CN1074923C - 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类 - Google Patents
微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类 Download PDFInfo
- Publication number
- CN1074923C CN1074923C CN94194190A CN94194190A CN1074923C CN 1074923 C CN1074923 C CN 1074923C CN 94194190 A CN94194190 A CN 94194190A CN 94194190 A CN94194190 A CN 94194190A CN 1074923 C CN1074923 C CN 1074923C
- Authority
- CN
- China
- Prior art keywords
- microgranule
- poly
- compositions
- hydrogen
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
表1:在给狗进行肌肉注射一种含有约2.5mg/kg剂量抗精神病的risperdone的微粒后,在一段连续的时间间隔内对阿朴吗啡引发的呕吐有无拮抗作用:有(+);无(-) | |||||
项目 | Prodex 2 | Prodex 3 | Prodex 4A | Prodex 4B | Prodex 4C |
狗重(kg) | 14.2 11.5 9 8 | 12.9 12.4 13.4 | 10.0 12.3 9.2 | 9.7 8.6 10.6 | 13.2 16.4 16.2 |
体积(ml/狗) | 0.5’ 0.5’ 0.5’ | 0.5’ 0.5’ 0.5’ | 0.5’ 0.5’ 0.5’ | 0.5’ 0.5’ 0.5’ | 0.5’ 0.5’ 0.5’ |
剂量(mg/kg) | 2.5 2.5 2.8 | 2.5 2.5 2.5 | 2.5 2.3 2.6 | 2.5 2.5 2.6 | 2.4 2.4 2.5 |
时间经过 | im im im | im im im | im im im | im im im | im im im |
1h | + + - | + + + | + + + | - + + | + + + |
5h | + + + | + + + | + + + | + - + | + + + |
1d | + + + | + + + | + + + | + + + | + + + |
4d | - - + | + - + | + + - | - - + | + + + |
7d | - - - | - + + | - - - | - - + | + + + |
11d | - - - | + + + | + + - | - - + | + + + |
14d | - | + + + | + + + | - + + | + + + |
18d | + + + | + + + | + + + | + + + | |
21d | + + + | + + + | + + + | + + + | |
25d | + + + | + + + | + + + | + + + | + + + |
29d | + + + | + + + | + + + | + + + | + + + |
32d | + + + | + + + | + + + | + + + | + + + |
35d | + + + | + + + | + + + | + + + | + + + |
表1:在给狗进行肌肉注射一种含有约2.5mg/kg剂量抗精神病的risperdone的微粒后,在一段连续的时间间隔内对阿朴吗啡引发的呕吐有无拮抗作用:有(+);无(-) | |||||
39d | - + + | + - + | + + - | - - - | + + + |
42d | - - - | + - + | + - - | - - - | + + - |
46d | - - - | + - - | - - - | - - - | + + - |
49d | 停止 | - - - | - - - | 停止 | + + - |
53d | 停止 | 停止 | - + - | ||
56d | - - - | ||||
停止 | |||||
3注射体积:0.5ml/狗;微粒的浓度根据狗的体重选择 |
Claims (14)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15440393A | 1993-11-19 | 1993-11-19 | |
US08/154,403 | 1993-11-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1137756A CN1137756A (zh) | 1996-12-11 |
CN1074923C true CN1074923C (zh) | 2001-11-21 |
Family
ID=22551225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN94194190A Expired - Lifetime CN1074923C (zh) | 1993-11-19 | 1994-11-11 | 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类 |
Country Status (30)
Country | Link |
---|---|
US (11) | US5688801A (zh) |
EP (1) | EP0729357B1 (zh) |
JP (1) | JP3645906B2 (zh) |
KR (1) | KR100354270B1 (zh) |
CN (1) | CN1074923C (zh) |
AT (1) | ATE288270T1 (zh) |
AU (1) | AU694147B2 (zh) |
BG (1) | BG63246B1 (zh) |
CL (1) | CL2004001182A1 (zh) |
CZ (1) | CZ293764B6 (zh) |
DE (1) | DE69434258T2 (zh) |
DK (1) | DK0729357T3 (zh) |
ES (1) | ES2236700T3 (zh) |
FI (1) | FI117122B (zh) |
HK (1) | HK1010694A1 (zh) |
HU (1) | HU219487B (zh) |
IL (1) | IL111647A (zh) |
MX (1) | MX9408969A (zh) |
MY (1) | MY113298A (zh) |
NO (1) | NO309226B1 (zh) |
NZ (1) | NZ276088A (zh) |
PL (1) | PL314481A1 (zh) |
PT (1) | PT729357E (zh) |
RO (1) | RO119224B1 (zh) |
RU (1) | RU2178695C2 (zh) |
SG (1) | SG47445A1 (zh) |
SI (1) | SI0729357T1 (zh) |
SK (1) | SK282231B6 (zh) |
WO (1) | WO1995013814A1 (zh) |
ZA (1) | ZA949191B (zh) |
Families Citing this family (132)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
DK0729353T4 (da) * | 1993-11-19 | 2012-10-01 | Alkermes Inc | Fremstilling af bionedbrydelige mikropartikler som indeholder et biologisk aktivt middel |
ATE288270T1 (de) | 1993-11-19 | 2005-02-15 | Janssen Pharmaceutica Nv | Mikroverkapselte 1,2-benzazole |
AU2587297A (en) * | 1996-03-25 | 1997-10-17 | Eli Lilly And Company | Method for treating pain |
ATE223206T1 (de) * | 1996-05-07 | 2002-09-15 | Alkermes Inc | Verfahren zur herstellung von mikropartikeln |
US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
US6150390A (en) * | 1997-02-04 | 2000-11-21 | Dong Wha Pharm. Ind. Co., Ltd. | 3-amino-1,2-benzoisoxazole derivatives, process for preparation, and use thereof |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
US6194006B1 (en) * | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
FR2797784B1 (fr) * | 1999-08-27 | 2001-11-30 | Mainelab | Procede d'encapsulation de matieres actives par coacervation de polymeres en solvant organique non-chlore |
KR100373485B1 (ko) * | 1999-09-28 | 2003-02-25 | 한국과학기술연구원 | 신규한 이소옥사졸 피페라진 유도체 및 그 제조방법 |
US6705757B2 (en) * | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
US6495166B1 (en) | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
US6331317B1 (en) | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
US6770478B2 (en) * | 2000-02-10 | 2004-08-03 | The Regents Of The University Of California | Erythrocytic cells and method for preserving cells |
US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
US6495164B1 (en) * | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
US6362308B1 (en) | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
CA2419115C (en) * | 2000-08-15 | 2011-03-08 | Board Of Trustees Of The University Of Illinois | Microparticles, and method and apparatus for forming same |
US6824822B2 (en) * | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
US6482440B2 (en) | 2000-09-21 | 2002-11-19 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
US6471995B1 (en) | 2000-09-27 | 2002-10-29 | Alkermes Controlled Therapeutics, Inc. Ii | Apparatus and method for preparing microparticles using liquid-liquid extraction |
US7666445B2 (en) * | 2000-10-20 | 2010-02-23 | The Trustees Of The University Of Pennsylvania | Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use |
US20020114843A1 (en) * | 2000-12-27 | 2002-08-22 | Ramstack J. Michael | Preparation of microparticles having improved flowability |
WO2003037337A1 (en) | 2001-10-30 | 2003-05-08 | Novartis Ag | Depot formulations of iloperidone and a star polymer |
KR100789567B1 (ko) * | 2001-11-06 | 2007-12-28 | 동화약품공업주식회사 | 3-아미도-1,2-벤조이소옥사졸 유도체, 그 염, 제조방법 및 용도 |
EP1509182A4 (en) * | 2002-05-31 | 2009-12-30 | Titan Pharmaceuticals Inc | IMPLANTABLE POLYMERS DEVICE FOR THE DELAYED RELEASE OF BUPRENORPHINE |
GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
KR20040034996A (ko) * | 2002-10-18 | 2004-04-29 | 한미약품 주식회사 | 리스페리돈의 개선된 제조방법 |
DK1610791T3 (da) | 2003-03-31 | 2011-05-09 | Titan Pharmaceuticals Inc | Implanterbar polymer anordning for vedvarende frigivelse af dopamin-agonist |
US20050036977A1 (en) * | 2003-08-11 | 2005-02-17 | Dilip Gole | Taste-masked resinate and preparation thereof |
MXPA06004489A (es) * | 2003-10-23 | 2006-06-20 | Otsuka Pharma Co Ltd | Formulacion y metodo de aripiprazol inyectable esteril de liberacion controlada. |
US7309500B2 (en) * | 2003-12-04 | 2007-12-18 | The Board Of Trustees Of The University Of Illinois | Microparticles |
AU2005206143B2 (en) * | 2004-01-12 | 2010-12-16 | The Trustees Of The University Of Pennsylvania | Long-term delivery formulations and methods of use thereof |
US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
US8329203B2 (en) | 2004-01-12 | 2012-12-11 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
SI2409707T1 (sl) | 2004-04-15 | 2015-07-31 | Alkermes Pharma Ireland Limited | Naprava s podaljšanim sproščanjem na osnovi polimerov |
ES2527286T3 (es) * | 2004-04-30 | 2015-01-22 | Abraxis Bioscience, Llc | Microesferas de liberación sostenida y métodos de fabricación y uso de las mismas |
FR2869801B1 (fr) * | 2004-05-05 | 2008-09-12 | Ethypharm Sa | Procede de preparation de compositions a liberation prolongee et utilisation de ces compositions pour le traitement des affections chroniques du systeme nerveux central (snc) |
US20050260272A1 (en) * | 2004-05-05 | 2005-11-24 | Alkermes Controlled Therapeutics, Inc. | Method of forming microparticles that include a bisphosphonate and a polymer |
US20050265955A1 (en) * | 2004-05-28 | 2005-12-01 | Mallinckrodt Inc. | Sustained release preparations |
US7748343B2 (en) | 2004-11-22 | 2010-07-06 | The Board Of Trustees Of The University Of Illinois | Electrohydrodynamic spraying system |
WO2006078841A1 (en) * | 2005-01-21 | 2006-07-27 | President And Fellows Of Harvard College | Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US8299025B2 (en) | 2005-02-03 | 2012-10-30 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
EP1743638A1 (en) | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Pharmaceutical formulations of substituted pyrazoline compounds |
MX362908B (es) * | 2005-07-18 | 2019-02-21 | Univ Pennsylvania | Implantes que contienen fármacos y métodos de uso de los mismos. |
DE102005034925B4 (de) * | 2005-07-26 | 2008-02-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Magnetorheologische Elastomerkomposite sowie deren Verwendung |
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
US7669732B2 (en) * | 2005-10-25 | 2010-03-02 | Imi Cornelius Inc. | Cup lid dispenser |
PL116330U1 (en) * | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
US7476405B2 (en) * | 2006-02-23 | 2009-01-13 | Iomedix Sleep International Srl | Compositions and methods for the induction and maintenance of quality sleep |
KR101200728B1 (ko) | 2006-08-09 | 2012-11-13 | 인타르시아 세라퓨틱스 인코포레이티드 | 삼투성 전달 시스템 및 피스톤 조립체 |
JP5302888B2 (ja) * | 2006-08-31 | 2013-10-02 | エスケー ケミカルズ カンパニー リミテッド | 薬物含有高分子微小球の製造方法及びその方法により製造された薬物含有高分子微小球 |
JP2010522196A (ja) * | 2007-03-22 | 2010-07-01 | アルカームズ,インコーポレイテッド | コアセルベーション工程 |
DE102007017589B3 (de) * | 2007-04-13 | 2008-10-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Dämpfungsvorrichtung mit feldsteuerbarer Flüssigkeit |
ES2562878T3 (es) | 2007-05-25 | 2016-03-08 | Indivior Uk Limited | Formulaciones de liberación sostenida de compuestos de risperidona |
WO2008157540A1 (en) * | 2007-06-20 | 2008-12-24 | Alkermes, Inc. | Quench liquids and washing systems for production of microparticles |
UA96342C2 (en) * | 2007-06-25 | 2011-10-25 | Оцука Фармасьютикал Ко., Лтд. | Microspheres having core/shell structure |
HUE036214T2 (hu) | 2007-07-31 | 2018-06-28 | Otsuka Pharma Co Ltd | Eljárások aripiprazol-szuszpenzió és fagyasztva szárított készítmény elõállítására |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
WO2010056065A2 (en) | 2008-11-14 | 2010-05-20 | Ewha University-Industry Collaboration Foundation | Method for preparing microspheres and microspheres produced thereby |
JP2012515790A (ja) * | 2009-01-23 | 2012-07-12 | サーモディクス ファーマシューティカルズ, インコーポレイテッド | 微粒子製造のための連続二重エマルジョン工程 |
HUE035862T2 (en) | 2009-09-28 | 2018-05-28 | Intarcia Therapeutics Inc | Rapid development and / or completion of substantially steady-state drug delivery |
EP2485767A1 (en) | 2009-10-06 | 2012-08-15 | Ascendis Pharma A/S | Carrier linked paliperidone prodrugs |
EP2485712A1 (en) | 2009-10-06 | 2012-08-15 | Ascendis Pharma A/S | Subcutaneous paliperidone composition |
US8641900B2 (en) * | 2009-11-05 | 2014-02-04 | Taiwan Biotech Co., Ltd | Method and device for continuously preparing microspheres, and collection unit thereof |
EA015780B1 (ru) * | 2010-03-11 | 2011-12-30 | Общество С Ограниченной Ответственностью "Цэм" (Ооо "Цэм") | Фармацевтическая композиция пролонгированного действия для снижения аппетита |
US8088594B2 (en) * | 2010-03-16 | 2012-01-03 | Saladax Biomedical Inc. | Risperidone immunoassay |
ES2602503T3 (es) | 2010-04-22 | 2017-02-21 | Intra-Cellular Therapies, Inc. | Compuestos orgánicos |
US10350159B2 (en) | 2010-05-31 | 2019-07-16 | Laboratories Farmacéuticos Rovi, S.A. | Paliperidone implant formulation |
US10285936B2 (en) | 2010-05-31 | 2019-05-14 | Laboratorios Farmacéuticos Rovi, S.A. | Injectable composition with aromatase inhibitor |
US10335366B2 (en) | 2010-05-31 | 2019-07-02 | Laboratorios Farmacéuticos Rovi, S.A. | Risperidone or paliperidone implant formulation |
US10881605B2 (en) | 2010-05-31 | 2021-01-05 | Laboratorios Farmaceuticos Rovi, S.A. | Methods for the preparation of injectable depot compositions |
ES2897976T3 (es) | 2010-05-31 | 2022-03-03 | Farm Rovi Lab Sa | Composiciones para implantes in situ biodegradables inyectables |
SI2394664T1 (sl) | 2010-05-31 | 2016-10-28 | Laboratorios Farmaceuticos Rovi, S.A. | Antipsihotični depojski sestavek za injiciranje |
US10463607B2 (en) | 2010-05-31 | 2019-11-05 | Laboratorios Farmaceutics Rofi S.A. | Antipsychotic Injectable Depot Composition |
US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
GB2481017B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
MX347090B (es) * | 2010-12-29 | 2017-04-11 | Medincell | Composiciones de suministro de farmacos biodegradables. |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
PL3199146T3 (pl) | 2011-04-25 | 2020-03-31 | Shan Dong Luye Pharmaceutical Co., Ltd. | Kompozycja mikrosfery rysperydonu o przedłużonym uwalnianiu |
PT2529756T (pt) | 2011-05-31 | 2021-07-28 | Farm Rovi Lab Sa | Formulação de implante de risperidona e/ou paliperidona |
JO3410B1 (ar) | 2011-06-07 | 2019-10-20 | Otsuka Pharma Co Ltd | تركيبة أريبيبرازول مجفف بالتبريد |
RU2014145682A (ru) | 2012-04-14 | 2016-06-10 | Интра-Селлулар Терапиз, Инк | Органические соединения |
EP2846772A4 (en) | 2012-05-10 | 2015-12-30 | Painreform Ltd | DEPOT FORMULATIONS OF A HYDROPHOBIC ACTIVE SUBSTANCE AND METHOD FOR THE PRODUCTION THEREOF |
DE102013011399A1 (de) | 2012-07-31 | 2014-02-06 | Amw Gmbh | Implantat mit Risperidon |
JP2015529199A (ja) | 2012-08-21 | 2015-10-05 | オルソ−クリニカル ダイアグノスティクス,インコーポレイティド | パリペリドンハプテンに対する抗体及びその使用 |
US9751953B2 (en) | 2012-08-21 | 2017-09-05 | Janssen Pharmaceutica Nv | Antibodies to risperidone haptens and use thereof |
JP6339569B2 (ja) | 2012-08-21 | 2018-06-06 | ヤンセン ファーマシューティカ エヌ.ベー. | リスペリドンへの抗体及びその使用 |
AU2013305965B2 (en) | 2012-08-21 | 2017-08-24 | Saladax Biomedical Inc. | Antibodies to paliperidone and use thereof |
US9708322B2 (en) | 2013-03-15 | 2017-07-18 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity |
RU2552303C2 (ru) * | 2013-07-02 | 2015-06-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ получения фармацевтической композиции, содержащей алпразолам |
MX2016001607A (es) * | 2013-08-06 | 2016-06-06 | Dong Kook Pharm Co Ltd | Microesferas de entecavir y composicion farmaceutica para administracion parenteral que contiene las mismas. |
WO2015036244A1 (en) * | 2013-09-13 | 2015-03-19 | Continental Automotive Gmbh | Fluid injector |
CN114366741A (zh) | 2013-12-03 | 2022-04-19 | 细胞内治疗公司 | 新方法 |
GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
DK3125893T3 (da) | 2014-04-04 | 2023-11-20 | Intra Cellular Therapies Inc | Deutererede heterocyklus-fusionerede gamma-carboliner som antagonister af 5-ht2a-receptorer |
WO2015154030A1 (en) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
WO2015191554A1 (en) | 2014-06-09 | 2015-12-17 | Intra-Cellular Therapies, Inc. | Compounds and methods of use to treat schizophrenia |
TW201613564A (en) * | 2014-08-06 | 2016-04-16 | Tty Biopharm Co Ltd | Process for the preparation of sustained-release microparticles having a controllable release profile |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
ES2808150T3 (es) | 2014-11-07 | 2021-02-25 | Indivior Uk Ltd | Regímenes de dosificación de buprenorfina |
EP3302354B1 (en) | 2015-06-03 | 2023-10-04 | i2o Therapeutics, Inc. | Implant placement systems |
ES2964696T3 (es) | 2015-11-16 | 2024-04-09 | Medincell S A | Un método para morselizar y/o dirigir principios farmacéuticamente activos al tejido sinovial |
EP3390449A1 (en) | 2015-12-17 | 2018-10-24 | Janssen Pharmaceutica N.V. | Antibodies to risperidone and use thereof |
WO2017132408A1 (en) | 2016-01-26 | 2017-08-03 | Intra-Cellular Therapies, Inc. | Organic compounds |
PT3407889T (pt) | 2016-03-25 | 2021-07-14 | Intra Cellular Therapies Inc | Compostos orgânicos e a sua utilização no tratamento ou prevenção de distúrbios do sistema nervoso central |
US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
BR112018073511A2 (pt) | 2016-05-16 | 2019-03-26 | Intarcia Therapeutics, Inc. | polipeptídeos seletivos do receptor de glucagon e métodos de uso dos mesmos |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
CN110072518B (zh) | 2016-10-12 | 2021-10-26 | 细胞内治疗公司 | 无定形固体分散体 |
WO2018126143A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
IL268970B2 (en) | 2017-03-24 | 2023-12-01 | Intra Cellular Therapies Inc | Oral preparations of heterocyclic gamma carboline derivatives fused for absorption through mucous membranes |
US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
AU2018307480B2 (en) | 2017-07-26 | 2023-11-23 | Intra-Cellular Therapies, Inc. | Organic compounds |
MX2020000968A (es) | 2017-07-26 | 2020-09-28 | Intra Cellular Therapies Inc | Compuestos organicos. |
RU2702012C2 (ru) * | 2017-10-24 | 2019-10-03 | федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ получения фармацевтической композиции, содержащей пентоксифиллин |
BR112020019119A2 (pt) | 2018-03-23 | 2021-01-12 | Intra-Cellular Therapies, Inc. | Compostos orgânicos |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
WO2020047407A1 (en) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
CA3108558A1 (en) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
EP3870044B1 (en) * | 2018-10-22 | 2024-04-10 | The General Hospital Corporation | Complexes and ligands |
HUP2100259A1 (hu) | 2021-07-07 | 2023-01-28 | Richter Gedeon Nyrt | Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények |
TW202313047A (zh) | 2021-09-21 | 2023-04-01 | 西班牙商禾霏藥品實驗室有限公司 | 抗精神病可注射儲積型組合物 |
US20230372336A1 (en) | 2022-05-18 | 2023-11-23 | Intra-Cellular Therapies, Inc. | Novel methods |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
EP0368388A2 (en) * | 1988-11-07 | 1990-05-16 | Janssen Pharmaceutica N.V. | 3-Piperidinyl-1,2-benzisoxazoles |
Family Cites Families (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL137652C (zh) * | 1962-07-11 | |||
US3197180A (en) * | 1963-10-11 | 1965-07-27 | Chemineer | Mixing device |
US3415493A (en) * | 1967-08-21 | 1968-12-10 | Chemineer | Mixing device |
BE744162A (fr) * | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
DE2010115A1 (de) * | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
GB1351811A (en) * | 1971-05-07 | 1974-05-01 | Kenics Corp | Mixing device |
JPS523342B2 (zh) * | 1972-01-26 | 1977-01-27 | ||
GB1413186A (en) * | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
US3923288A (en) * | 1973-12-27 | 1975-12-02 | Komax Systems Inc | Material mixing apparatus |
US4034965A (en) * | 1973-12-27 | 1977-07-12 | Komax Systems, Inc. | Material distributing and mixing apparatus |
US4128641A (en) * | 1975-07-31 | 1978-12-05 | Hzi Research Center Inc. | Tetracyclic psychotropic drug |
US4111402A (en) * | 1976-10-05 | 1978-09-05 | Chemineer, Inc. | Motionless mixer |
JPS54127064A (en) * | 1978-03-06 | 1979-10-02 | Komax Systems Inc | Charging instrument of stationary mixer |
DE2822096A1 (de) * | 1978-05-20 | 1979-11-22 | Bayer Ag | Gebohrte mischelemente fuer statische und dynamische mischer |
US4489055A (en) * | 1978-07-19 | 1984-12-18 | N.V. Sopar S.A. | Process for preparing biodegradable submicroscopic particles containing a biologically active substance and their use |
US4208136A (en) * | 1978-12-01 | 1980-06-17 | Komax Systems, Inc. | Static mixing apparatus |
US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
US4329331A (en) * | 1980-03-13 | 1982-05-11 | Kallick Charles A | Diagnostic method for detection of systemic lupus erythematosus |
US4342870A (en) * | 1980-03-28 | 1982-08-03 | Janssen Pharmaceutica N.V. | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
US4384975A (en) * | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
US4324870A (en) * | 1980-06-23 | 1982-04-13 | Uniroyal, Inc. | Scorch-safe acceleration of urethane vulcanization of unsaturated rubbers |
US4337261A (en) * | 1980-07-28 | 1982-06-29 | Hoechst-Roussel Pharmaceuticals Inc. | (1,2-Benzisoxazol)phenoxyacetic acids as diuretics |
US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
US4443451A (en) * | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
ATE24283T1 (de) * | 1981-07-28 | 1987-01-15 | Statiflo Inc | Statischer mischer. |
US4352811A (en) * | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
US4529727A (en) * | 1982-04-21 | 1985-07-16 | Janssen Pharmaceutical, N.V. | Pyrimido[2,1-b][1,3]-thiazines |
US4798786A (en) * | 1982-05-06 | 1989-01-17 | Stolle Research And Development Corporation | Living cells encapsulated in crosslinked protein |
GB2120113B (en) * | 1982-05-13 | 1985-10-09 | Komax Systems Inc | Mixing in flow |
US4808007A (en) * | 1982-05-13 | 1989-02-28 | Komax Systems, Inc. | Dual viscosity mixer |
US4542025A (en) * | 1982-07-29 | 1985-09-17 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4530840A (en) * | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4485107A (en) * | 1982-11-01 | 1984-11-27 | Janssen Pharmaceutica N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones |
US4511258A (en) * | 1983-03-25 | 1985-04-16 | Koflo Corporation | Static material mixing apparatus |
US4458076A (en) * | 1983-05-31 | 1984-07-03 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidinyl)-1,2-benzisothiazoles |
EP0129619B1 (en) * | 1983-06-22 | 1988-05-18 | The Stolle Research And Development Corporation | Encapsulated cells, their method of preparation and use |
CH661206A5 (fr) * | 1983-09-23 | 1987-07-15 | Debiopharm Sa | Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes. |
US4708861A (en) * | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
US4696258A (en) * | 1984-04-04 | 1987-09-29 | The Magrath Company | Method and substance for the detection of cows in estrus |
US4585482A (en) * | 1984-05-25 | 1986-04-29 | Southern Research Institute | Long-acting biocidal compositions and method therefor |
CA1236641A (en) * | 1984-07-06 | 1988-05-10 | Motoaki Tanaka | Copolymer of lactic acid and glycolic acid and method for producing same |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US4665075A (en) * | 1984-12-05 | 1987-05-12 | Janssen Pharmaceutica N.V. | Derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines |
US4614440A (en) * | 1985-03-21 | 1986-09-30 | Komax Systems, Inc. | Stacked motionless mixer |
US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
US4689330A (en) * | 1985-04-15 | 1987-08-25 | Janssen Pharmaceutica N.V. | Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines |
US4616937A (en) * | 1985-04-16 | 1986-10-14 | Komax Systems, Inc. | Intermittent mixing apparatus |
NL8601494A (nl) * | 1985-06-22 | 1987-01-16 | Sandoz Ag | Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten. |
US4643584A (en) * | 1985-09-11 | 1987-02-17 | Koch Engineering Company, Inc. | Motionless mixer |
US5102872A (en) * | 1985-09-20 | 1992-04-07 | Cetus Corporation | Controlled-release formulations of interleukin-2 |
EP0248531A3 (en) * | 1986-05-02 | 1988-09-28 | Southern Research Institute | Encapsulated nucleic acids |
ES2053549T3 (es) * | 1986-08-11 | 1994-08-01 | Innovata Biomed Ltd | Un proceso para la preparacion de una formulacion farmaceutica apropiada para inhalacion. |
US4765204A (en) * | 1986-09-03 | 1988-08-23 | Koch Engineering Company, Inc. | Method of manufacturing a motionless mixer |
US4731205A (en) * | 1986-09-08 | 1988-03-15 | Koch Engineering Company, Inc. | Random packing for fluid contact devices and method of preparing said packing |
US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
IL84167A (en) * | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
US4753535A (en) * | 1987-03-16 | 1988-06-28 | Komax Systems, Inc. | Motionless mixer |
US4793713A (en) * | 1987-04-06 | 1988-12-27 | Komax Systems, Inc. | Rotary mixer |
US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
US5143661A (en) | 1987-05-26 | 1992-09-01 | American Cyanamid Company | Silicone-hardened pharmaceutical microcapsules |
US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
IT1216570B (it) * | 1988-04-08 | 1990-03-08 | Vectorpharma Int | Composizione farmaceutiche a rilascio controllato e procedimento per la loro preparazione. |
EP0349486A3 (de) * | 1988-06-29 | 1990-12-05 | Ciba-Geigy Ag | Azofarbstoffe, deren Herstellung und Verwendung |
US4936689A (en) * | 1988-07-11 | 1990-06-26 | Koflo Corporation | Static material mixing apparatus |
US5158952A (en) * | 1988-11-07 | 1992-10-27 | Janssen Pharmaceutica N.V. | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use |
EP0471036B2 (en) * | 1989-05-04 | 2004-06-23 | Southern Research Institute | Encapsulation process |
HU221294B1 (en) | 1989-07-07 | 2002-09-28 | Novartis Ag | Process for producing retarde compositions containing the active ingredient in a polymeric carrier |
ATE135216T1 (de) | 1989-08-21 | 1996-03-15 | Beth Israel Hospital | Verwendung von spiperone-derivate zur immunosuppression |
US5478564A (en) * | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
AU7558991A (en) * | 1990-03-15 | 1991-10-10 | United States Of America, As Represented By The Secretary Of The Army, The | Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix |
CA2040141C (en) | 1990-04-13 | 2002-05-14 | Minoru Yamada | Biodegradable high-molecular polymers, production and use therof |
DE69133136T2 (de) * | 1990-05-16 | 2003-06-18 | Southern Res Inst Birmingham | Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstums |
MY108621A (en) * | 1990-08-01 | 1996-10-31 | Novartis Ag | Polylactide preparation and purification |
IT1243390B (it) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
JP3180421B2 (ja) * | 1992-03-30 | 2001-06-25 | 日本電気株式会社 | テスト回路を内蔵したアナログ・ディジタル混在マスタ |
DE4223169C1 (de) | 1992-07-10 | 1993-11-25 | Ferring Arzneimittel Gmbh | Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe |
EP0669128B1 (en) * | 1992-11-17 | 2000-01-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Sustained-release microsphere containing antipsychotic and process for producing the same |
DE4244466C2 (de) | 1992-12-24 | 1995-02-23 | Pharmatech Gmbh | Verfahren zur Herstellung von Pseudolatices und Mikro- oder Nanopartikeln und deren Verwendung zur Herstellung von pharmazeutischen Präparaten |
TW376319B (en) * | 1993-04-28 | 1999-12-11 | Janssen Pharmaceutica Nv | Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine |
DK0724433T3 (da) | 1993-10-22 | 1999-08-30 | Genentech Inc | Fremgangsmåde til fremstilling af mikrosfærer med et tørringstrin i fluidiseret leje |
US6080429A (en) | 1993-10-25 | 2000-06-27 | Genentech, Inc. | Method for drying microspheres |
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
ATE288270T1 (de) * | 1993-11-19 | 2005-02-15 | Janssen Pharmaceutica Nv | Mikroverkapselte 1,2-benzazole |
DK0729353T4 (da) * | 1993-11-19 | 2012-10-01 | Alkermes Inc | Fremstilling af bionedbrydelige mikropartikler som indeholder et biologisk aktivt middel |
DE69534780T2 (de) | 1994-04-08 | 2006-10-05 | Qlt Usa Inc., Fort Collins | Flüssige Zusammensetzungen zur Arzneistoffabgabe |
US5453425A (en) * | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
US6117455A (en) | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
TW448055B (en) | 1995-09-04 | 2001-08-01 | Takeda Chemical Industries Ltd | Method of production of sustained-release preparation |
CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
ES2205481T3 (es) | 1997-04-17 | 2004-05-01 | Amgen Inc. | Microparticulas biodegradables para la liberacion sostenida de farmacos terapeuticos. |
SE512663C2 (sv) | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
US6224794B1 (en) | 1998-05-06 | 2001-05-01 | Angiotech Pharmaceuticals, Inc. | Methods for microsphere production |
SE9903236D0 (sv) | 1999-09-10 | 1999-09-10 | Astra Ab | Method to obtain microparticles |
DE10055742B4 (de) | 2000-11-10 | 2006-05-11 | Schwarz Pharma Ag | Neue Polyester, Verfahren zu ihrer Herstellung und aus den Polyestern hergestellte Depot-Arzneiformen |
-
1994
- 1994-11-11 AT AT95900721T patent/ATE288270T1/de active
- 1994-11-11 ES ES95900721T patent/ES2236700T3/es not_active Expired - Lifetime
- 1994-11-11 NZ NZ276088A patent/NZ276088A/xx not_active IP Right Cessation
- 1994-11-11 SI SI9430473T patent/SI0729357T1/xx unknown
- 1994-11-11 HU HU9501942A patent/HU219487B/hu unknown
- 1994-11-11 AU AU81425/94A patent/AU694147B2/en not_active Expired
- 1994-11-11 SK SK640-96A patent/SK282231B6/sk not_active IP Right Cessation
- 1994-11-11 KR KR1019960702565A patent/KR100354270B1/ko not_active IP Right Cessation
- 1994-11-11 CN CN94194190A patent/CN1074923C/zh not_active Expired - Lifetime
- 1994-11-11 RU RU96113054/14A patent/RU2178695C2/ru active
- 1994-11-11 EP EP95900721A patent/EP0729357B1/en not_active Expired - Lifetime
- 1994-11-11 CZ CZ19961373A patent/CZ293764B6/cs not_active IP Right Cessation
- 1994-11-11 JP JP51420695A patent/JP3645906B2/ja not_active Expired - Lifetime
- 1994-11-11 PL PL94314481A patent/PL314481A1/xx unknown
- 1994-11-11 DK DK95900721T patent/DK0729357T3/da active
- 1994-11-11 DE DE69434258T patent/DE69434258T2/de not_active Expired - Lifetime
- 1994-11-11 SG SG1996001627A patent/SG47445A1/en unknown
- 1994-11-11 PT PT95900721T patent/PT729357E/pt unknown
- 1994-11-11 RO RO96-01013A patent/RO119224B1/ro unknown
- 1994-11-11 WO PCT/EP1994/003754 patent/WO1995013814A1/en active IP Right Grant
- 1994-11-15 IL IL11164794A patent/IL111647A/xx not_active IP Right Cessation
- 1994-11-18 ZA ZA949191A patent/ZA949191B/xx unknown
- 1994-11-18 MY MYPI94003088A patent/MY113298A/en unknown
- 1994-11-18 MX MX9408969A patent/MX9408969A/es unknown
-
1995
- 1995-03-14 US US08/403,432 patent/US5688801A/en not_active Expired - Lifetime
-
1996
- 1996-05-17 FI FI962111A patent/FI117122B/fi not_active IP Right Cessation
- 1996-05-20 NO NO962040A patent/NO309226B1/no not_active IP Right Cessation
- 1996-06-03 BG BG100632A patent/BG63246B1/bg unknown
-
1997
- 1997-02-28 US US08/808,261 patent/US5770231A/en not_active Expired - Fee Related
-
1998
- 1998-01-12 US US09/005,549 patent/US5965168A/en not_active Expired - Lifetime
- 1998-10-29 HK HK98111600A patent/HK1010694A1/xx unknown
-
1999
- 1999-02-18 US US09/252,486 patent/US6110921A/en not_active Expired - Lifetime
-
2000
- 2000-05-26 US US09/578,908 patent/US6368632B1/en not_active Expired - Lifetime
-
2002
- 2002-01-29 US US10/058,072 patent/US6544559B2/en not_active Expired - Fee Related
-
2003
- 2003-02-06 US US10/359,226 patent/US6803055B2/en not_active Expired - Fee Related
-
2004
- 2004-05-20 CL CL200401182A patent/CL2004001182A1/es unknown
- 2004-08-18 US US10/920,422 patent/US7118763B2/en not_active Expired - Fee Related
-
2006
- 2006-03-02 US US11/365,625 patent/US20060182810A1/en not_active Abandoned
-
2007
- 2007-07-13 US US11/826,381 patent/US20080069885A1/en not_active Abandoned
- 2007-07-13 US US11/826,384 patent/US7547452B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
EP0368388A2 (en) * | 1988-11-07 | 1990-05-16 | Janssen Pharmaceutica N.V. | 3-Piperidinyl-1,2-benzisoxazoles |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1074923C (zh) | 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类 | |
CN100387228C (zh) | 可注射的美沙酮、部分类鸦片激动剂或类鸦片拮抗剂微粒组合物及其用途 | |
US6306425B1 (en) | Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol | |
CN114748428B (zh) | 一种高载药量的盐酸卡利拉嗪长效缓释微球及其制备方法 | |
CN1867319A (zh) | 包含生理活性物质的乳化溶液及其制备方法和给药方法 | |
US20220265562A1 (en) | Microsphere formulations comprising lurasidone and methods for making and using the same | |
CA2175370C (en) | Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles | |
CN116916920A (zh) | 包含鲁拉西酮的微球制剂及其制备和使用方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee | ||
CP03 | Change of name, title or address |
Address after: Belgium Beals Co-patentee after: ALKERMES CONTROLLED THERAPEUTICS Inc. II Patentee after: JANSSEN PHARMACEUTICA N.V. Address before: Belgium Beals Co-patentee before: Alkmez Controls Medical Co. Patentee before: JANSSEN PHARMACEUTICA N.V. |
|
TR01 | Transfer of patent right |
Effective date of registration: 20091113 Address after: Belgium Beals Co-patentee after: Alkermes Controlled Therapeutics, Inc. Patentee after: JANSSEN PHARMACEUTICA N.V. Address before: Belgium Beals Co-patentee before: Alkermes Controlled Therapeutics Inc. II Patentee before: JANSSEN PHARMACEUTICA N.V. |
|
C17 | Cessation of patent right | ||
CX01 | Expiry of patent term |
Expiration termination date: 20141111 Granted publication date: 20011121 |