CN105769312A - Elasticity modulus determination method and preparation method of individualized limb bone fracture setting internal fixation device - Google Patents
Elasticity modulus determination method and preparation method of individualized limb bone fracture setting internal fixation device Download PDFInfo
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- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
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Abstract
The invention discloses an elasticity modulus determination method and preparation method of an individualized limb bone fracture setting internal fixation device.The elasticity modulus determination method comprises the steps that CT scanning is performed on a target limb bone, a three-dimensional model is rebuilt, the material attributes are given to the target limb bone, a finite element analysis model is built, and an elasticity modulus gradient distribution rule is obtained through analysis; the internal fixation device is drawn according to the operation requirements, and the elasticity modulus of the internal fixation device is obtained by aiming at the assembly relationship between the fracture part of the limb bone and the internal fixation device, combining the elasticity modulus gradient distribution rule and adopting an interpolation method.According to the elasticity modulus determination method and preparation method of the individualized limb bone fracture setting internal fixation device, internal individualization and external individualization are both achieved, the internal fixation device is externally fit with the human body limb bone and internally good in matching with the biomechanical characteristic of the individual bone, stress distribution of a steel plate and screws is more uniform and more reasonable, the stress shielding effect of an internal fixation material on the bone can be reduced, the compressing force of a fracture interface can be increased, the fracture heating fixation requirement is better met, and a scientific basis can be supplied to following research and development of a novel material, optimized design of an operation method and operative instruments and building of a relative database.
Description
Technical field
The present invention relates to fixation implant in orthopaedics, be specifically related to the personalized bones of limbs synthetism inner fixing device elastic modelling quantity that a kind of biomechanics meeting human limb bone requires and determine and preparation method.
Background technology
Fracture is a kind of common disease on clinical medicine, interior fixing then for usually needing the method used, and namely utilizes fixation implant in steel plate, screw etc. that fracture site directly carries out the method that operation is fixing.Good Fracture internal fixaiion implant should possess following condition: 1. good biocompatibility；2. sufficiently high intensity and stable fixing；3. the few complication of trying one's best also can promote union of fracture, namely requires not require nothing more than in fractures fixing solid, reduces shear stress and the stress shielding of fracture site simultaneously, be conducive to early functional exercise, promotion union of fracture.Stress shielding provides stable fixing in fracture early stage, union of fracture and callus are set up to have a negative impact and are made union of fracture growth of spur lack stress stimulation and make bone remoulding negative balance by the phase after the fracture, cause that bone density reduction, bone structure disorder, cortical bone and spongy bone loosen.
The interior fixation implant material adopted at present is homogeneous, although entirety has met skeleton dissects geometry and elastic modelling quantity, but skeleton elastic modelling quantity skewness and individual variation exist, still suffer from inside-fixture and do not mate phenomenon with skeleton not docile and local elastic modelling quantity, there is shear stress and stress shielding, cause inside-fixture to loosen, fracture, the complication such as fracture local osteoporosis, fracture delayed union not even healing around.Therefore, research and development meets the personalized interior fixation implant of skeleton biomechanical property, namely the bones of limbs personalization synthetism inner fixing device based on elastic modelling quantity registration is one of direction of research and development new implant, has important value to instructing scientific research personnel to find novel internal fixation material simultaneously.
Summary of the invention
The technical problem to be solved in the present invention: for above-mentioned interior fixation implant and the human limb bone not docile of prior art, the unmatched technical problem of elastic modelling quantity, one is provided to have concurrently inside and outside in personalization, with human limb bone docile, good with individual biomechanical properties in bones characteristics match, steel plate, the stress distribution of screw is more uniformly rationally, internal fixation material can be reduced to the stress-shielding effect of skeleton and the compression stress improving fracture interface, more conform to the fixing requirement of union of fracture, can be the research and development of next step new material, the personalized bones of limbs synthetism inner fixing device elastic modelling quantity designing and setting up Relational database offer scientific basis that optimizes of modus operandi and operating theater instruments is determined and preparation method.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is:
A kind of personalized bones of limbs synthetism inner fixing device elastic modelling quantity defining method, step includes:
1) carry out CT scan for the target bones of limbs that fracture occurs, CT scan data utilizes medical image control the threedimensional model of system reconstructing target bones of limbs；
2) utilizing medical image to control system and give the material properties of target bones of limbs, described material properties includes elastic modelling quantity and distribution, the Poisson's ratio of target bones of limbs；
3) set up the finite element analysis model of target bones of limbs, analyze, under the different operating modes specified, load and the contact definition specified, constraints, the elastic modelling quantity Gradient distribution rule drawing target bones of limbs by described finite element analysis model；
4) require to draw inner fixing device in mechanical drawing software according to operation, for the assembly relation between fracture site and the inner fixing device of target bones of limbs, the elastic modelling quantity Gradient distribution rule of combining target bones of limbs, takes interpolation method to obtain the elastic modelling quantity of inner fixing device.
Preferably, described step 2) in when utilizing medical image to control the material properties that system gives target bones of limbs, the calculating function expression of the elastic modelling quantity of target bones of limbs is as the formula (1)；
E-Modulus=-388.8+5925*Density(1)
In formula (1), E-Modulus is elastic modelling quantity, and Density is density, and the calculating function expression of density D ensity is as the formula (2)；
Density=-13.4+1017*Hu(2)
In formula (2), Density is density, and Hu is the gray value of CT scan.
Preferably, described step 2) in when utilizing medical image to control the material properties that system gives target bones of limbs, the value of the Poisson's ratio of target bones of limbs is 0.3.
The preparation method that the present invention also provides for a kind of personalized bones of limbs synthetism inner fixing device, step includes:
S1) the aforementioned personalized bones of limbs synthetism inner fixing device elastic modelling quantity defining method of the present invention is adopted to determine the elastic modelling quantity of inner fixing device；
S2) preparation of metal sintering technology is adopted to meet the inner fixing device of elastic modelling quantity requirement.
Personalization bones of limbs synthetism inner fixing device elastic modelling quantity defining method of the present invention has an advantage that the present invention is directed to target bones of limbs carries out CT scan and rebuild the threedimensional model of target bones of limbs；Give the material properties of target bones of limbs；Set up the finite element analysis model of target bones of limbs, analyze the elastic modelling quantity Gradient distribution rule drawing target bones of limbs, require to draw inner fixing device in mechanical drawing software according to operation, for the assembly relation between fracture site and the inner fixing device of target bones of limbs, the elastic modelling quantity Gradient distribution rule of combining target bones of limbs, takes interpolation method to obtain the elastic modelling quantity of inner fixing device.The present invention has concurrently inside and outside in personalization, with human limb bone docile, good with individual biomechanical properties in bones characteristics match, steel plate, screw stress distribution more uniformly rationally, internal fixation material can be reduced to the stress-shielding effect of skeleton and the compression stress improving fracture interface, more conform to the fixing requirement of union of fracture, it is possible to the optimization for the research and development of next step new material, modus operandi and operating theater instruments designs and sets up Relational database and provides scientific basis.
The preparation method of personalization bones of limbs synthetism inner fixing device of the present invention has an advantage that the further application that the preparation method of personalization bones of limbs synthetism inner fixing device of the present invention is personalization bones of limbs synthetism inner fixing device elastic modelling quantity defining method of the present invention, on the basis of elastic modelling quantity meansigma methods determining each segmentation of inner fixing device, metal sintering technology in application 3D printing technique is prepared and is met the inner fixing device that elastic modelling quantity requires, the inner fixing device obtained the not only external femur that meets dissects geometric properties, good with femoral surface sticking nature, and inherence meets skeleton material properties, namely elastic modelling quantity matches, biomechanical property is good, it is thus possible to realize the personalization of steel plate, fast custom, meet the rapid customization requirement of clinical operation.
Accompanying drawing explanation
Fig. 1 is the basic procedure schematic diagram of embodiment of the present invention method.
Fig. 2 is the three-dimensional femoral model set up in the embodiment of the present invention.
Fig. 3 is the material properties perspective view of femur in the embodiment of the present invention.
Fig. 4 is the material properties sectional structure schematic diagram of femur in the embodiment of the present invention.
Fig. 5 is that the material properties data representation given in the embodiment of the present invention is intended to.
Fig. 6 is the steel plate structure schematic diagram in the embodiment of the present invention.
Fig. 7 is the Facad structure schematic diagram of analog simulation internal fixation operation in the embodiment of the present invention.
Fig. 8 is the side structure schematic diagram of analog simulation internal fixation operation in the embodiment of the present invention.
Fig. 9 is simulation distal femur three-dimensional finite element model schematic diagram in the embodiment of the present invention.
Detailed description of the invention
Hereafter there is the femur special case as bones of limbs and four kinds of various sizes of inner fixing device A, B, C, D of correspondence of fracture of distal, first it is defined as example with the elastic modelling quantity of inner fixing device A, personalization bones of limbs synthetism inner fixing device elastic modelling quantity defining method of the present invention is described in further detail.
As it is shown in figure 1, the step of the present embodiment personalization distal femur synthetism inner fixing device elastic modelling quantity defining method includes:
1) carry out CT scan for the target femur that fracture occurs, CT scan data (Dicom data) utilizes medical image control the threedimensional model of system reconstructing target femur, as shown in Figure 2；In the present embodiment, medical image controls system and specifically adopts Mimics medical image to control system, can be used for the threedimensional model based on CT scan Dicom data reconstruction destination object, and give material properties for destination object, in order to follow-up carry out complete finite element analysis；
2) utilizing medical image to control system and give the material properties of target femur, material properties includes elastic modelling quantity and distribution, the Poisson's ratio of target femur；
3) set up the finite element analysis model of target femur, analyze, under the different operating modes specified, load and the contact definition specified, constraints, the elastic modelling quantity Gradient distribution rule drawing target femur by described finite element analysis model；
4) require to draw inner fixing device A in mechanical drawing software according to operation, for the assembly relation between fracture site and the inner fixing device A of target femur, the elastic modelling quantity Gradient distribution rule of combining target femur, takes interpolation method to obtain the elastic modelling quantity of inner fixing device A.
In the present embodiment, step 2) in when utilizing medical image to control the material properties that system gives target femur, the calculating function expression of the elastic modelling quantity of target femur is as the formula (1)；
E-Modulus=-388.8+5925*Density(1)
In formula (1), E-Modulus is elastic modelling quantity, and Density is density, and the calculating function expression of density D ensity is as the formula (2)；
Density=-13.4+1017*Hu(2)
In formula (2), Density is density, and Hu is the gray value of CT scan.
In the present embodiment, step 2) in when utilizing medical image to control the material properties that system gives target femur, the value of the Poisson's ratio of target femur is 0.3.
In the present embodiment target femur appearance material attribute as it is shown on figure 3, section material properties view as shown in Figure 4, the material properties of final calculated target femur is as shown in Figure 5.Referring to Fig. 5, when giving the material properties of target femur in the present embodiment, different material properties represents with different colors, left side is the color of hexadecimal representation, the Density on right side is density, and E-Modulus is elastic modelling quantity, and PoissonCoefficient is Poisson's ratio.
In the present embodiment, when requiring drafting inner fixing device A in mechanical drawing software according to operation, operation requires to specifically refer to the inner fixing device that doctor determines according to skeleton dissection geometric properties, the solid requirement of operation and country pharmaceuticals industry standard YY0017-2008, YY0017-2008.In the present embodiment, inner fixing device A is the outer inner fixing device of marrow, including steel plate and screw.In the present embodiment, as shown in Figure 6, further according to the position of Fracture of femur, screw selects os integumentale screw and two kinds of screws of cancellous bone screw to the structure of steel plate；Certainly, the present embodiment method can equally be well applied to inner fixing device in marrow, the present embodiment personalization distal femur synthetism inner fixing device elastic modelling quantity defining method is in that to determine the elastic modelling quantity Gradient distribution rule of inner fixing device, it there is no restrictive relation with the concrete structure of interior inner fixing device, does not repeat them here.
In order to verify the accuracy of the present embodiment personalization femur synthetism inner fixing device material properties defining method, the present embodiment adopts analog simulation operation to be verified.First, in medical image control system, steel plate and the screw of target three-dimensional femoral model and inner fixing device A that fracture occurs are carried out assembling and carry out analog simulation internal fixation operation, obtain result as shown in Figure 7 and Figure 8；Then, simulate in finite element analysis software in different operating modes, load and specifically contact under definition, constraints, obtaining the stress distribution cloud atlas of bone-steel plate-screw as shown in Figure 9.Finally, it is possible to checking analysis draws, if the material properties of internal fixation steel plate and screw meets the difference requirements of corresponding femur elastic modelling quantity Gradient distribution, then can solve the problem that interior fixation implant and human femur under loading not docile, the unmatched technical barrier of elastic modelling quantity.
Determining on the basis of elastic modelling quantity of inner fixing device A, obtain the elastic modelling quantity first determining inner fixing device B, C, D respectively with further reference to preceding method.Then, be respectively directed to identical operating mode, load and specifically contact definition, constraints carries out finite element analysis comparator biomechanics matching degree, it is determined that the inner fixing device that biomechanics coupling is best.In the present embodiment, the inner fixing device of the biomechanics coupling the best finally determined is inner fixing device A.
In addition it is also possible to the metal sintering technology applied in the present embodiment personalization femur synthetism inner fixing device material properties defining method and 3D printing technique realizes the preparation of inner fixing device A, step includes:
S1) aforementioned the present embodiment personalization bones of limbs synthetism inner fixing device elastic modelling quantity defining method is adopted to determine the elastic modelling quantity of inner fixing device A；
S2) preparation of metal sintering technology is adopted to meet the inner fixing device A of elastic modelling quantity requirement.The inner fixing device A obtained the not only external femur that meets dissects geometric properties, good with femoral surface sticking nature, and inherence meets skeleton material properties, namely elastic modelling quantity matches, biomechanical property is good, it is thus possible to realize the personalization of steel plate, fast custom, meet the rapid customization requirement of clinical operation.
It should be noted that, the present embodiment is only for femur, the exemplary illustration that personalization bones of limbs synthetism inner fixing device elastic modelling quantity defining method of the present invention is carried out, certainly, personalization bones of limbs synthetism inner fixing device elastic modelling quantity defining method of the present invention be can equally be well applied to other kinds of bones of limbs, do not repeat them here.
The above is only the preferred embodiment of the present invention, and protection scope of the present invention is not limited merely to above-described embodiment, and all technical schemes belonged under thinking of the present invention belong to protection scope of the present invention.It should be pointed out that, for those skilled in the art, some improvements and modifications without departing from the principles of the present invention, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (4)
1. a personalized bones of limbs synthetism inner fixing device elastic modelling quantity defining method, it is characterised in that step includes:
1) carry out CT scan for the target bones of limbs that fracture occurs, CT scan data utilizes medical image control the threedimensional model of system reconstructing target bones of limbs；
2) utilizing medical image to control system and give the material properties of target bones of limbs, described material properties includes elastic modelling quantity and distribution, the Poisson's ratio of target bones of limbs；
3) set up the finite element analysis model of target bones of limbs, analyze, under the different operating modes specified, load and the contact definition specified, constraints, the elastic modelling quantity Gradient distribution rule drawing target bones of limbs by described finite element analysis model；
4) require to draw inner fixing device in mechanical drawing software according to operation, for the assembly relation between fracture site and the inner fixing device of target bones of limbs, the elastic modelling quantity Gradient distribution rule of combining target bones of limbs, takes interpolation method to obtain the elastic modelling quantity of inner fixing device.
2. personalized bones of limbs synthetism inner fixing device elastic modelling quantity defining method according to claim 1, it is characterized in that, described step 2) in utilize medical image control system give target bones of limbs material properties time, the calculating function expression of the elastic modelling quantity of target bones of limbs is as the formula (1)；
E-Modulus=-388.8+5925*Density(1)
In formula (1), E-Modulus is elastic modelling quantity, and Density is density, and the calculating function expression of density D ensity is as the formula (2)；
Density=-13.4+1017*Hu(2)
In formula (2), Density is density, and Hu is the gray value of CT scan.
3. personalized bones of limbs synthetism inner fixing device elastic modelling quantity defining method according to claim 2, it is characterized in that, described step 2) in utilize medical image control system give target bones of limbs material properties time, the value of the Poisson's ratio of target bones of limbs is 0.3.
4. the preparation method of a personalized bones of limbs synthetism inner fixing device, it is characterised in that step includes:
S1) personalized bones of limbs synthetism inner fixing device elastic modelling quantity defining method described in any one in claims 1 to 3 is adopted to determine the elastic modelling quantity of inner fixing device；
S2) preparation of metal sintering technology is adopted to meet the inner fixing device of elastic modelling quantity requirement.
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Cited By (3)
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| CN108103427B (en) * | 2017-11-14 | 2020-07-28 | 广东工业大学 | Laser shock strengthening method and device for β -type medical titanium alloy bone fracture plate for long bone fracture |
| CN114617632A (en) * | 2022-02-17 | 2022-06-14 | 华中科技大学同济医学院附属协和医院 | Construction method of guide plate for reduction and fixation of long bone fracture |
| CN116741387A (en) * | 2023-06-26 | 2023-09-12 | 强联智创（北京）科技有限公司 | Method for simulating intervention consumable material by computer and related product |
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Cited By (3)
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| CN108103427B (en) * | 2017-11-14 | 2020-07-28 | 广东工业大学 | Laser shock strengthening method and device for β -type medical titanium alloy bone fracture plate for long bone fracture |
| CN114617632A (en) * | 2022-02-17 | 2022-06-14 | 华中科技大学同济医学院附属协和医院 | Construction method of guide plate for reduction and fixation of long bone fracture |
| CN116741387A (en) * | 2023-06-26 | 2023-09-12 | 强联智创（北京）科技有限公司 | Method for simulating intervention consumable material by computer and related product |
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Inventor after: Sheng Xiaolong Inventor after: Zhang Chaoyue Inventor after: Wu Wenxin Inventor after: Liu Min Inventor after: Shi Jian Inventor before: Zhang Chaoyue Inventor before: Sheng Xiaolong Inventor before: Wu Wenxin Inventor before: Liu Min Inventor before: Shi Jian |