CN1085106A - The ophthalmologic operation visco-elastic material that has fluorescence - Google Patents
The ophthalmologic operation visco-elastic material that has fluorescence Download PDFInfo
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- CN1085106A CN1085106A CN 93118792 CN93118792A CN1085106A CN 1085106 A CN1085106 A CN 1085106A CN 93118792 CN93118792 CN 93118792 CN 93118792 A CN93118792 A CN 93118792A CN 1085106 A CN1085106 A CN 1085106A
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- Prior art keywords
- visco
- elastic material
- hyaluronate sodium
- fluorescence
- ophthalmologic operation
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Abstract
A kind of ophthalmologic operation visco-elastic material that has fluorescence, be by 1-2% hyaluronate sodium or hyaluronate sodium and chondroitin sulfate mixture, methylcellulose, polyacrylamide, hydroxypropyl emthylcellulose, with 98-99% balanced salt solution or physiological buffer, and 0.1 * 10
-4～5 * 10
-4The medical fluorescent agent of % (weight) is formed.Its outward appearance has the fluorescence of oyster, but under natural light clear view visco-elastic material room before eyes distribution situation and the operation after whether visco-elastic material is rinsed well, help patient's postoperative recovery, through thousands of routine clinical verifications, effect is very good.
Description
The present invention relates to a kind of ophthalmologic operation with visco-elastic material (also claiming the viscoelasticity agent), especially a kind of visco-elastic material that has fluorescent.
Since the eighties, international ophthalmology educational circles is in intraocular surgery, and the widespread usage visco-elastic material is as the camera oculi anterior filler.The effect in ophthalmologic operation by a large amount of zooperies and clinical research proof visco-elastic material: can keep the ophthalmic space, make eye inner tissue's clear layer and keep original position; The protection endothelial cell is avoided mechanical injuries; Energy separation of synechia tissue; Also play lubricant simultaneously, the effect of filler and protectiveness machinery pad.
The visco-elastic material of using clinically mainly contains at present: hyaluronate sodium, hyaluronate sodium and chondroitin sulfate mixture, methylcellulose, hydroxypropyl emthylcellulose and polyacrylamide etc.Whether these visco-elastic materials mostly are colourless, and this promptly is unfavorable for observing the distribution situation of annotating people anterior chamber's visco-elastic material, visco-elastic material is rinsed well after also being unfavorable for observing operation.Because afterflush is clean more performing the operation, help patient's postoperative recovery more.Abroad once be reported in the visco-elastic material and add Placenta Hominis indigo plant it is had blueness, confirmed afterwards that this dyestuff had carcinogenesis disabled.
The objective of the invention is for a visco-elastic material that has a fluorescent is provided.
Use the visco-elastic material that has fluorescent at ophthalmologic operation, be by medical fluorescent agent, balanced salt solution or physiological buffer, hyaluronate sodium or hyaluronate sodium and chondroitin sulfate mixture, methylcellulose, polyacrylamide, hydroxypropyl emthylcellulose are formed, it is characterized in that weight at 1-2%() hyaluronate sodium or hyaluronate sodium and chondroitin sulfate mixture, methylcellulose, polyacrylamide, hydroxypropyl four basic celluloses, with 98-99%(weight) balanced salt solution or each visco-elastic material of forming of physiological buffer in, add 0.1 * 10
-4～5 * 10
-4%(weight) medical fluorescent agent.
Below in conjunction with embodiment technical characterictic of the present invention is further specified:
Embodiment 1, prepares 100 milliliter of 2% hydroxypropyl emthylcellulose that has fluorescent:
1, taking by weighing hydroxypropyl emthylcellulose is 2 grams.
2, make even the weighing apparatus saline solution be 30 milliliters, adding medical fluorescent agent therein is 0.1～5 * 10
-4Restrain, put into 80 ℃ water-bath then.
3, with 2 gram hydroxypropyl emthylcelluloses, join in the above-mentioned balanced salt solution, stirred 30 minutes.
4, take off the balanced salt solution that is mixed with medical fluorescent agent and hydroxypropyl emthylcellulose from water-bath, and then the balanced salt solution that adds pre-cooling is 68ml, and puts into its temperature of refrigerator and be controlled at 0～-10 ℃ of scope that the time is 18-24 hour.
5, after 18-24 hour, take out and treat to melt fully, with G-3 remelting funnel filter, sealing, 120 ℃ of reheat were through 20-40 minute autoclaving.
Embodiment 2, prepare the hyaluronate sodium of 100 milliliter of 1% band fluorescent:
1, rooster comb or people's umbilical cord are cleaned, chopping through protease hydrolysis, ethanol precipitation, chloroform processing, CPC complexation, ethanol repeated precipitation, drying, obtains the hyaluronate sodium elaboration.
2, taking by weighing the hyaluronate sodium elaboration is 1 gram.
3, getting physiological buffer is 99 milliliters, adds 0.1～5 * 10 therein
-4The medical fluorescent agent of gram.
4, the hyaluronate sodium elaboration of 1 grammes per square metre is joined in the above-mentioned physiological buffer that contains fluorescent agent, and carry out jolting it is fully dissolved.
5, with filter filtration, degerming.
6, under aseptic and ultra-clean condition, packing.
More than be to utilize hydroxypropyl emthylcellulose sodium and hyaluronate sodium manufacturing to have the concrete grammar of the viscoelasticity thing of fluorescent, also can adopt above-mentioned same procedure to make methylcellulose, other three kinds of visco-elastic materials that have fluorescent such as polyacrylamide and hyaluronate sodium and chondroitin sulfate mixture.
Visco-elastic material only helps out in ophthalmologic operation, do not play therapeutical effect, generally after operation, to as far as possible it be rinsed well, small amount of residual does not generally have any impact to ocular tissue, the residual patient's eyes voltage rise height that too much can cause, influence the postoperative recovery of patient, but the visco-elastic material great majority of producing are colourless at present, whether rinse well after being unfavorable for observing operation, visco-elastic material provided by the present invention, its outward appearance is the fluorescent that oyster is arranged, and with the naked eye can clearly differentiate under available light.Utilize it to have the characteristic of fluorescent, under operating microscope by the ultraviolet filter on the operating microscope, but whether visco-elastic material is rinsed well after clear view visco-elastic material room before eyes distribution situation and the operation, helped patient's postoperative recovery.More than employed hyaluronate sodium, hyaluronate sodium and chondroitin sulfate mixture, methylcellulose, hydroxypropyl emthylcellulose, polyacrylamide, balanced salt solution and medical fluorescent agent etc. are known products.
The present invention implements easily, is convenient to use, and through thousands of routine clinical verifications, effect is very good.
Claims (1)
- A kind of ophthalmologic operation visco-elastic material that has fluorescent, be by medical fluorescent agent, balanced salt solution or physiological buffer, hyaluronate sodium or hyaluronate sodium and chondroitin sulfate mixture, methylcellulose, polyacrylamide, hydroxypropyl emthylcellulose are formed, it is characterized in that the hyaluronate sodium of 1-2% (weight) or hyaluronate sodium and chondroitin sulfate mixture, methylcellulose, polyacrylamide, hydroxypropyl emthylcellulose, with the balanced salt solution of 98-99% (weight) or each visco-elastic material that physiological buffer is formed in, add 0.1 * 10 -4～5 * 10 -4The medical fluorescent agent of % (weight).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93118792 CN1085106A (en) | 1993-10-27 | 1993-10-27 | The ophthalmologic operation visco-elastic material that has fluorescence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93118792 CN1085106A (en) | 1993-10-27 | 1993-10-27 | The ophthalmologic operation visco-elastic material that has fluorescence |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1085106A true CN1085106A (en) | 1994-04-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93118792 Pending CN1085106A (en) | 1993-10-27 | 1993-10-27 | The ophthalmologic operation visco-elastic material that has fluorescence |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1085106A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088553C (en) * | 1998-08-14 | 2002-08-07 | 凌沛学 | Disinfecting gel containing transparent sodium phytate and its preparing process |
| CN100333804C (en) * | 2003-04-18 | 2007-08-29 | 上海建华精细生物制品有限公司 | Sodium hyaluronate anti-adhesion film, and its prepn. method |
| CN100353157C (en) * | 2005-05-24 | 2007-12-05 | 周大宁 | Liquid for testing effect of washing hands |
| AU2004249137B2 (en) * | 2003-06-13 | 2010-03-11 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| US7947295B2 (en) | 2003-06-13 | 2011-05-24 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| CN104349798A (en) * | 2012-05-10 | 2015-02-11 | 卡尔蔡司医疗技术股份公司 | Ophthalmic viscoelastic device |
| CN104814977A (en) * | 2015-05-07 | 2015-08-05 | 四川和凡医疗科技有限公司 | Soft hydrosol auxiliary agent used for ophthalmology |
-
1993
- 1993-10-27 CN CN 93118792 patent/CN1085106A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088553C (en) * | 1998-08-14 | 2002-08-07 | 凌沛学 | Disinfecting gel containing transparent sodium phytate and its preparing process |
| CN100333804C (en) * | 2003-04-18 | 2007-08-29 | 上海建华精细生物制品有限公司 | Sodium hyaluronate anti-adhesion film, and its prepn. method |
| AU2004249137B2 (en) * | 2003-06-13 | 2010-03-11 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| US7709012B2 (en) | 2003-06-13 | 2010-05-04 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| US7947295B2 (en) | 2003-06-13 | 2011-05-24 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| US8313754B2 (en) | 2003-06-13 | 2012-11-20 | Novartis Ag | Ophthalmic compositions containing a synergistic combination of two polymers |
| CN100353157C (en) * | 2005-05-24 | 2007-12-05 | 周大宁 | Liquid for testing effect of washing hands |
| CN104349798A (en) * | 2012-05-10 | 2015-02-11 | 卡尔蔡司医疗技术股份公司 | Ophthalmic viscoelastic device |
| CN104349798B (en) * | 2012-05-10 | 2016-05-25 | 卡尔蔡司医疗技术股份公司 | Ophthalmology viscoplasticity equipment |
| CN104814977A (en) * | 2015-05-07 | 2015-08-05 | 四川和凡医疗科技有限公司 | Soft hydrosol auxiliary agent used for ophthalmology |
| CN104814977B (en) * | 2015-05-07 | 2017-12-12 | 四川和凡医疗科技有限公司 | A kind of ophthalmic flexibility hydrosol assistant agent |
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