CN105816215A - Regional blood flow guiding device as well as preparation method and use method thereof - Google Patents
Regional blood flow guiding device as well as preparation method and use method thereof Download PDFInfo
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- CN105816215A CN105816215A CN201510908916.1A CN201510908916A CN105816215A CN 105816215 A CN105816215 A CN 105816215A CN 201510908916 A CN201510908916 A CN 201510908916A CN 105816215 A CN105816215 A CN 105816215A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
- A61B17/12118—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm for positioning in conjunction with a stent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
Abstract
The invention provides a regional blood flow guiding device as well as a preparation method and a use method thereof, and mainly aims to insulate a wide-necked aneurysm and a parent artery blood vessel and ensure blood flow in a collateral vessel to be unblocked. The regional blood flow guiding device comprises a skeleton, a regional dense net area, end part connection ribs and developing markers. The preparation method comprises the steps of skeleton cutting, residue removing, heat treatment and formation, acid pickling, polishing, marker assembling, and dense net area producting. The use method comprises the following steps: pressing the regional blood flow guiding device into a transferring sheath, sending the transferring sheath to a diseased region, locating under X rays via the developing marker of the regional blood flow guiding device, and releasing the device, wherein the dense net area completely covers the aneurysmal neck part of the wide-necked aneurysm, and blood flow in the collateral vessel is prevented from being unblocked. Compared with the prior art, the problem that the conventional regional blood flow guiding device is easy to cause blockage of the collateral vessel is solved, and operation risk is reduced effectively.
Description
Technical field
The present invention relates to the preparation and application of a kind of regional flow guider and this device thereof, belong to blood flow guider and the preparation method of this guider and using method technical field.
Background technology
Aneurysm is the angiomatoid projection produced due to tremulous pulse local vascular abnormal change.Cardinal symptom is many to be caused caused by subarachnoid hemorrhage by aneurysm rupture, and mortality rate is the highest.Along with increasingly sharpening of China's aged tendency of population, suffering from aneurysmal patient and get more and more, if not having preferable Therapeutic Method, patient may can be in peril of one's life.
Wide neck aneurysm being treated to the hot issue in always interventional therapy field, traditional Therapeutic Method has Coil embolization treatment, the treatment of sacculus secondary spring circle, support secondary spring circle treatment etc..The relapse rate of simple employing Coil embolization wide neck aneurysm is higher, although the treatment of support secondary spring circle reduces the relapse rate that aneurysm is at a specified future date, but still there is turn occupation time process and thromboembolism Operation Fee expensive (needing to fill multiple turn) etc., the treatment of blood flow guider is a kind of method of emerging treatment wide neck aneurysm, the ev3 company Pipeline device the most listed, this device is by effectively changing the hemodynamics at tumor neck, thus reach to change blood flow direction, realize the purpose of vascular remodeling, and it is low to have aneurysm late relapse rate, the advantages such as agravic occupation time process, but owing to this blood flow guider is while isolation aneurysm cavity, also the risk of closure collatoral vessel can be there is, bigger limitation is there is on being suitable for.At present as Pipeline this blood flow guider be mainly used near there is no the wide neck aneurysm of collatoral vessel.
Summary of the invention
It is an object of the invention to provide the preparation and application of a kind of regional flow guider and this device thereof, be mainly used in solving the treatment problem of the wide neck aneurysm with collatoral vessel.
It is an object of the invention to be achieved through the following technical solutions:
A kind of regional flow guider, including: skeleton, local dense net district, end development code is carved and end dowel, it is characterized in that, described skeleton uses Nitinol pipe to form through laser engraving, support bar quantity on skeleton is four to eight, and be uniformly distributed at circumferencial direction, centre position on skeleton is local dense net district, end development code carves the two ends being positioned on skeleton, every one end of quantity that end development code is carved is one to four, end dowel fixing and being connected between adjacent supports bar, the a length of L of developing mark in local dense net district, for being accurately positioned position in the blood vessel, local dense net district.
Described local dense net district is the close net that becomes of weaving filaments or with the unit grid of macromolecule membrane.
The shape of described skeleton is divided into spindle or cylindricality two kinds.
The diameter range of described skeleton is 2.5～6.0mm, and length range is 20～60mm, and developing mark length L in local dense net district accounts for the 20%～70% of skeleton total length.
The described unit grid with macromolecule membrane uses laser entirety engraving to form, and it is made up of rhombus or the open loop of polygonized structure or closed-loop element lattice.
Described end dowel uses laser entirety engraving to form, and it is shaped as W shape, sine and cosine waveform or V-arrangement.
The preparation method of a kind of regional flow guider, comprises the following steps: one, select external diameter 1.0～1.5mm, the superlastic state Nitinol pipe of wall thickness 0.15～0.25mm to carve on laser cutting machine；Two, utilize tiny frotton that the inwall of NiTi pipe is carried out polishing to remove slag, under the microscope the waste residue on tube wall peeled off one by one with precision tweezers simultaneously and remove；Three, being fixed on the rustless steel fixture of spindle or cylindricality by the NiTi pipe after the hollow out that removes slag, be then placed in vacuum heat treatment furnace, design temperature is 420～550 DEG C, temperature retention time 5～10 minutes, shapes skeleton diameter to 2.5～6.0mm through multi-step heat treatment；Four, stereotyped skeleton carries out in the mixed aqueous solution of concentrated nitric acid and Fluohydric acid. (mixed proportion 5:1～10:1, volumetric ratio) ultrasound wave pickling 5～10 minutes, and pickling uses purified water ultrasonic waves for cleaning 5～10 minutes again after completing, then dry；Five, using Nitinol special-purpose polishing liquid to be polished, sets the time of polishing as 20～40S, after having polished, skeleton is carried out by employing sodium bicarbonate solution, then rinses by purified water and dries；Six, by the two ends of skeleton fit on developing mark by the way of riveting or welding, and carry out gold-plated or tungsten on the inner frame surface, region that skeleton intermediate length is L or material that platinumiridio can develop, the thickness of coating is not more than 1 μm, or with the microfilament shuffling that can develop in close barrier, such as platinum wire, gold-plated tungsten wire or platinumiridio silk；Seven, use a diameter of 0.03～the nitinol alloy wire of 0.06mm, tungsten filament, politef silk, dacron thread, nylon yarn, polyester capillaries or polyurethane silk weave in the region that skeleton intermediate length is L, the micropore diameter range of braiding is 20～300 μm；Or use polished local with in the polymer organic solution of the nickel-titanium alloy framework immersion thickness of unit grid, at the uniform velocity mention skeleton, treat that organic solvent vapors away, grid plan is formed one layer of homogeneous terylene, nylon, polyester, polyurethane or politef densification macromolecule membrane and is finished product.
The using method of a kind of regional flow guider, it is characterised in that comprise the following steps: one, utilize support pressure to hold machine and regional flow's guider is contained in inside delivery sheath in advance；Two, stent delivery sheath pipe is at the lesion locations that guiding wire arrives blood vessel, makes the local dense net district being in squeezed state that tumor neck be completely covered under radiography, and makes close barrier at tumor neck two ends each reserved 4～6mm；Three, withdrawing delivery sheath makes device original place be discharged into blood vessel, and support automatic expansion is to nominal diameter, and close barrier is to reaching at tumor neck accurately to cover；Four, delivery sheath is withdrawn to external.
Beneficial effects of the present invention: regional flow's guider of the present invention, with the local dense net district that can develop, its support frame material is nickel-titanium alloy material, there is the most radially support force, when this device is placed at the wide neck aneurysm with collatoral vessel, doctor can select the device of appropriate size according to the width of aneurysm neck, and the local dense net district of development is placed exactly in the best of it of tumor neck, aneurysm cavity is completely cut off with arteries, reach the purpose that local vascular is reinvented, the skeleton that two ends are sparse simultaneously will not block collatoral vessel, it is substantially reduced the risk of operation process.
Accompanying drawing explanation
Fig. 1 is the regional flow's guider structural representation with the close net of braiding of a kind of cylindricality.
Fig. 2 is a kind of regional flow's guider structural representation with polymeric membrane.
Fig. 3 is a kind of fusiform with the regional flow's guider structural representation weaving close net.
Fig. 4 is a kind of delivery sheath structural representation being loaded with regional flow's guider.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is described in further detail: the present embodiment is implemented under premised on technical solution of the present invention, gives detailed embodiment, but protection scope of the present invention is not limited to following embodiment.
As shown in Figure 1, the present embodiment is the regional flow's guider with the close net of braiding of a kind of cylindricality, the skeleton 2 of regional flow's guider 1 is cylindrical, the quantity of its support bar is four, the angle of the most adjacent two support bars is 90 °, the most adjacent two support bars are connected by W shape or sine-shaped end dowel 5 in end, middle local dense net district 3 is with the braided wires that can develop, the entire length of this device is 30mm, a diameter of 3.0mm, the a length of 20mm of local dense net district L, its concrete preparation method is as follows: one, select diameter 1.0mm, the superlastic state Nitinol pipe of wall thickness 0.14mm, the StarcutTubeFiber laser cutting machine of Rofin company of Germany cuts；Two, utilize tiny frotton that the inwall of NiTi pipe is carried out polishing to remove slag, under the microscope the waste residue on tube wall peeled off one by one with precision tweezers simultaneously and remove；Three, the NiTi pipe after the hollow out that removes slag is fixed on the cylindrical stainless steel fixture of diameter 2.0mm, it is then placed in vacuum heat treatment furnace, design temperature 420 DEG C, temperature retention time is 5min, it is cold that insulation terminates laggard line space, then continues skeleton to be fixed on the spindle rustless steel fixture of diameter 3.0mm, design temperature 550 DEG C, temperature retention time is 5min, and it is cold that insulation carries out rapid water after terminating；Four, stereotyped skeleton is carried out ultrasound wave pickling 8 minutes in the concentrated nitric acid mixed aqueous solution (volume fraction 9%) with Fluohydric acid. (mixed proportion is 9:1), pickling uses purified water ultrasonic waves for cleaning 8 minutes after completing again, then dries；Five, using Nitinol special-purpose polishing liquid to be polished, sets the time of polishing as 25S, after having polished, skeleton is carried out by employing mass concentration 4% sodium bicarbonate aqueous solution, then rinses by purified water and dry；Six, using the platinum wire of a diameter of 0.03mm and nylon yarn shuffling in the region that skeleton intermediate length is L, the micropore diameter range of braiding is 120 μm, and close barrier weaves a length of 20mm.
As shown in Figure 2, the present embodiment is a kind of regional flow's guider with polymeric membrane, skeleton 13 with regional flow's guider 17 of polymeric membrane is cylindrical, the quantity of its support bar is eight, the angle of the most adjacent two support bars is 45 °, the most adjacent two support bars are connected by the end dowel 15 of V-arrangement in end, middle close barrier 14 consist of the unit grid 16 with fine and close macromolecule membrane, the entire length of this device is 40mm, a diameter of 5.0mm, the a length of 25mm of middle close barrier L, its concrete preparation method is as follows: one, select diameter 1.2mm, the superlastic state Nitinol pipe of wall thickness 0.16mm, the StarcutTubeFiber laser cutting machine of Rofin company of Germany cuts；Two, utilize tiny frotton that the inwall of NiTi pipe is carried out polishing to remove slag, under the microscope the waste residue on tube wall peeled off one by one with precision tweezers simultaneously and remove；Three, NiTi pipe after the hollow out that removes slag is fixed on the cylindrical stainless steel fixture of diameter 2.0mm, it is then placed in vacuum heat treatment furnace, design temperature 460 DEG C, temperature retention time is 10min, it is cold that insulation terminates laggard line space, then skeleton is fixed on the cylindrical stainless steel fixture of diameter 3.5mm, it is placed again in vacuum heat treatment furnace, design temperature 480 DEG C, temperature retention time is 10min, it is cold that insulation terminates laggard line space, skeleton is fixed on the cylindrical stainless steel fixture of diameter 5.0mm by the 3rd step, design temperature 530 DEG C, temperature retention time is 5min, it is cold that insulation carries out rapid water after terminating, with open unit grid in the stereotyped region that skeleton intermediate length is L, unit grid is rhombus；Four, stereotyped skeleton is carried out ultrasound wave pickling 8 minutes in the concentrated nitric acid mixed aqueous solution (volume fraction 8%) with Fluohydric acid. (mixed proportion is 8:1), pickling uses purified water ultrasonic waves for cleaning 8 minutes after completing again, then dries；Five, using Nitinol special-purpose polishing liquid to be polished, sets the time of polishing as 40S, after having polished, skeleton is carried out by employing mass concentration 5% sodium bicarbonate aqueous solution, then rinses by purified water and dry；Six, being the unit grid surface gold-plating in L region by the intermediate length of skeleton, the thickness of Gold plated Layer is 0.5 μm；Seven, terylene is dissolved in oxolane it is configured to the polymer solution of relative thickness, then use in the nickel-titanium alloy framework immersion solution with unit grid of the local, at the uniform velocity mention skeleton, treat that organic solvent vapors away, grid plan is formed one layer of homogeneous terylene macromolecule membrane.
As shown in Figure 3, the present embodiment is a kind of fusiform with the regional flow's guider weaving close net, with weaving the skeleton 19 of regional flow's guider 18 of close net in spindle, the quantity of its support bar is the six roots of sensation, the angle of the most adjacent two support bars is 60 °, two ends respectively carry a developing mark 21, intermediate length be close barrier 20 material of L be gold-plated tungsten filament, a diameter of 4.0mm of this device, overall length is 50mm, the a length of 20mm in the closeest barrier, its concrete preparation method is as follows: one, select diameter 1.1mm, the superlastic state Nitinol pipe of wall thickness 0.15mm, the StarcutTubeFiber laser cutting machine of Rofin company of Germany cuts；Two, utilize tiny frotton that the inwall of NiTi pipe is carried out polishing to remove slag, under the microscope the waste residue on tube wall peeled off one by one with precision tweezers simultaneously and remove；Three, the NiTi pipe after the hollow out that removes slag is fixed on the cylindrical stainless steel fixture of diameter 2.0mm, it is then placed in vacuum heat treatment furnace, design temperature 460 DEG C, temperature retention time is 10min, it is cold that insulation terminates laggard line space, then proceedes to be fixed on skeleton on the spindle rustless steel fixture of diameter 4.0mm, design temperature 530 DEG C, temperature retention time is 5min, and it is cold that insulation carries out rapid water after terminating；Four, stereotyped skeleton is carried out ultrasound wave pickling 5 minutes in the concentrated nitric acid mixed aqueous solution (volume fraction 10%) with Fluohydric acid. (mixed proportion is 10:1), pickling uses purified water ultrasonic waves for cleaning 5 minutes after completing again, then dries；Five, using Nitinol special-purpose polishing liquid to be polished, sets the time of polishing as 30S, after having polished, skeleton is carried out by employing mass concentration 5% sodium bicarbonate aqueous solution, then rinses by purified water and dry；Six, by the two ends of skeleton one developing mark of each fit on by the way of riveting or welding；Seven, the gold-plated tungsten wire using a diameter of 0.04mm weaves in the region that skeleton intermediate length is L, and the micropore diameter range of braiding is 100 μm, and close barrier weaves a length of 20mm.
As shown in Figure 4, a kind of typical cylindricality regional flow guider 1 utilizes Blockwise company of the U.S. special pressure of nick-eltitanium alloy stent to hold machine and is contained in advance in delivery sheath 12, delivery sheath 12 comprises outer sheath 6, interior sheath pipe 10, rotate haemostatic valve 9 and tapered point 11, delivery sheath is with two developing marks 7 and 8, for blood flow guider being accurately positioned in lesion locations region, specific embodiment is as follows: select 15 kilograms of dogs of body weight one, with 1% pentobarbital, experimental dog is carried out intraperitoneal anesthesia, the opening of vein capsule is fit to Carotid opening by application micro anastomosis technology, then sew up, set up wide neck aneurysm on the left of in the of, by Ink vessel transfusing radiography, record a length of 8mm of tumor neck, the a diameter of 3.0mm of parent artery.The a diameter of 4.0mm of regional flow's guider selected, overall length is 30mm, the a length of 12mm in close barrier, aperture is 100 μm, femoral artery puncture through dog, the delivery sheath being preinstalled with regional flow's guider arrives left carotid artery lesion through guiding wire, first tumor neck is generally under X-ray two developing mark centre positions of delivery sheath, then the developing mark carried by close barrier adjusts the position relative to tumor neck, the close barrier, make close barrier be completely covered at tumor neck, make each reserved about 3mm in device two ends in compressive state.Withdraw guiding wire, and the interior sheath pipe of fixing delivery sheath, withdrawing outer sheath, device discharges in Ink vessel transfusing original place simultaneously, and its diameter automatic expansion is fitted to blood vessel, close barrier is completely covered tumor neck, now two ends length in reserve about 2mm (device has certain cripetura rate), row arterio-angiography again, tumor intracavity contrast-agent-free, blood flow direction at tumor neck changes, and reaches the purpose of vascular remodeling.Being covered wide neck aneurysm accurately by regional flow's guider in this operation process, do not interfere with the blood flow smoothness of collatoral vessel, operation risk is relatively low, and cure rate is high.
The above; it is only the present invention preferably detailed description of the invention; these detailed description of the invention are all based on the different implementations under general idea of the present invention; and protection scope of the present invention is not limited thereto; any those familiar with the art is in the technical scope that the invention discloses; the change that can readily occur in or replacement, all should contain within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (8)
1. regional flow's guider, including: skeleton (2), local dense net district (3), end development code carves (4) and end dowel (5), it is characterized in that, described skeleton (2) uses Nitinol pipe to form through laser engraving, support bar quantity on skeleton (2) is four to eight, and be uniformly distributed at circumferencial direction, centre position on skeleton (2) is local dense net district (3), end development code is carved (4) and is positioned at the two ends on skeleton (2), end development code is carved the every one end of quantity of (4) and is one to four, end dowel (5) fixing and being connected between adjacent supports bar, the a length of L of developing mark in local dense net district (3), for being accurately positioned position in the blood vessel, local dense net district (3).
Regional flow the most according to claim 1 guider, it is characterised in that described local dense net district (3) is the close net that becomes of weaving filaments or with the unit grid of macromolecule membrane.
Regional flow the most according to claim 2 guider, it is characterised in that the shape of described skeleton (2) is divided into spindle or cylindricality two kinds.
Regional flow the most according to claim 3 guider, it is characterized in that, the diameter range of described skeleton (2) is 2.5～6.0mm, length range is 20～60mm, and developing mark length L of local dense net district (3) accounts for the 20%～70% of skeleton (2) total length.
Regional flow the most according to claim 2 guider, it is characterised in that the described unit grid with macromolecule membrane uses laser entirety engraving to form, and it is made up of rhombus or the open loop of polygonized structure or closed-loop element lattice.
Regional flow the most according to claim 5 guider, it is characterised in that described end dowel (5) uses laser entirety engraving to form, and it is shaped as W shape, sine and cosine waveform or V-arrangement.
7. the preparation method of the regional flow's guider described in claim 1～6 any claim, it is characterized in that, comprise the following steps: one, select external diameter 1.0～1.5mm, the superlastic state Nitinol pipe of wall thickness 0.15～0.25mm to carve on laser cutting machine；Two, utilize tiny frotton that the inwall of NiTi pipe is carried out polishing to remove slag, under the microscope the waste residue on tube wall peeled off one by one with precision tweezers simultaneously and remove；Three, being fixed on the rustless steel fixture of spindle or cylindricality by the NiTi pipe after the hollow out that removes slag, be then placed in vacuum heat treatment furnace, design temperature is 420～550 DEG C, temperature retention time 5～10 minutes, shapes skeleton diameter to 2.5～6.0mm through multi-step heat treatment；Four, stereotyped skeleton carries out in the mixed aqueous solution of concentrated nitric acid and Fluohydric acid. ultrasound wave pickling 5～10 minutes, and pickling uses purified water ultrasonic waves for cleaning 5～10 minutes again after completing, then dry；Five, using Nitinol special-purpose polishing liquid to be polished, sets the time of polishing as 20～40S, after having polished, skeleton is carried out by employing sodium bicarbonate solution, then rinses by purified water and dries；Six, by the two ends of skeleton fit on developing mark by the way of riveting or welding, and carry out gold-plated or tungsten on the inner frame surface, region that skeleton intermediate length is L or material that platinumiridio can develop, the thickness of coating is not more than 1 μm, or with the microfilament shuffling that can develop in close barrier, such as platinum wire, gold-plated tungsten wire or platinumiridio silk；Seven, use a diameter of 0.03～the nitinol alloy wire of 0.06mm, tungsten filament, politef silk, dacron thread, nylon yarn, polyester capillaries or polyurethane silk weave in the region that skeleton intermediate length is L, the micropore diameter range of braiding is 20～300 μm；Or use polished local with in the polymer organic solution of the nickel-titanium alloy framework immersion thickness of unit grid, at the uniform velocity mention skeleton, treat that organic solvent vapors away, grid plan is formed one layer of homogeneous terylene, nylon, polyester, polyurethane or politef densification macromolecule membrane and is finished product.
8. the using method of regional flow's guider described in claim 1～6 any claim, it is characterised in that comprise the following steps:, utilize support pressure to hold machine and regional flow's guider is contained in inside delivery sheath in advance；Two, stent delivery sheath pipe is at the lesion locations that guiding wire arrives blood vessel, makes the local dense net district being in squeezed state that tumor neck be completely covered under radiography, and makes close barrier at tumor neck two ends each reserved 4～6mm；Three, withdrawing delivery sheath makes device original place be discharged into blood vessel, and support automatic expansion is to nominal diameter, and close barrier is to reaching at tumor neck accurately to cover；Four, delivery sheath is withdrawn to external.
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| WO2018086464A1 (en) * | 2016-11-08 | 2018-05-17 | Yiran Lu | Stent delivery system, corresponding flow diversion device, and assembly method of flow diversion device |
| CN108272487A (en) * | 2018-02-11 | 2018-07-13 | 南京普微森医疗科技有限公司 | A kind of braided support system |
| CN110236622A (en) * | 2018-03-09 | 2019-09-17 | 北京大学人民医院 | Artificial nerve catheter and preparation method thereof for the suture of different size bridge grafting nerves |
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