CN105848561A - Forward scanning optical probes and associated devices, systems and methods - Google Patents

Forward scanning optical probes and associated devices, systems and methods Download PDF

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Publication number
CN105848561A
CN105848561A CN201480070474.1A CN201480070474A CN105848561A CN 105848561 A CN105848561 A CN 105848561A CN 201480070474 A CN201480070474 A CN 201480070474A CN 105848561 A CN105848561 A CN 105848561A
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China
Prior art keywords
fibre bundle
bundle
imaging apparatus
imaging
optical fiber
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Granted
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CN201480070474.1A
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CN105848561B (en
Inventor
俞凌峰
K·帕尔托
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Alcon Inc
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Novartis AG
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/102Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0008Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0066Optical coherence imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6814Head
    • A61B5/6821Eye
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163Optical arrangements
    • A61B1/00172Optical arrangements with means for scanning

Abstract

Devices, systems, and methods that utilize a technique of changing a position of the set of optical fibers of the fiber bundle in cooperation with the scanning of the imaging light across a proximal surface of the fiber bundle to improve the resolution of the scanned image. In particular, a bundle actuator can be provided to change a position of the set of optical fibers of the fiber bundle in cooperation with a scanning of the imaging light across the proximal surface of the fiber bundle to cover the areas of the gaps between the optical fibers and to increase a resolution of the scanned image.

Description

Scan forward optic probe and the device being associated, system and method
Yu Lingfeng (Lingfeng Yu) and kamu are than Zi Patuo (Kambiz Parto)
Technical field
Embodiment disclosed here be directed to use with scan forward optic probe scanning tissue device, system and Method, and relate more specifically to utilize the optical coherence tomography with the fibre bundle for ophthalmology imaging to become As art (OCT) pop one's head in device, system and method.
Background technology
Optical coherence tomography (OCT) system is for capturing and produce the image of patient tissue layer. These systems penetrate tissue so that tissue in the patient is carried out visual OCT with generally including Invasibility Probe.In ophthalmology, OCT probe is for the tissue obtained around eyes or the part forming eyes The detail image of tissue (such as retina).
OCT probe penetrates the prominent sleeve pipe of patient tissue with generally including Invasibility.By to passing The optical light beam of the lens being arranged in cannula tip reflects, and tissue is scanned by imaging probe.Sweep Retouch the controllable imaging of instrument to scan target tissue.Scanner can be placed in the far-end of the sleeve pipe of OCT probe. But, the far-end that scanner is placed on sleeve pipe can make the size of boot proximal end very greatly and have complexity Structure, is not suitable for inserting eyes.
Alternately, scanner can be placed in outside eyes, directly over eyes, it is possible to will Imaging is directly projected into eyes.But, scanner is placed on directly over eyes may interfere with operation micro- The light path of mirror, and the required working place between operating microscope and eyes can be occupied.
Correspondingly, it is advantageous that scanner is located remotely from the light path of operating microscope.Such as, scanning Instrument can be placed in the handpiece of OCT probe or be placed in single scanning element.If put away from light path Put scanner, then provide photoconduction so that imaging to be led back to insert the sleeve pipe of eyes.This photoconduction can be by The fibre bundle that a branch of optical fiber is formed, to have certain flexibility.But, in fibre bundle, optical fiber it Between form limited gap.Therefore, when making the proximal face of the inswept fibre bundle of imaging, at imaging Gap scanning between optical fiber can be able to be interrupted discontinuously.Therefore, the scanning light beam of output can To become to beat, this can cause scanogram to become the granular and noisy image that resolution is inadequate.
Accordingly for utilizing the device of the OCT image system with the scanner scanning fibre bundle, being There is demand in system and method, the device of such OCT image system, system and method improve scanning point Resolution is allowed to the optical fiber than fibre bundle-optical fiber and separates more preferably, and solves in demand discussed above One or more demands.
Summary of the invention
Embodiment disclosed here relates to the use of the device of actuator, system and method, and this actuator is adjustable The position of the optical fiber in whole fibre bundle, joins with the scanner of the proximal face scanning imagery light across fibre bundle Close, to improve imaging resolution.
Consistent with some embodiments has been to provide a kind of optical imaging apparatus.This optical imaging apparatus can To include there is the fibre bundle of the one group of optical fiber being configured to guiding imaging, being configured to receive from light Imaging is also redirected to the light beam formation unit of target area and is configured to by the fine imaging restrainted The bundle actuator that the position of this group optical fiber of this fibre bundle is adjusted.This optical imaging apparatus can wrap Including scanning element, this scanning element is configured to make imaging scan in the proximal face of fibre bundle and make The imaging being redirected is scanned along the scanning pattern in target area.
This optical imaging apparatus can also include the imaging source being configured to produce imaging and be joined It is set to make the scanning element of the proximal face of imaging scanning fibre bundle.
A kind of be to provide ophthalmology imaging the method consistent with some embodiments.The method can be wrapped Include: make imaging beam be scanned across the near-end of fibre bundle by scanning element;With bundle actuator to fibre bundle The configuration of distal part be adjusted;And utilize light beam to form unit to guide imaging to target area Territory.
The other aspects, features and advantages of the present invention will become obvious from described in detail below.
Accompanying drawing explanation
Fig. 1 illustrates exemplary OCT imaging system.
Fig. 2 a illustrates the cross sectional view of fibre bundle.
Fig. 2 b illustrates the cross sectional view of fibre bundle.
Fig. 2 c illustrates the cross sectional view of fibre bundle.
Fig. 2 d illustrates the cross sectional view of fibre bundle.
Fig. 3 illustrates exemplary OCT imaging system.
Fig. 4 illustrates the cross sectional view of imaging probe.
Fig. 5 illustrates imaging probe and the cross sectional view of OCT engine.
Fig. 6 a-b illustrates OCT image system.
Fig. 7 illustrates and connects subject eyes and exemplary OCT imaging system.
Detailed description of the invention
In the following description, detail is illustrated to describe specific embodiment.But, this area Technical staff is it will be clear that can be real in the case of some or all in not having these details Trample disclosed embodiment.The specific embodiment presented is intended to illustrative and not restrictive. It will be appreciated by those skilled in the art that, although be not explicitly described in this article, but other materials is also at this In the scope and spirit disclosed.It is right that skilled person involved by present disclosure expects the most completely In described device, system, any change of method and further modification and for present disclosure principle Any further application, and be contained in present disclosure.Specifically, it is fully contemplated that for one The spy that feature, assembly and/or the step that individual embodiment describes can describe with the other embodiments for present disclosure Levy, assembly and/or step combination.For simplicity's sake, but, a large amount of of these combinations will be respectively described Iteration scheme.
Present disclosure generally relates to OCT probe, OCT system and make imaging across target tissue scanning with The method producing OCT image.This imaging probe can include shell or handle and prominent from shell Sleeve pipe.This sleeve pipe penetrates the tissue of patient with can be configured to invasive, such as eyeball.This sleeve pipe can hold Receive lens and fibre bundle.This fibre bundle includes one group of optical fiber, and each optical fiber is configured to guide imaging to pass Lens also capture the imaging returning the reflection by these lens.Scanner can make imaging across fibre bundle Proximal face scan to obtain image.Because having intrinsic gap between each optical fiber in fibre bundle, sweep The image retouched is likely to become granular and has noise.
Illustrative aspects described herein utilizes a technology, i.e. scans the nearside table of fibre bundle with imaging Matching in face, the position of this group optical fiber in change fibre bundle, to improve the resolution of scanogram.Tool Body ground, it is provided that bundle actuator cooperatively changes light with the proximal face with imaging scanning fibre bundle The position of this group optical fiber in fine bundle or configuration, with the gap area covered between optical fiber and improve scanning figure The resolution of picture.The position changing this group optical fiber can overcome problem or the limit of one or more prior method System.Therefore, the embodiment of present disclosure can: (1) eliminates or reduces between each optical fiber of fibre bundle Spacing or the imaging artefacts that is associated of interval;(2) image definition and/or resolution are improved;And (3) image sampling density is increased.
Fig. 1 is the schematic diagram of exemplary OCT image equipment 100.Specifically, OCT image Equipment 100 can include that fibre bundle 102 and light beam form unit 104.Fibre bundle 102 can include being joined It is set to guide one group of optical fiber of imaging.Number of fibers in fibre bundle 102 can be in wider scope Change, is included in 2 optical fiber to 1, to 100 between 000,000 optical fiber, at 2 optical fiber, and 000 light Between fibre and between 2 optical fiber to 10,000 optical fiber.The size of every optical fiber or diameter can be Between 1 micron to 100 microns, between 2 microns to 50 microns or between 5 microns to 20 microns. Each optical fiber of optical fiber can be single-mode fiber, multimode fibre, single mode waveguide, multimode waveguide and hollow Pipe.
Light beam forms unit 104 and can be configured to receive from the imaging of fibre bundle 102 and by imaging It is redirected to target area.Light beam forms unit 104 and can be focused on target area by imaging.Example As, light beam forms unit 104 can include graded index (GRIN) lens, globe lens, diffraction unit Part, non-spherical lens or object lens.
OCT image equipment 100 can also include scanning element 106, and this scanning element is configured to make into Make the imaging of redirection along target area as the proximal face 114 of photoscanning/inswept fibre bundle 102 In scanning pattern be scanned.Scanning element 106 can include coupled lens 108, scanner 110 and Collimating lens 112.The imaging that imaging source generates can be guided to scanning element 106 by optical fiber 115. Collimating lens 112 can be utilized to receive the imaging from optical fiber 115.Scanner 110 can receive from In the collimated imaging of collimating lens 112 and imaging is guided to coupled lens 108.Coupled lens Imaging can be coupled in the single of fibre bundle 102 or several optical fiber by 108.
Scanner 110 can include the optics being configured to be scanned the collimated beam of light of imaging Element.Such as, scanner 110 can include following one or more: rotatable mirror, inspection stream Meter, resonance scanner, multiaspect scanner and MEMS scanner.Therefore, the controllable one-tenth of scanner 110 As the direction of light is so that imaging is scanned across the proximal face 114 of fibre bundle 102.The imaging of scanning property Light can be guided by fibre bundle 102 and form unit 104 towards light beam, and is formed unit by light beam 104 carry out guiding or export to scan target area along scanning pattern.
OCT image equipment 100 can include the bundle being configured to drive all or part of fibre bundle 102 Actuator 116.Bundle actuator 116 can be positioned at the portions of proximal, core of fibre bundle 102 And/or the vicinity of distal part.In some implementations, bundle actuator 116 adjustable fibre bundle 102 The position of optical fiber group of far-end or configuration.Such as, bundle actuator 116 can make the light of fibre bundle 102 Distal part rotation, torsion, transverse translation and/or the longitudinal translation of fine group.
Bundle actuator 116 can also is that a part for subsystem of manually or automatically focusing, and this subsystem is joined It is set to the distal part of the optical fiber group of longitudinally adjusted fibre bundle 102 or adjusts light beam formation unit 104, to adjust Whole light beam forms the focal length between unit 104 and target tissue.Such as, bundle actuator 116 can make optical fiber The distal part of bundle 102 forms unit 104 towards or away from light beam and moves, to adjust Jiao of imaging beam Point.Bundle actuator 116 can include being configured to beneficially fibre bundle 102 or the rotation of its part, torsion Turn, transverse translation and/or many parts of longitudinal translation.These parts can include but not limited to one or Multiple electro-motors, one or more biasing element (such as helical spring, leaf spring etc.), one or many Individual mechanical interface and/or one or more connector (such as pulley, ramp member, fixture, bolt, spiral shell Mother, screw, nail etc.), one or more electromagnetic component (such as permanent magnet, electric magnet, coil Deng), air impeller, piezo-electric type driver and/or combinations thereof.
Fig. 2 a-2d illustrates the cross sectional view of fibre bundle 102.Fig. 2 a illustrates fibre bundle 102 and has four The embodiment of root optical fiber: core 1, core 2, core 3 and core 4.However, it is to be appreciated that described below generally Read the fibre bundle being equally applicable to there is any amount of optical fiber, such as quantity at 2 optical fiber to 1,000,000 Between root optical fiber, between 2 optical fiber to 100,000 optical fiber and 2 optical fiber to 10,000 optical fiber it Between.
In the embodiment of four optical fiber or four cores, scanning element 106 can make imaging across proximal face 114, it is scanned across four core 1-4.But, as it has been described above, at fibre bundle 102 far-end by optical fiber 1- The imaging that 4 send successively clashes into four mesh spaced apart with distance D (i.e. the middle heart septum of adjacent fiber) Mark or scanning element.Distance D is the factor limiting imaging resolution.
Some embodiments utilize bundle actuator 116 to adjust the configuration of fibre bundle 102 and reduce relative to solid The interval of the scanning element of fixed fibre system.In certain embodiments, bundle actuator 116 can be single in scanning The configuration of fibre bundle 102 is adjusted after the first time scanning of unit 106.In certain embodiments, Shu Zhidong Device 116 can make at least some of fibre bundle 102 shift or rotate to the second position or configuration, such as Fig. 2 b Shown in.Such as, bundle actuator 116 can make fibre bundle 102 turn clockwise an angle to the second rotation Position.Fibre bundle 102 can rotate a less angle and rotate corresponding less than between core away from From or the less distance at interval, it can be at 0.1 micron between hundreds of micron, such as, at Fig. 2 B Middle fibre bundle 102 can rotate the less angle between 0 degree to 90 degree, in order to guide imaging beam extremely Scanning element between the point arrived before rotation.Then scanning element 106 makes imaging beam second time across light The proximal side 114 of fine bundle 102 is scanned.After second time scanning, fibre bundle 102 can be again It is rotated clockwise to the 3rd position, as shown in Figure 2 c.Then scanning element 106 can make imaging beam the 3rd The secondary near-end across four cores is scanned.In this embodiment, the core of fibre bundle 102 can be around optical fiber The central longitudinal axis of bundle 102 rotates.In an embodiment, the core being positioned at fibre bundle 102 center can revolve Then the position of the central longitudinal axis relative to fibre bundle 102 will not be changed.
Correspondingly, Fig. 2 d shows, by selecting the least anglec of rotation, these optical fiber can revolve Go to a series of position, cover the gap between optical fiber with small step one small step.When scanning element 106 When rescaning the proximal face 114 of fibre bundle 102 after each small angle rotation, can increase Add the density of scanning element, it is possible to realize the imaging of higher resolution.
In certain embodiments, actuator control 117 can control to restraint actuator 116, and thus Control the actuating of fibre bundle 102.Actuator control 117 can be with the scan operation of scanning element 106 Coordinate or synchronously perform actuating.Such as, the actuating of fibre bundle 102 can be opened after the scanning operation Begin, and terminated before scan operation subsequently starts.
Actuator control 117 can communicate with scanning element 106 with coordinating to activate and scan operation.Cause Dynamic device controller 117 can be a part for actuator 116, or it can be disposed in scanning element 106 Near, or it can be disposed in single control station, with the controller communication of scanning element 106.Cause Dynamic device controller 117 can via electrically connecting, mechanical attachment or electromechanical couple and with scanning element 106 Synchronize.
In certain embodiments, the portions of proximal of fibre bundle 102 can be with the distal part of fibre bundle 102 Move together or rotate.In certain embodiments, whole fibre bundle 102 can rotate together.Shu Zhidong Device 116 can be configured to make the portions of proximal of fibre bundle 102 rotate together with distal part, transverse translation And/or longitudinal translation.Therefore, if it is desirable to, fibre bundle 102 is the most rotatable without torsion or mobile.
Fig. 3 illustrates OCT image equipment 300.OCT image equipment 300 a lot of aspects all can with on The OCT image equipment 100 stated is similar.Such as, scanning element 106 can make imaging across fibre bundle The proximal face 114 of 102 scans.Further, bundle actuator 116 can drive fibre bundle 102 to carry High imaging resolution.
Furthermore it is possible to provide translational table 118 to perform the scanning motion of scanner 110.Translational table 118 can make scanning element 106 move so that imaging scans across the proximal face 114 of fibre bundle 102.Example As, translational table 118 can support collimating lens 112 and coupled lens 108.When translational table 118 moves Time, the light beam of imaging is removable to be scanned with the proximal face 114 to fibre bundle 102.Scanning is single Unit 106 can include multiple or multiple actuator, with motion scan unit on various different directions 106。
Fig. 4 illustrates the cross sectional view of imaging probe 402.In some designs, imaging probe 402 Embodiment can receive or accommodate OCT image equipment 100/300 or at least its part.Imaging probe 402 can To include the handle 122 and the sleeve pipe 120 that are configured to be operated in operation process by surgeon, should The far-end of sleeve pipe is configured to tissue to be inserted into, such as eyes.Scanning element 106 can be positioned in hands In handle 122.Sleeve pipe 120 could be attached to handle 122, or highlights from handle 122.Fibre bundle 102 can It is positioned in sleeve pipe 120, or during at least its part is positioned in sleeve pipe 120.Light beam forms unit 104 The far-end of sleeve pipe 120 can be positioned in.Scanning element 106 can make imaging across fibre bundle 102 Proximal face 114 scans.Fibre bundle 102 can be utilized to guide imaging or the light beam of scanning to light beam Form unit 104.Light beam forms unit 104 and can make the imaging beam orientation of scanning or redirect, and court Imaging beam to the scanning of target tissue output redirection.As discussed above, fibre bundle 102 can be driven To improve imaging resolution.
Fig. 5 illustrates OCT image equipment 500.In a cross sectional view, OCT image equipment 500 Imaging probe 502 and OCT engine 504 can be included.Imaging probe 502 a lot of aspects all can with on The imaging probe 402 stated is similar.Such as, imaging probe 502 can include being configured to by surgeon The handle 122 operated in operation process and sleeve pipe 120, the far-end of this sleeve pipe is configured to be inserted Enter tissue, such as eyes.Further, sleeve pipe 120 could be attached to handle 122.Fibre bundle 102 can It is positioned in sleeve pipe 120.Light beam forms unit 104 can be positioned in the far-end of sleeve pipe 120.
Compared with imaging probe 402, in the design illustrated at present, scanning element 106 can be positioned in In the single OCT engine 504 spaced apart with handle 122, as in single control station.Fibre bundle 102 can extend between OCT engine 504 and imaging probe 502.OCT engine 504 can be configured Becoming the imaging from the scanning returned to generate OCT image, this imaging returns from target tissue.
Such as, OCT engine 504 can control scanning element 106 so that imaging is across fibre bundle 102 Proximal face 114 scans.Fibre bundle 102 can be utilized to be guided to one-tenth from OCT engine 504 by imaging As probe 502.In imaging probe 502, imaging guiding can be formed list to light beam by fibre bundle 102 Unit 104 and be output to target tissue.Imaging then can be reflected by target tissue.The imaging of reflection can be through Formed unit 104 by light beam and be captured and return in fibre bundle 102.The imaging of reflection can be directed Return OCT engine 504.OCT engine 504 can use OCT method to carry out the imaging of reflection Analyze and produce OCT image, interfere including being formed with reference beam.Can with OCT engine 504 The OCT image generated to user (such as surgeon) display in the user interface display of communication.
Fig. 6 a shows, in certain embodiments, OCT image equipment 100/300/500 can wrap further Including removable optical beam manipulation unit 510, it is remote that this removable optical beam manipulation unit is positioned in fibre bundle 102 End, adjacent beams are formed at unit 104 and are configured to move with the scanning element in increase target tissue Density.Fig. 6 b shows, in certain embodiments, OCT image equipment 100/300/500 can be further Including removable optical beam manipulation unit 510, this removable optical beam manipulation unit is positioned in light beam and forms unit The far-end of 104 and be configured to the density of the mobile scanning element to increase in target tissue.
Fig. 7 illustrates and utilizes OCT image equipment 100/300/500 to carry out the eyes treated.Specifically, Show and connect subject eyes 600.Eyes 600 include sclera 602, cornea 604, anterior chamber 606 and Back room 608.Pouch 610 is illustrated in back room 608.Eyes 600 also include retina 612.
Also illustrate OCT image equipment 500 in the figure 7.As discussed above, OCT image equipment 500 imaging moieties that can be configured to eyes 600, such as retina 612.OCT image equipment 500 is permissible Including imaging source 622, optical coherence tomography (OCT) engine 504, controller 626, use Interface, family 628 and imaging probe 402/502.Light source 622 can be configured to offer can be imaged probe 502 The imaging of target goal biological tissue.Light source 622 can include providing bandwidth relatively wide (as 700 Between nm to 1400nm, between 900nm to 1200nm or 1000nm to 1100nm it Between) the superluminescent diode of light, ultrashort pulse laser, length scanning source or super continuous wave laser structure Become.Utilize the imaging reflecting from this target biological tissue and being captured by imaging probe 502 to generate mesh The image of mark biological tissue.
The imaging that OCT engine 504 is configured to make to receive from light source 622 splits into and is imaged probe 502 imaging beams being directed towards target biological tissue and the reference beam being guided on reference mirror. OCT engine 504 can be a kind of spectral domain system, swept light source system or time domain system.OCT engine 504 are further configured to receive the one-tenth being reflected and being imaged probe 502 capture by target biological tissue As light.OCT engine 504 then can interfere the imaging beam being returned and the ginseng returned from reference mirror Examine light beam, to form interference pattern.The interferogram between the imaging of reflection and reference beam can be utilized Sample generates the image of target biological tissue.Correspondingly, OCT engine 504 can include being configured to right Interference pattern carries out the detector detected.This detector can include photodiode detector, balance inspection Survey device, charge-coupled detector(CCD) (CCD), pixel or generate any of the signal of telecommunication based on detected light The array of other kinds of one or more sensor.Further, this detector can include two dimension biography Sensor array and detector photographing unit.
Controller 626 can include processor and memorizer, and it can include for controlling light source 622, using Interface, family 628, the actuator control 117 of bundle actuator 116 and/or the operation of imaging probe 502, And for performing and carry out function and program to perform journey to carry out the one or more of OCT image process Sequence.Such as, controller 626 can be configured to control the bundle actuator 116 in imaging probe 502, to drive The far-end of dynamic fibre bundle 102 is Tong Bu with the scan operation of OCT image equipment 500.
In light source 622, OCT engine 504, controller 626 and user interface 628 one or many Individual with can communicating with one another connection realization in single control station or in common control station.At some In design, the parts of OCT engine, such as its scanning element 106, may be accommodated in probe 402, As shown in Figure 4.In other design, scanning element can accommodate, as at Fig. 5 respectively with probe 502 In.
Such as, in some implementations, light source 622, OCT engine 504 and controller 626 can quilts It is positioned at and communicates with user interface 628 in the control station coupled.User interface 628 can be carried on this control On platform processed or formed control station a part.Further, user interface 628 or at least one or many Individual part can be separated with this control station.User interface 628 can include display, and this display is joined It is set to present image for user or patient, and shows in OCT image operating process by imaging probe The tissue of 502 scannings.User interface 628 can also include input equipment or system, in other input equipment Among include keyboard, mouse, stick, touch screen, graduated disc and button in a non-limiting manner.
In some designs, imaging probe 402/502 can carry out optical-fibre communications with OCT engine 504.? This on the one hand, imaging probe 402/502 be configured to present come from light source 622 through OCT engine The light of 504 to target biological tissue and for making the purpose of imaging of tissue.Further, imaging probe 402/502 can be in Electricity Federation with controller 626 leads to.At this on the one hand, controller 626 can via to The signal of telecommunication that imaging probe 402/502 sends controls the 116 of imaging probe 402/502, in order to make this cause Dynamic system makes imaging beam bundle actuator being scanned across target biological tissue.Optical cable 632 can will become As probe 402/502 is connected to OCT engine 504 and/or controller 626.At this on the one hand, optical cable 632 can include fibre bundle 102, optical fiber 115, one or more electric conductor, one or more insulation Body, one or more guard shield and/or be configured to beneficially imaging probe 402/502 and OCT engine 504 And/or other features of the optically and/or electrically UNICOM between controller 626.Further, it should reason Solving, optical cable 632 can include multiple single cable.Such as, in some cases, optical cable can will become As probe 402/502 is connected to OCT engine 504, and individually cable can be by imaging probe 402/502 It is connected to controller 626.
In the embodiment shown, optical cable 632 can terminate in connector 634, and this connector is joined It is set to beneficially removable for imaging probe 402/502 is attached to optical cable 632.Connector 634 can be by It is configured to be selectively engaged the connector 636 being associated with imaging probe 402/502, is beneficial to imaging and visits 402/502 couples with mechanical attachment, the optics of optical cable 632 and/or electrically connects.Such as, along imaging Probe 402/502 length extend fibre bundle 102 can via the connection of connector 634 and 636 light Student's federation is connected to OCT engine 504.In the embodiment shown, connector 636 can be configured to and connect Fitting 634 is threadedly engaged.It will be appreciated, however, that any kind of one or more selection can be utilized Imaging probe 402/502 is attached to optical cable 632 by property engagement features or connector, includes but not limited to Press-in cooperation, Luer lock, screw thread and combinations thereof.Connector 636 selectively engages with connector 634 Make whole probe 402/502 be disposably, be configured to the parts of use during single, and connect Fitting 634 and optical cable 632 are then (such as the using high-pressure sterilizing course) that can be sterilized can be many The reusable parts used during individual.In the 5 embodiment of figure 5, optical cable 632 can be into As the part of probe 402/502, and imaging probe 402/502 and optical cable 632 are attached to OCT draw Hold up the connector of 504 can be positioned in OCT engine 504, side or neighbouring.
Scanning element 106 can be positioned in the single use portion of handle 122 or non-the one of handle 122 In the reusable part of secondary property or in the unitary part of OCT engine 504, again make it can Reuse.
Can set handle 122 (otherwise referred to as shell 122) size and shape and make user (as Surgeon) it is held by hand holding.To this end, handle 122 can include surface of the texture 648 (such as hair side, Annular knurl or include convex/concave, taper, other surface character and/or a combination thereof) to strengthen user Grasping on handle 122.In use, user can control distally by control crank 122 Be attached to the position of sleeve pipe 120 of shell/handle 122, thus guide into towards this target biological tissue As light beam.
The size and shape of sleeve pipe 120 can be set and for inserting eye by the sclera 602 of eyes 600 Eyeball 600 and the imaging of beneficially retina 612.Sleeve pipe 120 can be one-body molded with handle 122.Can replace Dai Di, sleeve pipe 120 and handle 122 can be affixed to single parts each other.At this on the one hand, Probe 402/502 can include one or more connector machinery with beneficially sleeve pipe 120 with handle 122 Couple, optics couples and/or electrically connects.Therefore, sleeve pipe 120 or sleeve pipe 120 and a part of handle 122 Can be arranged to the disposable unit used during single, and handle 122 or handle 122 Remainder is then (such as the using high-pressure sterilizing course) that can be sterilized and can be during multiple The reusable parts used.In other embodiments again, whole handle 122 can be disposable 's.Finally, in some designs, whole probe 402/502 is all disposable.Light beam forms unit 104, such as lens, can be fixed in the far-end of sleeve pipe 120.Light beam forms unit 104 and can be configured Become to make imaging in the upper focusing of target biological tissue (such as retina 612).It is permissible that light beam forms unit 104 It is graded index (GRIN) lens.According to this embodiment, graded index can be spherical, Axial or radial direction.Light beam forms unit 104 and can also is that sphere lens.Other lenses can be used Shape.
Examples given above is exemplary only, it is not intended that limit.Those skilled in the art Can easily dream up the other system consistent with disclosed embodiment, described other system is intended to be in this In the range of disclosure.Therefore, the application is not limited except as by the appended claims.

Claims (24)

1. an optical imaging apparatus, including:
Fibre bundle, this fibre bundle includes the one group of optical fiber being configured to guide imaging;
Light beam formed unit, this light beam formed unit be configured to receive from this fibre bundle imaging also This imaging is redirected to target area;And
Bundle actuator, this bundle actuator is configured to the position of this group optical fiber to this fibre bundle and adjusts Whole.
2. optical imaging apparatus as claimed in claim 1, including:
Scanning element, this scanning element is configured to make this imaging sweep in the proximal face of this fibre bundle Retouch, so that the imaging being redirected is scanned along the scanning pattern in this target area.
3. optical imaging apparatus as claimed in claim 2, this scanning element includes at least in following item Individual:
Rotatable mirror, galvanometer, resonance scanner, multiaspect scanner, MEMS scanner and can Mobile station.
4. optical imaging apparatus as claimed in claim 2, wherein:
This scanning element includes translational table;And
The translational table of this scanning element moves together with coupling with the proximal face of this fibre bundle.
5. optical imaging apparatus as claimed in claim 2, this bundle actuator includes:
Actuator control, this actuator control is attached to this scanning element and is configured to control to be somebody's turn to do Bundle actuator is to be adjusted the position of this group optical fiber relatively with the scan operation of this scanning element.
6. optical imaging apparatus as claimed in claim 2, wherein:
The configuration of the distal part that this bundle actuator is configured to this group optical fiber to this fibre bundle is adjusted Whole;And
The distal part of this group optical fiber is disposed in the sleeve pipe of imaging probe.
7. optical imaging apparatus as claimed in claim 2, wherein:
This bundle actuator is configured to the configuration of this group optical fiber to this fibre bundle and is adjusted, to increase this target The density of the scanning element in region.
8. optical imaging apparatus as claimed in claim 2, wherein:
This bundle actuator is configured to the position of this group optical fiber to this fibre bundle and is adjusted, and thus adjusts Between the distance at the center of the optical fiber before and after adjustment is less than the center of the adjacent fiber of this fibre bundle Distance.
9. optical imaging apparatus as claimed in claim 2, wherein:
This bundle actuator is configured to make the distal part of this group optical fiber of this fibre bundle to rotate.
10. optical imaging apparatus as claimed in claim 2, wherein:
This bundle actuator is configured to make the distal part of this group optical fiber of this fibre bundle to reverse.
11. optical imaging apparatus as claimed in claim 2, wherein:
This bundle actuator is configured to make the distal part transverse translation of this group optical fiber of this fibre bundle.
12. optical imaging apparatus as claimed in claim 2, wherein;
This bundle actuator is configured to make the distal part of this group optical fiber of this fibre bundle and this light beam be formed At least one in unit carries out longitudinal translation.
13. optical imaging apparatus as claimed in claim 12, wherein:
This bundle actuator be manually or automatically focus subsystem a part, be configured to this fibre bundle At least one that the distal part of this group optical fiber and this light beam are formed in the position of unit carries out longitudinal tune Whole, with the operating distance formed between unit according to imageable target region and this light beam, this light beam is formed The focal length of unit is adjusted, in order to improve imaging features.
14. optical imaging apparatus as claimed in claim 2, including:
Imaging probe, it comprises
Handle, this handle is configured to accommodate this scanning element, and
Sleeve pipe, this sleeve pipe is attached to this handle and is configured to accommodate at least some of of this fibre bundle.
15. optical imaging apparatus as claimed in claim 14, wherein:
At least one in this handle and this imaging probe is disposable.
16. optical imaging apparatus as claimed in claim 2, including:
Imaging probe, this imaging probe is configured to accommodate at least some of of this fibre bundle;And
Optical coherence tomography (OCT) engine, this engine is configured to
Accommodate this scanning element, and
From the scanning imagery photogenerated OCT image returned, this imaging is returned from imageable target region.
17. optical imaging apparatus as claimed in claim 16, wherein:
This OCT engine is positioned in the console.
18. optical imaging apparatus as claimed in claim 2, this scanning element includes:
Multiple and multiple actuators.
19. optical imaging apparatus as claimed in claim 1, this group optical fiber of this fibre bundle includes in following item At least one:
Single-mode fiber, multimode fibre, single mode waveguide, multimode waveguide and hollow pipe.
20. optical imaging apparatus as claimed in claim 1, this light beam forms unit and includes in following item extremely Few one:
Lens, grin lens, globe lens, diffraction element, non-spherical lens and object lens.
21. optical imaging apparatus as claimed in claim 1, including:
Removable optical beam manipulation unit, this removable optical beam manipulation unit is in the distally of the far-end of this fibre bundle Position and be configured to increase the density of the scanning element in imageable target region.
22. optical imaging apparatus as claimed in claim 21, wherein:
This removable optical beam manipulation unit be manually or automatically focus subsystem a part, be configured to root Form the operating distance between unit according to imageable target region and this light beam and this light beam is formed the light of unit The position learning element carries out longitudinally adjusted, in order to improve imaging features.
The method of 23. 1 kinds of ophthalmology imagings, the method includes:
Imaging beam is made to be scanned across the near-end of fibre bundle by scanning element;
With bundle actuator, the configuration of the distal part of this fibre bundle is adjusted;And
Form unit by light beam to guide imaging to target area.
24. methods as claimed in claim 23, wherein, adjust configuration and include:
With bundle actuator the configuration of the distal part of this fibre bundle is adjusted, thus adjust before and adjust The distance at the center of the optical fiber after whole is less than the distance between the center of the adjacent fiber of this fibre bundle.
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