CN1093897A - The preparation method of surface anesthesia film - Google Patents
The preparation method of surface anesthesia film Download PDFInfo
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- CN1093897A CN1093897A CN 93104370 CN93104370A CN1093897A CN 1093897 A CN1093897 A CN 1093897A CN 93104370 CN93104370 CN 93104370 CN 93104370 A CN93104370 A CN 93104370A CN 1093897 A CN1093897 A CN 1093897A
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- anesthetis
- preparation
- lignocaine
- effect
- hydrochloride
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Abstract
The present invention relates to anaesthetize the preparation method of liniment, is a kind of adding anesthetis, the surface anesthesia film compound method of antibacterial and vasoconstrictor.Because used anesthetis in the cosmetic surgery at present, medicament contg is big, and anaesthetic effect is poor, also has the danger of toxigenicity effect.The present invention mixes anesthetis (tetracaine hydrochloride or lignocaine), chlorhexidine acetate, epinephrine, transdermal enhancer (propylene glycol, dimethyl sulfoxide, Mentholum etc.), soluble high-molecular filmogen (PVA, CMC etc.), ethanol, distilled water by a certain percentage, is made into the surface coating agent that contains anesthetis (tetracaine hydrochloride or lignocaine) 1.0~5.0%.This new anesthetis can very fast transdermal surface, anaesthetic effect is obviously improved, and have infection, reduces the effect of drug toxicity.
Description
The present invention relates to the preparation method of liniment, is a kind of adding anesthetis, the surface anesthesia film compound method of antibacterial and vasoconstrictor.
At present in beauty treatment and the clinical operation, normal employing topical anesthesia, anesthetis commonly used is 10~20% lignocaine sprays and 2~10% tetracaine solutions, because these two kinds of anesthetis all have the danger of toxigenicity effect, especially when profiling eyelid line, very easily cause corneal injury.Tetracaine solution anaesthetic effect is poor, and toxicity strengthened when content was big.Lignocaine spray anaesthetic effect is better, and dawn toxicity is big, needs special installation during preparation, and cost is higher.
In the problem and cosmetic surgery at above-mentioned anesthetis existence, the needs of topical anesthesia, the object of the present invention is to provide a kind of compound method of surface anesthesia film, be about to anesthetis, antibacterial, transdermal enhancer, vasoconstrictor, the soluble high-molecular filmogen, the second alcohol and water is mixed with surface anesthesia film in proportion, make this liniment of new preparation, be applied to very fast formation one thin film behind the skin surface, medicine energy quick penetration skin surface, strengthen anaesthetic effect, reducing toxic and side effects and can prevent local infection, is beauty treatment and the comparatively ideal anesthetis of clinical operation.
Technological means of the present invention is, (PVA, CMC etc.) are added in the distilled water with a certain amount of water soluble polymer filmogen, and fully swelling post-heating (being lower than 95 ℃) dissolves it fully, makes colloid solution (I).In addition anesthetis (tetracaine hydrochloride or lignocaine), chlorhexidine acetate, adrenalin hydrochloride, transdermal enhancer (propylene glycol, Mentholum, the inferior maple of dimethyl etc.) are dissolved in the alcoholic solution by a certain percentage, obtain medicine alcoholic solution (II).Then (II) under agitation is added in (I) of insulation about 60 ℃, mixed evenly after, be cooled to room temperature and both can.In its process for preparation, the consumption of various compositions by volume calculates, and its umber ratio is:
(Ⅰ)∶(Ⅱ)=20~30∶70~80
The percentage composition W/V(% of the various compositions in preparation back) is: anesthetis 1.0~5.0, chlorhexidine acetate 0.05~0.1, filmogen 2~3, transdermal enhancer 5~15, adrenalin hydrochloride 0.0005~0.001, ethanol 45~55, distilled water 30~50.
The surface anesthesia film that adopts compound method of the present invention to make has reduced narcotic content, has improved anaesthetic effect, clinical cosmetic surgery 336 examples that are used for, double-fold eyelid operation 60 examples wherein, profiling eyelid line 240 examples, lip tattooing line 12 examples, eyebrow tattooing 24 examples, the proof anaesthetic effect is good, easy and simple to handle, and consumption is little, cost is low, and skin is had no adverse reaction.
Embodiment one:
PVA-1750 2.7g is added in the 30ml distilled water, and abundant swelling post-heating to 80 ℃ dissolves about postcooling to 60 ℃ fully, get colloid solution, in addition with propylene glycol 10ml, tetracaine hydrochloride 2.5g, chlorhexidine acetate 0.1g, adrenalin hydrochloride 1mg, be dissolved in 60ml 80% alcoholic solution successively, behind the mix homogeneously, under agitation be added in the colloid solution, mix homogeneously, being cooled to room temperature, promptly to make tetracaine content be 2.5% surface anesthesia film.
Embodiment two:
PVA-1750 2.5g is mixed with the 30ml distilled water, fully swelling post-heating to 80 ℃ dissolving fully is cooled to about 60 ℃, gets colloid solution, in addition with propylene glycol 12ml, lignocaine 5.0g, chlorhexidine acetate 0.05g, adrenalin hydrochloride 0.5mg, be dissolved in successively in 58ml 75% alcoholic solution, mix homogeneously under agitation is added in the colloid solution, and behind the mix homogeneously, being cooled to room temperature, promptly to make lignocaine content be 5.0% surface anesthesia film.
Claims (3)
1, a kind of preparation method of surface anesthesia film, it is characterized in that: (PVA, CMC etc.) mix with distilled water in proportion with the water soluble polymer filmogen, fully swelling post-heating dissolving (being lower than 95 ℃), be cooled to and get colloid solution (I) about 60 ℃, be dissolved in tetracaine hydrochloride (or lignocaine), chlorhexidine acetate, adrenalin hydrochloride and propylene glycol (or the inferior maple of dimethyl, Mentholum etc.) in the alcoholic solution by a certain percentage in addition, get medicine alcoholic solution (II), under agitation (II) is added in (I), mix homogeneously postcooling to room temperature is made.
2, according to the described compound method of claim 1, it is characterized in that: during preparation, various compositions by volume calculate, and its umber ratio is:
(Ⅰ)∶(Ⅱ)=20~30∶70~80。
3, according to claim 1 and 2 described compound methods, it is characterized in that: the percentage composition w/v(% of the various compositions in preparation back) be:
Tetracaine hydrochloride (or lignocaine) 1.0~5.0, filmogen (PVA, CMC etc.) 2~3, chlorhexidine acetate 0.05~0.1, adrenalin hydrochloride 0.0005~0.001, propylene glycol (or the inferior maple of dimethyl, Mentholum etc.) 5~15, ethanol 45~55, distilled water 30~50.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN93104370A CN1050748C (en) | 1993-04-22 | 1993-04-22 | Production method for surface anesthesia film |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN93104370A CN1050748C (en) | 1993-04-22 | 1993-04-22 | Production method for surface anesthesia film |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1093897A true CN1093897A (en) | 1994-10-26 |
CN1050748C CN1050748C (en) | 2000-03-29 |
Family
ID=4985164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN93104370A Expired - Fee Related CN1050748C (en) | 1993-04-22 | 1993-04-22 | Production method for surface anesthesia film |
Country Status (1)
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CN (1) | CN1050748C (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1069826C (en) * | 1997-04-25 | 2001-08-22 | 浙江省中医院 | Freezing-dried tetracaine hydrochloride powder injection |
US6299902B1 (en) | 1999-05-19 | 2001-10-09 | The University Of Georgia Research Foundation, Inc. | Enhanced transdermal anesthesia of local anesthetic agents |
CN103505791A (en) * | 2012-06-28 | 2014-01-15 | 杨德普 | Transdermal-absorption local-anesthesia painless injection puncture alcohol pad |
CN104352485A (en) * | 2014-11-12 | 2015-02-18 | 武汉大学 | Tetracaine hydrochloride oral cavity anesthetic liquid and preparation method thereof |
US9272038B2 (en) | 2007-09-21 | 2016-03-01 | Innovation Ulster Limited | Wound care formulation |
CN106983740A (en) * | 2017-05-19 | 2017-07-28 | 中山大学孙逸仙纪念医院 | A kind of surface of a wound anesthesia lotion and preparation method thereof |
CN107252490A (en) * | 2017-07-12 | 2017-10-17 | 云平 | A kind of local anaesthesia medicine and preparation method thereof |
CN107847344A (en) * | 2015-05-21 | 2018-03-27 | 网关设备有限公司 | Vein access device |
CN110090197A (en) * | 2019-04-19 | 2019-08-06 | 广州芮一生物科技有限公司 | A kind of film-formable anesthesia face mask cream |
CN112972682A (en) * | 2014-10-19 | 2021-06-18 | 阿祖拉眼科有限公司 | Compositions and methods for treating meibomian gland dysfunction |
CN116585451A (en) * | 2023-01-18 | 2023-08-15 | 中国牧工商集团有限公司 | Lidocaine hydrochloride spray containing antibacterial and antioxidant moringa seed polypeptide for pets and preparation method of lidocaine hydrochloride spray |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01230514A (en) * | 1987-11-25 | 1989-09-14 | Osaka Aerosol Ind Corp | Aerosol type patch external use |
CN1041894C (en) * | 1990-04-30 | 1999-02-03 | 石光生 | Aerosols for protective film of medicine "Hemostatic-Yantongting" |
-
1993
- 1993-04-22 CN CN93104370A patent/CN1050748C/en not_active Expired - Fee Related
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1069826C (en) * | 1997-04-25 | 2001-08-22 | 浙江省中医院 | Freezing-dried tetracaine hydrochloride powder injection |
US6299902B1 (en) | 1999-05-19 | 2001-10-09 | The University Of Georgia Research Foundation, Inc. | Enhanced transdermal anesthesia of local anesthetic agents |
US9272038B2 (en) | 2007-09-21 | 2016-03-01 | Innovation Ulster Limited | Wound care formulation |
CN103505791A (en) * | 2012-06-28 | 2014-01-15 | 杨德普 | Transdermal-absorption local-anesthesia painless injection puncture alcohol pad |
CN112972682A (en) * | 2014-10-19 | 2021-06-18 | 阿祖拉眼科有限公司 | Compositions and methods for treating meibomian gland dysfunction |
US11633410B2 (en) | 2014-10-19 | 2023-04-25 | Azura Ophthalmics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
CN104352485A (en) * | 2014-11-12 | 2015-02-18 | 武汉大学 | Tetracaine hydrochloride oral cavity anesthetic liquid and preparation method thereof |
CN107847344A (en) * | 2015-05-21 | 2018-03-27 | 网关设备有限公司 | Vein access device |
CN106983740A (en) * | 2017-05-19 | 2017-07-28 | 中山大学孙逸仙纪念医院 | A kind of surface of a wound anesthesia lotion and preparation method thereof |
CN107252490A (en) * | 2017-07-12 | 2017-10-17 | 云平 | A kind of local anaesthesia medicine and preparation method thereof |
CN107252490B (en) * | 2017-07-12 | 2019-12-03 | 云平 | A kind of local anaesthesia drug and preparation method thereof |
CN110090197A (en) * | 2019-04-19 | 2019-08-06 | 广州芮一生物科技有限公司 | A kind of film-formable anesthesia face mask cream |
CN116585451A (en) * | 2023-01-18 | 2023-08-15 | 中国牧工商集团有限公司 | Lidocaine hydrochloride spray containing antibacterial and antioxidant moringa seed polypeptide for pets and preparation method of lidocaine hydrochloride spray |
CN116585451B (en) * | 2023-01-18 | 2024-01-02 | 中国牧工商集团有限公司 | Lidocaine hydrochloride spray containing antibacterial and antioxidant moringa seed polypeptide for pets and preparation method of lidocaine hydrochloride spray |
Also Published As
Publication number | Publication date |
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CN1050748C (en) | 2000-03-29 |
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