27 | 2003-09-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol for the treatment of painful conditions in the mouth and pharyngeal cavity |
US6946156B2 (en) * | 2002-05-15 | 2005-09-20 | Mcneil-Ppc, Inc. | Process for enrobing a core |
US7169450B2 (en) | 2002-05-15 | 2007-01-30 | Mcneil-Ppc, Inc. | Enrobed core |
US7429619B2 (en) * | 2002-08-02 | 2008-09-30 | Mcneil Consumer Healthcare | Polyacrylic film forming compositions |
EP1396263A1 (en) * | 2002-08-09 | 2004-03-10 | Warner-Lambert Company | Film coating for tablets and caplets |
NZ538842A (en) | 2002-09-28 | 2008-03-28 | Mcneil Ppc Inc | Immediate release dosage form comprising a solid core of density 0.9 g/ml surrounded by a shell that is readily soluble to gastrointestinal fluids |
US20050079213A1 (en) * | 2003-06-06 | 2005-04-14 | Unilab Pharmatech Ltd | Pharmaceutical compositions |
CN1893956A (zh) * | 2003-07-25 | 2007-01-10 | 沃纳奇尔科特公司 | 多西环素金属络合物固体剂型 |
ATE354354T1 (de) * | 2003-07-30 | 2007-03-15 | Merrion Res I Ltd | Verfahren und maschine für die automatische herstellung von magensaftresistenten kapseln |
US8067029B2 (en) | 2004-01-13 | 2011-11-29 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US7879354B2 (en) | 2004-01-13 | 2011-02-01 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US20050202079A1 (en) * | 2004-03-15 | 2005-09-15 | Mylan Pharmaceuticals Inc. | Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation |
US20080102116A1 (en) * | 2004-09-13 | 2008-05-01 | Perrigo Company | Quick Dissolve Medicament and Method of Manufacturing |
JP5235416B2 (ja) * | 2005-01-21 | 2013-07-10 | ワーナー・チルコット・カンパニー・エルエルシー | 固体投与形中のテトラサイクリン金属錯体 |
US20060222699A1 (en) * | 2005-03-29 | 2006-10-05 | Jonathan Gilinski | Flavored vegetarian cellulose capsule and methods for producing said capsule. |
US20070072910A1 (en) * | 2005-09-29 | 2007-03-29 | Smith Michael L | Compositions and methods for lowering plasma concentrations of low density lipoproteins in humans |
EP2001451B1 (en) * | 2006-03-28 | 2010-08-11 | Mcneil-PPC, Inc | Non-homogenous dosage form coatings |
JP5243434B2 (ja) | 2006-09-15 | 2013-07-24 | ファイザー・プロダクツ・インク | 急速に崩壊する錠剤 |
US20100029788A1 (en) * | 2006-09-29 | 2010-02-04 | John Pelesko | Wet edible pearlescent film coatings |
US20080145493A1 (en) * | 2006-12-14 | 2008-06-19 | Sensient Colors Inc. | Pearlescent pigment compositions and methods for making and using the same |
US20100172991A1 (en) * | 2007-06-08 | 2010-07-08 | Henry Joseph Horacek | Extended Release Formulation and Methods of Treating Adrenergic Dysregulation |
WO2008154339A2 (en) * | 2007-06-08 | 2008-12-18 | Addrenex Pharmaceuticals, Inc. | Extended release formulation and method of treating adrenergic dysregulation |
US20100092548A1 (en) * | 2008-08-28 | 2010-04-15 | Viva Pharmaceuticals Inc. | Chewable softgel capsules |
WO2010065069A2 (en) * | 2008-12-01 | 2010-06-10 | In Vasc Therapeutics, Inc. | Compositions comprising renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, and the use thereof for the treatment of renin-angiotensin aldosterone system related disorders |
EP2605760B1 (en) | 2010-08-18 | 2017-01-11 | Johnson & Johnson Consumer Inc. | Tablet sleeve for improved performance |
US9119793B1 (en) | 2011-06-28 | 2015-09-01 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for doxycycline |
CN102688212B (zh) * | 2012-05-29 | 2013-08-07 | 北京均大高科科技孵化器有限公司 | 一种单硝酸异山梨酯缓释片及其制备方法 |
US20140141075A1 (en) | 2012-11-21 | 2014-05-22 | Warner Chilcott Company, Llc | 5-aminosalicylic acid capsule formulation |
US10842802B2 (en) | 2013-03-15 | 2020-11-24 | Medicis Pharmaceutical Corporation | Controlled release pharmaceutical dosage forms |
CN103461336B (zh) * | 2013-09-26 | 2015-08-05 | 卞佳林 | 一种多杀菌素和灰黄霉素复合微囊杀虫剂 |
CN103461335B (zh) * | 2013-09-26 | 2015-08-05 | 卞佳林 | 一种多杀菌素和灰黄霉素复合微囊杀虫剂的制备方法 |
EP3167870B1 (en) | 2015-11-16 | 2024-01-03 | Capsugel Belgium NV | Tamperproof oral dosage form |
EP3167869A1 (en) | 2015-11-16 | 2017-05-17 | Capsugel Belgium NV | Tamperproof oral dosage form |
US11318101B2 (en) | 2016-07-06 | 2022-05-03 | Qualicaps Co., Ltd. | Hard capsule having improved hardness, and method for manufacturing same |
RU2749902C2 (ru) * | 2018-10-31 | 2021-06-18 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Фармацевтическая композиция для лечения инфекционно-воспалительных заболеваний |
CN110279890A (zh) * | 2019-04-15 | 2019-09-27 | 首都医科大学附属北京世纪坛医院 | 基于脂质体的地塞米松/米诺环素在peek表面的修饰方法及应用 |
EP3805577A1 (en) * | 2019-10-11 | 2021-04-14 | Hilti Aktiengesellschaft | Threadlike package |
Citations (5)
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US3258115A (en) * | 1965-05-12 | 1966-06-28 | Scherer Corp R P | Two-piece hard gelatin capsule |
GB1496737A (en) * | 1974-06-12 | 1977-12-30 | Scherer Corp R P | Capsule especially for medicaments |
US4466844A (en) * | 1983-09-19 | 1984-08-21 | Cosden Technology, Inc. | Gripper for capsule welder |
EP0225565A2 (de) * | 1985-12-06 | 1987-06-16 | Boehringer Ingelheim Kg | Teilbare Kapsel |
EP0435726A2 (en) * | 1989-12-29 | 1991-07-03 | Bristol-Myers Squibb Company | Capsule and caplet combination |
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CA2205553C (en) * | 1994-12-16 | 2009-04-07 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
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-
1995
- 1995-11-09 CA CA002205553A patent/CA2205553C/en not_active Expired - Lifetime
- 1995-11-09 CN CN95196811A patent/CN1132566C/zh not_active Expired - Lifetime
- 1995-11-09 DK DK95939890T patent/DK0797424T3/da active
- 1995-11-09 WO PCT/US1995/014651 patent/WO1996018370A1/en active IP Right Grant
- 1995-11-09 EP EP95939890A patent/EP0797424B1/en not_active Expired - Lifetime
- 1995-11-09 MX MX9703773A patent/MX9703773A/es unknown
- 1995-11-09 KR KR1019970704011A patent/KR100468335B1/ko not_active IP Right Cessation
- 1995-11-09 JP JP51881996A patent/JP3670016B2/ja not_active Expired - Fee Related
- 1995-11-09 DE DE69518006T patent/DE69518006T2/de not_active Expired - Lifetime
- 1995-11-09 ES ES95939890T patent/ES2150017T3/es not_active Expired - Lifetime
- 1995-11-09 AT AT95939890T patent/ATE194486T1/de active
- 1995-11-09 PT PT95939890T patent/PT797424E/pt unknown
-
1996
- 1996-01-11 US US08/585,549 patent/US6080426A/en not_active Expired - Lifetime
-
2000
- 2000-09-26 GR GR20000402180T patent/GR3034491T3/el unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3258115A (en) * | 1965-05-12 | 1966-06-28 | Scherer Corp R P | Two-piece hard gelatin capsule |
GB1496737A (en) * | 1974-06-12 | 1977-12-30 | Scherer Corp R P | Capsule especially for medicaments |
US4466844A (en) * | 1983-09-19 | 1984-08-21 | Cosden Technology, Inc. | Gripper for capsule welder |
EP0225565A2 (de) * | 1985-12-06 | 1987-06-16 | Boehringer Ingelheim Kg | Teilbare Kapsel |
EP0435726A2 (en) * | 1989-12-29 | 1991-07-03 | Bristol-Myers Squibb Company | Capsule and caplet combination |
Also Published As
Publication number | Publication date |
---|---|
DE69518006T2 (de) | 2000-12-21 |
US6080426A (en) | 2000-06-27 |
ES2150017T3 (es) | 2000-11-16 |
JP3670016B2 (ja) | 2005-07-13 |
GR3034491T3 (en) | 2000-12-29 |
EP0797424A1 (en) | 1997-10-01 |
DK0797424T3 (da) | 2000-10-23 |
EP0797424B1 (en) | 2000-07-12 |
CN1170346A (zh) | 1998-01-14 |
DE69518006D1 (de) | 2000-08-17 |
ATE194486T1 (de) | 2000-07-15 |
WO1996018370A1 (en) | 1996-06-20 |
JPH11500326A (ja) | 1999-01-12 |
MX9703773A (es) | 1997-08-30 |
CA2205553C (en) | 2009-04-07 |
CA2205553A1 (en) | 1996-06-20 |
PT797424E (pt) | 2000-10-31 |
KR980700050A (ko) | 1998-03-30 |
KR100468335B1 (ko) | 2005-09-02 |
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